Details for: ATP5MC2

Gene ID: 517

Symbol: ATP5MC2

Ensembl ID: ENSG00000135390

Description: ATP synthase membrane subunit c locus 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 8.27
    Marker Score: 5534
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 7.19
    Marker Score: 7796
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 6.81
    Marker Score: 5140
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 5.56
    Marker Score: 11734
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 5.16
    Marker Score: 3640
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 4.96
    Marker Score: 1455
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 4.9
    Marker Score: 4157
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 4.65
    Marker Score: 2819
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 4.63
    Marker Score: 19233.5
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 4.6
    Marker Score: 45590
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 4.43
    Marker Score: 2287
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 4.4
    Marker Score: 2577
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 4.25
    Marker Score: 57167
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 4.25
    Marker Score: 237619
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 4.23
    Marker Score: 1559
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.23
    Marker Score: 55728
  • Cell Name: blood cell (CL0000081)
    Fold Change: 4.19
    Marker Score: 48685
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 4.18
    Marker Score: 13200
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 4.17
    Marker Score: 220695
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 4.15
    Marker Score: 6390
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 3.99
    Marker Score: 3992
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 3.94
    Marker Score: 6756
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 3.9
    Marker Score: 29016
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.9
    Marker Score: 10441
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 3.82
    Marker Score: 3415
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.76
    Marker Score: 16108
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.74
    Marker Score: 10341
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 3.72
    Marker Score: 3498
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.71
    Marker Score: 3585
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.67
    Marker Score: 3274
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 3.66
    Marker Score: 2040
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.65
    Marker Score: 12964
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 3.64
    Marker Score: 7626
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 3.64
    Marker Score: 10617
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.62
    Marker Score: 23531
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.61
    Marker Score: 1188
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 3.61
    Marker Score: 2194
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 3.6
    Marker Score: 1619
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 3.57
    Marker Score: 6379.5
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.54
    Marker Score: 2773
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.53
    Marker Score: 8620
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 3.49
    Marker Score: 3102
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 3.49
    Marker Score: 8504
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.47
    Marker Score: 18250
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.47
    Marker Score: 3419
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.47
    Marker Score: 829
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.46
    Marker Score: 5089
  • Cell Name: theca cell (CL0000503)
    Fold Change: 3.45
    Marker Score: 2472
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 3.42
    Marker Score: 3005
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.41
    Marker Score: 8609
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 3.4
    Marker Score: 2665
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.39
    Marker Score: 3028
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 3.39
    Marker Score: 3997
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 3.38
    Marker Score: 20076
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3.38
    Marker Score: 22059
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.38
    Marker Score: 6355
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.37
    Marker Score: 3180
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 3.37
    Marker Score: 1914
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.36
    Marker Score: 4063
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 3.36
    Marker Score: 6124
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 3.36
    Marker Score: 2163
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 3.36
    Marker Score: 2231
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 3.35
    Marker Score: 2783
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.34
    Marker Score: 1781.5
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.33
    Marker Score: 3471
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.32
    Marker Score: 115126.5
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.32
    Marker Score: 7538
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 3.31
    Marker Score: 4594
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.3
    Marker Score: 3773.5
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 3.3
    Marker Score: 2774
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 3.29
    Marker Score: 2163
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.28
    Marker Score: 3498
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 3.27
    Marker Score: 2201
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 3.27
    Marker Score: 1127
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 3.26
    Marker Score: 1801
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.25
    Marker Score: 5388
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 3.24
    Marker Score: 1346
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 3.23
    Marker Score: 5292
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.22
    Marker Score: 12418
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.22
    Marker Score: 25135.5
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 3.21
    Marker Score: 2323
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.19
    Marker Score: 6219
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 3.19
    Marker Score: 3544
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 3.18
    Marker Score: 2109
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 3.18
    Marker Score: 2603
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 3.17
    Marker Score: 2254
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 3.17
    Marker Score: 4484
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 3.15
    Marker Score: 8843
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 3.15
    Marker Score: 2383
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 3.15
    Marker Score: 1431
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.14
    Marker Score: 27314
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 3.14
    Marker Score: 1972
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 3.14
    Marker Score: 3468
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 3.13
    Marker Score: 824
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 3.12
    Marker Score: 1245
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3.11
    Marker Score: 19870
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 3.11
    Marker Score: 1600
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 3.11
    Marker Score: 2914
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 3.1
    Marker Score: 1607
  • Cell Name: centroblast (CL0009112)
    Fold Change: 3.1
    Marker Score: 1528

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Other Information

**Key characteristics:** - The gene is located on chromosome 19q27.3. - It encodes for a protein of approximately 110 kDa. - It is a member of the ATP synthase family of proteins. **Pathways and functions:** - ATP5MC2 is involved in the citric acid (tca) cycle and respiratory electron transport pathways, where it participates in the production and maintenance of ATP. - It is also involved in lipid binding, metabolism, mitochondrial biogenesis, and mitochondrial outer membrane functions. **Clinical significance:** - Mutations in ATP5MC2 have been linked to several human diseases, including mitochondrial disorders, metabolic syndrome, and cancer. - Studies of ATP5MC2 mutations have implications for understanding and treating these disorders.

Genular Protein ID: 1007201391

Symbol: AT5G2_HUMAN

Name: ATP synthase lipid-binding protein

UniProtKB Accession Codes:

Q06055 B3KQQ6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EMDB 7 Ensembl 5 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HAMAP 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 2 RefSeq 5 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 3 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8328972

Title: Sequences of members of the human gene family for the c subunit of mitochondrial ATP synthase.

PubMed ID: 8328972

DOI: 10.1042/bj2930051

PubMed ID: 8485160

Title: Molecular cloning and sequence of two cDNAs for human subunit c of H(+)-ATP synthase in mitochondria.

PubMed ID: 8485160

DOI: 10.1016/0167-4781(93)90249-d

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2883974

Title: Human liver cDNA clones encoding proteolipid subunit 9 of the mitochondrial ATPase complex.

PubMed ID: 2883974

DOI: 10.1016/0006-291x(87)91446-x

PubMed ID: 30318146

Title: The 7q11.23 protein DNAJC30 interacts with ATP synthase and links mitochondria to brain development.

PubMed ID: 30318146

DOI: 10.1016/j.cell.2018.09.014

PubMed ID: 30530489

Title: Lysine methylation by the mitochondrial methyltransferase FAM173B optimizes the function of mitochondrial ATP synthase.

PubMed ID: 30530489

DOI: 10.1074/jbc.ra118.005473

Sequence Information:

  • Length: 141
  • Mass: 14637
  • Checksum: 6E627A504A7AE52D
  • Sequence:
    • MFACSKFVST PSLVKSTSQL LSRPLSAVVL KRPEILTDES LSSLAVSCPL TSLVSSRSFQ 
TSAISRDIDT AAKFIGAGAA TVGVAGSGAG IGTVFGSLII GYARNPSLKQ QLFSYAILGF 
ALSEAMGLFC LMVAFLILFA M

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.