ACOX1 | ENSG00000161533 | NCBI 51

Details for: ACOX1

Gene ID: 51

Symbol: ACOX1

Ensembl ID: ENSG00000161533

Description: acyl-CoA oxidase 1

Associated with

Alpha-linolenic (omega3) and linoleic (omega6) acid metabolism
(R-HSA-2046104)
Alpha-linolenic acid (ala) metabolism
(R-HSA-2046106)
Beta-oxidation of very long chain fatty acids
(R-HSA-390247)
Fatty acid metabolism
(R-HSA-8978868)
Metabolism
(R-HSA-1430728)
Metabolism of lipids
(R-HSA-556833)
Peroxisomal lipid metabolism
(R-HSA-390918)
Peroxisomal protein import
(R-HSA-9033241)
Ppara activates gene expression
(R-HSA-1989781)
Protein localization
(R-HSA-9609507)
Regulation of lipid metabolism by pparalpha
(R-HSA-400206)
Tysnd1 cleaves peroxisomal proteins
(R-HSA-9033500)
Acyl-coa oxidase activity
(GO:0003997)
Cytosol
(GO:0005829)
Fad binding
(GO:0071949)
Fatty acid beta-oxidation using acyl-coa oxidase
(GO:0033540)
Fatty acid binding
(GO:0005504)
Fatty acid catabolic process
(GO:0009062)
Fatty acid oxidation
(GO:0019395)
Flavin adenine dinucleotide binding
(GO:0050660)
Generation of precursor metabolites and energy
(GO:0006091)
Hydrogen peroxide biosynthetic process
(GO:0050665)
Lipid homeostasis
(GO:0055088)
Lipid metabolic process
(GO:0006629)
Membrane
(GO:0016020)
Palmitoyl-coa oxidase activity
(GO:0016401)
Pdz domain binding
(GO:0030165)
Peroxisomal matrix
(GO:0005782)
Peroxisomal membrane
(GO:0005778)
Peroxisome
(GO:0005777)
Prostaglandin metabolic process
(GO:0006693)
Protein binding
(GO:0005515)
Protein homodimerization activity
(GO:0042803)
Spermatogenesis
(GO:0007283)
Very long-chain fatty acid beta-oxidation
(GO:0140493)
Very long-chain fatty acid metabolic process
(GO:0000038)

Other Information

Proteins

Peroxisomal fatty acyl-CoA oxidase

Genular Protein ID: 4077081

Symbol: ACOX1_HUMAN

Name: Peroxisomal fatty acyl-CoA oxidase

UniProtKB Accession Codes:

Q15067 A8K6X8 A8KAA0 B4DK61 F5GYQ8 Q12863 Q15068 Q15101 Q16131 Q7Z3W5 Q9UD31

Database IDs:

Citations:

PubMed ID: 8159712

Title: Isolation of the human peroxisomal acyl-CoA oxidase gene: organization, promoter analysis, and chromosomal localization.

PubMed ID: 8159712

DOI: 10.1073/pnas.91.8.3107

PubMed ID: 7876265

Title: Overexpression and characterization of the human peroxisomal acyl-CoA oxidase in insect cells.

PubMed ID: 7876265

DOI: 10.1074/jbc.270.9.4908

PubMed ID: 8040306

Title: Large deletion of the peroxisomal acyl-CoA oxidase gene in pseudoneonatal adrenoleukodystrophy.

PubMed ID: 8040306

DOI: 10.1172/jci117365

PubMed ID: 8117268

Title: Molecular cloning and functional expression of a human peroxisomal acyl-coenzyme A oxidase.

PubMed ID: 8117268

DOI: 10.1006/bbrc.1994.1158

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15060085

Title: Identification of the peroxisomal beta-oxidation enzymes involved in the degradation of long-chain dicarboxylic acids.

PubMed ID: 15060085

DOI: 10.1194/jlr.m300512-jlr200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17603022

Title: Biochemical characterization of two functional human liver acyl-CoA oxidase isoforms 1a and 1b encoded by a single gene.

PubMed ID: 17603022

DOI: 10.1016/j.bbrc.2007.06.059

PubMed ID: 18281296

Title: Contribution of peroxisome-specific isoform of Lon protease in sorting PTS1 proteins to peroxisomes.

PubMed ID: 18281296

DOI: 10.1093/jb/mvn020

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20195242

Title: Reversal of mouse Acyl-CoA oxidase 1 (ACOX1) null phenotype by human ACOX1b isoform.

PubMed ID: 20195242

DOI: 10.1038/labinvest.2010.46

PubMed ID: 33234382

Title: Novel ACOX1 mutations in two siblings with peroxisomal acyl-CoA oxidase deficiency.

PubMed ID: 33234382

DOI: 10.1016/j.braindev.2020.10.011

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 11815777

Title: Peroxisomal acyl-CoA oxidase deficiency.

PubMed ID: 11815777

DOI: 10.1067/mpd.2002.120511

PubMed ID: 17458872

Title: Clinical, biochemical, and mutational spectrum of peroxisomal acyl-coenzyme A oxidase deficiency.

PubMed ID: 17458872

DOI: 10.1002/humu.20535

PubMed ID: 32169171

Title: Loss- or Gain-of-Function Mutations in ACOX1 Cause Axonal Loss via Different Mechanisms.

PubMed ID: 32169171

DOI: 10.1016/j.neuron.2020.02.021

Sequence Information:

Length: 660
Mass: 74424
Checksum: D713768A47374EA1
Sequence:

MNPDLRRERD SASFNPELLT HILDGSPEKT RRRREIENMI LNDPDFQHED LNFLTRSQRY 
EVAVRKSAIM VKKMREFGIA DPDEIMWFKK LHLVNFVEPV GLNYSMFIPT LLNQGTTAQK 
EKWLLSSKGL QIIGTYAQTE MGHGTHLRGL ETTATYDPET QEFILNSPTV TSIKWWPGGL 
GKTSNHAIVL AQLITKGKCY GLHAFIVPIR EIGTHKPLPG ITVGDIGPKF GYDEIDNGYL 
KMDNHRIPRE NMLMKYAQVK PDGTYVKPLS NKLTYGTMVF VRSFLVGEAA RALSKACTIA 
IRYSAVRHQS EIKPGEPEPQ ILDFQTQQYK LFPLLATAYA FQFVGAYMKE TYHRINEGIG 
QGDLSELPEL HALTAGLKAF TSWTANTGIE ACRMACGGHG YSHCSGLPNI YVNFTPSCTF 
EGENTVMMLQ TARFLMKSYD QVHSGKLVCG MVSYLNDLPS QRIQPQQVAV WPTMVDINSP 
ESLTEAYKLR AARLVEIAAK NLQKEVIHRK SKEVAWNLTS VDLVRASEAH CHYVVVKLFS 
EKLLKIQDKA IQAVLRSLCL LYSLYGISQN AGDFLQGSIM TEPQITQVNQ RVKELLTLIR 
SDAVALVDAF DFQDVTLGSV LGRYDGNVYE NLFEWAKNSP LNKAEVHESY KHLKSLQSKL

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ACOX1

Associated with

Other Information

Isolation of the human peroxisomal acyl-CoA oxidase gene: organization, promoter analysis, and chromosomal localization. PubMed ID: 8159712

Overexpression and characterization of the human peroxisomal acyl-CoA oxidase in insect cells. PubMed ID: 7876265

Large deletion of the peroxisomal acyl-CoA oxidase gene in pseudoneonatal adrenoleukodystrophy. PubMed ID: 8040306

Molecular cloning and functional expression of a human peroxisomal acyl-coenzyme A oxidase. PubMed ID: 8117268

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. PubMed ID: 16625196

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of the peroxisomal beta-oxidation enzymes involved in the degradation of long-chain dicarboxylic acids. PubMed ID: 15060085

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

Biochemical characterization of two functional human liver acyl-CoA oxidase isoforms 1a and 1b encoded by a single gene. PubMed ID: 17603022

Contribution of peroxisome-specific isoform of Lon protease in sorting PTS1 proteins to peroxisomes. PubMed ID: 18281296

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Reversal of mouse Acyl-CoA oxidase 1 (ACOX1) null phenotype by human ACOX1b isoform. PubMed ID: 20195242

Novel ACOX1 mutations in two siblings with peroxisomal acyl-CoA oxidase deficiency. PubMed ID: 33234382

Initial characterization of the human central proteome. PubMed ID: 21269460

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Peroxisomal acyl-CoA oxidase deficiency. PubMed ID: 11815777

Clinical, biochemical, and mutational spectrum of peroxisomal acyl-coenzyme A oxidase deficiency. PubMed ID: 17458872

Loss- or Gain-of-Function Mutations in ACOX1 Cause Axonal Loss via Different Mechanisms. PubMed ID: 32169171