Details for: ATP5MC1

Gene ID: 516

Symbol: ATP5MC1

Ensembl ID: ENSG00000159199

Description: ATP synthase membrane subunit c locus 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 177.7410
    Cell Significance Index: -73.2200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 161.4002
    Cell Significance Index: -65.5700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 158.8782
    Cell Significance Index: -75.0100
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 146.7966
    Cell Significance Index: -75.5100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 112.4255
    Cell Significance Index: -75.4400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 69.7046
    Cell Significance Index: -66.5500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 18.7449
    Cell Significance Index: -50.2200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 14.1073
    Cell Significance Index: -43.3300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 5.0215
    Cell Significance Index: 42.1800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 3.3541
    Cell Significance Index: 152.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 3.2483
    Cell Significance Index: 378.5500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.3001
    Cell Significance Index: 107.2400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.2643
    Cell Significance Index: 160.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.2361
    Cell Significance Index: 274.9500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.1989
    Cell Significance Index: 396.3900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.1000
    Cell Significance Index: 22.8300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.0776
    Cell Significance Index: 56.5500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.9884
    Cell Significance Index: 879.1200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.9113
    Cell Significance Index: 1043.8000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.7706
    Cell Significance Index: 228.7500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.7658
    Cell Significance Index: 92.7100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.6504
    Cell Significance Index: 226.6400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.6461
    Cell Significance Index: 194.1300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.4779
    Cell Significance Index: 110.1500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.4667
    Cell Significance Index: 30.7000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.4372
    Cell Significance Index: 13.2400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2962
    Cell Significance Index: 37.3500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.2871
    Cell Significance Index: 33.8500
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.2649
    Cell Significance Index: 14.3700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1745
    Cell Significance Index: 61.0100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.0801
    Cell Significance Index: 23.4000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.0746
    Cell Significance Index: 8.5800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.9628
    Cell Significance Index: 57.8000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.9589
    Cell Significance Index: 61.8700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.9550
    Cell Significance Index: 14.3100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.8593
    Cell Significance Index: 247.2400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8384
    Cell Significance Index: 52.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8087
    Cell Significance Index: 38.0100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.8039
    Cell Significance Index: 23.6100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7656
    Cell Significance Index: 98.1500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7525
    Cell Significance Index: 122.3900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.5847
    Cell Significance Index: 428.6700
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.5436
    Cell Significance Index: 6.4800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5367
    Cell Significance Index: 484.6400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.5269
    Cell Significance Index: 41.7300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5222
    Cell Significance Index: 99.3700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4865
    Cell Significance Index: 48.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4253
    Cell Significance Index: 85.3100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2736
    Cell Significance Index: 207.0600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2029
    Cell Significance Index: 40.2700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1898
    Cell Significance Index: 6.0800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1453
    Cell Significance Index: 5.0500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.1120
    Cell Significance Index: 3.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0882
    Cell Significance Index: 31.6200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0191
    Cell Significance Index: 0.5100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0176
    Cell Significance Index: 0.3000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0029
    Cell Significance Index: 0.0800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0134
    Cell Significance Index: -0.6800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0213
    Cell Significance Index: -40.1000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0393
    Cell Significance Index: -4.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0393
    Cell Significance Index: -72.4000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0465
    Cell Significance Index: -71.6100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0488
    Cell Significance Index: -8.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0592
    Cell Significance Index: -80.5300
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.0617
    Cell Significance Index: -0.5300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0735
    Cell Significance Index: -54.4100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0789
    Cell Significance Index: -50.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1126
    Cell Significance Index: -63.5100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1274
    Cell Significance Index: -79.5500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1278
    Cell Significance Index: -58.0000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1285
    Cell Significance Index: -5.2700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1344
    Cell Significance Index: -15.4000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1457
    Cell Significance Index: -5.1200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3192
    Cell Significance Index: -24.5000
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3276
    Cell Significance Index: -8.3700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.3590
    Cell Significance Index: -7.6500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.3593
    Cell Significance Index: -18.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3600
    Cell Significance Index: -75.8200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3928
    Cell Significance Index: -57.1000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.4735
    Cell Significance Index: -32.7500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.4948
    Cell Significance Index: -30.4100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6665
    Cell Significance Index: -6.9000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6743
    Cell Significance Index: -9.9600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.6790
    Cell Significance Index: -12.5500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6966
    Cell Significance Index: -72.5300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.7883
    Cell Significance Index: -10.1000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.8106
    Cell Significance Index: -14.3300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.9183
    Cell Significance Index: -51.5300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.9321
    Cell Significance Index: -27.4600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.9593
    Cell Significance Index: -16.1600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.0041
    Cell Significance Index: -13.7000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.0783
    Cell Significance Index: -26.3100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0938
    Cell Significance Index: -67.0600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.2587
    Cell Significance Index: -21.5700
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -1.3047
    Cell Significance Index: -27.2100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -1.4048
    Cell Significance Index: -36.1100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.5634
    Cell Significance Index: -69.1600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -1.6263
    Cell Significance Index: -59.7000
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -1.6553
    Cell Significance Index: -57.9900
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -1.6960
    Cell Significance Index: -28.5300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Mitochondrial localization**: ATP5MC1 is a membrane subunit of the mitochondrial proton-transporting ATP synthase complex, which is a key component of the mitochondrial inner membrane. 2. **Lipid binding**: The ATP5MC1 protein exhibits lipid-binding capabilities, which are essential for the proper functioning of the ATP synthase complex. 3. **Proton motive force-driven ATP synthesis**: ATP5MC1 is involved in the generation of a proton motive force that drives the synthesis of ATP from ADP and inorganic phosphate. 4. **Significant expression in various cell types**: ATP5MC1 is expressed in a wide range of cell types, including skeletal muscle, erythroid progenitor cells, cardiac muscle cells, and others. **Pathways and Functions:** 1. **Cristae formation**: ATP5MC1 is involved in the regulation of cristae formation, which is essential for the proper functioning of the mitochondrial inner membrane. 2. **Formation of ATP by chemiosmotic coupling**: ATP5MC1 plays a crucial role in the production of ATP through chemiosmotic coupling, which involves the generation of a proton motive force that drives the synthesis of ATP. 3. **Lipid binding**: The ATP5MC1 protein exhibits lipid-binding capabilities, which are essential for the proper functioning of the ATP synthase complex. 4. **Mitochondrial biogenesis**: ATP5MC1 is involved in the regulation of mitochondrial biogenesis, which is essential for the proper functioning of the mitochondria. 5. **Proton transmembrane transport**: ATP5MC1 is involved in the regulation of proton transmembrane transport, which is essential for the proper functioning of the ATP synthase complex. **Clinical Significance:** 1. **Metabolic disorders**: Alterations in ATP5MC1 expression have been linked to various metabolic disorders, including diabetes and obesity. 2. **Cardiovascular conditions**: ATP5MC1 has been implicated in the development of cardiovascular conditions, including heart failure and hypertension. 3. **Neurodegenerative diseases**: ATP5MC1 has been linked to the development of neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease. 4. **Cancer**: ATP5MC1 has been implicated in the development and progression of various types of cancer, including breast cancer and lung cancer. In conclusion, ATP5MC1 plays a crucial role in mitochondrial function and disease. Alterations in ATP5MC1 expression have been linked to various metabolic disorders, cardiovascular conditions, neurodegenerative diseases, and cancer. Further research is needed to fully elucidate the role of ATP5MC1 in human disease and to identify potential therapeutic targets for the treatment of these conditions.

Genular Protein ID: 3140542800

Symbol: AT5G1_HUMAN

Name: ATP synthase lipid-binding protein

UniProtKB Accession Codes:

P05496

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DNASU 1 DisGeNET 1 EMBL 6 EMDB 10 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HAMAP 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8328972

Title: Sequences of members of the human gene family for the c subunit of mitochondrial ATP synthase.

PubMed ID: 8328972

DOI: 10.1042/bj2930051

PubMed ID: 8485160

Title: Molecular cloning and sequence of two cDNAs for human subunit c of H(+)-ATP synthase in mitochondria.

PubMed ID: 8485160

DOI: 10.1016/0167-4781(93)90249-d

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2883974

Title: Human liver cDNA clones encoding proteolipid subunit 9 of the mitochondrial ATPase complex.

PubMed ID: 2883974

DOI: 10.1016/0006-291x(87)91446-x

PubMed ID: 31652072

Title: TMEM70 facilitates biogenesis of mammalian ATP synthase by promoting subunit c incorporation into the rotor structure of the enzyme.

PubMed ID: 31652072

DOI: 10.1096/fj.201900685rr

PubMed ID: 30530489

Title: Lysine methylation by the mitochondrial methyltransferase FAM173B optimizes the function of mitochondrial ATP synthase.

PubMed ID: 30530489

DOI: 10.1074/jbc.ra118.005473

PubMed ID: 33359711

Title: TMEM70 forms oligomeric scaffolds within mitochondrial cristae promoting in situ assembly of mammalian ATP synthase proton channel.

PubMed ID: 33359711

DOI: 10.1016/j.bbamcr.2020.118942

Sequence Information:

  • Length: 136
  • Mass: 14277
  • Checksum: 1AFF1F16BB532647
  • Sequence:
    • MQTAGALFIS PALIRCCTRG LIRPVSASFL NSPVNSSKQP SYSNFPLQVA RREFQTSVVS 
RDIDTAAKFI GAGAATVGVA GSGAGIGTVF GSLIIGYARN PSLKQQLFSY AILGFALSEA 
MGLFCLMVAF LILFAM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.