Exosc10 | ENSMUSG00000017264 | NCBI 50912

Details for: Exosc10

Gene ID: 50912

Symbol: Exosc10

Ensembl ID: ENSMUSG00000017264

Description: exosome component 10

Associated with

Major pathway of rrna processing in the nucleolus and cytosol
(R-MMU-6791226)
Metabolism of rna
(R-MMU-8953854)
Rrna processing
(R-MMU-72312)
Rrna processing in the nucleus and cytosol
(R-MMU-8868773)
3'-5'-rna exonuclease activity
(GO:0000175)
Cut catabolic process
(GO:0071034)
Cytoplasm
(GO:0005737)
Cytoplasmic exosome (rnase complex)
(GO:0000177)
Cytosol
(GO:0005829)
Dna repair
(GO:0006281)
Euchromatin
(GO:0000791)
Exonucleolytic trimming to generate mature 3'-end of 5.8s rrna from tricistronic rrna transcript (ssu-rrna, 5.8s rrna, lsu-rrna)
(GO:0000467)
Exosome (rnase complex)
(GO:0000178)
Histone mrna catabolic process
(GO:0071044)
Maturation of 5.8s rrna
(GO:0000460)
Metal ion binding
(GO:0046872)
Negative regulation of telomere maintenance via telomerase
(GO:0032211)
Nuclear-transcribed mrna catabolic process
(GO:0000956)
Nuclear-transcribed mrna catabolic process, nonsense-mediated decay
(GO:0000184)
Nuclear exosome (rnase complex)
(GO:0000176)
Nuclear mrna surveillance
(GO:0071028)
Nuclear polyadenylation-dependent antisense transcript catabolic process
(GO:0071040)
Nuclear polyadenylation-dependent cut catabolic process
(GO:0071039)
Nuclear polyadenylation-dependent rrna catabolic process
(GO:0071035)
Nuclear polyadenylation-dependent snorna catabolic process
(GO:0071036)
Nuclear polyadenylation-dependent snrna catabolic process
(GO:0071037)
Nucleolar exosome (rnase complex)
(GO:0101019)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleotide binding
(GO:0000166)
Nucleus
(GO:0005634)
Poly(a)-dependent snorna 3'-end processing
(GO:0071051)
Positive regulation of mrna cis splicing, via spliceosome
(GO:1905746)
Regulation of telomerase rna localization to cajal body
(GO:1904872)
Ribosomal small subunit biogenesis
(GO:0042274)
Rna catabolic process
(GO:0006401)
Rna exonuclease activity
(GO:0004532)
Rna processing
(GO:0006396)
Single-stranded rna binding
(GO:0003727)
Small-subunit processome
(GO:0032040)
Telomerase rna binding
(GO:0070034)
Tramp-dependent trna surveillance pathway
(GO:0071038)

Other Information

Proteins

Exosome complex component 10

Genular Protein ID: 526673300

Symbol: EXOSX_MOUSE

Name: Exosome complex component 10

UniProtKB Accession Codes:

P56960 B1ARY9 Q9QYS8 Q9R0B1

Database IDs:

Citations:

PubMed ID: 10708524

Title: Structure and localization of mouse Pmscl1 and Pmscl2 genes.

PubMed ID: 10708524

DOI: 10.1006/geno.2000.6118

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 26857222

Title: Cooling-induced SUMOylation of EXOSC10 down-regulates ribosome biogenesis.

PubMed ID: 26857222

DOI: 10.1261/rna.054411.115

PubMed ID: 29118343

Title: EXOSC10/Rrp6 is post-translationally regulated in male germ cells and controls the onset of spermatogenesis.

PubMed ID: 29118343

DOI: 10.1038/s41598-017-14643-y

PubMed ID: 32313933

Title: EXOSC10 sculpts the transcriptome during the growth-to-maturation transition in mouse oocytes.

PubMed ID: 32313933

DOI: 10.1093/nar/gkaa249

PubMed ID: 34965385

Title: EXOSC10/Rrp6 is essential for the eight-cell embryo/morula transition.

PubMed ID: 34965385

DOI: 10.1016/j.ydbio.2021.12.010

PubMed ID: 36923944

Title: Inactivation of Exosc10 in the oocyte impairs oocyte development and maturation, leading to a depletion of the ovarian reserve in mice.

PubMed ID: 36923944

DOI: 10.7150/ijbs.72889

Sequence Information:

Length: 887
Mass: 100942
Checksum: 173164944163620C
Sequence:

MAPPSPREHQ SAPATSATKP DAEMVLPGFP DADSFVKFAL GSVVAVTKAS GGLPQFGDEY 
DFYRSFPAFQ AFCETQGDRL LQCMSRVMQY HGCRSNIKDR SKVTELEDKF DLLVDTNDVI 
LERVGMLLDE ASGVNKHQQP VLPAGLQVPK TIVSSWNRKA GEYGKKAKSE TFRLLHAKNI 
VRPQLRFREK IDNSNTPFLP KIFVKPNARK PLPLALSKER RERPQDRPED LDVPPALADF 
IHQQRTQQVE QDMFAHPYQY ELDHFTPPQS VLQRPKPQLY RAVGETPCHL VSSLDELVEL 
NEKLLGCQEF AVDLEHHSYR SFLGLTCLMQ ISTRTEDFIV DTLELRSDMY ILNESLTDPA 
IVKVFHGADS DIEWLQKDFG LYVVNMFDTH QAARLLNLAR HSLDHLLRLY CGVESNKQYQ 
LADWRIRPLP EEMLSYARDD THYLLYIYDR MRLELWERGN HQPVQLQVVW QRSRDICLKK 
FVKPIFTDES YLELYRKQKK HLNSQQLTAF QLLFAWRDKT ARREDESYGY VLPNHMMLKI 
AEELPKEPQG IIACCNPVPP LVRQQINEMH LLIQQAREMP LLKSENAAGV RKSGPLPSAE 
RLENDLFGPH DCSHAPPDNY QNTSTDGTLP LQKQPSLFTE GKEETSVDAG CLLATAVITL 
FSEPNTEEGG KTPLTVAQKK AQNIMQSFEN PFRMFLPSLE HKAHISQAAK FDPSSKIYEI 
SNRWKLASQV QVQKEPKEAT KKKVAEQTAA REEAKEEAAA GVLEQAIPVR QQAALENATK 
KRERATSDLR TIEQKQEKKR LKSSKKAKDP DPPGKDFSPY DYSQSDFRAF AGDSKSKPSS 
QFDPNKLAPS GKKGVGAKKC KQSVGNKSMS FAVGKSDRGF RHNWPKR

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Exosc10

Associated with

Other Information

Structure and localization of mouse Pmscl1 and Pmscl2 genes. PubMed ID: 10708524

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Cooling-induced SUMOylation of EXOSC10 down-regulates ribosome biogenesis. PubMed ID: 26857222

EXOSC10/Rrp6 is post-translationally regulated in male germ cells and controls the onset of spermatogenesis. PubMed ID: 29118343

EXOSC10 sculpts the transcriptome during the growth-to-maturation transition in mouse oocytes. PubMed ID: 32313933

EXOSC10/Rrp6 is essential for the eight-cell embryo/morula transition. PubMed ID: 34965385

Inactivation of Exosc10 in the oocyte impairs oocyte development and maturation, leading to a depletion of the ovarian reserve in mice. PubMed ID: 36923944