Details for: Fbxl3

Gene ID: 50789

Symbol: Fbxl3

Ensembl ID: ENSMUSG00000022124

Description: F-box and leucine-rich repeat protein 3

Associated with

Other Information

Genular Protein ID: 1111045869

Symbol: FBXL3_MOUSE

Name: F-box/LRR-repeat protein 3

UniProtKB Accession Codes:

Q8C4V4 Q80V32 Q8K1W0 Q9QXW1

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 Ensembl 3 ExpressionAtlas 1 GO 13 Gene3D 2 GeneTree 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 4 SMART 1 SMR 1 STRING 1 SUPFAM 2 TreeFam 1 UCSC 2 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 10531037

Title: A family of mammalian F-box proteins.

PubMed ID: 10531037

DOI: 10.1016/s0960-9822(00)80021-4

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17462724

Title: Circadian mutant Overtime reveals F-box protein FBXL3 regulation of cryptochrome and period gene expression.

PubMed ID: 17462724

DOI: 10.1016/j.cell.2007.04.030

PubMed ID: 17463252

Title: The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period.

PubMed ID: 17463252

DOI: 10.1126/science.1141138

PubMed ID: 18953409

Title: Implication of the F-Box Protein FBXL21 in circadian pacemaker function in mammals.

PubMed ID: 18953409

DOI: 10.1371/journal.pone.0003530

PubMed ID: 23452855

Title: Competing E3 ubiquitin ligases govern circadian periodicity by degradation of CRY in nucleus and cytoplasm.

PubMed ID: 23452855

DOI: 10.1016/j.cell.2013.01.055

PubMed ID: 23452856

Title: FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes.

PubMed ID: 23452856

DOI: 10.1016/j.cell.2013.01.054

PubMed ID: 23616524

Title: Distinct and separable roles for endogenous CRY1 and CRY2 within the circadian molecular clockwork of the suprachiasmatic nucleus, as revealed by the Fbxl3(Afh) mutation.

PubMed ID: 23616524

DOI: 10.1523/jneurosci.4950-12.2013

PubMed ID: 26776516

Title: Distinct roles of HDAC3 in the core circadian negative feedback loop are critical for clock function.

PubMed ID: 26776516

DOI: 10.1016/j.celrep.2015.12.076

PubMed ID: 29937374

Title: Autophagy regulates the liver clock and glucose metabolism by degrading CRY1.

PubMed ID: 29937374

DOI: 10.1016/j.cmet.2018.05.023

PubMed ID: 30500822

Title: JMJD5 links CRY1 function and proteasomal degradation.

PubMed ID: 30500822

DOI: 10.1371/journal.pbio.2006145

Sequence Information:

  • Length: 428
  • Mass: 48682
  • Checksum: 73F2105C89F7F311
  • Sequence:
    • MKRGGRDSDQ DSAEEGTAEK PKRPRTTQER SQPCDWGNLL QDIVLHVFKY LPLLDRAHAS 
QVCRNWNQVF HMPDLWRCFE FELNQPATSY LKATHPELIK QIIKRHSNHL QYVSFKVDSS 
KESAEAACDI LSQLVNCSLK TLGLISTARP SFMDLPKSHF ISALTVVFVN SKSLSSLKID 
DTPVDDPSLK VLVANNSDTL KLLKMSSCPH VSPAGILCVA DQCHGLRELA LNYHLLSDEL 
LLALSSEKHV RLEHLRIDVV SENPGQTHFH TIQKSSWDAF IKHSPKVNLV MYFFLYEEEF 
DPFFRYEIPA THLYFGRSVS KDVLGRVGMT CPRLVELVVC ANGLRPLDEE LIRIAERCKN 
LSAIGLGECE VSCSAFVEFV KMCGGRLSQL SIMEEVLIPD QKYSLEQIHW EVSKHLGRVW 
FPDMMPTW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.