Rgs14 | ENSMUSG00000052087 | NCBI 51791

Details for: Rgs14

Gene ID: 51791

Symbol: Rgs14

Ensembl ID: ENSMUSG00000052087

Description: regulator of G-protein signaling 14

Associated with

G alpha (i) signalling events
(R-MMU-418594)
Gpcr downstream signalling
(R-MMU-388396)
Signaling by gpcr
(R-MMU-372790)
Signal transduction
(R-MMU-162582)
Cell division
(GO:0051301)
Centrosome
(GO:0005813)
Chromosome segregation
(GO:0007059)
Cytoplasm
(GO:0005737)
Dendrite
(GO:0030425)
Dendritic spine
(GO:0043197)
G-protein alpha-subunit binding
(GO:0001965)
Gdp-dissociation inhibitor activity
(GO:0005092)
Glutamatergic synapse
(GO:0098978)
G protein-coupled receptor signaling pathway
(GO:0007186)
Gtpase activating protein binding
(GO:0032794)
Gtpase activator activity
(GO:0005096)
Learning
(GO:0007612)
Long-term memory
(GO:0007616)
Long-term synaptic potentiation
(GO:0060291)
Microtubule
(GO:0005874)
Microtubule binding
(GO:0008017)
Mitotic cell cycle
(GO:0000278)
Modulation of chemical synaptic transmission
(GO:0050804)
Negative regulation of erk1 and erk2 cascade
(GO:0070373)
Negative regulation of g protein-coupled receptor signaling pathway
(GO:0045744)
Negative regulation of map kinase activity
(GO:0043407)
Negative regulation of synaptic plasticity
(GO:0031914)
Nuclear body
(GO:0016604)
Nucleocytoplasmic transport
(GO:0006913)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Platelet-derived growth factor receptor signaling pathway
(GO:0048008)
Pml body
(GO:0016605)
Positive regulation of gtpase activity
(GO:0043547)
Positive regulation of neurogenesis
(GO:0050769)
Postsynaptic density
(GO:0014069)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Regulation of g protein-coupled receptor signaling pathway
(GO:0008277)
Response to oxidative stress
(GO:0006979)
Signaling receptor complex adaptor activity
(GO:0030159)
Spindle
(GO:0005819)
Spindle organization
(GO:0007051)
Spindle pole
(GO:0000922)
Visual learning
(GO:0008542)
Zygote asymmetric cell division
(GO:0010070)

Other Information

Proteins

Regulator of G-protein signaling 14

Genular Protein ID: 2663724371

Symbol: RGS14_MOUSE

Name: Regulator of G-protein signaling 14

UniProtKB Accession Codes:

P97492 Q8K2R4 Q9DCD1

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 10926822

Title: RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao.

PubMed ID: 10926822

DOI: 10.1042/bj3500019

PubMed ID: 15112653

Title: The RGS (regulator of G-protein signalling) and GoLoco domains of RGS14 co-operate to regulate Gi-mediated signalling.

PubMed ID: 15112653

DOI: 10.1042/bj20031889

PubMed ID: 15525537

Title: RGS14 is a mitotic spindle protein essential from the first division of the mammalian zygote.

PubMed ID: 15525537

DOI: 10.1016/j.devcel.2004.10.004

PubMed ID: 15917656

Title: RGS14 is a microtubule-associated protein.

PubMed ID: 15917656

DOI: 10.4161/cc.4.7.1787

PubMed ID: 15520006

Title: RGS14 is a centrosomal and nuclear cytoplasmic shuttling protein that traffics to promyelocytic leukemia nuclear bodies following heat shock.

PubMed ID: 15520006

DOI: 10.1074/jbc.m408163200

PubMed ID: 16246175

Title: Biochemical characterization of RGS14: RGS14 activity towards G-protein alpha subunits is independent of its binding to Rap2A.

PubMed ID: 16246175

DOI: 10.1042/bj20051086

PubMed ID: 17635935

Title: Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division.

PubMed ID: 17635935

DOI: 10.1083/jcb.200604114

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20837545

Title: RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory.

PubMed ID: 20837545

DOI: 10.1073/pnas.1005362107

PubMed ID: 21158412

Title: Activation of the regulator of G protein signaling 14-Galphai1-GDP signaling complex is regulated by resistance to inhibitors of cholinesterase-8A.

PubMed ID: 21158412

DOI: 10.1021/bi101910n

Sequence Information:

Length: 547
Mass: 59847
Checksum: 51BDE89E58F1E2C3
Sequence:

MPGKPKHLGV PNGRMVLAVS DGELTSTAGS QAQGEGRGSS LSIHSLPSGP SSPFSTEEQP 
VASWAQSFER LLQDPRGLAY FTEFLKKEFS AENVTFWKAC ERFQQIPASD TKQLAQEAHN 
IYHEFLSSQA LSPVNIDRQA WLSEEVLAQP RPDMFRAQQL QIFNLMKFDS YARFVKSPLY 
QECLLAEAEG RPLREPGSSH LGSPDTARKK PKLKPGKSLP LGVEELGQLP LAEGPCGRPL 
RKSFRREMTG GAMNSALRRE SQGSLNSSAS LDLGFLAFVS SKSESHRKSL GSGESESESR 
PGKYCCVYLP DGTASLALAR PGLTIRDMLA GICEKRGLSL PDIKVYLVGN EQKALVLDQD 
CTVLADQEVR LENRITFQLE LVGLERVVRI SAKPTKRLQE ALQPILAKHG LSLDQVVLHR 
PGEKQPMDLE NPVSSVASQT LVLDTPPDAK MSEARSISPC RSQGCLPRTQ TKDSHLPPSS 
SSLLVEDASS STGNRQTCDI EGLVELLNRV QSSGAHDQRG LLRKEDLVLP EFLQLPSQRP 
GSREAPP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Rgs14

Associated with

Other Information

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao. PubMed ID: 10926822

The RGS (regulator of G-protein signalling) and GoLoco domains of RGS14 co-operate to regulate Gi-mediated signalling. PubMed ID: 15112653

RGS14 is a mitotic spindle protein essential from the first division of the mammalian zygote. PubMed ID: 15525537

RGS14 is a microtubule-associated protein. PubMed ID: 15917656

RGS14 is a centrosomal and nuclear cytoplasmic shuttling protein that traffics to promyelocytic leukemia nuclear bodies following heat shock. PubMed ID: 15520006

Biochemical characterization of RGS14: RGS14 activity towards G-protein alpha subunits is independent of its binding to Rap2A. PubMed ID: 16246175

Localization of Gi alpha proteins in the centrosomes and at the midbody: implication for their role in cell division. PubMed ID: 17635935

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

RGS14 is a natural suppressor of both synaptic plasticity in CA2 neurons and hippocampal-based learning and memory. PubMed ID: 20837545

Activation of the regulator of G protein signaling 14-Galphai1-GDP signaling complex is regulated by resistance to inhibitors of cholinesterase-8A. PubMed ID: 21158412