Details for: ATP5F1C

Gene ID: 509

Symbol: ATP5F1C

Ensembl ID: ENSG00000165629

Description: ATP synthase F1 subunit gamma

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 5.66
    Marker Score: 3786.5
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 4.72
    Marker Score: 62789.5
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 4.25
    Marker Score: 8969
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 4.11
    Marker Score: 2495
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 3.9
    Marker Score: 2749.5
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.62
    Marker Score: 3227
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 3.55
    Marker Score: 1474.5
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.42
    Marker Score: 1824
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 3.34
    Marker Score: 979
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.24
    Marker Score: 8670
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 3.03
    Marker Score: 12587
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 2.96
    Marker Score: 1649
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 2.89
    Marker Score: 3471
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.86
    Marker Score: 4744
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.86
    Marker Score: 941
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.84
    Marker Score: 98212
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.82
    Marker Score: 2991
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.82
    Marker Score: 10005.5
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.81
    Marker Score: 37052.5
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.8
    Marker Score: 7073
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.8
    Marker Score: 3967
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.73
    Marker Score: 31765
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 2.71
    Marker Score: 2937
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 2.7
    Marker Score: 2040
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 2.7
    Marker Score: 2294
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 2.68
    Marker Score: 1424
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.67
    Marker Score: 8369
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.64
    Marker Score: 2757
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.61
    Marker Score: 10688
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.6
    Marker Score: 16942
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.6
    Marker Score: 2601
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.57
    Marker Score: 20053
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.53
    Marker Score: 6989.5
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.52
    Marker Score: 14946
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.51
    Marker Score: 12066
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 2.51
    Marker Score: 924.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.5
    Marker Score: 140035.5
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.5
    Marker Score: 1318
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.5
    Marker Score: 25323
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.48
    Marker Score: 1559
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 2.48
    Marker Score: 2275
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.46
    Marker Score: 18302.5
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.44
    Marker Score: 2173.5
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.43
    Marker Score: 20983
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.43
    Marker Score: 5073.5
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.42
    Marker Score: 3352
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2.39
    Marker Score: 2824
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.39
    Marker Score: 2681
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.38
    Marker Score: 3671
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2.35
    Marker Score: 2439
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.35
    Marker Score: 2362
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.34
    Marker Score: 2502
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.34
    Marker Score: 6370
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.33
    Marker Score: 14880
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.32
    Marker Score: 1544
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.32
    Marker Score: 1681
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.32
    Marker Score: 22964
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.3
    Marker Score: 9911.5
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.29
    Marker Score: 8476
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.29
    Marker Score: 3236.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.28
    Marker Score: 2311
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.28
    Marker Score: 5358.5
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.27
    Marker Score: 4427
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.27
    Marker Score: 4267
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.27
    Marker Score: 1651.5
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.26
    Marker Score: 3706
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.26
    Marker Score: 539.5
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.25
    Marker Score: 1338
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.25
    Marker Score: 2118
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.25
    Marker Score: 5346
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.25
    Marker Score: 8841
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.25
    Marker Score: 3921
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.25
    Marker Score: 57535.5
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.24
    Marker Score: 1753
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.24
    Marker Score: 1471
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.23
    Marker Score: 1267
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.23
    Marker Score: 1487
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.22
    Marker Score: 22321
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.21
    Marker Score: 1250
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.21
    Marker Score: 3515
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.2
    Marker Score: 2341
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.2
    Marker Score: 2519
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.2
    Marker Score: 3736
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.2
    Marker Score: 1131
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 2.19
    Marker Score: 2115
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.19
    Marker Score: 2361
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.19
    Marker Score: 6483.5
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.18
    Marker Score: 872
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.18
    Marker Score: 2633
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.17
    Marker Score: 2299
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.17
    Marker Score: 24455.5
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 2.16
    Marker Score: 2267
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 2.16
    Marker Score: 1021
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 2.15
    Marker Score: 1467
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 2.15
    Marker Score: 1107.5
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.13
    Marker Score: 1048.5
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 2.13
    Marker Score: 804
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.12
    Marker Score: 4826
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.12
    Marker Score: 1166
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.12
    Marker Score: 679

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Other Information

**Key characteristics:** - ATP synthase F1 subunit gamma is a large protein with a molecular weight of approximately 150 kDa. - It is expressed in a variety of cell types, including skeletal muscle, cardiac muscle, pancreatic acinar cell, myeloid dendritic cell, CD14-low, CD16-positive monocyte, extravillous trophoblast, ventricular cardiac muscle cell, renal intercalated cell, tracheobronchial smooth muscle cell, and kidney loop of Henle thick ascending limb epithelial cell. - It is a highly regulated protein, with its expression being controlled by a variety of factors, including calcium ion concentration, metabolic state, and signaling pathways. **Pathways and functions:** - ATP synthase F1 subunit gamma is involved in the production of ATP from ADP (adenosine diphosphate) and inorganic phosphate (Pi). - It is a key enzyme in the citric acid (tca) cycle, where it catalyzes the transfer of electrons from phosphoglycerate to ADP. - It is also involved in the respiratory electron transport chain, where it catalyzes the transfer of electrons from NADH to oxygen. - It is also involved in the maintenance of mitochondrial function, where it is responsible for the production of ATP for oxidative phosphorylation. **Clinical significance:** - Mutations in ATP synthase F1 subunit gamma have been linked to a number of human diseases, including mitochondrial disorders, heart failure, and stroke. - These diseases are characterized by a decrease in ATP levels, which can lead to a variety of symptoms, including fatigue, weakness, and shortness of breath. - Targeting ATP synthase F1 subunit gamma with drugs is a promising new strategy for the treatment of these diseases.

Genular Protein ID: 1502060751

Symbol: ATPG_HUMAN

Name: F-ATPase gamma subunit

UniProtKB Accession Codes:

P36542 A8KA31 Q5VYP3 Q6I9V2 Q96AS8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 5 EMBL 15 EMDB 12 EPD 1 Ensembl 2 GO 12 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 12 PIR 1 PIRSF 1 PRIDE 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 2 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8227057

Title: Gene structure of human mitochondrial ATP synthase gamma-subunit. Tissue specificity produced by alternative RNA splicing.

PubMed ID: 8227057

DOI: 10.1016/s0021-9258(19)74556-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 298
  • Mass: 32996
  • Checksum: 021A95168FD53E04
  • Sequence:
    • MFSRAGVAGL SAWTLQPQWI QVRNMATLKD ITRRLKSIKN IQKITKSMKM VAAAKYARAE 
RELKPARIYG LGSLALYEKA DIKGPEDKKK HLLIGVSSDR GLCGAIHSSI AKQMKSEVAT 
LTAAGKEVML VGIGDKIRGI LYRTHSDQFL VAFKEVGRKP PTFGDASVIA LELLNSGYEF 
DEGSIIFNKF RSVISYKTEE KPIFSLNTVA SADSMSIYDD IDADVLQNYQ EYNLANIIYY 
SLKESTTSEQ SARMTAMDNA SKNASEMIDK LTLTFNRTRQ AVITKELIEI ISGAAALD

Genular Protein ID: 1104253534

Symbol: B4DL14_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DL14

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 2 GenomeRNAi 1 InterPro 3 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 1 ProteomicsDB 1 RefSeq 1 RuleBase 1 SMR 1 SUPFAM 1

Sequence Information:

  • Length: 250
  • Mass: 27513
  • Checksum: 3C94F2E76AE79E6E
  • Sequence:
    • MKMVAAAKYA RAERELKPAR IYGLGSLALY EKADIKGPED KKKHLLIGVS SDRGLCGAIH 
SSIAKQMKSE VATLTAAGKE VMLVGIGDKI RGILYRTHSD QFLVAFKEVG RKPPTFGDAS 
VIALELLNSG YEFDEGSIIF NKFRSVISYK TEEKPIFSLN TVASADSMSI YDDIDADVLQ 
NYQEYNLANI IYYSLKESTT SEQSARMTAM DNASKNASEM IDKLTLTFNR TRQAVITKEL 
IEIISGAAAL

Genular Protein ID: 2013419811

Symbol: Q8TAS0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8TAS0

Database IDs:

ARBA 8 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 GO 2 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PIRSF 1 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 3 RuleBase 1 SUPFAM 1

Sequence Information:

  • Length: 291
  • Mass: 32247
  • Checksum: 6F6A2693C73BF793
  • Sequence:
    • AGLSAWTLQP QWIQVRNMAT LKDITRRLKS IKNIQKITKS MKMVAAAKYA RAERELKPAR 
IYGLGSLALY EKADIKGPED KKKHLLIGVS SDRGLCGAIH SSIAKQMKSE VATLTAAGKE 
VMLVGIGDKI RGILYRTHSD QFLVAFKEVG RKPPTFGDAS VIALELLNSG YEFDEGSIIF 
NKFRSVISYK TEEKPIFSLN TVASADSMSI YDDIDADVLQ NYQEYNLANI IYYSLKESTT 
SEQSARMTAM DNASKNASEM IDKLTLTFNR TRQAVITKEL IEIISGAAAL D

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.