Details for: Fbxw7

Gene ID: 50754

Symbol: Fbxw7

Ensembl ID: ENSMUSG00000028086

Description: F-box and WD-40 domain protein 7

Associated with

Other Information

Genular Protein ID: 2696640912

Symbol: FBXW7_MOUSE

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11735228

Title: Characterization of a mouse gene (Fbxw6) that encodes a homologue of Caenorhabditis elegans SEL-10.

PubMed ID: 11735228

DOI: 10.1006/geno.2001.6658

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 11425854

Title: Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor.

PubMed ID: 11425854

DOI: 10.1074/jbc.m101343200

PubMed ID: 11461910

Title: The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog.

PubMed ID: 11461910

DOI: 10.1074/jbc.m103992200

PubMed ID: 21953459

Title: The Fbw7 tumor suppressor regulates nuclear factor E2-related factor 1 transcription factor turnover through proteasome-mediated proteolysis.

PubMed ID: 21953459

DOI: 10.1074/jbc.m111.253807

PubMed ID: 22748924

Title: Structure of a glomulin-RBX1-CUL1 complex: inhibition of a RING E3 ligase through masking of its E2-binding surface.

PubMed ID: 22748924

DOI: 10.1016/j.molcel.2012.05.044

PubMed ID: 27238018

Title: Circadian amplitude regulation via FBXW7-targeted REV-ERBalpha degradation.

PubMed ID: 27238018

DOI: 10.1016/j.cell.2016.05.012

PubMed ID: 29149593

Title: NOTCH2 Hajdu-Cheney mutations escape SCFFBW7-dependent proteolysis to promote osteoporosis.

PubMed ID: 29149593

DOI: 10.1016/j.molcel.2017.10.018

Sequence Information:

  • Length: 710
  • Mass: 79848
  • Checksum: 9D56F7E81E6E390B
  • Sequence:
  • MNQELLSVGS KRRRTGGSLR GNASSSQVDE GQMNRVVEED PQQQARHQEE EHTARNGELV 
    GANPRPGDQN DTQQGQVEEN NNRFISVDED SSGNQEEQEE DEEHAGEQEE EEEEEEEEEE 
    MDQESDDFDP SDDSSREDEH THNSNVTNCS SVSDLPAHQL SSPFYTKTTK MKRKLDHGSE 
    VRSFSLGKKP CKVSDYTSTT GLVPCSATPT TFGDLRAANG QGQQRRRITS VQPPTGLQEW 
    LKMFQSWSGP EKLLALDELI DSCEPTQVKH MMQVIEPQFQ RDFISLLPKE LALYVLSFLE 
    PKDLLQAAQT CRYWRILAED NLLWREKCKE EGIDEPLHIK RRKIIKPGFI HSPWKSAYIR 
    QHRIDTNWRR GELKSPKVLK GHDDHVITCL QFCGNRIVSG SDDNTLKVWS AVTGKCLRTL 
    VGHTGGVWSS QMRDNIIISG STDRTLKVWN AETGECIHTL YGHTSTVRCM HLHEKRVVSG 
    SRDATLRVWD IETGQCLHVL MGHVAAVRCV QYDGRRVVSG AYDFMVKVWD PETETCLHTL 
    QGHTNRVYSL QFDGIHVVSG SLDTSIRVWD VETGNCIHTL TGHQSLTSGM ELKDNILVSG 
    NADSTVKIWD IKTGQCLQTL QGPSKHQSAV TCLQFNKNFV ITSSDDGTVK LWDLKTGEFI 
    RNLVTLESGG SGGVVWRIRA SNTKLVCAVG SRNGTEETKL LVLDFDVDMK

Genular Protein ID: 3782452825

Symbol: D3YUA8_MOUSE

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21750661

Title: Modernizing reference genome assemblies.

PubMed ID: 21750661

Sequence Information:

  • Length: 589
  • Mass: 66035
  • Checksum: F1C0A15DC12924F4
  • Sequence:
  • MSKPGKAPVN HGLVPVDLKS AKDPLPHQTV MKIFSISIIA QGLPFCRRRM KRKLDHGSEV 
    RSFSLGKKPC KVSDYTSTTG LVPCSATPTT FGDLRAANGQ GQQRRRITSV QPPTGLQEWL 
    KMFQSWSGPE KLLALDELID SCEPTQVKHM MQVIEPQFQR DFISLLPKEL ALYVLSFLEP 
    KDLLQAAQTC RYWRILAEDN LLWREKCKEE GIDEPLHIKR RKIIKPGFIH SPWKSAYIRQ 
    HRIDTNWRRG ELKSPKVLKG HDDHVITCLQ FCGNRIVSGS DDNTLKVWSA VTGKCLRTLV 
    GHTGGVWSSQ MRDNIIISGS TDRTLKVWNA ETGECIHTLY GHTSTVRCMH LHEKRVVSGS 
    RDATLRVWDI ETGQCLHVLM GHVAAVRCVQ YDGRRVVSGA YDFMVKVWDP ETETCLHTLQ 
    GHTNRVYSLQ FDGIHVVSGS LDTSIRVWDV ETGNCIHTLT GHQSLTSGME LKDNILVSGN 
    ADSTVKIWDI KTGQCLQTLQ GPSKHQSAVT CLQFNKNFVI TSSDDGTVKL WDLKTGEFIR 
    NLVTLESGGS GGVVWRIRAS NTKLVCAVGS RNGTEETKLL VLDFDVDMK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.