Details for: ATP5F1C

Gene ID: 509

Symbol: ATP5F1C

Ensembl ID: ENSG00000165629

Description: ATP synthase F1 subunit gamma

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 237.9914
    Cell Significance Index: -98.0400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 217.2952
    Cell Significance Index: -102.5900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 211.2701
    Cell Significance Index: -85.8300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 195.0095
    Cell Significance Index: -100.3100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 153.5568
    Cell Significance Index: -103.0400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 91.3649
    Cell Significance Index: -87.2300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 25.2495
    Cell Significance Index: -67.6400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 20.0654
    Cell Significance Index: -61.6300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.9895
    Cell Significance Index: -26.2400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 4.1191
    Cell Significance Index: 43.7700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.0698
    Cell Significance Index: 80.7200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.8827
    Cell Significance Index: 60.3400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.8786
    Cell Significance Index: 1572.0500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.6729
    Cell Significance Index: 172.4500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.4966
    Cell Significance Index: 406.0400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.4099
    Cell Significance Index: 434.4400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.3997
    Cell Significance Index: 19.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.3677
    Cell Significance Index: 325.1600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.2417
    Cell Significance Index: 275.6400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.1459
    Cell Significance Index: 151.7700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.1067
    Cell Significance Index: 61.8700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.0350
    Cell Significance Index: 94.8800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.0311
    Cell Significance Index: 898.0000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.0237
    Cell Significance Index: 22.0000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.9124
    Cell Significance Index: 225.5300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.8991
    Cell Significance Index: 31.9900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.7343
    Cell Significance Index: 224.0700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.7310
    Cell Significance Index: 15.9400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.6921
    Cell Significance Index: 58.8000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.4022
    Cell Significance Index: 65.9000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.2440
    Cell Significance Index: 26.9500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.2440
    Cell Significance Index: 159.4700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.1775
    Cell Significance Index: 61.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1334
    Cell Significance Index: 58.8800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.0590
    Cell Significance Index: 78.9300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0500
    Cell Significance Index: 210.6200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9548
    Cell Significance Index: 189.4800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8619
    Cell Significance Index: 23.4600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7710
    Cell Significance Index: 22.2200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.6391
    Cell Significance Index: 49.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.5496
    Cell Significance Index: 15.3600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4521
    Cell Significance Index: 162.1700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.4260
    Cell Significance Index: 4.8400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4243
    Cell Significance Index: 26.7400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3781
    Cell Significance Index: 37.4000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.3654
    Cell Significance Index: 4.6800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.2899
    Cell Significance Index: 212.5500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2353
    Cell Significance Index: 44.7800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.2067
    Cell Significance Index: 3.8200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.1258
    Cell Significance Index: 1.5000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1011
    Cell Significance Index: 5.2600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0922
    Cell Significance Index: 4.6600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0692
    Cell Significance Index: 52.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0627
    Cell Significance Index: 118.0800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0491
    Cell Significance Index: 1.3100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0284
    Cell Significance Index: 4.8500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0019
    Cell Significance Index: -3.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0043
    Cell Significance Index: -6.5800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0083
    Cell Significance Index: -0.5100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0101
    Cell Significance Index: -0.3600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0134
    Cell Significance Index: -9.2800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0317
    Cell Significance Index: -0.5300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0391
    Cell Significance Index: -24.8100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0408
    Cell Significance Index: -4.1700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0562
    Cell Significance Index: -25.4900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0563
    Cell Significance Index: -76.5200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1024
    Cell Significance Index: -75.8300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1202
    Cell Significance Index: -9.5200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1539
    Cell Significance Index: -86.8200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1731
    Cell Significance Index: -108.1100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2373
    Cell Significance Index: -68.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2458
    Cell Significance Index: -11.1400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2568
    Cell Significance Index: -29.9300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3093
    Cell Significance Index: -9.9100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3260
    Cell Significance Index: -47.3900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3350
    Cell Significance Index: -38.3900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3522
    Cell Significance Index: -5.2000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4572
    Cell Significance Index: -11.6800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4944
    Cell Significance Index: -104.1300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6717
    Cell Significance Index: -37.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.8888
    Cell Significance Index: -92.5500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.9097
    Cell Significance Index: -37.2700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.9761
    Cell Significance Index: -27.9800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.0356
    Cell Significance Index: -10.7200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.1591
    Cell Significance Index: -31.0100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.1885
    Cell Significance Index: -21.0000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.1916
    Cell Significance Index: -20.4200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.2720
    Cell Significance Index: -19.0600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.3237
    Cell Significance Index: -33.0900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.3735
    Cell Significance Index: -60.7500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.3897
    Cell Significance Index: -18.9600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.4013
    Cell Significance Index: -96.9100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.4140
    Cell Significance Index: -84.8900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.4893
    Cell Significance Index: -12.5100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.5919
    Cell Significance Index: -40.9200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.6541
    Cell Significance Index: -101.4100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.6875
    Cell Significance Index: -63.9000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.7742
    Cell Significance Index: -43.2900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.8656
    Cell Significance Index: -54.9500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.0325
    Cell Significance Index: -74.6100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Mitochondrial localization**: The ATP5F1C gene is specifically localized to the mitochondrial inner membrane, where it interacts with the F1 subunit alpha and beta to form the ATP synthase complex. 2. **Energy metabolism**: The ATP5F1C gene is essential for the production of ATP through chemiosmotic coupling, a process that harnesses the energy generated by the electron transport chain to drive ATP synthesis. 3. **Proton transport**: The F1 subunit gamma of the ATP synthase complex is responsible for the rotation of the stalk subunits, which in turn drives the transport of protons across the mitochondrial inner membrane. 4. **Regulation of ATP production**: The ATP5F1C gene is subject to various regulatory mechanisms, including phosphorylation, which modulates the activity of the ATP synthase complex. **Pathways and Functions:** 1. **Atp biosynthetic process**: The ATP5F1C gene is involved in the production of ATP through chemiosmotic coupling, a process that is essential for energy metabolism in cells. 2. **Atp hydrolysis activity**: The ATP synthase complex, which contains the F1 subunit gamma, hydrolyzes ATP to ADP (adenosine diphosphate) and inorganic phosphate, releasing energy that is then used to drive cellular processes. 3. **Cristae formation**: The ATP5F1C gene is involved in the formation of cristae, the infoldings of the mitochondrial inner membrane that increase the surface area available for ATP synthesis. 4. **Mitochondrial biogenesis**: The ATP5F1C gene is also involved in the regulation of mitochondrial biogenesis, the process by which mitochondria are synthesized and assembled. **Clinical Significance:** 1. **Mitochondrial diseases**: Mutations in the ATP5F1C gene have been associated with various mitochondrial diseases, including Leber's hereditary optic neuropathy (LHON) and Kearns-Sayre syndrome. 2. **Cancer**: The ATP5F1C gene has been implicated in the development and progression of certain cancers, including breast cancer and lung cancer. 3. **Neurodegenerative diseases**: The ATP5F1C gene has also been linked to neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 4. **Cardiovascular disease**: The ATP5F1C gene plays a critical role in the regulation of energy metabolism in cardiac muscle cells, and mutations in the gene have been associated with cardiac arrhythmias and other cardiovascular disorders. In conclusion, the ATP5F1C gene is a crucial regulator of mitochondrial function and energy metabolism, and its dysregulation has been implicated in various diseases, including mitochondrial diseases, cancer, neurodegenerative diseases, and cardiovascular disease. Further research is needed to fully understand the role of the ATP5F1C gene in human health and disease.

Genular Protein ID: 1502060751

Symbol: ATPG_HUMAN

Name: F-ATPase gamma subunit

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8227057

Title: Gene structure of human mitochondrial ATP synthase gamma-subunit. Tissue specificity produced by alternative RNA splicing.

PubMed ID: 8227057

DOI: 10.1016/s0021-9258(19)74556-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 298
  • Mass: 32996
  • Checksum: 021A95168FD53E04
  • Sequence:
  • MFSRAGVAGL SAWTLQPQWI QVRNMATLKD ITRRLKSIKN IQKITKSMKM VAAAKYARAE 
    RELKPARIYG LGSLALYEKA DIKGPEDKKK HLLIGVSSDR GLCGAIHSSI AKQMKSEVAT 
    LTAAGKEVML VGIGDKIRGI LYRTHSDQFL VAFKEVGRKP PTFGDASVIA LELLNSGYEF 
    DEGSIIFNKF RSVISYKTEE KPIFSLNTVA SADSMSIYDD IDADVLQNYQ EYNLANIIYY 
    SLKESTTSEQ SARMTAMDNA SKNASEMIDK LTLTFNRTRQ AVITKELIEI ISGAAALD

Genular Protein ID: 2013419811

Symbol: Q8TAS0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 291
  • Mass: 32247
  • Checksum: 6F6A2693C73BF793
  • Sequence:
  • AGLSAWTLQP QWIQVRNMAT LKDITRRLKS IKNIQKITKS MKMVAAAKYA RAERELKPAR 
    IYGLGSLALY EKADIKGPED KKKHLLIGVS SDRGLCGAIH SSIAKQMKSE VATLTAAGKE 
    VMLVGIGDKI RGILYRTHSD QFLVAFKEVG RKPPTFGDAS VIALELLNSG YEFDEGSIIF 
    NKFRSVISYK TEEKPIFSLN TVASADSMSI YDDIDADVLQ NYQEYNLANI IYYSLKESTT 
    SEQSARMTAM DNASKNASEM IDKLTLTFNR TRQAVITKEL IEIISGAAAL D

Genular Protein ID: 1104253534

Symbol: B4DL14_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 250
  • Mass: 27513
  • Checksum: 3C94F2E76AE79E6E
  • Sequence:
  • MKMVAAAKYA RAERELKPAR IYGLGSLALY EKADIKGPED KKKHLLIGVS SDRGLCGAIH 
    SSIAKQMKSE VATLTAAGKE VMLVGIGDKI RGILYRTHSD QFLVAFKEVG RKPPTFGDAS 
    VIALELLNSG YEFDEGSIIF NKFRSVISYK TEEKPIFSLN TVASADSMSI YDDIDADVLQ 
    NYQEYNLANI IYYSLKESTT SEQSARMTAM DNASKNASEM IDKLTLTFNR TRQAVITKEL 
    IEIISGAAAL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.