Details for: ACOX1

Gene ID: 51

Symbol: ACOX1

Ensembl ID: ENSG00000161533

Description: acyl-CoA oxidase 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.95
    Marker Score: 6,120
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.83
    Marker Score: 8,793
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.72
    Marker Score: 2,539
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.64
    Marker Score: 8,804
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.63
    Marker Score: 10,499
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.62
    Marker Score: 593
  • Cell Name: midzonal region hepatocyte (CL0019028)
    Fold Change: 1.62
    Marker Score: 6,970
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.57
    Marker Score: 1,070
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.55
    Marker Score: 2,391
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.53
    Marker Score: 5,022
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 1.52
    Marker Score: 9,729
  • Cell Name: germ cell (CL0000586)
    Fold Change: 1.36
    Marker Score: 2,377
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.31
    Marker Score: 732
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.31
    Marker Score: 2,761
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.28
    Marker Score: 318
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.22
    Marker Score: 4,341
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.16
    Marker Score: 2,636
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.15
    Marker Score: 688
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.12
    Marker Score: 4,558
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.11
    Marker Score: 744
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.1
    Marker Score: 952
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.09
    Marker Score: 9,416
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.09
    Marker Score: 529
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.08
    Marker Score: 1,124
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.02
    Marker Score: 8,800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.02
    Marker Score: 15,989
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 1.01
    Marker Score: 691
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.01
    Marker Score: 587
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.01
    Marker Score: 422
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.01
    Marker Score: 3,899
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1
    Marker Score: 10,342
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,704
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,927
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.99
    Marker Score: 1,047
  • Cell Name: acinar cell (CL0000622)
    Fold Change: 0.99
    Marker Score: 696
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.98
    Marker Score: 60,464
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,388
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 0.98
    Marker Score: 365
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.98
    Marker Score: 2,298
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.97
    Marker Score: 24,918
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.97
    Marker Score: 1,497
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.96
    Marker Score: 3,715
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.96
    Marker Score: 2,188
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.95
    Marker Score: 9,060
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.95
    Marker Score: 945
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2,396
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.94
    Marker Score: 18,619
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 480
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.93
    Marker Score: 993
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.92
    Marker Score: 19,703
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.92
    Marker Score: 435
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.92
    Marker Score: 5,234
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.91
    Marker Score: 1,477
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 0.9
    Marker Score: 20,214
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2,702
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.9
    Marker Score: 3,528
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.9
    Marker Score: 2,399
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.89
    Marker Score: 8,333
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.87
    Marker Score: 212
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,293
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.87
    Marker Score: 2,196
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.86
    Marker Score: 31,807
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.86
    Marker Score: 6,394
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.85
    Marker Score: 12,667
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.83
    Marker Score: 192
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.83
    Marker Score: 243
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.83
    Marker Score: 289
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.82
    Marker Score: 1,799
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.82
    Marker Score: 782
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.81
    Marker Score: 213
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.8
    Marker Score: 298
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.8
    Marker Score: 608
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.79
    Marker Score: 30,037
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.79
    Marker Score: 369
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 313
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.77
    Marker Score: 1,281
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.77
    Marker Score: 289
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.77
    Marker Score: 247
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.76
    Marker Score: 845
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.76
    Marker Score: 823
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.76
    Marker Score: 1,810
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.76
    Marker Score: 955
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.76
    Marker Score: 804
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.76
    Marker Score: 2,802
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.75
    Marker Score: 372
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.75
    Marker Score: 217
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.74
    Marker Score: 183
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.74
    Marker Score: 4,826
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.74
    Marker Score: 452
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.74
    Marker Score: 1,041
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.73
    Marker Score: 843
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.73
    Marker Score: 1,160
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.73
    Marker Score: 401
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.73
    Marker Score: 874
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.72
    Marker Score: 5,551
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.72
    Marker Score: 661
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 372
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 0.72
    Marker Score: 207
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.72
    Marker Score: 923

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subcellular localization:** ACOX1 is primarily located in the peroxisome, a organelle responsible for the degradation of fatty acids and amino acids. 2. **Enzymatic activity:** ACOX1 catalyzes the oxidative decarboxylation of acyl-CoA esters, producing acyl-CoA and CO2. 3. **Regulation:** ACOX1 is regulated by various factors, including transcription factors (e.g., PPARα) and protein-protein interactions (e.g., Tysnd1). 4. **Substrate specificity:** ACOX1 prefers long-chain fatty acids (C16-C22) for oxidation, while short-chain fatty acids (C4-C15) are primarily metabolized by other enzymes. **Pathways and Functions:** ACOX1 is involved in the following pathways: 1. **Fatty acid beta-oxidation:** ACOX1 plays a critical role in the breakdown of fatty acids, which provides energy for various tissues. 2. **Lipid metabolism:** ACOX1 regulates lipid metabolism by influencing the levels of acyl-CoA esters, which are involved in various biological processes, including energy storage, signaling, and membrane synthesis. 3. **Energy production:** ACOX1 contributes to the generation of precursor metabolites and energy, which is essential for maintaining cellular homeostasis. 4. **Redox balance:** ACOX1 helps maintain the redox balance by producing H2O2, which is involved in various cellular processes, including signaling and detoxification. **Clinical Significance:** Dysregulation of ACOX1 has been implicated in various diseases, including: 1. **Metabolic disorders:** ACOX1 deficiency has been linked to metabolic disorders, such as obesity, insulin resistance, and type 2 diabetes. 2. **Fatty liver disease:** ACOX1 plays a crucial role in the development of fatty liver disease, which is characterized by excessive fat accumulation in the liver. 3. **Cancer:** ACOX1 has been implicated in the progression of various cancers, including colorectal, breast, and prostate cancer. 4. **Neurological disorders:** ACOX1 has been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, ACOX1 is a vital enzyme involved in fatty acid metabolism, playing a crucial role in regulating lipid metabolism, energy production, and redox balance. Dysregulation of ACOX1 has been implicated in various diseases, highlighting the importance of this enzyme in maintaining cellular homeostasis. Further research is needed to fully understand the mechanisms of ACOX1 and its clinical implications.

Genular Protein ID: 4077081

Symbol: ACOX1_HUMAN

Name: Peroxisomal fatty acyl-CoA oxidase

UniProtKB Accession Codes:

Q15067 A8K6X8 A8KAA0 B4DK61 F5GYQ8 Q12863 Q15068 Q15101 Q16131 Q7Z3W5 Q9UD31

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 87 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EC 3 EMBL 38 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 25 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 5 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PIR 3 PIRSF 1 PRIDE 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 5 RefSeq 3 Rhea 42 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissLipids 2 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniPathway 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8159712

Title: Isolation of the human peroxisomal acyl-CoA oxidase gene: organization, promoter analysis, and chromosomal localization.

PubMed ID: 8159712

DOI: 10.1073/pnas.91.8.3107

PubMed ID: 7876265

Title: Overexpression and characterization of the human peroxisomal acyl-CoA oxidase in insect cells.

PubMed ID: 7876265

DOI: 10.1074/jbc.270.9.4908

PubMed ID: 8040306

Title: Large deletion of the peroxisomal acyl-CoA oxidase gene in pseudoneonatal adrenoleukodystrophy.

PubMed ID: 8040306

DOI: 10.1172/jci117365

PubMed ID: 8117268

Title: Molecular cloning and functional expression of a human peroxisomal acyl-coenzyme A oxidase.

PubMed ID: 8117268

DOI: 10.1006/bbrc.1994.1158

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15060085

Title: Identification of the peroxisomal beta-oxidation enzymes involved in the degradation of long-chain dicarboxylic acids.

PubMed ID: 15060085

DOI: 10.1194/jlr.m300512-jlr200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17603022

Title: Biochemical characterization of two functional human liver acyl-CoA oxidase isoforms 1a and 1b encoded by a single gene.

PubMed ID: 17603022

DOI: 10.1016/j.bbrc.2007.06.059

PubMed ID: 18281296

Title: Contribution of peroxisome-specific isoform of Lon protease in sorting PTS1 proteins to peroxisomes.

PubMed ID: 18281296

DOI: 10.1093/jb/mvn020

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20195242

Title: Reversal of mouse Acyl-CoA oxidase 1 (ACOX1) null phenotype by human ACOX1b isoform.

PubMed ID: 20195242

DOI: 10.1038/labinvest.2010.46

PubMed ID: 33234382

Title: Novel ACOX1 mutations in two siblings with peroxisomal acyl-CoA oxidase deficiency.

PubMed ID: 33234382

DOI: 10.1016/j.braindev.2020.10.011

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 11815777

Title: Peroxisomal acyl-CoA oxidase deficiency.

PubMed ID: 11815777

DOI: 10.1067/mpd.2002.120511

PubMed ID: 17458872

Title: Clinical, biochemical, and mutational spectrum of peroxisomal acyl-coenzyme A oxidase deficiency.

PubMed ID: 17458872

DOI: 10.1002/humu.20535

PubMed ID: 32169171

Title: Loss- or Gain-of-Function Mutations in ACOX1 Cause Axonal Loss via Different Mechanisms.

PubMed ID: 32169171

DOI: 10.1016/j.neuron.2020.02.021

Sequence Information:

  • Length: 660
  • Mass: 74424
  • Checksum: D713768A47374EA1
  • Sequence:
    • MNPDLRRERD SASFNPELLT HILDGSPEKT RRRREIENMI LNDPDFQHED LNFLTRSQRY 
EVAVRKSAIM VKKMREFGIA DPDEIMWFKK LHLVNFVEPV GLNYSMFIPT LLNQGTTAQK 
EKWLLSSKGL QIIGTYAQTE MGHGTHLRGL ETTATYDPET QEFILNSPTV TSIKWWPGGL 
GKTSNHAIVL AQLITKGKCY GLHAFIVPIR EIGTHKPLPG ITVGDIGPKF GYDEIDNGYL 
KMDNHRIPRE NMLMKYAQVK PDGTYVKPLS NKLTYGTMVF VRSFLVGEAA RALSKACTIA 
IRYSAVRHQS EIKPGEPEPQ ILDFQTQQYK LFPLLATAYA FQFVGAYMKE TYHRINEGIG 
QGDLSELPEL HALTAGLKAF TSWTANTGIE ACRMACGGHG YSHCSGLPNI YVNFTPSCTF 
EGENTVMMLQ TARFLMKSYD QVHSGKLVCG MVSYLNDLPS QRIQPQQVAV WPTMVDINSP 
ESLTEAYKLR AARLVEIAAK NLQKEVIHRK SKEVAWNLTS VDLVRASEAH CHYVVVKLFS 
EKLLKIQDKA IQAVLRSLCL LYSLYGISQN AGDFLQGSIM TEPQITQVNQ RVKELLTLIR 
SDAVALVDAF DFQDVTLGSV LGRYDGNVYE NLFEWAKNSP LNKAEVHESY KHLKSLQSKL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.