Details for: ATP5MC2

Gene ID: 517

Symbol: ATP5MC2

Ensembl ID: ENSG00000135390

Description: ATP synthase membrane subunit c locus 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 403.4979
    Cell Significance Index: -166.2200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 339.4457
    Cell Significance Index: -160.2600
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 319.7312
    Cell Significance Index: -164.4700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 239.8431
    Cell Significance Index: -160.9400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 37.6988
    Cell Significance Index: -115.7900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 26.9592
    Cell Significance Index: -72.2200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 19.4646
    Cell Significance Index: -42.6000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 8.4024
    Cell Significance Index: 220.9400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 7.7741
    Cell Significance Index: 99.5600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 6.8122
    Cell Significance Index: 54.3900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 6.7315
    Cell Significance Index: 73.1800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 6.2767
    Cell Significance Index: 184.3400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 5.8127
    Cell Significance Index: 121.6700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 5.5200
    Cell Significance Index: 713.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 5.4066
    Cell Significance Index: 252.0800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 5.2179
    Cell Significance Index: 716.5700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 5.1221
    Cell Significance Index: 177.9900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 4.8058
    Cell Significance Index: 2624.5500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 4.7777
    Cell Significance Index: 861.2700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 4.7239
    Cell Significance Index: 352.0700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 4.7105
    Cell Significance Index: 579.2000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 4.5209
    Cell Significance Index: 51.3600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.4104
    Cell Significance Index: 284.5400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 4.3160
    Cell Significance Index: 508.9900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 4.1257
    Cell Significance Index: 291.7900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.9978
    Cell Significance Index: 73.8900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 3.8269
    Cell Significance Index: 179.8600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.7174
    Cell Significance Index: 195.1800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 3.6925
    Cell Significance Index: 1632.5400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 3.3175
    Cell Significance Index: 30.5500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 3.0836
    Cell Significance Index: 395.3000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.2217
    Cell Significance Index: 219.7800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.1846
    Cell Significance Index: 38.6100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.8366
    Cell Significance Index: 49.9900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.6877
    Cell Significance Index: 87.6700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.4912
    Cell Significance Index: 295.9300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.2867
    Cell Significance Index: 1161.7800
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8876
    Cell Significance Index: 12.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.5547
    Cell Significance Index: 419.8500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4977
    Cell Significance Index: 99.8400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.3844
    Cell Significance Index: 281.8700
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.3643
    Cell Significance Index: 2.1400
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3374
    Cell Significance Index: 64.2100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3239
    Cell Significance Index: 116.1700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2215
    Cell Significance Index: 11.1900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0881
    Cell Significance Index: 1.4800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0247
    Cell Significance Index: 46.4300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0054
    Cell Significance Index: 0.5500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0453
    Cell Significance Index: -83.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0498
    Cell Significance Index: -76.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0559
    Cell Significance Index: -9.5500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0798
    Cell Significance Index: -2.1300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1113
    Cell Significance Index: -151.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1196
    Cell Significance Index: -5.4200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1286
    Cell Significance Index: -8.1100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1624
    Cell Significance Index: -120.3000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1837
    Cell Significance Index: -116.7000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2351
    Cell Significance Index: -6.5700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2422
    Cell Significance Index: -136.5800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2803
    Cell Significance Index: -8.0400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2965
    Cell Significance Index: -185.1300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.3013
    Cell Significance Index: -136.7700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.3923
    Cell Significance Index: -13.7900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.4770
    Cell Significance Index: -137.2600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.5076
    Cell Significance Index: -40.2000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.6063
    Cell Significance Index: -24.8400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.6827
    Cell Significance Index: -17.4400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6938
    Cell Significance Index: -8.2700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.7965
    Cell Significance Index: -115.7800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.8414
    Cell Significance Index: -177.2200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.8839
    Cell Significance Index: -103.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.8877
    Cell Significance Index: -101.7000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.9150
    Cell Significance Index: -148.8200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.9151
    Cell Significance Index: -51.3500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.9309
    Cell Significance Index: -57.2200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.9902
    Cell Significance Index: -68.4800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.0527
    Cell Significance Index: -33.7100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.2546
    Cell Significance Index: -27.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.3392
    Cell Significance Index: -102.7700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.4599
    Cell Significance Index: -152.0100
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -1.5132
    Cell Significance Index: -9.3100
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -1.6386
    Cell Significance Index: -12.6300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.9703
    Cell Significance Index: -33.1900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -2.0322
    Cell Significance Index: -30.4500
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -2.3279
    Cell Significance Index: -40.1300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.4239
    Cell Significance Index: -148.6100
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -2.8715
    Cell Significance Index: -24.1200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -3.0844
    Cell Significance Index: -90.8500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -3.2392
    Cell Significance Index: -55.5100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -3.4624
    Cell Significance Index: -89.0000
  • Cell Name: germ cell (CL0000586)
    Fold Change: -3.5388
    Cell Significance Index: -26.7200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -3.5567
    Cell Significance Index: -157.3200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -3.8666
    Cell Significance Index: -141.9400
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -3.9922
    Cell Significance Index: -83.2600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -4.1502
    Cell Significance Index: -145.3900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -4.1995
    Cell Significance Index: -159.0300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -4.3161
    Cell Significance Index: -44.6800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -4.3370
    Cell Significance Index: -142.0000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -4.4174
    Cell Significance Index: -140.6900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -4.6044
    Cell Significance Index: -100.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Location**: The ATP5MC2 gene is located on the mitochondrial DNA (mtDNA) and encodes a subunit of the mitochondrial ATP synthase complex. 2. **Expression**: This gene is highly expressed in various cell types, including skeletal muscle satellite cells, follicular B cells, and pancreatic acinar cells. 3. **Protein structure**: The ATP5MC2 protein is a lipid-binding protein that interacts with other subunits of the ATP synthase complex to facilitate proton transport and ATP synthesis. 4. **Function**: The ATP5MC2 protein plays a critical role in the formation of cristae, mitochondrial biogenesis, and proton transport, ultimately contributing to the production of ATP through chemiosmotic coupling. **Pathways and Functions** The ATP5MC2 gene is involved in several key pathways, including: 1. **Cristae formation**: The ATP5MC2 protein helps to establish the cristae structure, which is essential for the efficient production of ATP. 2. **Mitochondrial biogenesis**: This gene is involved in the regulation of mitochondrial biogenesis, which is critical for maintaining cellular energy homeostasis. 3. **Proton transport**: The ATP5MC2 protein facilitates proton transport across the mitochondrial inner membrane, which is essential for the production of ATP through chemiosmotic coupling. 4. **Proton motive force-driven ATP synthesis**: The ATP5MC2 protein plays a critical role in the generation of the proton motive force, which drives ATP synthesis through chemiosmotic coupling. 5. **Heat production by uncoupling proteins**: The ATP5MC2 protein may also interact with uncoupling proteins to regulate heat production in cells. **Clinical Significance** Dysregulation of the ATP5MC2 gene has been implicated in various diseases, including: 1. **Mitochondrial disorders**: Mutations in the ATP5MC2 gene have been associated with mitochondrial disorders, such as mitochondrial myopathies and encephalopathies. 2. **Metabolic disorders**: Alterations in ATP5MC2 expression have been linked to metabolic disorders, including type 2 diabetes and obesity. 3. **Cancer**: The ATP5MC2 gene is overexpressed in various types of cancer, including colorectal and breast cancer, highlighting its potential role in tumorigenesis. 4. **Atherosclerosis**: The ATP5MC2 protein may also play a role in the development of atherosclerosis, a condition characterized by the buildup of fatty plaques in arteries. In conclusion, the ATP5MC2 gene is a critical component of the mitochondrial ATP synthase complex, and its dysregulation has been implicated in various diseases. Further research is needed to fully understand the role of this gene in human health and disease.

Genular Protein ID: 1007201391

Symbol: AT5G2_HUMAN

Name: ATP synthase lipid-binding protein

UniProtKB Accession Codes:

Q06055 B3KQQ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 5 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 5 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 3 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8328972

Title: Sequences of members of the human gene family for the c subunit of mitochondrial ATP synthase.

PubMed ID: 8328972

DOI: 10.1042/bj2930051

PubMed ID: 8485160

Title: Molecular cloning and sequence of two cDNAs for human subunit c of H(+)-ATP synthase in mitochondria.

PubMed ID: 8485160

DOI: 10.1016/0167-4781(93)90249-d

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2883974

Title: Human liver cDNA clones encoding proteolipid subunit 9 of the mitochondrial ATPase complex.

PubMed ID: 2883974

DOI: 10.1016/0006-291x(87)91446-x

PubMed ID: 30318146

Title: The 7q11.23 protein DNAJC30 interacts with ATP synthase and links mitochondria to brain development.

PubMed ID: 30318146

DOI: 10.1016/j.cell.2018.09.014

PubMed ID: 30530489

Title: Lysine methylation by the mitochondrial methyltransferase FAM173B optimizes the function of mitochondrial ATP synthase.

PubMed ID: 30530489

DOI: 10.1074/jbc.ra118.005473

Sequence Information:

  • Length: 141
  • Mass: 14637
  • Checksum: 6E627A504A7AE52D
  • Sequence:
    • MFACSKFVST PSLVKSTSQL LSRPLSAVVL KRPEILTDES LSSLAVSCPL TSLVSSRSFQ 
TSAISRDIDT AAKFIGAGAA TVGVAGSGAG IGTVFGSLII GYARNPSLKQ QLFSYAILGF 
ALSEAMGLFC LMVAFLILFA M

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.