Details for: Keap1
Associated with
Other Information
Genular Protein ID: 2446926196
Symbol: KEAP1_MOUSE
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 9887101
Title: Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain.
PubMed ID: 9887101
DOI: 10.1101/gad.13.1.76
PubMed ID: 14621295
Title: Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
PubMed ID: 14621295
PubMed ID: 16141072
Title: The transcriptional landscape of the mammalian genome.
PubMed ID: 16141072
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 12193649
Title: Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants.
PubMed ID: 12193649
PubMed ID: 12682069
Title: Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression.
PubMed ID: 12682069
PubMed ID: 14517554
Title: Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation.
PubMed ID: 14517554
DOI: 10.1038/ng1248
PubMed ID: 15379550
Title: Fetal Alz-50 clone 1 interacts with the human orthologue of the Kelch-like Ech-associated protein.
PubMed ID: 15379550
DOI: 10.1021/bi0494166
PubMed ID: 15282312
Title: Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2.
PubMed ID: 15282312
PubMed ID: 15367669
Title: The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase.
PubMed ID: 15367669
PubMed ID: 14764894
Title: Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers.
PubMed ID: 14764894
PubMed ID: 15581590
Title: Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome.
PubMed ID: 15581590
PubMed ID: 16790436
Title: Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a 'tethering' mechanism: a two-site interaction model for the Nrf2-Keap1 complex.
PubMed ID: 16790436
PubMed ID: 16581765
Title: Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model.
PubMed ID: 16581765
PubMed ID: 17903176
Title: Subcellular localization and cytoplasmic complex status of endogenous Keap1.
PubMed ID: 17903176
PubMed ID: 17906641
Title: Protein S-guanylation by the biological signal 8-nitroguanosine 3',5'-cyclic monophosphate.
PubMed ID: 17906641
PubMed ID: 18268004
Title: Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity.
PubMed ID: 18268004
DOI: 10.1128/mcb.01704-07
PubMed ID: 20495340
Title: Keap1 facilitates p62-mediated ubiquitin aggregate clearance via autophagy.
PubMed ID: 20495340
PubMed ID: 21183079
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
PubMed ID: 21183079
PubMed ID: 20498371
Title: The critical role of nitric oxide signaling, via protein S-guanylation and nitrated cyclic GMP, in the antioxidant adaptive response.
PubMed ID: 20498371
PubMed ID: 20421418
Title: A noncanonical mechanism of Nrf2 activation by autophagy deficiency: direct interaction between Keap1 and p62.
PubMed ID: 20421418
DOI: 10.1128/mcb.00248-10
PubMed ID: 20956331
Title: Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals.
PubMed ID: 20956331
PubMed ID: 22014577
Title: Renal cyst formation in Fh1-deficient mice is independent of the Hif/Phd pathway: roles for fumarate in KEAP1 succination and Nrf2 signaling.
PubMed ID: 22014577
PubMed ID: 22872865
Title: Keap1 degradation by autophagy for the maintenance of redox homeostasis.
PubMed ID: 22872865
PubMed ID: 26527616
Title: Characterizations of Three Major Cysteine Sensors of Keap1 in Stress Response.
PubMed ID: 26527616
DOI: 10.1128/mcb.00868-15
PubMed ID: 27697860
Title: Absolute Amounts and Status of the Nrf2-Keap1-Cul3 Complex within Cells.
PubMed ID: 27697860
DOI: 10.1128/mcb.00389-16
PubMed ID: 28380357
Title: Keap1/cullin3 modulates p62/SQSTM1 activity via UBA domain ubiquitination.
PubMed ID: 28380357
PubMed ID: 28842501
Title: Stress-sensing mechanisms and the physiological roles of the Keap1-Nrf2 system during cellular stress.
PubMed ID: 28842501
PubMed ID: 29590092
Title: Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1.
PubMed ID: 29590092
DOI: 10.1038/nature25986
PubMed ID: 16507366
Title: Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer.
PubMed ID: 16507366
PubMed ID: 20173742
Title: The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1.
PubMed ID: 20173742
DOI: 10.1038/ncb2021
PubMed ID: 24011591
Title: Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.
PubMed ID: 24011591
Sequence Information:
- Length: 624
- Mass: 69553
- Checksum: 4645DB0122FB5F54
- Sequence:
MQPEPKLSGA PRSSQFLPLW SKCPEGAGDA VMYASTECKA EVTPSQDGNR TFSYTLEDHT KQAFGVMNEL RLSQQLCDVT LQVKYEDIPA AQFMAHKVVL ASSSPVFKAM FTNGLREQGM EVVSIEGIHP KVMERLIEFA YTASISVGEK CVLHVMNGAV MYQIDSVVRA CSDFLVQQLD PSNAIGIANF AEQIGCTELH QRAREYIYMH FGEVAKQEEF FNLSHCQLAT LISRDDLNVR CESEVFHACI DWVKYDCPQR RFYVQALLRA VRCHALTPRF LQTQLQKCEI LQADARCKDY LVQIFQELTL HKPTQAVPCR APKVGRLIYT AGGYFRQSLS YLEAYNPSNG SWLRLADLQV PRSGLAGCVV GGLLYAVGGR NNSPDGNTDS SALDCYNPMT NQWSPCASMS VPRNRIGVGV IDGHIYAVGG SHGCIHHSSV ERYEPERDEW HLVAPMLTRR IGVGVAVLNR LLYAVGGFDG TNRLNSAECY YPERNEWRMI TPMNTIRSGA GVCVLHNCIY AAGGYDGQDQ LNSVERYDVE TETWTFVAPM RHHRSALGIT VHQGKIYVLG GYDGHTFLDS VECYDPDSDT WSEVTRMTSG RSGVGVAVTM EPCRKQIDQQ NCTC
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.