Details for: ATP5MC1

Gene ID: 516

Symbol: ATP5MC1

Ensembl ID: ENSG00000159199

Description: ATP synthase membrane subunit c locus 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 5.79
    Marker Score: 3876
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 4.29
    Marker Score: 4478
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 3.98
    Marker Score: 1166.5
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 3.92
    Marker Score: 1625
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 3.85
    Marker Score: 8118
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 3.62
    Marker Score: 2195
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.55
    Marker Score: 9511
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.34
    Marker Score: 2978
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.15
    Marker Score: 5220
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 3.02
    Marker Score: 3271
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.87
    Marker Score: 7236
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 2.82
    Marker Score: 37468
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.81
    Marker Score: 9963
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.77
    Marker Score: 21595
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 2.76
    Marker Score: 910
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 2.73
    Marker Score: 1456.5
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 2.64
    Marker Score: 2064
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.6
    Marker Score: 3675
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.59
    Marker Score: 19302.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.58
    Marker Score: 2741
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 2.55
    Marker Score: 12250
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.55
    Marker Score: 6221
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.54
    Marker Score: 1015
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.52
    Marker Score: 1777.5
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.5
    Marker Score: 7854
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 2.48
    Marker Score: 1383
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.45
    Marker Score: 2181
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.4
    Marker Score: 3864
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.4
    Marker Score: 5441
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.37
    Marker Score: 2275
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.37
    Marker Score: 2405
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.36
    Marker Score: 20381.5
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.35
    Marker Score: 9629
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.34
    Marker Score: 2500
  • Cell Name: stem cell (CL0000034)
    Fold Change: 2.3
    Marker Score: 5467
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.29
    Marker Score: 2764
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.28
    Marker Score: 5192
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.26
    Marker Score: 14434
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 2.26
    Marker Score: 1704
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.26
    Marker Score: 9731.5
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.22
    Marker Score: 76807
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 2.2
    Marker Score: 8131
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.19
    Marker Score: 2458
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 2.19
    Marker Score: 1164
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.17
    Marker Score: 25273
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.16
    Marker Score: 3323
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.15
    Marker Score: 1532
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.15
    Marker Score: 24237.5
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.15
    Marker Score: 8454
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 2.15
    Marker Score: 1792
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.14
    Marker Score: 3409
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.13
    Marker Score: 1336.5
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.12
    Marker Score: 1668
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.1
    Marker Score: 1787
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.07
    Marker Score: 3395.5
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.06
    Marker Score: 7952
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 2.05
    Marker Score: 1739
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 2.04
    Marker Score: 767
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.03
    Marker Score: 1047
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.03
    Marker Score: 2993
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.02
    Marker Score: 3113
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2
    Marker Score: 2076
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2
    Marker Score: 5514
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.99
    Marker Score: 1352
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.99
    Marker Score: 26237
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.99
    Marker Score: 26710
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.98
    Marker Score: 2138
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.98
    Marker Score: 2098
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.97
    Marker Score: 4632.5
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.97
    Marker Score: 2616
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.96
    Marker Score: 50160
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.96
    Marker Score: 4086
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.96
    Marker Score: 1030
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.95
    Marker Score: 1301
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.95
    Marker Score: 12694.5
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 1.94
    Marker Score: 5544
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.94
    Marker Score: 561
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.94
    Marker Score: 3645.5
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 1.93
    Marker Score: 2062
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.92
    Marker Score: 897
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.91
    Marker Score: 10044
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 1.91
    Marker Score: 1255
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.9
    Marker Score: 676
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.9
    Marker Score: 707
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.89
    Marker Score: 1190
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.89
    Marker Score: 981
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.89
    Marker Score: 5605
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.88
    Marker Score: 789
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.88
    Marker Score: 1877
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.87
    Marker Score: 931
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.86
    Marker Score: 3239.5
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.86
    Marker Score: 12069
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.85
    Marker Score: 552
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.85
    Marker Score: 1020
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.85
    Marker Score: 4833.5
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 1.84
    Marker Score: 830
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.84
    Marker Score: 62612
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.84
    Marker Score: 1076
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.83
    Marker Score: 588
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.83
    Marker Score: 7590.5

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Other Information

**Key characteristics:** * ATP5MC1 is a transmembrane protein that is found in the mitochondrial inner membrane. * It is a key component of the mitochondrial proton-transporting ATP synthase complex, which is responsible for the flow of protons across the mitochondrial inner membrane. * ATP5MC1 is a heterodimeric protein, with two subunits that are connected by a linker peptide. * Each subunit of ATP5MC1 is responsible for the formation of a proton gradient across the mitochondrial inner membrane. **Pathways and functions:** * ATP5MC1 is involved in the citric acid (tca) cycle and respiratory electron transport. * It is also involved in the formation of ATP by chemiosmotic coupling. * In the citric acid cycle, ATP5MC1 is responsible for the formation of ATP from ADP and inorganic phosphate. * In the respiratory electron transport chain, ATP5MC1 is involved in the transfer of protons across the mitochondrial inner membrane, which drives the synthesis of ATP. **Clinical significance:** Mutations in ATP5MC1 have been linked to a number of human diseases, including mitochondrial disorders and metabolic syndrome. These diseases are characterized by a decrease in mitochondrial function, which can lead to a number of symptoms, including muscle weakness, fatigue, and impaired metabolism.

Genular Protein ID: 3140542800

Symbol: AT5G1_HUMAN

Name: ATP synthase lipid-binding protein

UniProtKB Accession Codes:

P05496

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 6 EMDB 1 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HAMAP 1 HGNC 2 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 8 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8328972

Title: Sequences of members of the human gene family for the c subunit of mitochondrial ATP synthase.

PubMed ID: 8328972

DOI: 10.1042/bj2930051

PubMed ID: 8485160

Title: Molecular cloning and sequence of two cDNAs for human subunit c of H(+)-ATP synthase in mitochondria.

PubMed ID: 8485160

DOI: 10.1016/0167-4781(93)90249-d

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2883974

Title: Human liver cDNA clones encoding proteolipid subunit 9 of the mitochondrial ATPase complex.

PubMed ID: 2883974

DOI: 10.1016/0006-291x(87)91446-x

PubMed ID: 31652072

Title: TMEM70 facilitates biogenesis of mammalian ATP synthase by promoting subunit c incorporation into the rotor structure of the enzyme.

PubMed ID: 31652072

DOI: 10.1096/fj.201900685rr

PubMed ID: 30530489

Title: Lysine methylation by the mitochondrial methyltransferase FAM173B optimizes the function of mitochondrial ATP synthase.

PubMed ID: 30530489

DOI: 10.1074/jbc.ra118.005473

PubMed ID: 33359711

Title: TMEM70 forms oligomeric scaffolds within mitochondrial cristae promoting in situ assembly of mammalian ATP synthase proton channel.

PubMed ID: 33359711

DOI: 10.1016/j.bbamcr.2020.118942

Sequence Information:

  • Length: 136
  • Mass: 14277
  • Checksum: 1AFF1F16BB532647
  • Sequence:
    • MQTAGALFIS PALIRCCTRG LIRPVSASFL NSPVNSSKQP SYSNFPLQVA RREFQTSVVS 
RDIDTAAKFI GAGAATVGVA GSGAGIGTVF GSLIIGYARN PSLKQQLFSY AILGFALSEA 
MGLFCLMVAF LILFAM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.