Details for: Prkn

Gene ID: 50873

Symbol: Prkn

Ensembl ID: ENSMUSG00000023826

Description: parkin RBR E3 ubiquitin protein ligase

Associated with

Other Information

Genular Protein ID: 983042732

Symbol: PRKN_MOUSE

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10818204

Title: Molecular cloning, gene expression, and identification of a splicing variant of the mouse parkin gene.

PubMed ID: 10818204

DOI: 10.1007/s003350010080

PubMed ID: 11122330

Title: Parkin expression in the adult mouse brain.

PubMed ID: 11122330

DOI: 10.1111/j.1460-9568.2000.01314.x

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11675120

Title: Differential expression and tissue distribution of parkin isoforms during mouse development.

PubMed ID: 11675120

DOI: 10.1016/s0165-3806(01)00234-6

PubMed ID: 15105460

Title: S-nitrosylation of parkin regulates ubiquitination and compromises parkin's protective function.

PubMed ID: 15105460

DOI: 10.1126/science.1093891

PubMed ID: 19801972

Title: Transcriptional repression of p53 by parkin and impairment by mutations associated with autosomal recessive juvenile Parkinson's disease.

PubMed ID: 19801972

DOI: 10.1038/ncb1981

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21753002

Title: Parkin interacts with Ambra1 to induce mitophagy.

PubMed ID: 21753002

DOI: 10.1523/jneurosci.1917-11.2011

PubMed ID: 22082830

Title: Parkin interacts with Klokin1 for mitochondrial import and maintenance of membrane potential.

PubMed ID: 22082830

DOI: 10.1093/hmg/ddr530

PubMed ID: 24192653

Title: Mitochondrial contagion induced by Parkin deficiency in Drosophila hearts and its containment by suppressing mitofusin.

PubMed ID: 24192653

DOI: 10.1161/circresaha.114.302734

PubMed ID: 24898855

Title: MUL1 acts in parallel to the PINK1/parkin pathway in regulating mitofusin and compensates for loss of PINK1/parkin.

PubMed ID: 24898855

DOI: 10.7554/elife.01958

PubMed ID: 25474007

Title: Phosphorylation of mitochondrial polyubiquitin by PINK1 promotes Parkin mitochondrial tethering.

PubMed ID: 25474007

DOI: 10.1371/journal.pgen.1004861

PubMed ID: 29311685

Title: Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson's disease-like pathology.

PubMed ID: 29311685

DOI: 10.1038/s41467-017-02593-y

PubMed ID: 32047033

Title: Decision between mitophagy and apoptosis by Parkin via VDAC1 ubiquitination.

PubMed ID: 32047033

DOI: 10.1073/pnas.1909814117

PubMed ID: 12652124

Title: NMR structure of ubiquitin-like domain in PARKIN: gene product of familial Parkinson's disease.

PubMed ID: 12652124

DOI: 10.1023/a:1022254432039

Sequence Information:

  • Length: 464
  • Mass: 51618
  • Checksum: 5574A285A9A1B080
  • Sequence:
  • MIVFVRFNSS YGFPVEVDSD TSILQLKEVV AKRQGVPADQ LRVIFAGKEL PNHLTVQNCD 
    LEQQSIVHIV QRPRRRSHET NASGGDEPQS TSEGSIWESR SLTRVDLSSH TLPVDSVGLA 
    VILDTDSKRD SEAARGPVKP TYNSFFIYCK GPCHKVQPGK LRVQCGTCKQ ATLTLAQGPS 
    CWDDVLIPNR MSGECQSPDC PGTRAEFFFK CGAHPTSDKD TSVALNLITS NRRSIPCIAC 
    TDVRSPVLVF QCNHRHVICL DCFHLYCVTR LNDRQFVHDA QLGYSLPCVA GCPNSLIKEL 
    HHFRILGEEQ YTRYQQYGAE ECVLQMGGVL CPRPGCGAGL LPEQGQRKVT CEGGNGLGCG 
    FVFCRDCKEA YHEGDCDSLL EPSGATSQAY RVDKRAAEQA RWEEASKETI KKTTKPCPRC 
    NVPIEKNGGC MHMKCPQPQC KLEWCWNCGC EWNRACMGDH WFDV

Genular Protein ID: 2345334497

Symbol: A0A3B2W489_MOUSE

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21750661

Title: Modernizing reference genome assemblies.

PubMed ID: 21750661

Sequence Information:

  • Length: 274
  • Mass: 30632
  • Checksum: 6C993E7022E7492A
  • Sequence:
  • MSGECQSPDC PGTRAEFFFK CGAHPTSDKD TSVALNLITS NRRSIPCIAC TDVRSPVLVF 
    QCNHRHVICL DCFHLYCVTR LNDRQFVHDA QLGYSLPCVA GCPNSLIKEL HHFRILGEEQ 
    YTRYQQYGAE ECVLQMGGVL CPRPGCGAGL LPEQGQRKVT CEGGNGLGCG FVFCRDCKEA 
    YHEGDCDSLL EPSGATSQAY RVDKRAAEQA RWEEASKETI KKTTKPCPRC NVPIEKNGGC 
    MHMKCPQPQC KLEWCWNCGC EWNRACMGDH WFDV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.