Chek2 | ENSMUSG00000029521 | NCBI 50883

Details for: Chek2

Gene ID: 50883

Symbol: Chek2

Ensembl ID: ENSMUSG00000029521

Description: checkpoint kinase 2

Associated with

Cell cycle
(R-MMU-1640170)
Cell cycle checkpoints
(R-MMU-69620)
Chk1/chk2(cds1) mediated inactivation of cyclin b:cdk1 complex
(R-MMU-75035)
Dna double-strand break repair
(R-MMU-5693532)
Dna double strand break response
(R-MMU-5693606)
Dna repair
(R-MMU-73894)
G1/s dna damage checkpoints
(R-MMU-69615)
G2/m checkpoints
(R-MMU-69481)
G2/m dna damage checkpoint
(R-MMU-69473)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
P53-dependent g1 dna damage response
(R-MMU-69563)
P53-dependent g1/s dna damage checkpoint
(R-MMU-69580)
P53-independent dna damage response
(R-MMU-69610)
P53-independent g1/s dna damage checkpoint
(R-MMU-69613)
Recruitment and atm-mediated phosphorylation of repair and signaling proteins at dna double strand breaks
(R-MMU-5693565)
Regulation of tp53 activity
(R-MMU-5633007)
Regulation of tp53 activity through methylation
(R-MMU-6804760)
Regulation of tp53 activity through phosphorylation
(R-MMU-6804756)
Regulation of tp53 degradation
(R-MMU-6804757)
Regulation of tp53 expression and degradation
(R-MMU-6806003)
Rna polymerase ii transcription
(R-MMU-73857)
Stabilization of p53
(R-MMU-69541)
Transcriptional regulation by tp53
(R-MMU-3700989)
Ubiquitin mediated degradation of phosphorylated cdc25a
(R-MMU-69601)
Atp binding
(GO:0005524)
Cell division
(GO:0051301)
Cellular response to gamma radiation
(GO:0071480)
Chromatin remodeling
(GO:0006338)
Chromosome, telomeric region
(GO:0000781)
Cytoplasm
(GO:0005737)
Dna damage checkpoint signaling
(GO:0000077)
Dna damage response
(GO:0006974)
Dna damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
(GO:0006978)
Double-strand break repair
(GO:0006302)
G2/m transition of mitotic cell cycle
(GO:0000086)
Golgi apparatus
(GO:0005794)
Histone h2as1 kinase activity
(GO:0044024)
Identical protein binding
(GO:0042802)
Intrinsic apoptotic signaling pathway in response to dna damage
(GO:0008630)
Intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator
(GO:0042771)
Kinase activity
(GO:0016301)
Metal ion binding
(GO:0046872)
Mitotic dna damage checkpoint signaling
(GO:0044773)
Mitotic g2 phase
(GO:0000085)
Mitotic intra-s dna damage checkpoint signaling
(GO:0031573)
Mitotic spindle assembly
(GO:0090307)
Negative regulation of dna damage checkpoint
(GO:2000002)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Peptidyl-serine phosphorylation
(GO:0018105)
Pml body
(GO:0016605)
Positive regulation of anoikis
(GO:2000210)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of protein phosphorylation
(GO:0001934)
Protein autophosphorylation
(GO:0046777)
Protein catabolic process
(GO:0030163)
Protein homodimerization activity
(GO:0042803)
Protein kinase activity
(GO:0004672)
Protein kinase binding
(GO:0019901)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Protein stabilization
(GO:0050821)
Regulation of autophagosome assembly
(GO:2000785)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of protein catabolic process
(GO:0042176)
Response to gamma radiation
(GO:0010332)
Signal transduction in response to dna damage
(GO:0042770)
Thymocyte apoptotic process
(GO:0070242)
Ubiquitin protein ligase binding
(GO:0031625)

Other Information

Proteins

CHK2 checkpoint homolog

Genular Protein ID: 1826516849

Symbol: CHK2_MOUSE

Name: CHK2 checkpoint homolog

UniProtKB Accession Codes:

Q9Z265

Database IDs:

Citations:

PubMed ID: 9836640

Title: Linkage of ATM to cell cycle regulation by the Chk2 protein kinase.

PubMed ID: 9836640

DOI: 10.1126/science.282.5395.1893

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12192050

Title: Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner.

PubMed ID: 12192050

DOI: 10.1128/mcb.22.18.6521-6532.2002

PubMed ID: 25619829

Title: A novel recurrent CHEK2 Y390C mutation identified in high-risk Chinese breast cancer patients impairs its activity and is associated with increased breast cancer risk.

PubMed ID: 25619829

DOI: 10.1038/onc.2014.443

Sequence Information:

Length: 546
Mass: 61088
Checksum: A7949EFB5572CDAA
Sequence:

MKSHHQSHSS TSSKAHDSAS CSQSQGGFSQ PQGTPSQLHE LSQYQGSSSS STGTVPSSSQ 
SSHSSSGTLS SLETVSTQEL CSIPEDQEPE EPGPAPWARL WALQDGFSNL DCVNDNYWFG 
RDKSCEYCFD GPLLRRTDKY RTYSKKHFRI FREMGPKNCY IVYIEDHSGN GTFVNTELIG 
KGKRCPLSNN SEIALSLCRN KVFVFFDLTV DDQSVYPKEL RDEYIMSKTL GSGACGEVKM 
AFERKTCQKV AIKIISKRRF ALGSSREADT APSVETEIEI LKKLNHPCII KIKDVFDAED 
YYIVLELMEG GELFDRVVGN KRLKEATCKL YFYQMLVAVQ YLHENGIIHR DLKPENVLLS 
SQEEDCLIKI TDFGQSKILG ETSLMRTLCG TPTYLAPEVL VSNGTAGYSR AVDCWSLGVI 
LFICLSGYPP FSEHKTQVSL KDQITSGKYN FIPEVWTDVS EEALDLVKKL LVVDPKARLT 
TEEALNHPWL QDEYMKKKFQ DLLVQEKNSV TLPVAPAQTS SQKRPLELEV EGMPSTKRLS 
VCGAVL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Chek2

Associated with

Other Information

Linkage of ATM to cell cycle regulation by the Chk2 protein kinase. PubMed ID: 9836640

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. PubMed ID: 12192050

A novel recurrent CHEK2 Y390C mutation identified in high-risk Chinese breast cancer patients impairs its activity and is associated with increased breast cancer risk. PubMed ID: 25619829

Database document:

PubMed ID: 9836640

PubMed ID: 15489334

PubMed ID: 12192050

PubMed ID: 25619829