Details for: ATP5PB

Gene ID: 515

Symbol: ATP5PB

Ensembl ID: ENSG00000116459

Description: ATP synthase peripheral stalk-membrane subunit b

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 5.77
    Marker Score: 3,862
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 4.43
    Marker Score: 2,691
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 3.95
    Marker Score: 2,788
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.74
    Marker Score: 7,902
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 3.56
    Marker Score: 3,860
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.55
    Marker Score: 3,703
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.5
    Marker Score: 3,125
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 3.22
    Marker Score: 13,359
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 2.97
    Marker Score: 1,586
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 2.95
    Marker Score: 865
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.88
    Marker Score: 33,465
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.77
    Marker Score: 36,516
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.64
    Marker Score: 147,621
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.64
    Marker Score: 20,599
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 2.63
    Marker Score: 1,469
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 2.63
    Marker Score: 1,398
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 2.63
    Marker Score: 3,156
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.63
    Marker Score: 19,541
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 2.6
    Marker Score: 34,630
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.6
    Marker Score: 2,601
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.57
    Marker Score: 22,117
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.51
    Marker Score: 10,254
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.49
    Marker Score: 7,805
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.46
    Marker Score: 15,750
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.46
    Marker Score: 15,996
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 2.44
    Marker Score: 1,011
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.43
    Marker Score: 4,232
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.42
    Marker Score: 3,482
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.42
    Marker Score: 4,715
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.41
    Marker Score: 5,033
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.39
    Marker Score: 3,389
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.38
    Marker Score: 6,385
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.37
    Marker Score: 23,509
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 2.37
    Marker Score: 2,012
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.36
    Marker Score: 7,010
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.36
    Marker Score: 10,161
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.36
    Marker Score: 2,101
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.33
    Marker Score: 767
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.31
    Marker Score: 1,450
  • Cell Name: centroblast (CL0009112)
    Fold Change: 2.3
    Marker Score: 1,132
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 2.3
    Marker Score: 1,733
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 2.29
    Marker Score: 1,184
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.29
    Marker Score: 10,995
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.28
    Marker Score: 2,298
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 2.27
    Marker Score: 1,332
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.26
    Marker Score: 2,415
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2.26
    Marker Score: 2,344
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.24
    Marker Score: 5,274
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.23
    Marker Score: 29,950
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.22
    Marker Score: 3,415
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.21
    Marker Score: 3,624
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.2
    Marker Score: 5,232
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.2
    Marker Score: 5,007
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.2
    Marker Score: 2,067
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.2
    Marker Score: 76,108
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.19
    Marker Score: 3,717
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.18
    Marker Score: 5,938
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.17
    Marker Score: 1,451
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 2.17
    Marker Score: 2,275
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.17
    Marker Score: 8,522
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.16
    Marker Score: 1,316
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.16
    Marker Score: 1,575
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.16
    Marker Score: 2,087
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.16
    Marker Score: 55,257
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.15
    Marker Score: 2,458
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.11
    Marker Score: 2,245
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.11
    Marker Score: 1,529
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.11
    Marker Score: 6,663
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.11
    Marker Score: 2,926
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.11
    Marker Score: 5,252
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.11
    Marker Score: 2,229
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.11
    Marker Score: 21,344
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.1
    Marker Score: 1,194
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.1
    Marker Score: 838
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.08
    Marker Score: 1,951
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 2.07
    Marker Score: 765
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.06
    Marker Score: 2,308
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.06
    Marker Score: 1,220
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.05
    Marker Score: 3,023
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.05
    Marker Score: 3,402
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.05
    Marker Score: 1,127
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.04
    Marker Score: 3,278
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.04
    Marker Score: 3,996
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.04
    Marker Score: 8,741
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.03
    Marker Score: 2,150
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.02
    Marker Score: 106,739
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.01
    Marker Score: 2,171
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.01
    Marker Score: 1,681
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 2.01
    Marker Score: 1,059
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 2.01
    Marker Score: 2,668
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2
    Marker Score: 20,139
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2
    Marker Score: 478
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 2
    Marker Score: 943
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2
    Marker Score: 4,529
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 2
    Marker Score: 978
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.99
    Marker Score: 1,751
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.99
    Marker Score: 1,873
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.98
    Marker Score: 3,543
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.98
    Marker Score: 3,154
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.98
    Marker Score: 490

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ATP5PB is a peripheral stalk-membrane subunit of the mitochondrial ATP synthase complex. It is part of the F0 subunit, which is responsible for proton transport across the mitochondrial inner membrane. The protein has a unique structure, with a stalk region that connects the membrane to the stalk-membrane complex. This subunit is essential for the proper functioning of the ATP synthase complex, as it enables the rotation of the stalk-membrane complex in response to proton flow, ultimately driving ATP synthesis. **Pathways and Functions** The ATP synthase complex, including ATP5PB, is involved in the following pathways: 1. **Cristae formation**: The ATP synthase complex plays a crucial role in the formation of cristae, the infoldings of the mitochondrial inner membrane that increase the surface area for ATP synthesis. 2. **Formation of ATP by chemiosmotic coupling**: ATP5PB is essential for the production of ATP through chemiosmotic coupling, a process that harnesses the energy generated by the respiratory electron transport chain to drive ATP synthesis. 3. **Proton-transporting atp synthase activity**: The ATP synthase complex, including ATP5PB, is responsible for transporting protons across the mitochondrial inner membrane, which drives the rotation of the stalk-membrane complex and ultimately ATP synthesis. 4. **Rotational mechanism**: ATP5PB is involved in the rotational mechanism of the ATP synthase complex, which enables the conversion of chemical energy into mechanical energy. 5. **Proton motive force-driven atp synthesis**: The ATP synthase complex, including ATP5PB, is responsible for the production of ATP through the proton motive force, a mechanism that harnesses the energy generated by proton flow to drive ATP synthesis. **Clinical Significance** Dysregulation of the ATP synthase complex, including ATP5PB, has been implicated in various diseases, including: 1. **Mitochondrial disorders**: Mutations in the ATP5PB gene have been associated with mitochondrial disorders, such as MERRF (myoclonic epilepsy with ragged-red fibers) and MELAS (mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes). 2. **Neurodegenerative diseases**: The ATP synthase complex, including ATP5PB, has been implicated in neurodegenerative diseases such as Alzheimer's and Parkinson's disease, where mitochondrial dysfunction is a key feature. 3. **Cancer**: The ATP synthase complex, including ATP5PB, has been shown to be overexpressed in certain types of cancer, including pancreatic and breast cancer, highlighting its potential as a therapeutic target. In conclusion, ATP5PB is a critical protein subunit of the mitochondrial ATP synthase complex, essential for the production of ATP through chemiosmotic coupling. Its dysregulation has been implicated in various diseases, highlighting its importance in cellular energy metabolism and its potential as a therapeutic target.

Genular Protein ID: 481862021

Symbol: AT5F1_HUMAN

Name: ATP synthase proton-transporting mitochondrial F(0) complex subunit B1

UniProtKB Accession Codes:

P24539 Q9BQ68 Q9BRU8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 EMBL 5 EMDB 12 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 12 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1831354

Title: Molecular cloning of cDNA for the import precursor of human subunit B of H(+)-ATP synthase in mitochondria.

PubMed ID: 1831354

DOI: 10.1016/0006-291x(91)90993-h

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 256
  • Mass: 28909
  • Checksum: 743B1C54BFFEBBBD
  • Sequence:
    • MLSRVVLSAA ATAAPSLKNA AFLGPGVLQA TRTFHTGQPH LVPVPPLPEY GGKVRYGLIP 
EEFFQFLYPK TGVTGPYVLG TGLILYALSK EIYVISAETF TALSVLGVMV YGIKKYGPFV 
ADFADKLNEQ KLAQLEEAKQ ASIQHIQNAI DTEKSQQALV QKRHYLFDVQ RNNIAMALEV 
TYRERLYRVY KEVKNRLDYH ISVQNMMRRK EQEHMINWVE KHVVQSISTQ QEKETIAKCI 
ADLKLLAKKA QAQPVM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.