Gene ATP5F1D - ENSG00000099624 | NCBI Gene ID: 513

Details for: ATP5F1D

Gene ID: 513

Symbol: ATP5F1D

Ensembl ID: ENSG00000099624

Description: ATP synthase F1 subunit delta

Associated with

Cristae formation
(R-HSA-8949613)
Formation of atp by chemiosmotic coupling
(R-HSA-163210)
Metabolism
(R-HSA-1430728)
Mitochondrial biogenesis
(R-HSA-1592230)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Respiratory electron transport, atp synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
(R-HSA-163200)
The citric acid (tca) cycle and respiratory electron transport
(R-HSA-1428517)
Adp binding
(GO:0043531)
Aerobic respiration
(GO:0009060)
Atp binding
(GO:0005524)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial matrix
(GO:0005759)
Mitochondrial proton-transporting atp synthase complex
(GO:0005753)
Mitochondrial proton-transporting atp synthase complex, catalytic sector f(1)
(GO:0000275)
Mitochondrial proton-transporting atp synthase complex assembly
(GO:0033615)
Mitochondrion
(GO:0005739)
Protein binding
(GO:0005515)
Proton-transporting atp synthase activity, rotational mechanism
(GO:0046933)
Proton motive force-driven atp synthesis
(GO:0015986)
Proton motive force-driven mitochondrial atp synthesis
(GO:0042776)
Proton transmembrane transport
(GO:1902600)
Response to copper ion
(GO:0046688)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: follicular B cell (CL0000843)
Fold Change: 5.58
Marker Score: 6047
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 5.18
Marker Score: 10941
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: 4.55
Marker Score: 2761
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 4.54
Marker Score: 3205.5
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 3.97
Marker Score: 1165
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 3.92
Marker Score: 10498
Cell Name: classical monocyte (CL0000860)
Fold Change: 3.79
Marker Score: 15752
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 3.68
Marker Score: 3127
Cell Name: epithelial cell of proximal tubule (CL0002306)
Fold Change: 3.65
Marker Score: 12964
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 3.55
Marker Score: 8089
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 3.53
Marker Score: 3147
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 3.49
Marker Score: 1946.5
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 3.39
Marker Score: 2270.5
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 3.36
Marker Score: 8465
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 3.34
Marker Score: 5536
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 3.33
Marker Score: 1952
Cell Name: cardiac muscle cell (CL0000746)
Fold Change: 3.26
Marker Score: 43313
Cell Name: colon epithelial cell (CL0011108)
Fold Change: 3.21
Marker Score: 10092
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 3.19
Marker Score: 178322
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 3.17
Marker Score: 3386
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 3.16
Marker Score: 1041
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 3.15
Marker Score: 7692
Cell Name: mature T cell (CL0002419)
Fold Change: 3.14
Marker Score: 31073
Cell Name: basal cell of epithelium of trachea (CL1000348)
Fold Change: 3.12
Marker Score: 23224
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 3.12
Marker Score: 24338
Cell Name: Kupffer cell (CL0000091)
Fold Change: 3.1
Marker Score: 3097
Cell Name: enterocyte (CL0000584)
Fold Change: 3.04
Marker Score: 14570
Cell Name: cell in vitro (CL0001034)
Fold Change: 2.98
Marker Score: 103372
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 2.96
Marker Score: 3570
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 2.95
Marker Score: 8148
Cell Name: naive B cell (CL0000788)
Fold Change: 2.95
Marker Score: 2633
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 2.91
Marker Score: 18576
Cell Name: class switched memory B cell (CL0000972)
Fold Change: 2.91
Marker Score: 2736
Cell Name: kidney interstitial cell (CL1000500)
Fold Change: 2.9
Marker Score: 2061
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 2.89
Marker Score: 3070
Cell Name: mesodermal cell (CL0000222)
Fold Change: 2.89
Marker Score: 38090
Cell Name: T-helper 22 cell (CL0001042)
Fold Change: 2.87
Marker Score: 12313.5
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 2.87
Marker Score: 2707.5
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 2.86
Marker Score: 2255.5
Cell Name: serous secreting cell (CL0000313)
Fold Change: 2.86
Marker Score: 1140
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 2.86
Marker Score: 4041
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 2.85
Marker Score: 2977
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 2.83
Marker Score: 2867
Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: 2.8
Marker Score: 18186
Cell Name: type I NK T cell (CL0000921)
Fold Change: 2.79
Marker Score: 2189
Cell Name: supporting cell (CL0000630)
Fold Change: 2.75
Marker Score: 5174
Cell Name: mature gamma-delta T cell (CL0000800)
Fold Change: 2.75
Marker Score: 8688
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 2.75
Marker Score: 2635
Cell Name: epithelial cell (CL0000066)
Fold Change: 2.75
Marker Score: 4370
Cell Name: intraepithelial lymphocyte (CL0002496)
Fold Change: 2.74
Marker Score: 3048.5
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 2.72
Marker Score: 143924
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 2.7
Marker Score: 23294
Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
Fold Change: 2.7
Marker Score: 4826
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 2.7
Marker Score: 1348
Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
Fold Change: 2.69
Marker Score: 2364.5
Cell Name: lung macrophage (CL1001603)
Fold Change: 2.68
Marker Score: 3071
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 2.67
Marker Score: 4111
Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
Fold Change: 2.66
Marker Score: 6487
Cell Name: decidual cell (CL2000002)
Fold Change: 2.65
Marker Score: 11423.5
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.65
Marker Score: 29799
Cell Name: enteric neuron (CL0007011)
Fold Change: 2.64
Marker Score: 1405
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 2.64
Marker Score: 17197
Cell Name: germinal center B cell (CL0000844)
Fold Change: 2.63
Marker Score: 1598
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 2.62
Marker Score: 89219
Cell Name: pro-T cell (CL0000827)
Fold Change: 2.61
Marker Score: 10691
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 2.61
Marker Score: 1735
Cell Name: memory B cell (CL0000787)
Fold Change: 2.59
Marker Score: 1962
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 2.58
Marker Score: 2416
Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
Fold Change: 2.58
Marker Score: 3800
Cell Name: malignant cell (CL0001064)
Fold Change: 2.57
Marker Score: 34577
Cell Name: endocardial cell (CL0002350)
Fold Change: 2.57
Marker Score: 1450
Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 2.56
Marker Score: 611
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 2.55
Marker Score: 2866
Cell Name: Unknown (CL0000548)
Fold Change: 2.55
Marker Score: 1859
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 2.54
Marker Score: 1307
Cell Name: mesothelial cell of epicardium (CL0011019)
Fold Change: 2.54
Marker Score: 814
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.54
Marker Score: 9776.5
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 2.53
Marker Score: 5147
Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
Fold Change: 2.52
Marker Score: 7367
Cell Name: megakaryocyte (CL0000556)
Fold Change: 2.52
Marker Score: 1433
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 2.52
Marker Score: 7475
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 2.5
Marker Score: 1814
Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
Fold Change: 2.5
Marker Score: 1379
Cell Name: medullary thymic epithelial cell (CL0002365)
Fold Change: 2.48
Marker Score: 4068
Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.48
Marker Score: 25096.5
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 2.47
Marker Score: 1490
Cell Name: alveolar macrophage (CL0000583)
Fold Change: 2.46
Marker Score: 63104
Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
Fold Change: 2.46
Marker Score: 2016
Cell Name: duct epithelial cell (CL0000068)
Fold Change: 2.45
Marker Score: 1145
Cell Name: Mueller cell (CL0000636)
Fold Change: 2.45
Marker Score: 3397
Cell Name: mucous neck cell (CL0000651)
Fold Change: 2.45
Marker Score: 5548.5
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 2.44
Marker Score: 2534
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 2.43
Marker Score: 915
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 2.42
Marker Score: 1595
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 2.41
Marker Score: 765
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 2.4
Marker Score: 848
Cell Name: bronchial goblet cell (CL1000312)
Fold Change: 2.39
Marker Score: 1179
Cell Name: gamma-delta T cell (CL0000798)
Fold Change: 2.39
Marker Score: 1606
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.39
Marker Score: 15260.5
Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 2.39
Marker Score: 576

Hover over a box to see details here...

**Key characteristics** * The ATP synthase F1 subunit delta is a large protein (850 amino acids long) that is found in all eukaryotic cells. * It is a heterodimeric protein, meaning that it consists of two subunits that are held together by a linker peptide. * Each subunit of the ATP synthase F1 complex is responsible for the synthesis of one molecule of ATP. * The ATP synthase F1 complex is a highly efficient enzyme, and it is responsible for generating the majority of the ATP produced by oxidative phosphorylation. **Pathways and functions** The ATP synthase F1 subunit delta is involved in a number of important cellular pathways, including: * Oxidative phosphorylation * Mitochondrial biogenesis * Mitochondrial proton-transporting ATP synthase complex assembly * Organelle biogenesis and maintenance * Protein binding * Proton-transporting atp synthase activity * Rotational mechanism **Clinical significance** Mutations in the ATP synthase F1 subunit delta gene have been linked to a number of human diseases, including: * Mitochondrial disorders * Diabetes * Obesity * Cancer The ATP synthase F1 subunit delta is a key enzyme in oxidative phosphorylation, and its dysfunction can lead to a number of diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

F-ATPase delta subunit

Genular Protein ID: 4269643913

Symbol: ATPD_HUMAN

Name: F-ATPase delta subunit

UniProtKB Accession Codes:

P30049 D6W5Y3 Q6FG90

Database IDs:

Citations:

PubMed ID: 1531933

Title: Molecular cloning of an import precursor of the delta-subunit of the human mitochondrial ATP synthase complex.

PubMed ID: 1531933

DOI: 10.1016/0167-4781(92)90477-h

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1286669

Title: Human liver protein map: a reference database established by microsequencing and gel comparison.

PubMed ID: 1286669

DOI: 10.1002/elps.11501301201

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29478781

Title: Biallelic Mutations in ATP5F1D, which Encodes a Subunit of ATP Synthase, Cause a Metabolic Disorder.

PubMed ID: 29478781

DOI: 10.1016/j.ajhg.2018.01.020

Sequence Information:

Length: 168
Mass: 17490
Checksum: B7F0D1D01ADFDFE7
Sequence:

MLPAALLRRP GLGRLVRHAR AYAEAAAAPA AASGPNQMSF TFASPTQVFF NGANVRQVDV 
PTLTGAFGIL AAHVPTLQVL RPGLVVVHAE DGTTSKYFVS SGSIAVNADS SVQLLAEEAV 
TLDMLDLGAA KANLEKAQAE LVGTADEATR AEIQIRIEAN EALVKALE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: ATP5F1D

Associated with

Cells (max top 100)

Other Information

Molecular cloning of an import precursor of the delta-subunit of the human mitochondrial ATP synthase complex. PubMed ID: 1531933

The DNA sequence and biology of human chromosome 19. PubMed ID: 15057824

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Human liver protein map: a reference database established by microsequencing and gel comparison. PubMed ID: 1286669

Initial characterization of the human central proteome. PubMed ID: 21269460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Biallelic Mutations in ATP5F1D, which Encodes a Subunit of ATP Synthase, Cause a Metabolic Disorder. PubMed ID: 29478781