Uchl3 | ENSMUSG00000022111 | NCBI 50933

Details for: Uchl3

Gene ID: 50933

Symbol: Uchl3

Ensembl ID: ENSMUSG00000022111

Description: ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)

Associated with

Deubiquitination
(R-MMU-5688426)
Metabolism of proteins
(R-MMU-392499)
Neddylation
(R-MMU-8951664)
Post-translational protein modification
(R-MMU-597592)
Protein ubiquitination
(R-MMU-8852135)
Synthesis of active ubiquitin: roles of e1 and e2 enzymes
(R-MMU-8866652)
Uch proteinases
(R-MMU-5689603)
Adult walking behavior
(GO:0007628)
Cellular response to insulin stimulus
(GO:0032869)
Cysteine-type deubiquitinase activity
(GO:0004843)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Deubiquitinase activity
(GO:0101005)
Eating behavior
(GO:0042755)
Nucleoplasm
(GO:0005654)
Peptidase activity
(GO:0008233)
Positive regulation of fat cell differentiation
(GO:0045600)
Protein catabolic process
(GO:0030163)
Protein deubiquitination
(GO:0016579)
Retina development in camera-type eye
(GO:0060041)
Ubiquitin-dependent protein catabolic process
(GO:0006511)
Ubiquitin binding
(GO:0043130)

Other Information

Proteins

Ubiquitin carboxyl-terminal hydrolase isozyme L3
Q8BWQ9_MOUSE

Genular Protein ID: 1903927228

Symbol: UCHL3_MOUSE

Name: Ubiquitin carboxyl-terminal hydrolase isozyme L3

UniProtKB Accession Codes:

Q9JKB1 Q9EQX7

Database IDs:

Citations:

PubMed ID: 10713173

Title: Expression and functional analysis of Uch-L3 during mouse development.

PubMed ID: 10713173

DOI: 10.1128/mcb.20.7.2498-2504.2000

PubMed ID: 11341770

Title: Cloning, expression, and mapping of a mouse gene, Uchl4, highly homologous to human and mouse Uchl3.

PubMed ID: 11341770

DOI: 10.1006/bbrc.2001.4841

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9790970

Title: Cleavage of the C-terminus of NEDD8 by UCH-L3.

PubMed ID: 9790970

DOI: 10.1006/bbrc.1998.9532

PubMed ID: 15884048

Title: Ubiquitin C-terminal hydrolase L3 (Uchl3) is involved in working memory.

PubMed ID: 15884048

DOI: 10.1002/hipo.20082

PubMed ID: 16816367

Title: Photoreceptor cell apoptosis in the retinal degeneration of Uchl3-deficient mice.

PubMed ID: 16816367

DOI: 10.2353/ajpath.2006.060085

PubMed ID: 17460351

Title: The new function of two ubiquitin C-terminal hydrolase isozymes as reciprocal modulators of germ cell apoptosis.

PubMed ID: 17460351

DOI: 10.1538/expanim.56.71

PubMed ID: 17967898

Title: The deubiquitinating enzyme UCH-L3 regulates the apical membrane recycling of the epithelial sodium channel.

PubMed ID: 17967898

DOI: 10.1074/jbc.m707989200

PubMed ID: 19837878

Title: Ubiquitin carboxyl-terminal hydrolase l3 promotes insulin signaling and adipogenesis.

PubMed ID: 19837878

DOI: 10.1210/en.2009-0332

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20380862

Title: Skeletal muscles of Uchl3 knockout mice show polyubiquitinated protein accumulation and stress responses.

PubMed ID: 20380862

DOI: 10.1016/j.neuint.2010.03.021

PubMed ID: 21762696

Title: Mutant ubiquitin (UBB(+1)) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3).

PubMed ID: 21762696

DOI: 10.1016/j.febslet.2011.06.037

Sequence Information:

Length: 230
Mass: 26152
Checksum: F147991F3ED69AC3
Sequence:

MEGQRWLPLE ANPEVTNQFL KQLGLHPNWQ FVDVYGMEPE LLSMVPRPVC AVLLLFPITE 
KYEVFRTEEE EKIKSQGQDV TSSVYFMKQT ISNACGTIGL IHAIANNKDK MHFESGSTLK 
KFLEESVSMS PEERAKFLEN YDAIRVTHET SAHEGQTEAP SIDEKVDLHF IALVHVDGHL 
YELDGRKPFP INHGKTSDET LLEDAIEVCK KFMERDPDEL RFNAIALSAA

Genular Protein ID: 1102643330

Symbol: Q8BWQ9_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q8BWQ9

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

Sequence Information:

Length: 211
Mass: 23662
Checksum: A844D7D53F3E8408
Sequence:

MEGQRWLPLE ANPEVTNQFL KQLGLHPNWQ FVDVYGMEPE LLSMVPRPVC AVLLLFPITE 
KYEVFRTEEE EKIKSQGQDV TSSVYFMKQT ISNACGTIGL IHAIANNKDK MHFESGSTLK 
KFLEESVSMS PEERAKFLEN YDVSTLPSIQ PHPRAVLQDC RLCSAVCLEA IVWGSIIVLS 
VRKGFGFTEG AVPQISVMLV YKLNPGPSDP V

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Uchl3

Associated with

Other Information

Expression and functional analysis of Uch-L3 during mouse development. PubMed ID: 10713173

Cloning, expression, and mapping of a mouse gene, Uchl4, highly homologous to human and mouse Uchl3. PubMed ID: 11341770

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Cleavage of the C-terminus of NEDD8 by UCH-L3. PubMed ID: 9790970

Ubiquitin C-terminal hydrolase L3 (Uchl3) is involved in working memory. PubMed ID: 15884048

Photoreceptor cell apoptosis in the retinal degeneration of Uchl3-deficient mice. PubMed ID: 16816367

The new function of two ubiquitin C-terminal hydrolase isozymes as reciprocal modulators of germ cell apoptosis. PubMed ID: 17460351

The deubiquitinating enzyme UCH-L3 regulates the apical membrane recycling of the epithelial sodium channel. PubMed ID: 17967898

Ubiquitin carboxyl-terminal hydrolase l3 promotes insulin signaling and adipogenesis. PubMed ID: 19837878

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Skeletal muscles of Uchl3 knockout mice show polyubiquitinated protein accumulation and stress responses. PubMed ID: 20380862

Mutant ubiquitin (UBB(+1)) associated with neurodegenerative disorders is hydrolyzed by ubiquitin C-terminal hydrolase L3 (UCH-L3). PubMed ID: 21762696

High-efficiency full-length cDNA cloning. PubMed ID: 10349636

Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. PubMed ID: 11042159

RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. PubMed ID: 11076861

Functional annotation of a full-length mouse cDNA collection. PubMed ID: 11217851

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. PubMed ID: 12466851

Antisense Transcription in the Mammalian Transcriptome. PubMed ID: 16141073