Details for: ATP5F1D

Gene ID: 513

Symbol: ATP5F1D

Ensembl ID: ENSG00000099624

Description: ATP synthase F1 subunit delta

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 5.58
    Marker Score: 6,047
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 5.18
    Marker Score: 10,941
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 4.55
    Marker Score: 2,761
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 4.54
    Marker Score: 3,206
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 3.97
    Marker Score: 1,165
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.92
    Marker Score: 10,498
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 3.79
    Marker Score: 15,752
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 3.68
    Marker Score: 3,127
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.65
    Marker Score: 12,964
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.55
    Marker Score: 8,089
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.53
    Marker Score: 3,147
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 3.49
    Marker Score: 1,947
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 3.39
    Marker Score: 2,271
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.36
    Marker Score: 8,465
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.34
    Marker Score: 5,536
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 3.33
    Marker Score: 1,952
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 3.26
    Marker Score: 43,313
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.21
    Marker Score: 10,092
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.19
    Marker Score: 178,322
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.17
    Marker Score: 3,386
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.16
    Marker Score: 1,041
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.15
    Marker Score: 7,692
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.14
    Marker Score: 31,073
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.12
    Marker Score: 23,224
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.12
    Marker Score: 24,338
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 3.1
    Marker Score: 3,097
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 3.04
    Marker Score: 14,570
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.98
    Marker Score: 103,372
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.96
    Marker Score: 3,570
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.95
    Marker Score: 8,148
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 2.95
    Marker Score: 2,633
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.91
    Marker Score: 18,576
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.91
    Marker Score: 2,736
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.9
    Marker Score: 2,061
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.89
    Marker Score: 3,070
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.89
    Marker Score: 38,090
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.87
    Marker Score: 12,314
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.87
    Marker Score: 2,708
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.86
    Marker Score: 2,256
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.86
    Marker Score: 1,140
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.86
    Marker Score: 4,041
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.85
    Marker Score: 2,977
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.83
    Marker Score: 2,867
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.8
    Marker Score: 18,186
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.79
    Marker Score: 2,189
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 2.75
    Marker Score: 5,174
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.75
    Marker Score: 8,688
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.75
    Marker Score: 2,635
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.75
    Marker Score: 4,370
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.74
    Marker Score: 3,049
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.72
    Marker Score: 143,924
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.7
    Marker Score: 23,294
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.7
    Marker Score: 4,826
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.7
    Marker Score: 1,348
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.69
    Marker Score: 2,365
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.68
    Marker Score: 3,071
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.67
    Marker Score: 4,111
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.66
    Marker Score: 6,487
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.65
    Marker Score: 11,424
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.65
    Marker Score: 29,799
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 2.64
    Marker Score: 1,405
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.64
    Marker Score: 17,197
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.63
    Marker Score: 1,598
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.62
    Marker Score: 89,219
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.61
    Marker Score: 10,691
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.61
    Marker Score: 1,735
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.59
    Marker Score: 1,962
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.58
    Marker Score: 2,416
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.58
    Marker Score: 3,800
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.57
    Marker Score: 34,577
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.57
    Marker Score: 1,450
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.56
    Marker Score: 611
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.55
    Marker Score: 2,866
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.55
    Marker Score: 1,859
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.54
    Marker Score: 1,307
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.54
    Marker Score: 814
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.54
    Marker Score: 9,777
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.53
    Marker Score: 5,147
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.52
    Marker Score: 7,367
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.52
    Marker Score: 1,433
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.52
    Marker Score: 7,475
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.5
    Marker Score: 1,814
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 2.5
    Marker Score: 1,379
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.48
    Marker Score: 4,068
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.48
    Marker Score: 25,097
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.47
    Marker Score: 1,490
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.46
    Marker Score: 63,104
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 2.46
    Marker Score: 2,016
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.45
    Marker Score: 1,145
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.45
    Marker Score: 3,397
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.45
    Marker Score: 5,549
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2.44
    Marker Score: 2,534
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 2.43
    Marker Score: 915
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.42
    Marker Score: 1,595
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.41
    Marker Score: 765
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.4
    Marker Score: 848
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 2.39
    Marker Score: 1,179
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 2.39
    Marker Score: 1,606
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.39
    Marker Score: 15,261
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 2.39
    Marker Score: 576

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The ATP5F1D gene encodes for the F1 subunit delta of the mitochondrial ATP synthase complex. This subunit is a crucial component of the complex, responsible for binding to the F1 subunit alpha and facilitating the rotation of the stalk subunits, which in turn drives the synthesis of ATP. The F1 subunit delta is highly conserved across species, suggesting its essential role in mitochondrial function. **Pathways and Functions:** The ATP5F1D gene is involved in several key pathways, including: 1. **Aerobic Respiration:** The ATP synthase complex plays a critical role in generating ATP during aerobic respiration, a process that involves the transfer of electrons from NADH to oxygen. 2. **Cristae Formation:** The F1 subunit delta is involved in the formation of the cristae, the infoldings of the mitochondrial inner membrane that increase the surface area for ATP synthesis. 3. **Mitochondrial Biogenesis:** The ATP synthase complex is also involved in the biogenesis of mitochondria, ensuring the proper assembly and function of the organelle. 4. **Proton-Transporting ATP Synthase Activity:** The F1 subunit delta is responsible for the rotational mechanism of the ATP synthase complex, which drives the synthesis of ATP. **Clinical Significance:** Dysfunction of the ATP5F1D gene has been implicated in various diseases, including: 1. **Mitochondrial Myopathies:** Mutations in the ATP5F1D gene have been associated with mitochondrial myopathies, a group of diseases characterized by muscle weakness and fatigue. 2. **Neurodegenerative Disorders:** The ATP synthase complex has also been implicated in neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer:** The F1 subunit delta has been shown to be overexpressed in certain types of cancer, suggesting its potential role in tumorigenesis. In conclusion, the ATP5F1D gene plays a crucial role in mitochondrial function and disease pathogenesis. Further research is needed to fully understand the mechanisms by which the F1 subunit delta contributes to disease, and to explore potential therapeutic strategies for targeting this gene. **Significantly Expressed Cells:** The ATP5F1D gene is significantly expressed in various cell types, including: 1. **Follicular B Cell:** The ATP synthase complex is essential for the survival and function of follicular B cells, which are critical for the adaptive immune response. 2. **Pancreatic Acinar Cell:** The F1 subunit delta is involved in the regulation of pancreatic acinar cell function, which is essential for the production of digestive enzymes. 3. **Myeloid Dendritic Cell:** The ATP synthase complex is also expressed in myeloid dendritic cells, which play a critical role in the initiation of immune responses. **Proteins:** The ATP5F1D gene encodes for the F-ATPase delta subunit, which is also known as ATPD_HUMAN. This protein is a crucial component of the mitochondrial proton-transporting ATP synthase complex.

Genular Protein ID: 4269643913

Symbol: ATPD_HUMAN

Name: F-ATPase delta subunit

UniProtKB Accession Codes:

P30049 D6W5Y3 Q6FG90

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 12 EMDB 8 EPD 1 Ensembl 3 ExpressionAtlas 1 GO 11 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 8 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 2 SWISS-2DPAGE 1 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCD-2DPAGE 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1531933

Title: Molecular cloning of an import precursor of the delta-subunit of the human mitochondrial ATP synthase complex.

PubMed ID: 1531933

DOI: 10.1016/0167-4781(92)90477-h

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1286669

Title: Human liver protein map: a reference database established by microsequencing and gel comparison.

PubMed ID: 1286669

DOI: 10.1002/elps.11501301201

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29478781

Title: Biallelic Mutations in ATP5F1D, which Encodes a Subunit of ATP Synthase, Cause a Metabolic Disorder.

PubMed ID: 29478781

DOI: 10.1016/j.ajhg.2018.01.020

Sequence Information:

  • Length: 168
  • Mass: 17490
  • Checksum: B7F0D1D01ADFDFE7
  • Sequence:
    • MLPAALLRRP GLGRLVRHAR AYAEAAAAPA AASGPNQMSF TFASPTQVFF NGANVRQVDV 
PTLTGAFGIL AAHVPTLQVL RPGLVVVHAE DGTTSKYFVS SGSIAVNADS SVQLLAEEAV 
TLDMLDLGAA KANLEKAQAE LVGTADEATR AEIQIRIEAN EALVKALE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.