Details for: ATP5PB

Gene ID: 515

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: ATP5PB

Ensembl ID: ENSG00000116459

Description: ATP synthase peripheral stalk-membrane subunit b

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 81.54
    rCSI 73.63%
    PRS 7.77
  • hematopoietic stem cell CL0000037
    CSI 79.62
    rCSI 52.92%
    PRS 10.5
  • stem cell CL0000034
    CSI 79.15
    rCSI 76.32%
    PRS 5.74
  • common myeloid progenitor CL0000049
    CSI 77.13
    rCSI 62.37%
    PRS 8.68
  • colon epithelial cell CL0011108
    CSI 69.66
    rCSI 72.97%
    PRS 8.18
  • intestinal epithelial cell CL0002563
    CSI 68.82
    rCSI 71.93%
    PRS 9.28
  • transit amplifying cell of colon CL0009011
    CSI 65.37
    rCSI 76.77%
    PRS 10.47
  • granulocyte monocyte progenitor cell CL0000557
    CSI 63.1
    rCSI 54.63%
    PRS 9.81
  • early lymphoid progenitor CL0000936
    CSI 62.63
    rCSI 55.01%
    PRS 9.88
  • fraction A pre-pro B cell CL0002045
    CSI 60.58
    rCSI 69.35%
    PRS 18.2
  • fallopian tube secretory epithelial cell CL4030006
    CSI 59.16
    rCSI 56.95%
    PRS 9.1
  • common dendritic progenitor CL0001029
    CSI 58.4
    rCSI 73.29%
    PRS 11.23
  • keratinocyte CL0000312
    CSI 57.29
    rCSI 48.03%
    PRS 10.52
  • plasmablast CL0000980
    CSI 54.65
    rCSI 42.99%
    PRS 10.49
  • epithelial cell of lung CL0000082
    CSI 49.71
    rCSI 41.21%
    PRS 8.35
  • ciliated epithelial cell CL0000067
    CSI 47.24
    rCSI 41.54%
    PRS 6.38
  • intestine goblet cell CL0019031
    CSI 44.66
    rCSI 39.64%
    PRS 8.8
  • enterocyte CL0000584
    CSI 43.4
    rCSI 69.98%
    PRS 14.08
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 38.89
    rCSI 29.96%
    PRS 7.95
  • transit amplifying cell CL0009010
    CSI 38.18
    rCSI 58.39%
    PRS 14.3
  • promyelocyte CL0000836
    CSI 38.03
    rCSI 54.85%
    PRS 12.3
  • promonocyte CL0000559
    CSI 34.52
    rCSI 59.15%
    PRS 11.8
  • M cell of gut CL0000682
    CSI 33.88
    rCSI 36%
    PRS 15.72
  • mucous neck cell CL0000651
    CSI 33.45
    rCSI 48.21%
    PRS 14.19
  • enteric smooth muscle cell CL0002504
    CSI 33.05
    rCSI 47.16%
    PRS 9.95
  • pancreatic D cell CL0000173
    CSI 31.85
    rCSI 31.33%
    PRS 9.55
  • T-helper 17 cell CL0000899
    CSI 31.4
    rCSI 24.94%
    PRS 15.53
  • conventional dendritic cell CL0000990
    CSI 31.26
    rCSI 26.1%
    PRS 27.2
  • pancreatic A cell CL0000171
    CSI 31.07
    rCSI 32.55%
    PRS 9.37
  • peripheral nervous system neuron CL2000032
    CSI 30.08
    rCSI 40.98%
    PRS 7.88
  • colon goblet cell CL0009039
    CSI 29.3
    rCSI 69.65%
    PRS 13.21
  • double-positive, alpha-beta thymocyte CL0000809
    CSI 29.08
    rCSI 29.64%
    PRS 12.57
  • placental villous trophoblast CL2000060
    CSI 28.48
    rCSI 44.01%
    PRS 8.23
  • goblet cell CL0000160
    CSI 27.95
    rCSI 26.41%
    PRS 9.19
  • colonocyte CL1000347
    CSI 27.34
    rCSI 39.19%
    PRS 12.06
  • muscle cell CL0000187
    CSI 25.8
    rCSI 52.97%
    PRS 21.03
  • myeloid leukocyte CL0000766
    CSI 25.73
    rCSI 23.74%
    PRS 8.95
  • foveolar cell of stomach CL0002179
    CSI 24.68
    rCSI 52.52%
    PRS 14.2
  • kidney epithelial cell CL0002518
    CSI 24.17
    rCSI 46.15%
    PRS 21.1
  • pro-B cell CL0000826
    CSI 23.86
    rCSI 19.76%
    PRS 8.79
  • extravillous trophoblast CL0008036
    CSI 23.08
    rCSI 28.55%
    PRS 7.71
  • large pre-B-II cell CL0000957
    CSI 22.58
    rCSI 64.46%
    PRS 15.55
  • intestinal crypt stem cell of small intestine CL0009017
    CSI 22.27
    rCSI 60.04%
    PRS 11.35
  • microcirculation associated smooth muscle cell CL0008035
    CSI 21.47
    rCSI 62.16%
    PRS 9.97
  • common lymphoid progenitor CL0000051
    CSI 20.2
    rCSI 27%
    PRS 16.84
  • elicited macrophage CL0000861
    CSI 19.54
    rCSI 17.94%
    PRS 10.05
  • enteroendocrine cell CL0000164
    CSI 19.21
    rCSI 26.25%
    PRS 9.71
  • ionocyte CL0005006
    CSI 18.92
    rCSI 20.28%
    PRS 8.09
  • progenitor cell CL0011026
    CSI 18.65
    rCSI 39.67%
    PRS 16.08
  • retina horizontal cell CL0000745
    CSI 18.24
    rCSI 27.81%
    PRS 8.22
  • renal alpha-intercalated cell CL0005011
    CSI 18.18
    rCSI 24.3%
    PRS 11.72
  • forebrain radial glial cell CL0013000
    CSI 17.44
    rCSI 55.97%
    PRS 13.09
  • pancreatic ductal cell CL0002079
    CSI 16.78
    rCSI 32.64%
    PRS 8.97
  • pancreatic acinar cell CL0002064
    CSI 15.76
    rCSI 20.95%
    PRS 9.58
  • plasmacytoid dendritic cell, human CL0001058
    CSI 15.71
    rCSI 10.97%
    PRS 9.27
  • epithelial cell CL0000066
    CSI 15.67
    rCSI 24.08%
    PRS 12.62
  • myeloid lineage restricted progenitor cell CL0000839
    CSI 15.03
    rCSI 77.59%
    PRS 17.63
  • double negative thymocyte CL0002489
    CSI 14.26
    rCSI 9.91%
    PRS 10.3
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 13.64
    rCSI 16.48%
    PRS 10.36
  • tracheal goblet cell CL1000329
    CSI 13.12
    rCSI 28.65%
    PRS 17.93
  • mucus secreting cell CL0000319
    CSI 12.9
    rCSI 20.48%
    PRS 11.41
  • multi-ciliated epithelial cell CL0005012
    CSI 12.77
    rCSI 12.75%
    PRS 7.55
  • neural crest cell CL0011012
    CSI 12.43
    rCSI 9.83%
    PRS 6.05
  • pulmonary ionocyte CL0017000
    CSI 12.2
    rCSI 14.85%
    PRS 11.1
  • lymphoid lineage restricted progenitor cell CL0000838
    CSI 11.91
    rCSI 46.36%
    PRS 14.55
  • type EC enteroendocrine cell CL0000577
    CSI 11.9
    rCSI 42.25%
    PRS 14.43
  • transit amplifying cell of small intestine CL0009012
    CSI 11.83
    rCSI 51.95%
    PRS 16.44
  • central memory CD4-positive, alpha-beta T cell CL0000904
    CSI 11.75
    rCSI 6.94%
    PRS 12.19
  • primitive red blood cell CL0002355
    CSI 11.67
    rCSI 62.97%
    PRS 16.74
  • intestinal crypt stem cell of colon CL0009043
    CSI 11.54
    rCSI 86.64%
    PRS 16.3
  • respiratory basal cell CL0002633
    CSI 11.5
    rCSI 11.91%
    PRS 10.35
  • plasma cell CL0000786
    CSI 11.47
    rCSI 15.04%
    PRS 41.64
  • mature T cell CL0002419
    CSI 10.91
    rCSI 8.49%
    PRS 12.66
  • CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell CL0000915
    CSI 10.74
    rCSI 48.84%
    PRS 32.32
  • acinar cell CL0000622
    CSI 10.68
    rCSI 15.66%
    PRS 11.6
  • mesodermal cell CL0000222
    CSI 10.57
    rCSI 12.69%
    PRS 8.73
  • mammary gland epithelial cell CL0002327
    CSI 10.25
    rCSI 35.95%
    PRS 15.95
  • group 3 innate lymphoid cell CL0001071
    CSI 10.17
    rCSI 7.65%
    PRS 9.09
  • professional antigen presenting cell CL0000145
    CSI 10.09
    rCSI 34.73%
    PRS 36.04
  • cerebral cortex GABAergic interneuron CL0010011
    CSI 10.09
    rCSI 29.77%
    PRS 10.97
  • pancreatic stellate cell CL0002410
    CSI 10.05
    rCSI 58.48%
    PRS 13.25
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 9.98
    rCSI 6.72%
    PRS 10.58
  • activated type II NK T cell CL0000931
    CSI 9.92
    rCSI 11.16%
    PRS 14.28
  • germinal center B cell CL0000844
    CSI 9.83
    rCSI 29.3%
    PRS 22.7
  • perivascular cell CL4033054
    CSI 9.58
    rCSI 13.1%
    PRS 10
  • club cell CL0000158
    CSI 9.56
    rCSI 14%
    PRS 10.3
  • group 2 innate lymphoid cell CL0001069
    CSI 9.51
    rCSI 51.42%
    PRS 30.36
  • activated CD4-positive, alpha-beta T cell CL0000896
    CSI 9.45
    rCSI 8.73%
    PRS 16.14
  • neuroendocrine cell CL0000165
    CSI 9.31
    rCSI 36%
    PRS 18.66
  • luminal epithelial cell of mammary gland CL0002326
    CSI 9.29
    rCSI 16.88%
    PRS 13.43
  • dendritic cell CL0000451
    CSI 9.28
    rCSI 11.43%
    PRS 29.1
  • bronchial goblet cell CL1000312
    CSI 9.23
    rCSI 36.88%
    PRS 19.48
  • Cajal-Retzius cell CL0000695
    CSI 9.18
    rCSI 71.91%
    PRS 19.87
  • memory B cell CL0000787
    CSI 9.16
    rCSI 9.04%
    PRS 35.88
  • mesenchymal stem cell CL0000134
    CSI 9.11
    rCSI 99.78%
    PRS 16.08
  • radial glial cell CL0000681
    CSI 8.92
    rCSI 12.39%
    PRS 9.08
  • naive thymus-derived CD4-positive, alpha-beta T cell CL0000895
    CSI 8.77
    rCSI 11.02%
    PRS 41.68
  • melanocyte CL0000148
    CSI 8.76
    rCSI 6.49%
    PRS 7.95
  • naive thymus-derived CD8-positive, alpha-beta T cell CL0000900
    CSI 8.65
    rCSI 6.07%
    PRS 24.44
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 8.65
    rCSI 11.1%
    PRS 8.57
  • sncg GABAergic cortical interneuron CL4023015
    CSI -7.5
    rCSI -12.0%
    PRS 5.7%
  • vascular leptomeningeal cell CL4023051
    CSI -5.4
    rCSI -9.4%
    PRS 6.5%
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI -5.1
    rCSI -18.3%
    PRS 4.7%
  • pulmonary artery endothelial cell CL1001568
    CSI -5.1
    rCSI -6.9%
    PRS 13.5%
  • cerebellar granule cell CL0001031
    CSI -5.0
    rCSI -7.3%
    PRS 8.4%
  • effector memory CD8-positive, alpha-beta T cell CL0000913
    CSI -4.2
    rCSI -3.9%
    PRS 13.6%
  • squamous epithelial cell CL0000076
    CSI -3.0
    rCSI -7.1%
    PRS 11.5%
  • tracheobronchial smooth muscle cell CL0019019
    CSI -3.0
    rCSI -5.2%
    PRS 11.7%
  • CD8-positive, alpha-beta thymocyte CL0000811
    CSI -2.9
    rCSI -4.5%
    PRS 21.9%
  • astrocyte of the cerebral cortex CL0002605
    CSI -2.3
    rCSI -5.1%
    PRS 5.4%
  • retinal blood vessel endothelial cell CL0002585
    CSI -2.1
    rCSI -3.3%
    PRS 9.6%
  • centrilobular region hepatocyte CL0019029
    CSI -1.8
    rCSI -4.6%
    PRS 14.8%
  • CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792
    CSI -1.4
    rCSI -1.4%
    PRS 13.9%
  • indirect pathway medium spiny neuron CL4023029
    CSI -1.3
    rCSI -31.5%
    PRS 4.6%
  • serous secreting cell CL0000313
    CSI -1.1
    rCSI -5.8%
    PRS 38.4%
  • basophil CL0000767
    CSI -0.9
    rCSI -1.9%
    PRS 18.7%
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI -0.9
    rCSI -5.2%
    PRS 5.5%
  • effector CD4-positive, alpha-beta T cell CL0001044
    CSI -0.8
    rCSI -2.2%
    PRS 12.8%
  • blood vessel endothelial cell CL0000071
    CSI -0.7
    rCSI -1.5%
    PRS 8.8%
  • pvalb GABAergic cortical interneuron CL4023018
    CSI -0.7
    rCSI -0.9%
    PRS 4.8%
  • alveolar adventitial fibroblast CL4028006
    CSI -0.7
    rCSI -1.1%
    PRS 8.8%
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI -0.7
    rCSI -2.5%
    PRS 5.3%
  • CD8-positive, alpha-beta cytotoxic T cell CL0000794
    CSI -0.6
    rCSI -0.8%
    PRS 15.3%
  • direct pathway medium spiny neuron CL4023026
    CSI -0.6
    rCSI -15.4%
    PRS 3.8%
  • renal interstitial pericyte CL1001318
    CSI -0.6
    rCSI -1.7%
    PRS 8.7%
  • uterine smooth muscle cell CL0002601
    CSI -0.5
    rCSI -3.1%
    PRS 54.5%
  • L6b glutamatergic cortical neuron CL4023038
    CSI -0.3
    rCSI -0.8%
    PRS 5.6%
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI -0.1
    rCSI -0.3%
    PRS 5.0%
  • skeletal muscle satellite cell CL0000594
    CSI -0.1
    rCSI -0.1%
    PRS 31.7%
  • regular ventricular cardiac myocyte CL0002131
    CSI 0.0
    rCSI 0.2%
    PRS 7.0%
  • odontoblast CL0000060
    CSI 0.1
    rCSI 1.5%
    PRS 43.3%
  • epithelial cell of urethra CL1000296
    CSI 0.1
    rCSI 2.5%
    PRS 29.6%
  • cytotoxic T cell CL0000910
    CSI 0.1
    rCSI 0.6%
    PRS 13.2%
  • NKp44-negative group 3 innate lymphoid cell, human CL0001080
    CSI 0.2
    rCSI 4.7%
    PRS 70.5%
  • osteoblast CL0000062
    CSI 0.2
    rCSI 3.9%
    PRS 63.2%
  • prostate gland microvascular endothelial cell CL2000059
    CSI 0.2
    rCSI 4.3%
    PRS 31.6%
  • cord blood hematopoietic stem cell CL2000095
    CSI 0.2
    rCSI 4.0%
    PRS 59.4%
  • vasa recta ascending limb cell CL1001131
    CSI 0.2
    rCSI 1.0%
    PRS 35.4%
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 0.2
    rCSI 0.3%
    PRS 12.4%
  • helper T cell CL0000912
    CSI 0.3
    rCSI 0.4%
    PRS 12.6%
  • neuroplacodal cell CL0000032
    CSI 0.3
    rCSI 2.4%
    PRS 29.8%
  • luminal cell of prostate epithelium CL0002340
    CSI 0.3
    rCSI 1.5%
    PRS 16.0%
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 0.3
    rCSI 0.5%
    PRS 5.2%
  • amacrine cell CL0000561
    CSI 0.4
    rCSI 1.1%
    PRS 7.1%
  • retinal bipolar neuron CL0000748
    CSI 0.4
    rCSI 0.8%
    PRS 6.5%
  • follicular dendritic cell CL0000442
    CSI 0.4
    rCSI 6.8%
    PRS 48.8%
  • transitional stage B cell CL0000818
    CSI 0.5
    rCSI 1.5%
    PRS 26.1%
  • Bergmann glial cell CL0000644
    CSI 0.5
    rCSI 0.7%
    PRS 9.2%
  • Schwann cell CL0002573
    CSI 0.5
    rCSI 1.5%
    PRS 11.1%
  • endothelial cell of lymphatic vessel CL0002138
    CSI 0.5
    rCSI 1.1%
    PRS 27.3%
  • kidney connecting tubule epithelial cell CL1000768
    CSI 0.6
    rCSI 1.5%
    PRS 6.8%
  • glycinergic amacrine cell CL4030028
    CSI 0.6
    rCSI 1.5%
    PRS 9.3%
  • lung pericyte CL0009089
    CSI 0.6
    rCSI 1.6%
    PRS 10.5%
  • vasa recta descending limb cell CL1001285
    CSI 0.6
    rCSI 5.1%
    PRS 37.6%
  • myelocyte CL0002193
    CSI 0.7
    rCSI 4.3%
    PRS 29.3%
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 0.7
    rCSI 2.1%
    PRS 6.0%
  • enteroendocrine cell of small intestine CL0009006
    CSI 0.7
    rCSI 1.5%
    PRS 13.5%
  • VIP GABAergic cortical interneuron CL4023016
    CSI 0.7
    rCSI 0.8%
    PRS 5.1%
  • bronchiolar smooth muscle cell CL4033017
    CSI 0.7
    rCSI 10.7%
    PRS 28.7%
  • vein endothelial cell of respiratory system CL4033008
    CSI 0.7
    rCSI 4.9%
    PRS 17.3%
  • metallothionein-positive alveolar macrophage CL4033042
    CSI 0.7
    rCSI 8.0%
    PRS 37.4%
  • corneal epithelial cell CL0000575
    CSI 0.8
    rCSI 2.2%
    PRS 16.2%
  • retinal rod cell CL0000604
    CSI 0.8
    rCSI 1.4%
    PRS 8.9%
  • fibroblast of breast CL4006000
    CSI 0.8
    rCSI 3.3%
    PRS 23.5%
  • neural progenitor cell CL0011020
    CSI 0.8
    rCSI 3.5%
    PRS 8.7%
  • myeloid dendritic cell CL0000782
    CSI 0.8
    rCSI 1.2%
    PRS 13.0%
  • periportal region hepatocyte CL0019026
    CSI 0.9
    rCSI 3.3%
    PRS 13.3%
  • tracheobronchial serous cell CL0019001
    CSI 0.9
    rCSI 3.8%
    PRS 17.1%
  • stratified epithelial cell CL0000079
    CSI 0.9
    rCSI 5.6%
    PRS 39.0%
  • tuft cell of colon CL0009041
    CSI 1.0
    rCSI 2.2%
    PRS 19.8%
  • antibody secreting cell CL0000946
    CSI 1.1
    rCSI 4.7%
    PRS 37.6%
  • effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062
    CSI 1.1
    rCSI 5.4%
    PRS 11.6%
  • keratocyte CL0002363
    CSI 1.1
    rCSI 2.6%
    PRS 13.4%
  • alveolar type 1 fibroblast cell CL4028004
    CSI 1.1
    rCSI 1.2%
    PRS 10.2%
  • chondrocyte CL0000138
    CSI 1.1
    rCSI 1.8%
    PRS 7.7%
  • brush cell CL0002204
    CSI 1.2
    rCSI 2.3%
    PRS 24.4%
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 1.2
    rCSI 2.0%
    PRS 5.2%
  • mature alpha-beta T cell CL0000791
    CSI 1.2
    rCSI 4.3%
    PRS 15.2%
  • adventitial cell CL0002503
    CSI 1.2
    rCSI 2.8%
    PRS 14.0%
  • inhibitory interneuron CL0000498
    CSI 1.3
    rCSI 2.9%
    PRS 7.4%
  • mast cell CL0000097
    CSI 1.3
    rCSI 2.7%
    PRS 44.8%
  • mesenchymal lymphangioblast CL0005021
    CSI 1.3
    rCSI 34.3%
    PRS 43.7%
  • myeloid dendritic cell, human CL0001057
    CSI 1.4
    rCSI 7.7%
    PRS 28.1%
  • Merkel cell CL0000242
    CSI 1.4
    rCSI 31.8%
    PRS 56.5%
  • alternatively activated macrophage CL0000890
    CSI 1.5
    rCSI 1.8%
    PRS 13.5%
  • tendon cell CL0000388
    CSI 1.5
    rCSI 3.8%
    PRS 25.6%
  • vascular associated smooth muscle cell CL0000359
    CSI 1.5
    rCSI 4.8%
    PRS 10.8%
  • B-2 B cell CL0000822
    CSI 1.5
    rCSI 32.2%
    PRS 48.7%
  • natural T-regulatory cell CL0000903
    CSI 1.5
    rCSI 2.9%
    PRS 24.9%
  • mononuclear phagocyte CL0000113
    CSI 1.5
    rCSI 3.4%
    PRS 9.7%
  • renal principal cell CL0005009
    CSI 1.6
    rCSI 4.2%
    PRS 12.2%
  • bronchus fibroblast of lung CL2000093
    CSI 1.6
    rCSI 1.3%
    PRS 9.4%
  • podocyte CL0000653
    CSI 1.6
    rCSI 7.3%
    PRS 8.8%
  • glial cell CL0000125
    CSI 1.7
    rCSI 6.3%
    PRS 9.2%
  • IgM plasma cell CL0000986
    CSI 1.7
    rCSI 7.5%
    PRS 43.1%
  • BEST4+ enteroycte CL4030026
    CSI 1.7
    rCSI 2.1%
    PRS 9.4%
  • basal cell of prostate epithelium CL0002341
    CSI 1.8
    rCSI 5.1%
    PRS 19.8%
  • pulmonary alveolar type 2 cell CL0002063
    CSI 1.8
    rCSI 2.7%
    PRS 13.6%
  • innate lymphoid cell CL0001065
    CSI 1.8
    rCSI 3.6%
    PRS 13.8%
  • epithelial cell of nephron CL1000449
    CSI 1.8
    rCSI 17.0%
    PRS 38.1%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [ATP5PB](/details-gene/515), also known as ATP synthase peripheral stalk-membrane subunit b, is a protein-coding gene located on chromosome 1p13.2. It encodes a critical component of the mitochondrial F(0) complex, which forms part of the proton channel of mitochondrial ATP synthase. This enzyme is fundamental for cellular energy production via oxidative phosphorylation. Consistent with this core metabolic role, the expression of [ATP5PB](/details-gene/515) is a significant feature of cells with high energy and proliferative demands, such as hematopoietic progenitors, stem cells, and various active epithelial cell populations. Its function was first described in a study that cloned the cDNA for its human import precursor [Link](https://doi.org/10.1016/0006-291x(91)90993-h). ## Cellular Roles and Expression Landscape The expression profile of [ATP5PB](/details-gene/515) highlights its essential role in cellular energetics, particularly in highly proliferative and metabolically active cell populations. **Overall**, the gene shows the highest significance in progenitor and stem cell populations within the hematopoietic system. It is a top marker for `[megakaryocyte-erythroid progenitor cell](/details-cell/CL0000050)` (CSI: 81.54), `[hematopoietic stem cell](/details-cell/CL0000037)` (CSI: 79.62), and `[common myeloid progenitor](/details-cell/CL0000049)` (CSI: 77.13). This strong association suggests that robust ATP production, facilitated by [ATP5PB](/details-gene/515), is indispensable for the processes of self-renewal, division, and lineage commitment in these foundational cell types. Beyond the hematopoietic system, [ATP5PB](/details-gene/515) is also highly significant in epithelial cells that are either rapidly dividing or have high metabolic loads associated with barrier function and secretion. These include `[colon epithelial cell](/details-cell/CL0011108)` (CSI: 69.66), `[intestinal epithelial cell](/details-cell/CL0002563)` (CSI: 68.82), and `[fallopian tube secretory epithelial cell](/details-cell/CL4030006)` (CSI: 59.16). Its high expression in `[keratinocyte](/details-cell/CL0000312)` (CSI: 57.29) further supports its role in maintaining tissues with high turnover rates. Conversely, [ATP5PB](/details-gene/515) expression is notably low in several terminally differentiated cell types, particularly within the central nervous system and the immune system. It serves as an anti-marker for neuronal populations like `[sncg GABAergic cortical interneuron](/details-cell/CL4023015)` (CSI: -7.45) and `[L5 extratelencephalic projecting glutamatergic cortical neuron](/details-cell/CL4023041)` (CSI: -5.09). Similarly, its low significance in quiescent or mature lymphocytes such as `[effector memory CD8-positive, alpha-beta T cell](/details-cell/CL0000913)` (CSI: -4.24) suggests that while these cells still require ATP, the expression of this specific synthase subunit is not a defining feature of their metabolic state compared to progenitor cells. This pattern indicates that the significance of [ATP5PB](/details-gene/515) expression correlates directly with a cell's proliferative capacity and baseline metabolic activity. ## Pathways and Molecular Function The molecular functions of [ATP5PB](/details-gene/515) are centered on energy metabolism, as reflected by its gene ontology and pathway annotations. It is a core component of the `[proton-transporting atp synthase complex](/details-cell/GO:0045259)` located in the `[mitochondrial inner membrane](/details-cell/GO:0005743)`. **Biological Process:** The primary role of [ATP5PB](/details-gene/515) is in 'Proton motive force-driven atp synthesis' ([GO:0015986](https://www.ebi.ac.uk/QuickGO/term/GO:0015986)), the final step of cellular respiration where the energy stored in a proton gradient is converted into ATP. This is a key event in major metabolic pathways. **Reactome Pathways:** Its involvement is explicitly detailed in the '[Formation of atp by chemiosmotic coupling](/details-reactome/R-HSA-163210)' and '[Aerobic respiration and respiratory electron transport](/details-reactome/R-HSA-1428517)' pathways. This functional context directly explains its high expression in metabolically demanding cells like hematopoietic progenitors and proliferative epithelial tissues. Furthermore, its annotation in '[Mitochondrial biogenesis](/details-reactome/R-HSA-1592230)' is consistent with its high significance in stem and progenitor cells, which must generate new mitochondria to support their expansion and differentiation. ## Research Directions The expression pattern of [ATP5PB](/details-gene/515) points toward a fundamental role in defining the metabolic capacity of progenitor and highly active somatic cells, which opens several avenues for future investigation. **Testable Hypotheses:** 1. The expression level of [ATP5PB](/details-gene/515) is a key regulator of hematopoietic stem cell fate, where high expression is permissive for differentiation, while lower levels are associated with the maintenance of quiescence. 2. In intestinal epithelial cells, [ATP5PB](/details-gene/515)-driven ATP production is critical not just for proliferation but also for powering the ion pumps and synthetic machinery required to maintain the gut's mucosal barrier integrity. **Proposed Experiment:** To test the first hypothesis regarding hematopoietic stem cell fate, one could perform a targeted knockdown of [ATP5PB](/details-gene/515) in primary human CD34+ `[hematopoietic stem cell](/details-cell/CL0000037)`. Following shRNA- or CRISPRi-mediated suppression, the cells would be cultured in vitro under conditions that promote differentiation into myeloid and lymphoid lineages. The primary readouts would be flow cytometry analysis of lineage-specific markers (e.g., CD33, CD14 for myeloid; CD19 for B-lymphoid) and colony-forming unit (CFU) assays to quantify the functional output of progenitors. A parallel metabolic analysis using a Seahorse XF Analyzer would confirm that the knockdown impairs oxidative phosphorylation. A significant reduction in differentiation efficiency and colony formation following [ATP5PB](/details-gene/515) knockdown would support the hypothesis that its high expression is essential for exiting quiescence and executing differentiation programs. **Therapeutic Potential:** As a central component of ATP synthesis, [ATP5PB](/details-gene/515) represents a potential therapeutic target, particularly in diseases characterized by metabolic reprogramming and uncontrolled proliferation, such as cancer. Many malignancies, especially those derived from hematopoietic or epithelial tissues, exhibit heightened dependence on oxidative phosphorylation. Therefore, **inhibition** of [ATP5PB](/details-gene/515) or the ATP synthase complex could selectively target the energy supply of cancer cells. However, its ubiquitous and essential role in healthy, high-turnover tissues (e.g., gut epithelium, hematopoietic progenitors) presents a major challenge, as systemic inhibition would likely lead to significant on-target, off-tumor toxicity. A successful therapeutic strategy would likely require the development of inhibitors that are either selectively activated within the tumor microenvironment or delivered via a highly targeted modality.

Genular Protein ID: 481862021

Symbol: AT5F1_HUMAN

Name: ATP synthase proton-transporting mitochondrial F(0) complex subunit B1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1831354

Title: Molecular cloning of cDNA for the import precursor of human subunit B of H(+)-ATP synthase in mitochondria.

PubMed ID: 1831354

DOI: 10.1016/0006-291x(91)90993-h

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 256
  • Mass: 28909
  • Checksum: 743B1C54BFFEBBBD
  • Sequence:
  • MLSRVVLSAA ATAAPSLKNA AFLGPGVLQA TRTFHTGQPH LVPVPPLPEY GGKVRYGLIP 
    EEFFQFLYPK TGVTGPYVLG TGLILYALSK EIYVISAETF TALSVLGVMV YGIKKYGPFV 
    ADFADKLNEQ KLAQLEEAKQ ASIQHIQNAI DTEKSQQALV QKRHYLFDVQ RNNIAMALEV 
    TYRERLYRVY KEVKNRLDYH ISVQNMMRRK EQEHMINWVE KHVVQSISTQ QEKETIAKCI 
    ADLKLLAKKA QAQPVM