Dmrt1 | ENSMUSG00000024837 | NCBI 50796

Details for: Dmrt1

Gene ID: 50796

Symbol: Dmrt1

Ensembl ID: ENSMUSG00000024837

Description: doublesex and mab-3 related transcription factor 1

Associated with

Cell morphogenesis
(GO:0000902)
Chromatin binding
(GO:0003682)
Cis-regulatory region sequence-specific dna binding
(GO:0000987)
Cytoplasm
(GO:0005737)
Developmental process involved in reproduction
(GO:0003006)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Female germ cell nucleus
(GO:0001674)
Germ cell migration
(GO:0008354)
Identical protein binding
(GO:0042802)
Intracellular signal transduction
(GO:0035556)
Male germ cell proliferation
(GO:0002176)
Male gonad development
(GO:0008584)
Male sex determination
(GO:0030238)
Male sex differentiation
(GO:0046661)
Meiosis i
(GO:0007127)
Metal ion binding
(GO:0046872)
Negative regulation of meiotic nuclear division
(GO:0045835)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Oocyte development
(GO:0048599)
Positive regulation of male gonad development
(GO:2000020)
Positive regulation of meiosis i
(GO:0060903)
Positive regulation of mitotic nuclear division
(GO:0045840)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of nodal signaling pathway
(GO:1900107)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Sertoli cell development
(GO:0060009)
Sertoli cell differentiation
(GO:0060008)
Sex differentiation
(GO:0007548)
Spermatogenesis
(GO:0007283)

Other Information

Proteins

Doublesex- and mab-3-related transcription factor 1

Genular Protein ID: 2200116309

Symbol: DMRT1_MOUSE

Name: Doublesex- and mab-3-related transcription factor 1

UniProtKB Accession Codes:

Q9QZ59 Q19AV2 Q2TDQ9 Q6Y951 Q6Y953 Q9QZ37 Q9QZA4

Database IDs:

Citations:

PubMed ID: 10545231

Title: Expression of Dmrt1 in the genital ridge of mouse and chicken embryos suggests a role in vertebrate sexual development.

PubMed ID: 10545231

DOI: 10.1006/dbio.1999.9461

PubMed ID: 10640721

Title: The expression pattern of a mouse doublesex-related gene is consistent with a role in gonadal differentiation.

PubMed ID: 10640721

DOI: 10.1016/s0925-4773(99)00282-8

PubMed ID: 17141192

Title: Multiple alternative splicing of mouse Dmrt1 during gonadal differentiation.

PubMed ID: 17141192

DOI: 10.1016/j.bbrc.2006.11.066

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10604464

Title: Conservation of a sex-determining gene.

PubMed ID: 10604464

DOI: 10.1038/45130

PubMed ID: 11040213

Title: Dmrt1, a gene related to worm and fly sexual regulators, is required for mammalian testis differentiation.

PubMed ID: 11040213

DOI: 10.1101/gad.834100

PubMed ID: 17540358

Title: Cell type-autonomous and non-autonomous requirements for Dmrt1 in postnatal testis differentiation.

PubMed ID: 17540358

DOI: 10.1016/j.ydbio.2007.04.046

PubMed ID: 20007774

Title: The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency.

PubMed ID: 20007774

DOI: 10.1073/pnas.0905431106

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20616082

Title: Genome-wide analysis of DNA binding and transcriptional regulation by the mammalian Doublesex homolog DMRT1 in the juvenile testis.

PubMed ID: 20616082

DOI: 10.1073/pnas.1006243107

PubMed ID: 20951351

Title: The mammalian doublesex homolog DMRT1 is a transcriptional gatekeeper that controls the mitosis versus meiosis decision in male germ cells.

PubMed ID: 20951351

DOI: 10.1016/j.devcel.2010.09.010

PubMed ID: 21621532

Title: DMRT1 promotes oogenesis by transcriptional activation of Stra8 in the mammalian fetal ovary.

PubMed ID: 21621532

DOI: 10.1016/j.ydbio.2011.05.658

PubMed ID: 21775990

Title: DMRT1 prevents female reprogramming in the postnatal mammalian testis.

PubMed ID: 21775990

DOI: 10.1038/nature10239

Sequence Information:

Length: 374
Mass: 39444
Checksum: B6C4601432007C35
Sequence:

MPNDDTFGKP STPTEVPHAP GAPPQGKAGG YSKAAGAMAG AAGGSGAGGS GGASGSGPSG 
LGSGSKKSPR LPKCARCRNH GYASPLKGHK RFCMWRDCQC KKCSLIAERQ RVMAAQVALR 
RQQAQEEELG ISHPIPLPSA AELLVKRENN ASNPCLMAEN SSSAQPPPAS TPTPAASEGR 
MVIQDIPAVT SRGHMENTSD LVSDPAYYSS FYQPSLFPYY NNLYNYPQYS MALSAESSSG 
EVGNSLGGSP VKNSLRSLPA PYVPAQTGNQ WQMKTSESRH PVSSQYRMHS YYGPPSYLGQ 
SMSQIFTFEE GPSYSEAKAS VFSPPSSQDS GLVSLSSSSP MSNESSKGVL ECESASSEPS 
SYAVNQVLEE DEDE

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Dmrt1

Associated with

Other Information

Expression of Dmrt1 in the genital ridge of mouse and chicken embryos suggests a role in vertebrate sexual development. PubMed ID: 10545231

The expression pattern of a mouse doublesex-related gene is consistent with a role in gonadal differentiation. PubMed ID: 10640721

Multiple alternative splicing of mouse Dmrt1 during gonadal differentiation. PubMed ID: 17141192

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Conservation of a sex-determining gene. PubMed ID: 10604464

Dmrt1, a gene related to worm and fly sexual regulators, is required for mammalian testis differentiation. PubMed ID: 11040213

Cell type-autonomous and non-autonomous requirements for Dmrt1 in postnatal testis differentiation. PubMed ID: 17540358

The DM domain protein DMRT1 is a dose-sensitive regulator of fetal germ cell proliferation and pluripotency. PubMed ID: 20007774

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Genome-wide analysis of DNA binding and transcriptional regulation by the mammalian Doublesex homolog DMRT1 in the juvenile testis. PubMed ID: 20616082

The mammalian doublesex homolog DMRT1 is a transcriptional gatekeeper that controls the mitosis versus meiosis decision in male germ cells. PubMed ID: 20951351

DMRT1 promotes oogenesis by transcriptional activation of Stra8 in the mammalian fetal ovary. PubMed ID: 21621532

DMRT1 prevents female reprogramming in the postnatal mammalian testis. PubMed ID: 21775990