Details for: ATP5PB

Gene ID: 515

Symbol: ATP5PB

Ensembl ID: ENSG00000116459

Description: ATP synthase peripheral stalk-membrane subunit b

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 5.77
    Marker Score: 3861.5
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 4.43
    Marker Score: 2691
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 3.95
    Marker Score: 2788
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.74
    Marker Score: 7902
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 3.56
    Marker Score: 3859.5
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.55
    Marker Score: 3703
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.5
    Marker Score: 3125
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 3.22
    Marker Score: 13359
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 2.97
    Marker Score: 1586
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 2.95
    Marker Score: 865
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.88
    Marker Score: 33465
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.77
    Marker Score: 36516
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.64
    Marker Score: 147620.5
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.64
    Marker Score: 20599
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 2.63
    Marker Score: 1469
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 2.63
    Marker Score: 1398
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 2.63
    Marker Score: 3156
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.63
    Marker Score: 19541
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 2.6
    Marker Score: 34630
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.6
    Marker Score: 2601
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.57
    Marker Score: 22117
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.51
    Marker Score: 10254
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.49
    Marker Score: 7805
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.46
    Marker Score: 15750
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.46
    Marker Score: 15996
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 2.44
    Marker Score: 1011
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.43
    Marker Score: 4232
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.42
    Marker Score: 3482
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.42
    Marker Score: 4715
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.41
    Marker Score: 5032.5
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.39
    Marker Score: 3388.5
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.38
    Marker Score: 6385
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.37
    Marker Score: 23509
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 2.37
    Marker Score: 2012
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.36
    Marker Score: 7009.5
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.36
    Marker Score: 10161
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.36
    Marker Score: 2101
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.33
    Marker Score: 767
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.31
    Marker Score: 1449.5
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.3
    Marker Score: 1132
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 2.3
    Marker Score: 1733
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 2.29
    Marker Score: 1184
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.29
    Marker Score: 10995
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.28
    Marker Score: 2298
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 2.27
    Marker Score: 1332
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.26
    Marker Score: 2415
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2.26
    Marker Score: 2344
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.24
    Marker Score: 5274
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.23
    Marker Score: 29950
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.22
    Marker Score: 3415
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.21
    Marker Score: 3624
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.2
    Marker Score: 5232
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.2
    Marker Score: 5007
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.2
    Marker Score: 2067
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.2
    Marker Score: 76108
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.19
    Marker Score: 3717
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.18
    Marker Score: 5938
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.17
    Marker Score: 1451
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 2.17
    Marker Score: 2275
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.17
    Marker Score: 8522
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.16
    Marker Score: 1316
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.16
    Marker Score: 1574.5
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.16
    Marker Score: 2087
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.16
    Marker Score: 55257
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.15
    Marker Score: 2458
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.11
    Marker Score: 2245
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.11
    Marker Score: 1529
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.11
    Marker Score: 6663
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.11
    Marker Score: 2925.5
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.11
    Marker Score: 5252
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.11
    Marker Score: 2229
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.11
    Marker Score: 21344
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.1
    Marker Score: 1194
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.1
    Marker Score: 838
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.08
    Marker Score: 1951
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 2.07
    Marker Score: 765
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.06
    Marker Score: 2308
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.06
    Marker Score: 1220
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.05
    Marker Score: 3023
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.05
    Marker Score: 3402
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.05
    Marker Score: 1127
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.04
    Marker Score: 3278
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.04
    Marker Score: 3996
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.04
    Marker Score: 8741
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.03
    Marker Score: 2149.5
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.02
    Marker Score: 106739
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.01
    Marker Score: 2171
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.01
    Marker Score: 1681
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.01
    Marker Score: 1059
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 2.01
    Marker Score: 2668
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2
    Marker Score: 20138.5
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2
    Marker Score: 478
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 2
    Marker Score: 943
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2
    Marker Score: 4529
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 2
    Marker Score: 977.5
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.99
    Marker Score: 1750.5
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.99
    Marker Score: 1873
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.98
    Marker Score: 3542.5
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.98
    Marker Score: 3154
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.98
    Marker Score: 490

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Other Information

**Key characteristics:** * ATP5PB is a large protein with a molecular weight of approximately 130 kDa. * It is found in the mitochondrial outer membrane. * It is a subunit of the mitochondrial ATP synthase complex. **Pathways and functions:** * ATP5PB is involved in the formation of ATP by chemiosmotic coupling. * It is also involved in the mitochondrial proton-transporting ATP synthase complex, which is responsible for the flow of protons across the mitochondrial inner membrane. * ATP5PB is also involved in the respiratory electron transport chain, where it helps to generate ATP through the transfer of protons from NADH and FADH2 to oxygen. **Clinical significance:** * Mutations in ATP5PB have been linked to several human diseases, including mitochondrial disorders and cancer. * These diseases are characterized by a decrease in mitochondrial function, which can lead to a decrease in ATP production and an increase in cellular stress. * Targeting ATP5PB has been explored as a therapeutic strategy for these diseases. **Conclusion:** ATP5PB is an essential enzyme for mitochondrial energy production. Mutations in ATP5PB have a significant impact on human health, and targeting this gene is a promising therapeutic strategy for several human diseases.

Genular Protein ID: 481862021

Symbol: AT5F1_HUMAN

Name: ATP synthase proton-transporting mitochondrial F(0) complex subunit B1

UniProtKB Accession Codes:

P24539 Q9BQ68 Q9BRU8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 EMBL 5 EMDB 12 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 12 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1831354

Title: Molecular cloning of cDNA for the import precursor of human subunit B of H(+)-ATP synthase in mitochondria.

PubMed ID: 1831354

DOI: 10.1016/0006-291x(91)90993-h

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 256
  • Mass: 28909
  • Checksum: 743B1C54BFFEBBBD
  • Sequence:
    • MLSRVVLSAA ATAAPSLKNA AFLGPGVLQA TRTFHTGQPH LVPVPPLPEY GGKVRYGLIP 
EEFFQFLYPK TGVTGPYVLG TGLILYALSK EIYVISAETF TALSVLGVMV YGIKKYGPFV 
ADFADKLNEQ KLAQLEEAKQ ASIQHIQNAI DTEKSQQALV QKRHYLFDVQ RNNIAMALEV 
TYRERLYRVY KEVKNRLDYH ISVQNMMRRK EQEHMINWVE KHVVQSISTQ QEKETIAKCI 
ADLKLLAKKA QAQPVM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.