Details for: ATP5PB

Gene ID: 515

Symbol: ATP5PB

Ensembl ID: ENSG00000116459

Description: ATP synthase peripheral stalk-membrane subunit b

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 204.9532
    Cell Significance Index: -84.4300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 187.5044
    Cell Significance Index: -76.1800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 177.1044
    Cell Significance Index: -83.6200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 165.7318
    Cell Significance Index: -85.2500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 125.1002
    Cell Significance Index: -83.9500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 20.5797
    Cell Significance Index: -55.1300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 16.5215
    Cell Significance Index: -50.7500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 11.3269
    Cell Significance Index: -24.7900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.1888
    Cell Significance Index: 93.6500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.8120
    Cell Significance Index: 30.5700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.7232
    Cell Significance Index: 57.0000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.4324
    Cell Significance Index: 286.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.4231
    Cell Significance Index: 436.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.3970
    Cell Significance Index: 111.7600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.3174
    Cell Significance Index: 284.9400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.2950
    Cell Significance Index: 162.3100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.2469
    Cell Significance Index: 17.9400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.1384
    Cell Significance Index: 128.3800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.9805
    Cell Significance Index: 271.9800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.8074
    Cell Significance Index: 799.0800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.7792
    Cell Significance Index: 1606.4700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.7749
    Cell Significance Index: 114.5100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.7671
    Cell Significance Index: 965.0400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.7592
    Cell Significance Index: 121.6600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.5357
    Cell Significance Index: 40.3800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.4875
    Cell Significance Index: 192.1700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.4720
    Cell Significance Index: 51.1500
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.3523
    Cell Significance Index: 18.4500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2251
    Cell Significance Index: 63.6400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.1907
    Cell Significance Index: 152.6400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.1757
    Cell Significance Index: 61.7300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.1663
    Cell Significance Index: 86.9200
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.0858
    Cell Significance Index: 18.2900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.0242
    Cell Significance Index: 22.1900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.0150
    Cell Significance Index: 18.7600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.9909
    Cell Significance Index: 9.1300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.9862
    Cell Significance Index: 12.6300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8953
    Cell Significance Index: 40.5800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.8362
    Cell Significance Index: 22.7600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.8160
    Cell Significance Index: 9.2700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.8118
    Cell Significance Index: 233.5900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6053
    Cell Significance Index: 121.4300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5327
    Cell Significance Index: 105.7200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4757
    Cell Significance Index: 77.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3434
    Cell Significance Index: 11.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3154
    Cell Significance Index: 60.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2925
    Cell Significance Index: 104.9200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2626
    Cell Significance Index: 7.5700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1646
    Cell Significance Index: 120.6500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0957
    Cell Significance Index: 72.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0637
    Cell Significance Index: 2.2400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0547
    Cell Significance Index: 5.4100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0204
    Cell Significance Index: 0.5500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0097
    Cell Significance Index: 0.4900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0073
    Cell Significance Index: 0.4600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0021
    Cell Significance Index: -0.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0152
    Cell Significance Index: -28.5400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0284
    Cell Significance Index: -4.8500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0361
    Cell Significance Index: -2.7700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0373
    Cell Significance Index: -3.8100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0451
    Cell Significance Index: -83.2300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0550
    Cell Significance Index: -84.6000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0661
    Cell Significance Index: -89.9200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0816
    Cell Significance Index: -51.8400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0880
    Cell Significance Index: -65.1700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1234
    Cell Significance Index: -55.9900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1305
    Cell Significance Index: -73.5900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1427
    Cell Significance Index: -89.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3139
    Cell Significance Index: -35.9600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3210
    Cell Significance Index: -25.4200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3229
    Cell Significance Index: -37.6400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3903
    Cell Significance Index: -9.9700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.3965
    Cell Significance Index: -11.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.4019
    Cell Significance Index: -18.8900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.4131
    Cell Significance Index: -60.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4152
    Cell Significance Index: -87.4600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5018
    Cell Significance Index: -30.8400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5087
    Cell Significance Index: -20.8400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6208
    Cell Significance Index: -7.4000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.6863
    Cell Significance Index: -38.5100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.7614
    Cell Significance Index: -13.4600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7657
    Cell Significance Index: -79.7300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.8762
    Cell Significance Index: -9.0700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.9903
    Cell Significance Index: -21.0900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0640
    Cell Significance Index: -31.3400
  • Cell Name: germ cell (CL0000586)
    Fold Change: -1.0641
    Cell Significance Index: -8.0400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0989
    Cell Significance Index: -67.3700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.2890
    Cell Significance Index: -34.4800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.3845
    Cell Significance Index: -61.2400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.3848
    Cell Significance Index: -35.6000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.4485
    Cell Significance Index: -24.8200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.4544
    Cell Significance Index: -75.7600
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.5254
    Cell Significance Index: -22.5200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.5703
    Cell Significance Index: -13.1900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.6070
    Cell Significance Index: -24.0800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.6530
    Cell Significance Index: -41.3200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -1.6584
    Cell Significance Index: -62.8000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.8728
    Cell Significance Index: -38.8500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.9009
    Cell Significance Index: -69.7800
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -1.9150
    Cell Significance Index: -26.8600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ATP5PB is a peripheral stalk-membrane subunit of the mitochondrial ATP synthase complex. It is part of the F0 subunit, which is responsible for proton transport across the mitochondrial inner membrane. The protein has a unique structure, with a stalk region that connects the membrane to the stalk-membrane complex. This subunit is essential for the proper functioning of the ATP synthase complex, as it enables the rotation of the stalk-membrane complex in response to proton flow, ultimately driving ATP synthesis. **Pathways and Functions** The ATP synthase complex, including ATP5PB, is involved in the following pathways: 1. **Cristae formation**: The ATP synthase complex plays a crucial role in the formation of cristae, the infoldings of the mitochondrial inner membrane that increase the surface area for ATP synthesis. 2. **Formation of ATP by chemiosmotic coupling**: ATP5PB is essential for the production of ATP through chemiosmotic coupling, a process that harnesses the energy generated by the respiratory electron transport chain to drive ATP synthesis. 3. **Proton-transporting atp synthase activity**: The ATP synthase complex, including ATP5PB, is responsible for transporting protons across the mitochondrial inner membrane, which drives the rotation of the stalk-membrane complex and ultimately ATP synthesis. 4. **Rotational mechanism**: ATP5PB is involved in the rotational mechanism of the ATP synthase complex, which enables the conversion of chemical energy into mechanical energy. 5. **Proton motive force-driven atp synthesis**: The ATP synthase complex, including ATP5PB, is responsible for the production of ATP through the proton motive force, a mechanism that harnesses the energy generated by proton flow to drive ATP synthesis. **Clinical Significance** Dysregulation of the ATP synthase complex, including ATP5PB, has been implicated in various diseases, including: 1. **Mitochondrial disorders**: Mutations in the ATP5PB gene have been associated with mitochondrial disorders, such as MERRF (myoclonic epilepsy with ragged-red fibers) and MELAS (mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes). 2. **Neurodegenerative diseases**: The ATP synthase complex, including ATP5PB, has been implicated in neurodegenerative diseases such as Alzheimer's and Parkinson's disease, where mitochondrial dysfunction is a key feature. 3. **Cancer**: The ATP synthase complex, including ATP5PB, has been shown to be overexpressed in certain types of cancer, including pancreatic and breast cancer, highlighting its potential as a therapeutic target. In conclusion, ATP5PB is a critical protein subunit of the mitochondrial ATP synthase complex, essential for the production of ATP through chemiosmotic coupling. Its dysregulation has been implicated in various diseases, highlighting its importance in cellular energy metabolism and its potential as a therapeutic target.

Genular Protein ID: 481862021

Symbol: AT5F1_HUMAN

Name: ATP synthase proton-transporting mitochondrial F(0) complex subunit B1

UniProtKB Accession Codes:

P24539 Q9BQ68 Q9BRU8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 14 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 14 PDBsum 14 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1831354

Title: Molecular cloning of cDNA for the import precursor of human subunit B of H(+)-ATP synthase in mitochondria.

PubMed ID: 1831354

DOI: 10.1016/0006-291x(91)90993-h

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 256
  • Mass: 28909
  • Checksum: 743B1C54BFFEBBBD
  • Sequence:
    • MLSRVVLSAA ATAAPSLKNA AFLGPGVLQA TRTFHTGQPH LVPVPPLPEY GGKVRYGLIP 
EEFFQFLYPK TGVTGPYVLG TGLILYALSK EIYVISAETF TALSVLGVMV YGIKKYGPFV 
ADFADKLNEQ KLAQLEEAKQ ASIQHIQNAI DTEKSQQALV QKRHYLFDVQ RNNIAMALEV 
TYRERLYRVY KEVKNRLDYH ISVQNMMRRK EQEHMINWVE KHVVQSISTQ QEKETIAKCI 
ADLKLLAKKA QAQPVM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.