Details for: Slc7a8

Gene ID: 50934

Symbol: Slc7a8

Ensembl ID: ENSMUSG00000022180

Description: solute carrier family 7 (cationic amino acid transporter, y+ system), member 8

Associated with

Other Information

Genular Protein ID: 509740635

Symbol: LAT2_MOUSE

Name: Large neutral amino acids transporter small subunit 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10574970

Title: LAT2, a new basolateral 4F2hc/CD98-associated amino acid transporter of kidney and intestine.

PubMed ID: 10574970

DOI: 10.1074/jbc.274.49.34948

PubMed ID: 10610726

Title: SLC7A8, a gene mapping within the lysinuric protein intolerance critical region, encodes a new member of the glycoprotein-associated amino acid transporter family.

PubMed ID: 10610726

DOI: 10.1006/geno.1999.5978

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21726201

Title: Aminoaciduria, but normal thyroid hormone levels and signalling, in mice lacking the amino acid and thyroid hormone transporter Slc7a8.

PubMed ID: 21726201

DOI: 10.1042/bj20110759

PubMed ID: 26601072

Title: Involvement of the L-Type Amino Acid Transporter Lat2 in the Transport of 3,3'-Diiodothyronine across the Plasma Membrane.

PubMed ID: 26601072

DOI: 10.1159/000381542

PubMed ID: 28108384

Title: Molecular features of the L-type amino acid transporter 2 determine different import and export profiles for thyroid hormones and amino acids.

PubMed ID: 28108384

DOI: 10.1016/j.mce.2017.01.024

PubMed ID: 29355479

Title: Mutations in L-type amino acid transporter-2 support SLC7A8 as a novel gene involved in age-related hearing loss.

PubMed ID: 29355479

DOI: 10.7554/elife.31511

PubMed ID: 31231240

Title: Dysfunctional LAT2 Amino Acid Transporter Is Associated With Cataract in Mouse and Humans.

PubMed ID: 31231240

DOI: 10.3389/fphys.2019.00688

Sequence Information:

  • Length: 531
  • Mass: 57873
  • Checksum: AE9C3B42F3B24F8C
  • Sequence:
  • MEKGARQRNN TAKNHPGSDT SPEAEASSGG GGVALKKEIG LVSACGIIVG NIIGSGIFVS 
    PKGVLENAGS VGLALIVWIV TGIITAVGAL CYAELGVTIP KSGGDYSYVK DIFGGLAGFL 
    RLWIAVLVIY PTNQAVIALT FSNYVLQPLF PTCFPPESGL RLLAAICLLL LTWVNCSSVR 
    WATRVQDIFT AGKLLALALI IIMGIVQICK GEFFWLEPKN AFENFQEPDI GLVALAFLQG 
    SFAYGGWNFL NYVTEELVDP YKNLPRAIFI SIPLVTFVYV FANIAYVTAM SPQELLASNA 
    VAVTFGEKLL GVMAWIMPIS VALSTFGGVN GSLFTSSRLF FAGAREGHLP SVLAMIHVKR 
    CTPIPALLFT CLSTLLMLVT SDMYTLINYV GFINYLFYGV TVAGQIVLRW KKPDIPRPIK 
    VSLLFPIIYL LFWAFLLIFS LWSEPVVCGI GLAIMLTGVP VYFLGVYWQH KPKCFNDFIK 
    SLTLVSQKMC VVVYPQEGNS GAEETTDDLE EQHKPIFKPT PVKDPDSEEQ P

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.