Details for: ATP5F1C

Gene ID: 509

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: ATP5F1C

Ensembl ID: ENSG00000165629

Description: ATP synthase F1 subunit gamma

Cell Significance Landscape

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • hematopoietic stem cell CL0000037
    CSI 111.73
    rCSI 74.26%
    PRS 11.29
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 88.18
    rCSI 79.63%
    PRS 8.35
  • stem cell CL0000034
    CSI 84.71
    rCSI 81.68%
    PRS 6.24
  • colon epithelial cell CL0011108
    CSI 82.21
    rCSI 86.12%
    PRS 8.78
  • common myeloid progenitor CL0000049
    CSI 80.58
    rCSI 65.15%
    PRS 9.33
  • intestinal epithelial cell CL0002563
    CSI 78.2
    rCSI 81.73%
    PRS 9.97
  • fallopian tube secretory epithelial cell CL4030006
    CSI 76.88
    rCSI 74.01%
    PRS 9.76
  • early lymphoid progenitor CL0000936
    CSI 75.59
    rCSI 66.39%
    PRS 10.62
  • plasmablast CL0000980
    CSI 73.51
    rCSI 57.83%
    PRS 11.23
  • granulocyte monocyte progenitor cell CL0000557
    CSI 72.33
    rCSI 62.62%
    PRS 10.53
  • keratinocyte CL0000312
    CSI 71.56
    rCSI 59.99%
    PRS 11.3
  • transit amplifying cell of colon CL0009011
    CSI 71.25
    rCSI 83.69%
    PRS 11.24
  • M cell of gut CL0000682
    CSI 71.13
    rCSI 75.58%
    PRS 16.87
  • fraction A pre-pro B cell CL0002045
    CSI 64.48
    rCSI 73.82%
    PRS 19.51
  • neural crest cell CL0011012
    CSI 63.64
    rCSI 50.3%
    PRS 6.5
  • intestine goblet cell CL0019031
    CSI 59.53
    rCSI 52.85%
    PRS 9.45
  • common dendritic progenitor CL0001029
    CSI 58.52
    rCSI 73.45%
    PRS 12.06
  • extravillous trophoblast CL0008036
    CSI 55.41
    rCSI 68.55%
    PRS 8.28
  • pro-B cell CL0000826
    CSI 55.32
    rCSI 45.81%
    PRS 9.46
  • ciliated epithelial cell CL0000067
    CSI 54.54
    rCSI 47.96%
    PRS 6.84
  • enterocyte CL0000584
    CSI 50.02
    rCSI 80.65%
    PRS 15.13
  • peripheral nervous system neuron CL2000032
    CSI 49.25
    rCSI 67.11%
    PRS 8.48
  • epithelial cell of lung CL0000082
    CSI 48.96
    rCSI 40.59%
    PRS 8.96
  • placental villous trophoblast CL2000060
    CSI 48.28
    rCSI 74.61%
    PRS 8.84
  • pancreatic A cell CL0000171
    CSI 47.48
    rCSI 49.74%
    PRS 10.06
  • enteric smooth muscle cell CL0002504
    CSI 43.22
    rCSI 61.68%
    PRS 10.68
  • pancreatic acinar cell CL0002064
    CSI 41.54
    rCSI 55.22%
    PRS 10.29
  • mucous neck cell CL0000651
    CSI 40.35
    rCSI 58.16%
    PRS 15.25
  • transit amplifying cell CL0009010
    CSI 39.36
    rCSI 60.2%
    PRS 15.36
  • colonocyte CL1000347
    CSI 37.76
    rCSI 54.13%
    PRS 12.94
  • pancreatic ductal cell CL0002079
    CSI 37.4
    rCSI 72.74%
    PRS 9.63
  • goblet cell CL0000160
    CSI 37.36
    rCSI 35.3%
    PRS 9.86
  • promyelocyte CL0000836
    CSI 37.09
    rCSI 53.49%
    PRS 13.22
  • progenitor cell CL0011026
    CSI 34.71
    rCSI 73.82%
    PRS 17.2
  • promonocyte CL0000559
    CSI 34.58
    rCSI 59.24%
    PRS 12.69
  • intrahepatic cholangiocyte CL0002538
    CSI 34.13
    rCSI 81.91%
    PRS 17.5
  • common lymphoid progenitor CL0000051
    CSI 33.62
    rCSI 44.92%
    PRS 18.07
  • plasmacytoid dendritic cell, human CL0001058
    CSI 31.47
    rCSI 21.97%
    PRS 9.95
  • pancreatic D cell CL0000173
    CSI 31.21
    rCSI 30.7%
    PRS 10.26
  • colon goblet cell CL0009039
    CSI 31.18
    rCSI 74.13%
    PRS 14.18
  • respiratory suprabasal cell CL4033048
    CSI 30.64
    rCSI 39.3%
    PRS 10.89
  • foveolar cell of stomach CL0002179
    CSI 30.28
    rCSI 64.46%
    PRS 15.26
  • enteroendocrine cell CL0000164
    CSI 30.16
    rCSI 41.2%
    PRS 10.43
  • myeloid leukocyte CL0000766
    CSI 27.55
    rCSI 25.42%
    PRS 9.62
  • T-helper 17 cell CL0000899
    CSI 27.01
    rCSI 21.45%
    PRS 16.62
  • double-positive, alpha-beta thymocyte CL0000809
    CSI 26.98
    rCSI 27.5%
    PRS 13.48
  • microcirculation associated smooth muscle cell CL0008035
    CSI 26.37
    rCSI 76.35%
    PRS 10.71
  • epithelial cell CL0000066
    CSI 26.22
    rCSI 40.29%
    PRS 13.56
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 25.95
    rCSI 69.95%
    PRS 12.18
  • conventional dendritic cell CL0000990
    CSI 25.38
    rCSI 21.19%
    PRS 28.93
  • double negative thymocyte CL0002489
    CSI 25.08
    rCSI 17.44%
    PRS 11.06
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 24.83
    rCSI 19.13%
    PRS 8.53
  • large pre-B-II cell CL0000957
    CSI 24.27
    rCSI 69.29%
    PRS 16.62
  • ionocyte CL0005006
    CSI 22.08
    rCSI 23.67%
    PRS 8.69
  • kidney epithelial cell CL0002518
    CSI 21.89
    rCSI 41.78%
    PRS 22.66
  • glandular epithelial cell CL0000150
    CSI 21.67
    rCSI 57.06%
    PRS 18.52
  • type B pancreatic cell CL0000169
    CSI 20.94
    rCSI 46.35%
    PRS 8.76
  • renal alpha-intercalated cell CL0005011
    CSI 20.88
    rCSI 27.91%
    PRS 12.58
  • tracheal goblet cell CL1000329
    CSI 20.41
    rCSI 44.55%
    PRS 19.18
  • pulmonary ionocyte CL0017000
    CSI 20.33
    rCSI 24.74%
    PRS 11.92
  • epithelial cell of proximal tubule CL0002306
    CSI 17.7
    rCSI 43.22%
    PRS 9.53
  • hematopoietic multipotent progenitor cell CL0000837
    CSI 17.15
    rCSI 41.26%
    PRS 15.06
  • mesodermal cell CL0000222
    CSI 17.09
    rCSI 20.51%
    PRS 9.38
  • forebrain radial glial cell CL0013000
    CSI 17.02
    rCSI 54.6%
    PRS 14.01
  • transit amplifying cell of small intestine CL0009012
    CSI 17
    rCSI 74.61%
    PRS 17.65
  • granulocyte CL0000094
    CSI 16.99
    rCSI 25.95%
    PRS 11.93
  • VIP GABAergic cortical interneuron CL4023016
    CSI 16.95
    rCSI 20.25%
    PRS 5.5
  • duct epithelial cell CL0000068
    CSI 16.73
    rCSI 24.48%
    PRS 9.99
  • muscle cell CL0000187
    CSI 16.1
    rCSI 33.06%
    PRS 22.49
  • BEST4+ enteroycte CL4030026
    CSI 15.96
    rCSI 19.85%
    PRS 10.02
  • cerebral cortex GABAergic interneuron CL0010011
    CSI 15.48
    rCSI 45.69%
    PRS 11.81
  • lymphoid lineage restricted progenitor cell CL0000838
    CSI 15.45
    rCSI 60.16%
    PRS 15.59
  • melanocyte CL0000148
    CSI 15.28
    rCSI 11.31%
    PRS 8.53
  • acinar cell CL0000622
    CSI 15.18
    rCSI 22.26%
    PRS 12.45
  • elicited macrophage CL0000861
    CSI 15.11
    rCSI 13.87%
    PRS 10.8
  • ON-bipolar cell CL0000749
    CSI 14.96
    rCSI 22.24%
    PRS 11.69
  • Langerhans cell CL0000453
    CSI 14.84
    rCSI 22.66%
    PRS 16.52
  • Hofbauer cell CL3000001
    CSI 14.75
    rCSI 27.85%
    PRS 11.7
  • secretory cell CL0000151
    CSI 14.69
    rCSI 15.32%
    PRS 9.69
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 14.61
    rCSI 18.74%
    PRS 9.22
  • endothelial cell of placenta CL0009092
    CSI 14.57
    rCSI 71.83%
    PRS 12.84
  • respiratory hillock cell CL4030023
    CSI 14.2
    rCSI 25.32%
    PRS 16.12
  • primitive red blood cell CL0002355
    CSI 13.67
    rCSI 73.78%
    PRS 17.95
  • neuroblast (sensu Nematoda and Protostomia) CL0000338
    CSI 13.57
    rCSI 15.67%
    PRS 8.38
  • CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell CL0000915
    CSI 13.49
    rCSI 61.31%
    PRS 34.35
  • conjunctival epithelial cell CL1000432
    CSI 13.42
    rCSI 20.5%
    PRS 9.45
  • ventricular cardiac muscle cell CL2000046
    CSI 13.06
    rCSI 44.73%
    PRS 38.91
  • hepatocyte CL0000182
    CSI 13
    rCSI 23.27%
    PRS 8.86
  • group 3 innate lymphoid cell CL0001071
    CSI 12.9
    rCSI 9.69%
    PRS 9.77
  • activated type II NK T cell CL0000931
    CSI 12.66
    rCSI 14.24%
    PRS 15.23
  • stromal cell of ovary CL0002132
    CSI 12.63
    rCSI 34.71%
    PRS 15.7
  • pancreatic PP cell CL0002275
    CSI 12.51
    rCSI 49.81%
    PRS 16.66
  • mammary gland epithelial cell CL0002327
    CSI 12.51
    rCSI 43.9%
    PRS 17.14
  • bronchial goblet cell CL1000312
    CSI 12.46
    rCSI 49.79%
    PRS 20.92
  • T follicular helper cell CL0002038
    CSI 12.31
    rCSI 9.21%
    PRS 15.41
  • late pro-B cell CL0002048
    CSI 12.29
    rCSI 30.8%
    PRS 29.29
  • myeloid lineage restricted progenitor cell CL0000839
    CSI 12.11
    rCSI 62.52%
    PRS 18.9
  • hematopoietic precursor cell CL0008001
    CSI 12.05
    rCSI 12.4%
    PRS 15.4
  • pancreatic stellate cell CL0002410
    CSI 11.97
    rCSI 69.65%
    PRS 14.23
  • intestinal crypt stem cell of colon CL0009043
    CSI 11.87
    rCSI 89.16%
    PRS 17.5
  • retinal bipolar neuron CL0000748
    CSI -14.4
    rCSI -27.0%
    PRS 7.0%
  • sncg GABAergic cortical interneuron CL4023015
    CSI -11.3
    rCSI -18.2%
    PRS 6.2%
  • Schwann cell CL0002573
    CSI -6.2
    rCSI -17.7%
    PRS 11.7%
  • L6b glutamatergic cortical neuron CL4023038
    CSI -5.6
    rCSI -17.4%
    PRS 6.0%
  • fibroblast of cardiac tissue CL0002548
    CSI -4.7
    rCSI -22.7%
    PRS 6.0%
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI -4.7
    rCSI -7.9%
    PRS 5.6%
  • squamous epithelial cell CL0000076
    CSI -4.7
    rCSI -11.1%
    PRS 12.2%
  • endothelial cell of periportal hepatic sinusoid CL0019021
    CSI -4.5
    rCSI -20.8%
    PRS 29.0%
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI -3.8
    rCSI -4.7%
    PRS 13.2%
  • cardiac neuron CL0010022
    CSI -3.8
    rCSI -12.3%
    PRS 6.8%
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI -3.7
    rCSI -13.9%
    PRS 5.8%
  • alternatively activated macrophage CL0000890
    CSI -3.1
    rCSI -3.9%
    PRS 14.5%
  • brush cell of tracheobronchial tree CL0002075
    CSI -2.9
    rCSI -8.6%
    PRS 14.8%
  • brush cell CL0002204
    CSI -2.8
    rCSI -5.6%
    PRS 25.8%
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI -2.8
    rCSI -6.7%
    PRS 5.4%
  • decidual natural killer cell, human CL0002343
    CSI -2.3
    rCSI -23.7%
    PRS 61.8%
  • tracheobronchial smooth muscle cell CL0019019
    CSI -2.2
    rCSI -3.9%
    PRS 12.5%
  • renal interstitial pericyte CL1001318
    CSI -2.0
    rCSI -5.5%
    PRS 9.2%
  • alpha-beta T cell CL0000789
    CSI -1.8
    rCSI -2.1%
    PRS 13.4%
  • lung interstitial macrophage CL4033043
    CSI -1.7
    rCSI -3.9%
    PRS 20.7%
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI -1.6
    rCSI -9.5%
    PRS 5.9%
  • inhibitory interneuron CL0000498
    CSI -1.6
    rCSI -3.7%
    PRS 7.9%
  • effector CD4-positive, alpha-beta T cell CL0001044
    CSI -1.3
    rCSI -3.7%
    PRS 13.7%
  • CD4-positive, alpha-beta thymocyte CL0000810
    CSI -1.2
    rCSI -1.0%
    PRS 17.2%
  • alveolar adventitial fibroblast CL4028006
    CSI -0.9
    rCSI -1.5%
    PRS 9.5%
  • pvalb GABAergic cortical interneuron CL4023018
    CSI -0.9
    rCSI -1.2%
    PRS 5.1%
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI -0.9
    rCSI -2.3%
    PRS 9.3%
  • astrocyte of the cerebral cortex CL0002605
    CSI -0.9
    rCSI -1.9%
    PRS 5.8%
  • effector memory CD8-positive, alpha-beta T cell CL0000913
    CSI -0.5
    rCSI -0.5%
    PRS 14.5%
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI -0.5
    rCSI -1.6%
    PRS 6.5%
  • cytotoxic T cell CL0000910
    CSI 0.1
    rCSI 0.4%
    PRS 14.1%
  • macula densa epithelial cell CL1000850
    CSI 0.1
    rCSI 1.9%
    PRS 57.8%
  • ciliated cell CL0000064
    CSI 0.1
    rCSI 0.2%
    PRS 9.7%
  • luminal cell of prostate epithelium CL0002340
    CSI 0.2
    rCSI 0.8%
    PRS 17.1%
  • parietal epithelial cell CL1000452
    CSI 0.2
    rCSI 0.5%
    PRS 8.6%
  • cord blood hematopoietic stem cell CL2000095
    CSI 0.2
    rCSI 3.8%
    PRS 61.1%
  • CD8-positive, alpha-beta cytotoxic T cell CL0000794
    CSI 0.2
    rCSI 0.3%
    PRS 16.4%
  • OFF midget ganglion cell CL4033047
    CSI 0.2
    rCSI 4.8%
    PRS 8.4%
  • Kupffer cell CL0000091
    CSI 0.3
    rCSI 0.6%
    PRS 9.1%
  • mesenchymal lymphangioblast CL0005021
    CSI 0.3
    rCSI 7.6%
    PRS 46.2%
  • CD8-positive, alpha-beta thymocyte CL0000811
    CSI 0.4
    rCSI 0.5%
    PRS 23.4%
  • endothelial cell of venule CL1000414
    CSI 0.4
    rCSI 3.3%
    PRS 42.3%
  • double negative T regulatory cell CL0011024
    CSI 0.4
    rCSI 7.4%
    PRS 57.2%
  • ON parasol ganglion cell CL4033052
    CSI 0.4
    rCSI 5.6%
    PRS 6.5%
  • mature T cell CL0002419
    CSI 0.4
    rCSI 0.3%
    PRS 13.6%
  • ON midget ganglion cell CL4033046
    CSI 0.4
    rCSI 8.1%
    PRS 7.6%
  • myelocyte CL0002193
    CSI 0.4
    rCSI 2.7%
    PRS 31.1%
  • transitional stage B cell CL0000818
    CSI 0.4
    rCSI 1.4%
    PRS 27.8%
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 0.5
    rCSI 0.8%
    PRS 5.6%
  • follicular dendritic cell CL0000442
    CSI 0.5
    rCSI 7.6%
    PRS 50.9%
  • regular ventricular cardiac myocyte CL0002131
    CSI 0.5
    rCSI 3.1%
    PRS 7.6%
  • neural progenitor cell CL0011020
    CSI 0.6
    rCSI 2.5%
    PRS 9.4%
  • vasa recta descending limb cell CL1001285
    CSI 0.6
    rCSI 5.0%
    PRS 39.6%
  • activated CD4-positive, alpha-beta T cell, human CL0001043
    CSI 0.7
    rCSI 1.6%
    PRS 53.2%
  • helper T cell CL0000912
    CSI 0.7
    rCSI 1.0%
    PRS 13.5%
  • lung pericyte CL0009089
    CSI 0.8
    rCSI 2.0%
    PRS 11.3%
  • mononuclear phagocyte CL0000113
    CSI 0.8
    rCSI 1.7%
    PRS 10.4%
  • class switched memory B cell CL0000972
    CSI 0.8
    rCSI 0.6%
    PRS 15.9%
  • vasa recta ascending limb cell CL1001131
    CSI 0.8
    rCSI 3.6%
    PRS 37.0%
  • retinal ganglion cell CL0000740
    CSI 0.8
    rCSI 1.8%
    PRS 6.8%
  • innate lymphoid cell CL0001065
    CSI 0.9
    rCSI 1.8%
    PRS 14.8%
  • endothelial cell of pericentral hepatic sinusoid CL0019022
    CSI 0.9
    rCSI 2.7%
    PRS 15.8%
  • periportal region hepatocyte CL0019026
    CSI 0.9
    rCSI 3.6%
    PRS 14.0%
  • direct pathway medium spiny neuron CL4023026
    CSI 1.0
    rCSI 22.7%
    PRS 4.2%
  • CD14-positive monocyte CL0001054
    CSI 1.0
    rCSI 1.2%
    PRS 13.5%
  • metallothionein-positive alveolar macrophage CL4033042
    CSI 1.0
    rCSI 10.7%
    PRS 39.4%
  • blood vessel smooth muscle cell CL0019018
    CSI 1.0
    rCSI 8.0%
    PRS 9.9%
  • inflammatory macrophage CL0000863
    CSI 1.0
    rCSI 1.7%
    PRS 19.2%
  • lung microvascular endothelial cell CL2000016
    CSI 1.0
    rCSI 19.2%
    PRS 31.3%
  • basophil CL0000767
    CSI 1.2
    rCSI 2.6%
    PRS 19.8%
  • prostate gland microvascular endothelial cell CL2000059
    CSI 1.2
    rCSI 29.7%
    PRS 33.8%
  • macroglial cell CL0000126
    CSI 1.3
    rCSI 3.3%
    PRS 14.4%
  • chondrocyte CL0000138
    CSI 1.3
    rCSI 2.0%
    PRS 8.2%
  • hepatic stellate cell CL0000632
    CSI 1.3
    rCSI 4.9%
    PRS 8.1%
  • mature alpha-beta T cell CL0000791
    CSI 1.4
    rCSI 5.0%
    PRS 16.2%
  • indirect pathway medium spiny neuron CL4023029
    CSI 1.4
    rCSI 34.4%
    PRS 5.0%
  • effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062
    CSI 1.5
    rCSI 7.4%
    PRS 12.4%
  • natural T-regulatory cell CL0000903
    CSI 1.5
    rCSI 2.8%
    PRS 26.5%
  • epithelial cell of urethra CL1000296
    CSI 1.5
    rCSI 37.8%
    PRS 31.6%
  • lung macrophage CL1001603
    CSI 1.5
    rCSI 3.4%
    PRS 10.7%
  • B-1 B cell CL0000819
    CSI 1.6
    rCSI 41.1%
    PRS 48.0%
  • cardiac muscle cell CL0000746
    CSI 1.6
    rCSI 2.3%
    PRS 7.5%
  • antibody secreting cell CL0000946
    CSI 1.6
    rCSI 7.3%
    PRS 39.3%
  • stromal cell CL0000499
    CSI 1.7
    rCSI 4.7%
    PRS 13.6%
  • lung secretory cell CL1000272
    CSI 1.7
    rCSI 4.2%
    PRS 8.8%
  • IgG plasma cell CL0000985
    CSI 1.7
    rCSI 2.1%
    PRS 16.3%
  • activated CD4-positive, alpha-beta T cell CL0000896
    CSI 1.8
    rCSI 1.7%
    PRS 17.3%
  • rod bipolar cell CL0000751
    CSI 1.9
    rCSI 3.3%
    PRS 7.9%
  • immature B cell CL0000816
    CSI 1.9
    rCSI 1.4%
    PRS 14.1%
  • retinal blood vessel endothelial cell CL0002585
    CSI 1.9
    rCSI 3.1%
    PRS 10.3%
  • glial cell CL0000125
    CSI 1.9
    rCSI 7.3%
    PRS 9.9%
  • intermediate monocyte CL0002393
    CSI 1.9
    rCSI 2.9%
    PRS 9.3%
  • lung endothelial cell CL1001567
    CSI 2.0
    rCSI 4.7%
    PRS 23.2%
  • paneth cell of colon CL0009009
    CSI 2.0
    rCSI 20.1%
    PRS 27.7%
  • CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human CL0001074
    CSI 2.1
    rCSI 24.2%
    PRS 37.3%
  • primordial germ cell CL0000670
    CSI 2.1
    rCSI 10.5%
    PRS 54.3%
  • kidney loop of Henle epithelial cell CL1000909
    CSI 2.1
    rCSI 44.2%
    PRS 60.7%
  • Merkel cell CL0000242
    CSI 2.1
    rCSI 48.8%
    PRS 59.9%
  • neuroplacodal cell CL0000032
    CSI 2.1
    rCSI 19.7%
    PRS 31.0%
  • GABAergic neuron CL0000617
    CSI 2.1
    rCSI 7.1%
    PRS 7.0%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [ATP5F1C](/details-gene/509), or ATP Synthase F1 Subunit Gamma, is a protein-coding gene located on chromosome 10 that encodes a core component of the mitochondrial F-type ATP synthase. This protein is essential for the final step of [oxidative phosphorylation](/details-cell/GO:0006119), where it participates in the synthesis of ATP from ADP in the presence of a proton gradient across the inner mitochondrial membrane. Consistent with its fundamental role in cellular energy production, [ATP5F1C](/details-gene/509) shows significant expression in cells with high metabolic demands. **Overall**, its expression is particularly prominent in highly proliferative populations, including [hematopoietic stem cell](/details-cell/CL0000037)s and other progenitor cells, as well as in rapidly turning over epithelial tissues such as the [colon epithelial cell](/details-cell/CL0011108) and [intestinal epithelial cell](/details-cell/CL0002563), highlighting its critical function in fueling cell division and specialized secretory activities. ## Cellular Roles and Expression Landscape The expression profile of [ATP5F1C](/details-gene/509) underscores its importance in cellular energetics, particularly in contexts of high proliferation and metabolic activity. **Overall**, the gene demonstrates its highest significance in a diverse array of progenitor cells, including [hematopoietic stem cell](/details-cell/CL0000037) (CSI: 111.73), [megakaryocyte-erythroid progenitor cell](/details-cell/CL0000050) (CSI: 88.18), and [common myeloid progenitor](/details-cell/CL0000049) (CSI: 80.58). This suggests that robust ATP production via oxidative phosphorylation is a key feature of stem and progenitor cell biology, likely fueling the processes of self-renewal and differentiation. Beyond progenitor populations, [ATP5F1C](/details-gene/509) is also a key marker in metabolically active epithelial tissues. Its high significance in [colon epithelial cell](/details-cell/CL0011108) (CSI: 82.21), [intestinal epithelial cell](/details-cell/CL0002563) (CSI: 78.20), and [fallopian tube secretory epithelial cell](/details-cell/CL4030006) (CSI: 76.88) is consistent with the energetic requirements for rapid cell turnover, nutrient absorption, and protein secretion in these tissues. Early work has suggested that tissue specificity may be achieved through alternative RNA splicing, which could contribute to these distinct expression patterns ([Link](https://doi.org/10.1016/s0021-9258(19)74556-6)). Conversely, the gene's specificity is defined by its notably low significance in several terminally differentiated, non-proliferative cell types. This is most apparent in various neuronal subtypes, such as [retinal bipolar neuron](/details-cell/CL0000748) (CSI: -14.41) and multiple cortical neurons. Furthermore, low significance in [CD8-positive, alpha-beta memory T cell, CD45RO-positive](/details-cell/CL0001203) (CSI: -3.83) may reflect the metabolically quiescent state characteristic of memory lymphocytes. This expression landscape suggests a functional dichotomy where [ATP5F1C](/details-gene/509)-driven oxidative phosphorylation is a dominant energy pathway in proliferative and biosynthetically active cells, but may be less central in certain quiescent or terminally differentiated cells. ## Pathways and Molecular Function [ATP5F1C](/details-gene/509) is functionally annotated as a structural component of the [proton-transporting ATP synthase complex, catalytic core F(1)](/details-cell/GO:0045261), which is localized to the [mitochondrial inner membrane](/details-cell/GO:0005743). Its molecular function is central to the [proton-transporting ATP synthase activity, rotational mechanism](/details-cell/GO:0046933), which couples proton flow across the membrane to ATP synthesis. This molecular activity is integral to several fundamental biological processes. It is a key player in the [ATP biosynthetic process](/details-cell/GO:0006754) and specifically, [oxidative phosphorylation](/details-cell/GO:0006119), the primary mechanism for ATP production in aerobic organisms. Reactome pathway analysis further situates [ATP5F1C](/details-gene/509) within the broader contexts of [Metabolism](/details-cell/R-HSA-1430728) and specifically the [Formation of ATP by chemiosmotic coupling](/details-cell/R-HSA-163210). This core metabolic function directly accounts for its high expression in cells with substantial energy requirements for growth, division, and maintenance, such as hematopoietic progenitors and intestinal epithelial cells. ## Research Directions The stark contrast in [ATP5F1C](/details-gene/509) significance between highly proliferative progenitor cells and certain terminally differentiated cell types, such as neurons and memory T cells, suggests a pivotal role in the metabolic reprogramming that accompanies cellular differentiation and quiescence. This observation leads to several testable hypotheses. 1. **Hypothesis on Cellular Differentiation:** The downregulation of [ATP5F1C](/details-gene/509) may be a critical step in the metabolic shift from high-rate oxidative phosphorylation to a lower energy, quiescent state during the terminal differentiation of specific neuronal lineages or the transition from effector to memory T cells. This shift could be regulated at the level of transcription or through the expression of different splice variants. 2. **Hypothesis on Oncogenesis:** Given its high expression in rapidly dividing progenitor and transit-amplifying cells, [ATP5F1C](/details-gene/509) is likely a critical facilitator of tumorigenesis in cancers derived from these tissues, such as acute myeloid leukemia or colorectal cancer. Upregulation of [ATP5F1C](/details-gene/509), potentially specific isoforms, could be a mechanism by which cancer cells meet the extraordinary energetic demands of uncontrolled proliferation. To test the role of [ATP5F1C](/details-gene/509) in metabolic reprogramming during hematopoietic differentiation (Hypothesis 1), a targeted experiment could be performed. One could utilize an *in vitro* system by isolating human CD34+ [hematopoietic stem cell](/details-cell/CL0000037)s and inducing their differentiation towards the lymphoid lineage. Using a CRISPR interference (CRISPRi) system to achieve a stable knockdown of [ATP5F1C](/details-gene/509), the impact on differentiation efficiency into memory T cell precursors could be quantified by flow cytometry. Parallel metabolic flux analysis using a Seahorse XF Analyzer would directly measure changes in the oxygen consumption rate (OCR) and extracellular acidification rate (ECAR), providing a direct link between [ATP5F1C](/details-gene/509) expression, oxidative phosphorylation, and the adoption of a quiescent metabolic profile. Given that [ATP5F1C](/details-gene/509) is a core component of a universally essential enzyme, it presents a challenging therapeutic target, as systemic inhibition would likely lead to severe toxicity. However, the potential existence of tissue- or disease-specific splice variants ([Link](https://doi.org/10.1016/s0021-9258(19)74556-6)) could offer a therapeutic window. If cancer cells rely on a specific isoform of [ATP5F1C](/details-gene/509) to sustain their metabolism, developing inhibitors that selectively target that variant could disrupt tumor bioenergetics while sparing healthy tissues, making isoform-specific inhibition a plausible therapeutic strategy.

Genular Protein ID: 1502060751

Symbol: ATPG_HUMAN

Name: F-ATPase gamma subunit

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8227057

Title: Gene structure of human mitochondrial ATP synthase gamma-subunit. Tissue specificity produced by alternative RNA splicing.

PubMed ID: 8227057

DOI: 10.1016/s0021-9258(19)74556-6

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 298
  • Mass: 32996
  • Checksum: 021A95168FD53E04
  • Sequence:
  • MFSRAGVAGL SAWTLQPQWI QVRNMATLKD ITRRLKSIKN IQKITKSMKM VAAAKYARAE 
    RELKPARIYG LGSLALYEKA DIKGPEDKKK HLLIGVSSDR GLCGAIHSSI AKQMKSEVAT 
    LTAAGKEVML VGIGDKIRGI LYRTHSDQFL VAFKEVGRKP PTFGDASVIA LELLNSGYEF 
    DEGSIIFNKF RSVISYKTEE KPIFSLNTVA SADSMSIYDD IDADVLQNYQ EYNLANIIYY 
    SLKESTTSEQ SARMTAMDNA SKNASEMIDK LTLTFNRTRQ AVITKELIEI ISGAAALD

Genular Protein ID: 2013419811

Symbol: Q8TAS0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 291
  • Mass: 32247
  • Checksum: 6F6A2693C73BF793
  • Sequence:
  • AGLSAWTLQP QWIQVRNMAT LKDITRRLKS IKNIQKITKS MKMVAAAKYA RAERELKPAR 
    IYGLGSLALY EKADIKGPED KKKHLLIGVS SDRGLCGAIH SSIAKQMKSE VATLTAAGKE 
    VMLVGIGDKI RGILYRTHSD QFLVAFKEVG RKPPTFGDAS VIALELLNSG YEFDEGSIIF 
    NKFRSVISYK TEEKPIFSLN TVASADSMSI YDDIDADVLQ NYQEYNLANI IYYSLKESTT 
    SEQSARMTAM DNASKNASEM IDKLTLTFNR TRQAVITKEL IEIISGAAAL D

Genular Protein ID: 1104253534

Symbol: B4DL14_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 250
  • Mass: 27513
  • Checksum: 3C94F2E76AE79E6E
  • Sequence:
  • MKMVAAAKYA RAERELKPAR IYGLGSLALY EKADIKGPED KKKHLLIGVS SDRGLCGAIH 
    SSIAKQMKSE VATLTAAGKE VMLVGIGDKI RGILYRTHSD QFLVAFKEVG RKPPTFGDAS 
    VIALELLNSG YEFDEGSIIF NKFRSVISYK TEEKPIFSLN TVASADSMSI YDDIDADVLQ 
    NYQEYNLANI IYYSLKESTT SEQSARMTAM DNASKNASEM IDKLTLTFNR TRQAVITKEL 
    IEIISGAAAL