Details for: ATP5MC1
Gene ID: 516
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: ATP5MC1
Ensembl ID: ENSG00000159199
Description: ATP synthase membrane subunit c locus 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 81.9rCSI 78.97%PRS 4.28
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CSI 74.77rCSI 66.36%PRS 6.94
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CSI 73.75rCSI 58.02%PRS 8.3
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CSI 73.48rCSI 63.62%PRS 7.74
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CSI 73.28rCSI 86.07%PRS 8.3
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CSI 70.61rCSI 57.09%PRS 6.85
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CSI 63.1rCSI 56.99%PRS 6.14
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CSI 61.89rCSI 64.68%PRS 7.3
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CSI 59.15rCSI 56.94%PRS 7.19
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CSI 58.89rCSI 49.36%PRS 8.31
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CSI 52.83rCSI 55.34%PRS 6.46
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CSI 48.67rCSI 47.87%PRS 7.53
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CSI 47.37rCSI 50.34%PRS 12.43
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CSI 45.79rCSI 66%PRS 11.25
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CSI 44.68rCSI 64.44%PRS 9.7
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CSI 44.06rCSI 46.16%PRS 7.38
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CSI 43.64rCSI 70.36%PRS 11.22
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CSI 42.4rCSI 53.22%PRS 8.85
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CSI 42.29rCSI 64.68%PRS 11.34
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CSI 39.76rCSI 54.17%PRS 6.23
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CSI 39.35rCSI 60.81%PRS 6.53
-
CSI 34.96rCSI 50.12%PRS 9.57
-
CSI 33.08rCSI 78.63%PRS 10.45
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CSI 33.03rCSI 70.3%PRS 11.25
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CSI 31.51rCSI 29.78%PRS 7.27
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CSI 28.81rCSI 19.15%PRS 8.29
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CSI 27.05rCSI 51.63%PRS 16.83
-
CSI 26.98rCSI 36.87%PRS 7.7
-
CSI 26.69rCSI 71.94%PRS 8.98
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CSI 26.42rCSI 45.26%PRS 9.33
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CSI 25.43rCSI 32.61%PRS 8.02
-
CSI 21.78rCSI 33.46%PRS 10.01
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CSI 20.99rCSI 17.4%PRS 6.6
-
CSI 20.52rCSI 59.4%PRS 7.88
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CSI 19.82rCSI 37.2%PRS 13.77
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CSI 19.41rCSI 34.75%PRS 6.56
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CSI 19.24rCSI 53.92%PRS 10.86
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CSI 18.56rCSI 41.09%PRS 6.44
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CSI 18.39rCSI 16.17%PRS 5.02
-
CSI 18.29rCSI 25.93%PRS 6.57
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CSI 17.73rCSI 15.57%PRS 7.8
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CSI 17.25rCSI 27.4%PRS 9.03
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CSI 16.83rCSI 73.87%PRS 13.12
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CSI 16.74rCSI 39.91%PRS 8.67
-
CSI 16.58rCSI 35.26%PRS 13.04
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CSI 16.56rCSI 47.27%PRS 12.39
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CSI 16.52rCSI 24.55%PRS 8.79
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CSI 16.31rCSI 55.88%PRS 30.19
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CSI 16.22rCSI 30.63%PRS 8.63
-
CSI 15.94rCSI 14.71%PRS 7.07
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CSI 15.5rCSI 40.8%PRS 13.61
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CSI 15.2rCSI 29.56%PRS 7.07
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CSI 15.07rCSI 11.91%PRS 4.79
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CSI 15.04rCSI 15.01%PRS 5.95
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CSI 14.92rCSI 32.56%PRS 14.18
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CSI 14.54rCSI 21.32%PRS 9.16
-
CSI 14.52rCSI 46.58%PRS 10.42
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CSI 13.57rCSI 33.58%PRS 6.44
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CSI 13.42rCSI 17.94%PRS 9.3
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CSI 12.94rCSI 10.28%PRS 12.29
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CSI 12.9rCSI 17.15%PRS 7.55
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CSI 12.41rCSI 12.77%PRS 11.3
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CSI 12.34rCSI 22%PRS 11.97
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CSI 12.31rCSI 16.14%PRS 35.25
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CSI 12.21rCSI 17.42%PRS 7.84
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CSI 12.1rCSI 14.97%PRS 6.09
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CSI 11.7rCSI 18.83%PRS 5.32
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CSI 11.53rCSI 13.2%PRS 14.43
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CSI 11.33rCSI 15.49%PRS 7.91
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CSI 11.26rCSI 84.6%PRS 12.95
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CSI 11.2rCSI 27.35%PRS 7.06
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CSI 11.17rCSI 58.66%PRS 13.26
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CSI 11.16rCSI 60.23%PRS 13.41
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CSI 11.15rCSI 16.99%PRS 6.51
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CSI 11.1rCSI 64.61%PRS 10.49
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CSI 10.99rCSI 86.11%PRS 15.99
-
CSI 10.8rCSI 42.98%PRS 12.3
-
CSI 10.76rCSI 37.75%PRS 12.69
-
CSI 10.71rCSI 9.83%PRS 7.91
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CSI 10.65rCSI 11.41%PRS 6.39
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CSI 10.11rCSI 23.55%PRS 16.17
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CSI 9.87rCSI 56.6%PRS 10.94
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CSI 9.82rCSI 8.13%PRS 6.97
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CSI 9.76rCSI 14.9%PRS 12.22
-
CSI 9.66rCSI 6.72%PRS 8.14
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CSI 9.63rCSI 6.76%PRS 19.94
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CSI 9.52rCSI 28.4%PRS 18.28
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CSI 9.12rCSI 26.92%PRS 8.73
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CSI 9.03rCSI 8.92%PRS 29.41
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CSI 9.01rCSI 42%PRS 17.16
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CSI 8.84rCSI 12.69%PRS 5.63
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CSI 8.8rCSI 18.06%PRS 16.77
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CSI 8.8rCSI 15.5%PRS 7.14
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CSI 8.67rCSI 12.7%PRS 8.22
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CSI 8.53rCSI 10.72%PRS 35.01
-
CSI 8.43rCSI 6.41%PRS 9.23
-
CSI 8.42rCSI 12.32%PRS 7.36
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CSI 8.33rCSI 39.05%PRS 19.09
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CSI 8.15rCSI 8.51%PRS 7.14
-
CSI 8.06rCSI 5.62%PRS 7.34
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CSI -19.6rCSI -25.7%PRS 9.8%
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CSI -7.6rCSI -7.5%PRS 11.1%
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CSI -6.6rCSI -8.2%PRS 3.8%
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CSI -3.9rCSI -8.7%PRS 4.3%
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CSI -3.9rCSI -11.1%PRS 10.1%
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CSI -3.8rCSI -5.2%PRS 10.7%
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CSI -3.6rCSI -11.6%PRS 8.5%
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CSI -3.3rCSI -4.9%PRS 8.0%
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CSI -2.8rCSI -2.1%PRS 7.2%
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CSI -2.8rCSI -8.7%PRS 4.4%
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CSI -2.7rCSI -4.5%PRS 4.1%
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CSI -1.7rCSI -3.8%PRS 7.7%
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CSI -1.1rCSI -4.2%PRS 4.2%
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CSI -0.8rCSI -4.7%PRS 4.3%
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CSI -0.7rCSI -1.3%PRS 5.3%
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CSI -0.7rCSI -0.7%PRS 10.9%
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CSI -0.7rCSI -0.8%PRS 12.1%
-
CSI -0.4rCSI -2.2%PRS 32.3%
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CSI 0.0rCSI 0.0%PRS 47.0%
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CSI 0.1rCSI 0.2%PRS 15.0%
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CSI 0.1rCSI 0.8%PRS 10.6%
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CSI 0.2rCSI 1.0%PRS 5.7%
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CSI 0.2rCSI 0.3%PRS 7.6%
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CSI 0.2rCSI 0.3%PRS 6.2%
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CSI 0.2rCSI 4.8%PRS 55.2%
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CSI 0.2rCSI 4.3%PRS 24.6%
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CSI 0.3rCSI 1.5%PRS 24.5%
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CSI 0.4rCSI 0.5%PRS 6.8%
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CSI 0.4rCSI 10.7%PRS 36.6%
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CSI 0.4rCSI 7.9%PRS 51.5%
-
CSI 0.5rCSI 1.2%PRS 11.2%
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CSI 0.5rCSI 0.9%PRS 5.2%
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CSI 0.5rCSI 3.9%PRS 30.9%
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CSI 0.5rCSI 1.3%PRS 4.0%
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CSI 0.6rCSI 1.1%PRS 4.1%
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CSI 0.6rCSI 2.7%PRS 6.9%
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CSI 0.6rCSI 4.2%PRS 23.8%
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CSI 0.7rCSI 2.0%PRS 4.8%
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CSI 0.7rCSI 1.4%PRS 9.4%
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CSI 0.7rCSI 0.6%PRS 11.8%
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CSI 0.7rCSI 1.1%PRS 6.9%
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CSI 0.8rCSI 3.1%PRS 6.9%
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CSI 0.8rCSI 1.0%PRS 4.3%
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CSI 0.8rCSI 2.2%PRS 8.3%
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CSI 0.9rCSI 2.2%PRS 21.0%
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CSI 0.9rCSI 2.3%PRS 8.7%
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CSI 0.9rCSI 22.0%PRS 25.9%
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CSI 0.9rCSI 1.8%PRS 19.8%
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CSI 1.0rCSI 3.4%PRS 3.8%
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CSI 1.0rCSI 1.4%PRS 10.3%
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CSI 1.0rCSI 23.3%PRS 11.3%
-
CSI 1.1rCSI 6.7%PRS 23.2%
-
CSI 1.1rCSI 1.8%PRS 23.0%
-
CSI 1.1rCSI 4.9%PRS 12.9%
-
CSI 1.2rCSI 2.3%PRS 5.1%
-
CSI 1.2rCSI 3.5%PRS 11.3%
-
CSI 1.2rCSI 4.5%PRS 6.0%
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CSI 1.2rCSI 6.1%PRS 45.4%
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CSI 1.3rCSI 5.2%PRS 7.7%
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CSI 1.4rCSI 3.8%PRS 10.1%
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CSI 1.5rCSI 4.2%PRS 5.8%
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CSI 1.5rCSI 30.8%PRS 51.1%
-
CSI 1.5rCSI 2.4%PRS 4.5%
-
CSI 1.5rCSI 1.3%PRS 8.6%
-
CSI 1.5rCSI 9.3%PRS 16.2%
-
CSI 1.5rCSI 3.5%PRS 6.8%
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CSI 1.6rCSI 4.0%PRS 7.1%
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CSI 1.6rCSI 1.9%PRS 4.1%
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CSI 1.6rCSI 3.8%PRS 11.7%
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CSI 1.6rCSI 4.4%PRS 11.5%
-
CSI 1.6rCSI 7.4%PRS 25.9%
-
CSI 1.7rCSI 1.9%PRS 10.3%
-
CSI 1.7rCSI 39.5%PRS 47.8%
-
CSI 1.7rCSI 15.3%PRS 53.7%
-
CSI 1.7rCSI 2.4%PRS 11.9%
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CSI 1.8rCSI 3.5%PRS 19.6%
-
CSI 1.8rCSI 4.1%PRS 7.3%
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CSI 1.8rCSI 3.6%PRS 22.0%
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CSI 1.8rCSI 7.1%PRS 14.9%
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CSI 2.0rCSI 4.5%PRS 7.9%
-
CSI 2.0rCSI 6.9%PRS 30.1%
-
CSI 2.0rCSI 10.1%PRS 9.1%
-
CSI 2.1rCSI 14.2%PRS 13.8%
-
CSI 2.1rCSI 53.2%PRS 24.2%
-
CSI 2.1rCSI 1.8%PRS 11.5%
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CSI 2.1rCSI 23.2%PRS 42.5%
-
CSI 2.2rCSI 9.7%PRS 7.0%
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CSI 2.2rCSI 24.5%PRS 12.8%
-
CSI 2.3rCSI 2.8%PRS 10.1%
-
CSI 2.3rCSI 2.9%PRS 7.9%
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CSI 2.3rCSI 3.7%PRS 5.4%
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CSI 2.3rCSI 3.6%PRS 17.8%
-
CSI 2.3rCSI 18.6%PRS 7.3%
-
CSI 2.3rCSI 4.1%PRS 9.2%
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CSI 2.4rCSI 31.2%PRS 24.3%
-
CSI 2.4rCSI 10.7%PRS 36.3%
-
CSI 2.5rCSI 74.7%PRS 16.8%
-
CSI 2.5rCSI 9.6%PRS 7.4%
-
CSI 2.5rCSI 2.0%PRS 6.3%
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CSI 2.6rCSI 24.3%PRS 30.7%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3140542800
Symbol: AT5G1_HUMAN
Name: ATP synthase lipid-binding protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8328972
Title: Sequences of members of the human gene family for the c subunit of mitochondrial ATP synthase.
PubMed ID: 8328972
DOI: 10.1042/bj2930051
PubMed ID: 8485160
Title: Molecular cloning and sequence of two cDNAs for human subunit c of H(+)-ATP synthase in mitochondria.
PubMed ID: 8485160
PubMed ID: 11230166
Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.
PubMed ID: 11230166
DOI: 10.1101/gr.gr1547r
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2883974
Title: Human liver cDNA clones encoding proteolipid subunit 9 of the mitochondrial ATPase complex.
PubMed ID: 2883974
PubMed ID: 31652072
Title: TMEM70 facilitates biogenesis of mammalian ATP synthase by promoting subunit c incorporation into the rotor structure of the enzyme.
PubMed ID: 31652072
PubMed ID: 30530489
Title: Lysine methylation by the mitochondrial methyltransferase FAM173B optimizes the function of mitochondrial ATP synthase.
PubMed ID: 30530489
PubMed ID: 33359711
Title: TMEM70 forms oligomeric scaffolds within mitochondrial cristae promoting in situ assembly of mammalian ATP synthase proton channel.
PubMed ID: 33359711
Sequence Information:
- Length: 136
- Mass: 14277
- Checksum: 1AFF1F16BB532647
- Sequence:
MQTAGALFIS PALIRCCTRG LIRPVSASFL NSPVNSSKQP SYSNFPLQVA RREFQTSVVS RDIDTAAKFI GAGAATVGVA GSGAGIGTVF GSLIIGYARN PSLKQQLFSY AILGFALSEA MGLFCLMVAF LILFAM