Atp8a2 | ENSMUSG00000021983 | NCBI 50769

Details for: Atp8a2

Gene ID: 50769

Symbol: Atp8a2

Ensembl ID: ENSMUSG00000021983

Description: ATPase, aminophospholipid transporter-like, class I, type 8A, member 2

Associated with

Ion channel transport
(R-MMU-983712)
Ion transport by p-type atpases
(R-MMU-936837)
Transport of small molecules
(R-MMU-382551)
Aminophospholipid flippase activity
(GO:0015247)
Aminophospholipid translocation
(GO:0140331)
Atpase-coupled intramembrane lipid transporter activity
(GO:0140326)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Axonogenesis
(GO:0007409)
Cell projection
(GO:0042995)
Detection of light stimulus involved in visual perception
(GO:0050908)
Determination of adult lifespan
(GO:0008340)
Eating behavior
(GO:0042755)
Endosome
(GO:0005768)
Endosome membrane
(GO:0010008)
Golgi apparatus
(GO:0005794)
Golgi membrane
(GO:0000139)
Inner ear morphogenesis
(GO:0042472)
Involuntary skeletal muscle contraction
(GO:0003011)
Magnesium ion binding
(GO:0000287)
Membrane
(GO:0016020)
Neurofilament cytoskeleton organization
(GO:0060052)
Neuromuscular process controlling posture
(GO:0050884)
Neuron development
(GO:0048666)
Neuron projection development
(GO:0031175)
Nucleoplasm
(GO:0005654)
Phosphatidylethanolamine flippase activity
(GO:0090555)
Phosphatidylserine flippase activity
(GO:0140346)
Phosphatidylserine floppase activity
(GO:0090556)
Phospholipid-translocating atpase complex
(GO:1990531)
Phospholipid translocation
(GO:0045332)
Plasma membrane
(GO:0005886)
Positive regulation of multicellular organism growth
(GO:0040018)
Positive regulation of neuron projection development
(GO:0010976)
Positive regulation of phospholipid translocation
(GO:0061092)
Response to auditory stimulus
(GO:0010996)
Retina layer formation
(GO:0010842)
Skin development
(GO:0043588)

Other Information

Proteins

ATPase class I type 8A member 2

Genular Protein ID: 1689094828

Symbol: AT8A2_MOUSE

Name: ATPase class I type 8A member 2

UniProtKB Accession Codes:

P98200 B2RQF2

Database IDs:

Citations:

PubMed ID: 11015572

Title: Differential expression of putative transbilayer amphipath transporters.

PubMed ID: 11015572

DOI: 10.1152/physiolgenomics.1999.1.3.139

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19778899

Title: Localization, purification, and functional reconstitution of the P4-ATPase Atp8a2, a phosphatidylserine flippase in photoreceptor disc membranes.

PubMed ID: 19778899

DOI: 10.1074/jbc.m109.047415

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22641037

Title: P4-ATPase ATP8A2 acts in synergy with CDC50A to enhance neurite outgrowth.

PubMed ID: 22641037

DOI: 10.1016/j.febslet.2012.05.018

PubMed ID: 22912588

Title: Mutations in a P-type ATPase gene cause axonal degeneration.

PubMed ID: 22912588

DOI: 10.1371/journal.pgen.1002853

PubMed ID: 24413176

Title: Phospholipid flippase ATP8A2 is required for normal visual and auditory function and photoreceptor and spiral ganglion cell survival.

PubMed ID: 24413176

DOI: 10.1242/jcs.145052

Sequence Information:

Length: 1148
Mass: 129417
Checksum: A668D6F343CAAAB8
Sequence:

MSRATSVGDQ LEAPARIIYL NQSHLNKFCD NRISTAKYSV LTFLPRFLYE QIRRAANAFF 
LFIALLQQIP DVSPTGRYTT LVPLVIILTI AGIKEIIEDF KRHKADNAVN KKKTIVLRNG 
MWHTIMWKEV AVGDIVKVLN GQYLPADMVL FSSSEPQGMC YVETANLDGE TNLKIRQGLS 
HTTDMQTRDV LMKLSGRIEC EGPNRHLYDF TGNLHLDGKS SVALGPDQIL LRGTQLRNTQ 
WVFGVVVYTG HDSKLMQNST KAPLKRSNVE KVTNVQILVL FGILLVMALV SSVGALFWNG 
SHGGKSWYIK KMDTNSDNFG YNLLTFIILY NNLIPISLLV TLEVVKYTQA LFINWDMDMY 
YIENDTPAMA RTSNLNEELG QVKYLFSDKT GTLTCNIMNF KKCSIAGVTY GHFPELAREQ 
SSDDFCRMTS CTNDSCDFND PRLLKNIEDQ HPTAPCIQEF LTLLAVCHTV VPEKDGDEII 
YQASSPDEAA LVKGAKKLGF VFTGRTPYSV IIEAMGQEQT FGILNVLEFS SDRKRMSVIV 
RLPSGQLRLY CKGADNVIFE RLSKDSKYME ETLCHLEYFA TEGLRTLCVA YADLSENEYE 
EWLKVYQEAS IILKDRAQRL EECYEIIEKN LLLLGATAIE DRLQAGVPET IATLLKAEIK 
IWVLTGDKQE TAINIGYSCR LVSQNMALIL LKEDSLDATR AAITQHCTDL GNLLGKENDV 
ALIIDGHTLK YALSFEVRRS FLDLALSCKA VICCRVSPLQ KSEIVDVVKK RVKAITLAIG 
DGANDVGMIQ TAHVGVGISG NEGMQATNNS DYAIAQFSYL EKLLLVHGAW SYNRVTKCIL 
YCFYKNVVLY IIELWFAFVN GFSGQILFER WCIGLYNVIF TALPPFTLGI FERSCTQESM 
LRFPQLYRIT QNAEGFNTKV FWGHCINALV HSLILFWVPM KALEHDTPVT SGHATDYLFV 
GNIVYTYVVV TVCLKAGLET TAWTKFSHLA VWGSMLIWLV FFGVYSTIWP TIPIAPDMKG 
QATMVLSSAY FWLGLFLVPT ACLIEDVAWR AAKHTCKKTL LEEVQELETK SRVMGKAMLR 
DSNGKRMNER DRLIKRLSRK TPPTLFRTGS IQQCVSHGYA FSQEEHGAVT QEEIVRAYDT 
TKENSRKK

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Atp8a2

Associated with

Other Information

Differential expression of putative transbilayer amphipath transporters. PubMed ID: 11015572

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Localization, purification, and functional reconstitution of the P4-ATPase Atp8a2, a phosphatidylserine flippase in photoreceptor disc membranes. PubMed ID: 19778899

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

P4-ATPase ATP8A2 acts in synergy with CDC50A to enhance neurite outgrowth. PubMed ID: 22641037

Mutations in a P-type ATPase gene cause axonal degeneration. PubMed ID: 22912588

Phospholipid flippase ATP8A2 is required for normal visual and auditory function and photoreceptor and spiral ganglion cell survival. PubMed ID: 24413176