Details for: Sirt6

Gene ID: 50721

Symbol: Sirt6

Ensembl ID: ENSMUSG00000034748

Description: sirtuin 6

Associated with

  • Dna double-strand break repair
    (R-MMU-5693532)
  • Dna repair
    (R-MMU-73894)
  • Hdr through homologous recombination (hrr) or single strand annealing (ssa)
    (R-MMU-5693567)
  • Homology directed repair
    (R-MMU-5693538)
  • Processing of dna double-strand break ends
    (R-MMU-5693607)
  • Base-excision repair
    (GO:0006284)
  • Cardiac muscle cell differentiation
    (GO:0055007)
  • Chromatin
    (GO:0000785)
  • Chromatin binding
    (GO:0003682)
  • Chromatin dna binding
    (GO:0031490)
  • Chromatin remodeling
    (GO:0006338)
  • Circadian regulation of gene expression
    (GO:0032922)
  • Damaged dna binding
    (GO:0003684)
  • Determination of adult lifespan
    (GO:0008340)
  • Dna damage sensor activity
    (GO:0140612)
  • Dna repair-dependent chromatin remodeling
    (GO:0140861)
  • Double-strand break repair
    (GO:0006302)
  • Glucose homeostasis
    (GO:0042593)
  • Ketone biosynthetic process
    (GO:0042181)
  • Lncrna binding
    (GO:0106222)
  • Nad+-protein-arginine adp-ribosyltransferase activity
    (GO:0106274)
  • Nad+-protein-lysine adp-ribosyltransferase activity
    (GO:0140804)
  • Nad+-protein adp-ribosyltransferase activity
    (GO:1990404)
  • Nad+ binding
    (GO:0070403)
  • Nad-dependent histone deacetylase activity
    (GO:0017136)
  • Nad-dependent histone h3k9 deacetylase activity
    (GO:0046969)
  • Nad-dependent histone h3k18 deacetylase activity
    (GO:0097372)
  • Nad-dependent histone h3k56 deacetylase activity
    (GO:0140765)
  • Nad-dependent protein demyristoylase activity
    (GO:0140773)
  • Nad-dependent protein depalmitoylase activity
    (GO:0140774)
  • Nad-dependent protein lysine deacetylase activity
    (GO:0034979)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of cellular senescence
    (GO:2000773)
  • Negative regulation of d-glucose import
    (GO:0046325)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of gene expression, epigenetic
    (GO:0045814)
  • Negative regulation of gluconeogenesis
    (GO:0045721)
  • Negative regulation of glycolytic process
    (GO:0045820)
  • Negative regulation of protein import into nucleus
    (GO:0042308)
  • Negative regulation of protein localization to chromatin
    (GO:0120186)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of transcription elongation by rna polymerase ii
    (GO:0034244)
  • Nucleosome binding
    (GO:0031491)
  • Nucleotidyltransferase activity
    (GO:0016779)
  • Nucleus
    (GO:0005634)
  • Pericentric heterochromatin formation
    (GO:0031508)
  • Positive regulation of blood vessel branching
    (GO:1905555)
  • Positive regulation of chondrocyte proliferation
    (GO:1902732)
  • Positive regulation of cold-induced thermogenesis
    (GO:0120162)
  • Positive regulation of double-strand break repair
    (GO:2000781)
  • Positive regulation of fat cell differentiation
    (GO:0045600)
  • Positive regulation of fibroblast proliferation
    (GO:0048146)
  • Positive regulation of insulin secretion
    (GO:0032024)
  • Positive regulation of proteasomal ubiquitin-dependent protein catabolic process
    (GO:0032436)
  • Positive regulation of protein export from nucleus
    (GO:0046827)
  • Positive regulation of protein localization to chromatin
    (GO:0120187)
  • Positive regulation of stem cell differentiation
    (GO:2000738)
  • Positive regulation of stem cell population maintenance
    (GO:1902459)
  • Positive regulation of stem cell proliferation
    (GO:2000648)
  • Positive regulation of telomere maintenance
    (GO:0032206)
  • Positive regulation of vascular endothelial cell proliferation
    (GO:1905564)
  • Post-embryonic cardiac muscle cell growth involved in heart morphogenesis
    (GO:0003247)
  • Post-translational protein modification
    (GO:0043687)
  • Protein deacetylation
    (GO:0006476)
  • Protein delipidation
    (GO:0051697)
  • Protein destabilization
    (GO:0031648)
  • Protein homodimerization activity
    (GO:0042803)
  • Protein import into nucleus
    (GO:0006606)
  • Protein localization to site of double-strand break
    (GO:1990166)
  • Protein lysine deacetylase activity
    (GO:0033558)
  • Regulation of circadian rhythm
    (GO:0042752)
  • Regulation of double-strand break repair via homologous recombination
    (GO:0010569)
  • Regulation of lipid catabolic process
    (GO:0050994)
  • Regulation of lipid metabolic process
    (GO:0019216)
  • Regulation of protein localization to plasma membrane
    (GO:1903076)
  • Regulation of protein secretion
    (GO:0050708)
  • Response to uv
    (GO:0009411)
  • Retrotransposon silencing
    (GO:0010526)
  • Subtelomeric heterochromatin formation
    (GO:0031509)
  • Torc2 complex binding
    (GO:1904841)
  • Transcription corepressor activity
    (GO:0003714)
  • Zinc ion binding
    (GO:0008270)

Other Information

Genular Protein ID: 3130242631

Symbol: SIR6_MOUSE

Name: SIR2-like protein 6

UniProtKB Accession Codes:

P59941

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChEBI 45 ChiTaRS 1 DNASU 1 EC 1 EMBL 1 Ensembl 1 ExpressionAtlas 1 GO 77 Gene3D 2 GeneTree 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 20 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15795229

Title: Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase.

PubMed ID: 15795229

DOI: 10.1074/jbc.m413296200

PubMed ID: 16439206

Title: Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.

PubMed ID: 16439206

DOI: 10.1016/j.cell.2005.11.044

PubMed ID: 19220062

Title: Investigating the ADP-ribosyltransferase activity of sirtuins with NAD analogues and 32P-NAD.

PubMed ID: 19220062

DOI: 10.1021/bi802093g

PubMed ID: 19135889

Title: SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span.

PubMed ID: 19135889

DOI: 10.1016/j.cell.2008.10.052

PubMed ID: 19597350

Title: The sirtuin SIRT6 deacetylates H3 K56Ac in vivo to promote genomic stability.

PubMed ID: 19597350

DOI: 10.4161/cc.8.16.9329

PubMed ID: 19151729

Title: Intracellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner.

PubMed ID: 19151729

DOI: 10.1038/nm.1906

PubMed ID: 20141841

Title: The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1alpha.

PubMed ID: 20141841

DOI: 10.1016/j.cell.2009.12.041

PubMed ID: 20816089

Title: Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis.

PubMed ID: 20816089

DOI: 10.1016/j.cmet.2010.06.009

PubMed ID: 20847051

Title: SIRT6 deficiency results in severe hypoglycemia by enhancing both basal and insulin-stimulated glucose uptake in mice.

PubMed ID: 20847051

DOI: 10.1074/jbc.m110.168039

PubMed ID: 21098266

Title: Neural sirtuin 6 (Sirt6) ablation attenuates somatic growth and causes obesity.

PubMed ID: 21098266

DOI: 10.1073/pnas.1016306107

PubMed ID: 21680843

Title: SIRT6 promotes DNA repair under stress by activating PARP1.

PubMed ID: 21680843

DOI: 10.1126/science.1202723

PubMed ID: 23217706

Title: The histone deacetylase SIRT6 is a tumor suppressor that controls cancer metabolism.

PubMed ID: 23217706

DOI: 10.1016/j.cell.2012.10.047

PubMed ID: 22367546

Title: The sirtuin SIRT6 regulates lifespan in male mice.

PubMed ID: 22367546

DOI: 10.1038/nature10815

PubMed ID: 23142079

Title: The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis.

PubMed ID: 23142079

DOI: 10.1016/j.molcel.2012.09.030

PubMed ID: 23974119

Title: FoxO3 transcription factor and Sirt6 deacetylase regulate low density lipoprotein (LDL)-cholesterol homeostasis via control of the proprotein convertase subtilisin/kexin type 9 (Pcsk9) gene expression.

PubMed ID: 23974119

DOI: 10.1074/jbc.m113.481473

PubMed ID: 23911928

Title: SIRT6 recruits SNF2H to DNA break sites, preventing genomic instability through chromatin remodeling.

PubMed ID: 23911928

DOI: 10.1016/j.molcel.2013.06.018

PubMed ID: 23552949

Title: SIRT6 regulates TNF-alpha secretion through hydrolysis of long-chain fatty acyl lysine.

PubMed ID: 23552949

DOI: 10.1038/nature12038

PubMed ID: 25083875

Title: Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism.

PubMed ID: 25083875

DOI: 10.1016/j.cell.2014.06.050

PubMed ID: 25247314

Title: SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age.

PubMed ID: 25247314

DOI: 10.1038/ncomms6011

PubMed ID: 25009184

Title: Tumor suppressor p53 cooperates with SIRT6 to regulate gluconeogenesis by promoting FoxO1 nuclear exclusion.

PubMed ID: 25009184

DOI: 10.1073/pnas.1411026111

PubMed ID: 25915124

Title: The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosine.

PubMed ID: 25915124

DOI: 10.1038/ncb3147

PubMed ID: 27180906

Title: SIRT6 suppresses pancreatic cancer through control of Lin28b.

PubMed ID: 27180906

DOI: 10.1016/j.cell.2016.04.033

PubMed ID: 27322069

Title: Identifying the functional contribution of the defatty-acylase activity of SIRT6.

PubMed ID: 27322069

DOI: 10.1038/nchembio.2106

PubMed ID: 27457971

Title: Insulin secretion impairment in Sirt6 knockout pancreatic beta cells is mediated by suppression of the FoxO1-Pdx1-Glut2 pathway.

PubMed ID: 27457971

DOI: 10.1038/srep30321

PubMed ID: 28355567

Title: SIRT6 is essential for adipocyte differentiation by regulating mitotic clonal expansion.

PubMed ID: 28355567

DOI: 10.1016/j.celrep.2017.03.006

PubMed ID: 28723567

Title: Cold-inducible SIRT6 regulates thermogenesis of brown and beige fat.

PubMed ID: 28723567

DOI: 10.1016/j.celrep.2017.06.069

PubMed ID: 28250020

Title: Fat-Specific Sirt6 Ablation Sensitizes Mice to High-Fat Diet-Induced Obesity and Insulin Resistance by Inhibiting Lipolysis.

PubMed ID: 28250020

DOI: 10.2337/db16-1225

PubMed ID: 28871079

Title: Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling.

PubMed ID: 28871079

DOI: 10.1038/s41467-017-00498-4

PubMed ID: 28448551

Title: Characterization of physiological defects in adult SIRT6-/- mice.

PubMed ID: 28448551

DOI: 10.1371/journal.pone.0176371

PubMed ID: 29474172

Title: Haploinsufficiency of Trp53 dramatically extends the lifespan of Sirt6-deficient mice.

PubMed ID: 29474172

DOI: 10.7554/elife.32127

PubMed ID: 29555651

Title: An inactivating mutation in the histone deacetylase SIRT6 causes human perinatal lethality.

PubMed ID: 29555651

DOI: 10.1101/gad.307330.117

PubMed ID: 29599436

Title: SIRT6 facilitates directional telomere movement upon oxidative damage.

PubMed ID: 29599436

DOI: 10.1038/s41598-018-23602-0

PubMed ID: 30782483

Title: Sirt6 deacetylase activity regulates circadian rhythms via Per2.

PubMed ID: 30782483

DOI: 10.1016/j.bbrc.2019.01.143

PubMed ID: 31002797

Title: SIRT6 is responsible for more efficient DNA double-strand break repair in long-lived species.

PubMed ID: 31002797

DOI: 10.1016/j.cell.2019.03.043

PubMed ID: 30853213

Title: LINE1 derepression in aged wild-type and SIRT6-deficient mice drives inflammation.

PubMed ID: 30853213

DOI: 10.1016/j.cmet.2019.02.014

PubMed ID: 31851938

Title: SIRT6 promotes hepatic beta-oxidation via activation of PPARalpha.

PubMed ID: 31851938

DOI: 10.1016/j.celrep.2019.11.067

PubMed ID: 30530497

Title: Hepatocyte-specific Sirt6 deficiency impairs ketogenesis.

PubMed ID: 30530497

DOI: 10.1074/jbc.ra118.005309

PubMed ID: 31399344

Title: The histone deacetylase SIRT6 restrains transcription elongation via promoter-proximal pausing.

PubMed ID: 31399344

DOI: 10.1016/j.molcel.2019.06.034

PubMed ID: 31442424

Title: Non-canonical mTORC2 signaling regulates brown adipocyte lipid catabolism through SIRT6-FoxO1.

PubMed ID: 31442424

DOI: 10.1016/j.molcel.2019.07.023

PubMed ID: 31216030

Title: SIRT6 promotes transcription of a subset of NRF2 targets by mono-ADP-ribosylating BAF170.

PubMed ID: 31216030

DOI: 10.1093/nar/gkz528

PubMed ID: 32584788

Title: SIRT6 mono-ADP ribosylates KDM2A to locally increase H3K36me2 at DNA damage sites to inhibit transcription and promote repair.

PubMed ID: 32584788

DOI: 10.18632/aging.103567

PubMed ID: 32538779

Title: Synergy between SIRT1 and SIRT6 helps recognize DNA breaks and potentiates the DNA damage response and repair in humans and mice.

PubMed ID: 32538779

DOI: 10.7554/elife.55828

PubMed ID: 34050173

Title: Restoration of energy homeostasis by SIRT6 extends healthy lifespan.

PubMed ID: 34050173

DOI: 10.1038/s41467-021-23545-7

Sequence Information:

  • Length: 334
  • Mass: 36920
  • Checksum: 75FD950B42D68A1A
  • Sequence:
    • MSVNYAAGLS PYADKGKCGL PEIFDPPEEL ERKVWELARL MWQSSSVVFH TGAGISTASG 
IPDFRGPHGV WTMEERGLAP KFDTTFENAR PSKTHMALVQ LERMGFLSFL VSQNVDGLHV 
RSGFPRDKLA ELHGNMFVEE CPKCKTQYVR DTVVGTMGLK ATGRLCTVAK TRGLRACRGE 
LRDTILDWED SLPDRDLMLA DEASRTADLS VTLGTSLQIR PSGNLPLATK RRGGRLVIVN 
LQPTKHDRQA DLRIHGYVDE VMCRLMKHLG LEIPAWDGPC VLDKALPPLP RPVALKAEPP 
VHLNGAVHVS YKSKPNSPIL HRPPKRVKTE AAPS

Genular Protein ID: 2361029289

Symbol: Q3UKP1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3UKP1

Database IDs:

AGR 1 ARBA 5 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 EMBL 2 Ensembl 2 GO 3 Gene3D 2 GeneTree 1 InterPro 4 MGI 2 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PROSITE 2 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SAM 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21750661

Title: Modernizing reference genome assemblies.

PubMed ID: 21750661

Sequence Information:

  • Length: 294
  • Mass: 32443
  • Checksum: 3541FDBBFF16A7FE
  • Sequence:
    • MWQSSSVVFH TGAGISTASG IPDFRGPHGV WTMEERGLAP KFDTTFENAR PSKTHMALVQ 
LERMGFLSFL VSQNVDGLHV RSGFPRDKLA ELHGNMFVEE CPKCKTQYVR DTVVGTMGLK 
ATGRLCTVAK TRGLRACRGE LRDTILDWED SLPDRDLMLA DEASRTADLS VTLGTSLQIR 
PSGNLPLATK RRGGRLVIVN LQPTKHDRQA DLRIHGYVDE VMCRLMKHLG LEIPAWDGPC 
VLDKALPPLP RPVALKAEPP VHLNGAVHVS YKSKPNSPIL HRPPKRVKTE AAPS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.