Details for: Spast

Gene ID: 50850

Symbol: Spast

Ensembl ID: ENSMUSG00000024068

Description: spastin

Associated with

Other Information

Genular Protein ID: 1075740923

Symbol: SPAST_MOUSE

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 14621295

Title: Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PubMed ID: 14621295

DOI: 10.1093/dnares/10.4.167

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 10610178

Title: Spastin, a new AAA protein, is altered in the most frequent form of autosomal dominant spastic paraplegia.

PubMed ID: 10610178

DOI: 10.1038/15472

PubMed ID: 15345747

Title: Phosphoproteomic analysis of the developing mouse brain.

PubMed ID: 15345747

DOI: 10.1074/mcp.m400085-mcp200

PubMed ID: 16026783

Title: Spastin subcellular localization is regulated through usage of different translation start sites and active export from the nucleus.

PubMed ID: 16026783

DOI: 10.1016/j.yexcr.2005.06.009

PubMed ID: 17101632

Title: A mutation of spastin is responsible for swellings and impairment of transport in a region of axon characterized by changes in microtubule composition.

PubMed ID: 17101632

DOI: 10.1093/hmg/ddl431

PubMed ID: 18234839

Title: The microtubule-severing proteins spastin and katanin participate differently in the formation of axonal branches.

PubMed ID: 18234839

DOI: 10.1091/mbc.e07-09-0878

PubMed ID: 18495362

Title: Microtubule stabilizing effect of notch activation in primary cortical neurons.

PubMed ID: 18495362

DOI: 10.1016/j.neuroscience.2008.04.025

PubMed ID: 19141076

Title: Pleiotropic effects of spastin on neurite growth depending on expression levels.

PubMed ID: 19141076

DOI: 10.1111/j.1471-4159.2009.05875.x

PubMed ID: 19453301

Title: Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients.

PubMed ID: 19453301

DOI: 10.1111/j.1471-4159.2009.06104.x

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20530212

Title: Tubulin polyglutamylation stimulates spastin-mediated microtubule severing.

PubMed ID: 20530212

DOI: 10.1083/jcb.201001024

PubMed ID: 22773755

Title: Microtubule-targeting drugs rescue axonal swellings in cortical neurons from spastin knockout mice.

PubMed ID: 22773755

DOI: 10.1242/dmm.008946

Sequence Information:

  • Length: 614
  • Mass: 66456
  • Checksum: C0D235031A7E4C8F
  • Sequence:
  • MSSPAGRRKK KGSGGASPAP ARPPPPAAVP APAAGPAPAA GSPPKRNPSS FSSPLVVGFA 
    LLRLLACHLG LLFAWLCQRF SRALMAAKRS SGTAPAPASP SPPEPGPGGE AESVRVFHKQ 
    AFEYISIALR IDEEEKAGQK EQAVEWYKKG IEELEKGIAV IVTGQGEQYE RARRLQAKMM 
    TNLVMAKDRL QLLEKLQPVL QFSKSQTDVY NESTNLTCRN GHLQSESGAV PKRKDPLTHA 
    SNSLPRSKTV LKSGSAGLSG HHRAPSCSGL SMVSGARPGP GPAATTHKGT PKPNRTNKPS 
    TPTTAVRKKK DLKNFRNVDS NLANLIMNEI VDNGTAVKFD DIAGQELAKQ ALQEIVILPS 
    LRPELFTGLR APARGLLLFG PPGNGKTMLA KAVAAESNAT FFNISAASLT SKYVGEGEKL 
    VRALFAVARE LQPSIIFIDE VDSLLCERRE GEHDASRRLK TEFLIEFDGV QSAGDDRVLV 
    MGATNRPQEL DEAVLRRFIK RVYVSLPNEE TRLLLLKNLL CKQGSPLTQK ELAQLARMTD 
    GYSGSDLTAL AKDAALGPIR ELKPEQVKNM SASEMRNIRL SDFTESLKKI KRSVSPQTLE 
    AYIRWNKDFG DTTV

Genular Protein ID: 3449804483

Symbol: A0A286YE25_MOUSE

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15345747

Title: Phosphoproteomic analysis of the developing mouse brain.

PubMed ID: 15345747

DOI: 10.1074/mcp.M400085-MCP200

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21750661

Title: Modernizing reference genome assemblies.

PubMed ID: 21750661

Sequence Information:

  • Length: 613
  • Mass: 66385
  • Checksum: F65DBA0E53A488B8
  • Sequence:
  • MSSPAGRRKK KGSGGASPAP ARPPPPAAVP APAAGPAPAA GSPPKRNPSS FSSPLVVGFA 
    LLRLLACHLG LLFAWLCQRF SRALMAAKRS SGTAPAPASP SPPEPGPGGE AESVRVFHKQ 
    AFEYISIALR IDEEEKGQKE QAVEWYKKGI EELEKGIAVI VTGQGEQYER ARRLQAKMMT 
    NLVMAKDRLQ LLEKLQPVLQ FSKSQTDVYN ESTNLTCRNG HLQSESGAVP KRKDPLTHAS 
    NSLPRSKTVL KSGSAGLSGH HRAPSCSGLS MVSGARPGPG PAATTHKGTP KPNRTNKPST 
    PTTAVRKKKD LKNFRNVDSN LANLIMNEIV DNGTAVKFDD IAGQELAKQA LQEIVILPSL 
    RPELFTGLRA PARGLLLFGP PGNGKTMLAK AVAAESNATF FNISAASLTS KYVGEGEKLV 
    RALFAVAREL QPSIIFIDEV DSLLCERREG EHDASRRLKT EFLIEFDGVQ SAGDDRVLVM 
    GATNRPQELD EAVLRRFIKR VYVSLPNEET RLLLLKNLLC KQGSPLTQKE LAQLARMTDG 
    YSGSDLTALA KDAALGPIRE LKPEQVKNMS ASEMRNIRLS DFTESLKKIK RSVSPQTLEA 
    YIRWNKDFGD TTV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.