Ppp2r1a | ENSMUSG00000007564 | NCBI 51792

Details for: Ppp2r1a

Gene ID: 51792

Symbol: Ppp2r1a

Ensembl ID: ENSMUSG00000007564

Description: protein phosphatase 2, regulatory subunit A, alpha

Associated with

Adaptive immune system
(R-MMU-1280218)
Amplification of signal from the kinetochores
(R-MMU-141424)
Amplification of signal from unattached kinetochores via a mad2 inhibitory signal
(R-MMU-141444)
Anchoring of the basal body to the plasma membrane
(R-MMU-5620912)
Antiviral mechanism by ifn-stimulated genes
(R-MMU-1169410)
Aurka activation by tpx2
(R-MMU-8854518)
Beta-catenin phosphorylation cascade
(R-MMU-196299)
Cell cycle
(R-MMU-1640170)
Cell cycle, mitotic
(R-MMU-69278)
Cell cycle checkpoints
(R-MMU-69620)
Cellular responses to mechanical stimuli
(R-MMU-9855142)
Cellular responses to stimuli
(R-MMU-8953897)
Centrosome maturation
(R-MMU-380287)
Cilium assembly
(R-MMU-5617833)
Costimulation by the cd28 family
(R-MMU-388841)
Ctla4 inhibitory signaling
(R-MMU-389513)
Cyclin a/b1/b2 associated events during g2/m transition
(R-MMU-69273)
Cyclin d associated events in g1
(R-MMU-69231)
Cytokine signaling in immune system
(R-MMU-1280215)
Degradation of beta-catenin by the destruction complex
(R-MMU-195253)
Disassembly of the destruction complex and recruitment of axin to the membrane
(R-MMU-4641262)
E2f mediated regulation of dna replication
(R-MMU-113510)
Eml4 and nudc in mitotic spindle formation
(R-MMU-9648025)
G1 phase
(R-MMU-69236)
G1/s transition
(R-MMU-69206)
G2/m transition
(R-MMU-69275)
G alpha (i) signalling events
(R-MMU-418594)
Gene expression (transcription)
(R-MMU-74160)
Generic transcription pathway
(R-MMU-212436)
Gpcr downstream signalling
(R-MMU-388396)
Hemostasis
(R-MMU-109582)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interferon signaling
(R-MMU-913531)
Interleukin-17 signaling
(R-MMU-448424)
Intracellular signaling by second messengers
(R-MMU-9006925)
Mapk1/mapk3 signaling
(R-MMU-5684996)
Mapk family signaling cascades
(R-MMU-5683057)
Metabolism of rna
(R-MMU-8953854)
Mitotic anaphase
(R-MMU-68882)
Mitotic g1 phase and g1/s transition
(R-MMU-453279)
Mitotic g2-g2/m phases
(R-MMU-453274)
Mitotic metaphase and anaphase
(R-MMU-2555396)
Mitotic prometaphase
(R-MMU-68877)
Mitotic spindle checkpoint
(R-MMU-69618)
M phase
(R-MMU-68886)
Myd88 dependent cascade initiated on endosome
(R-MMU-975155)
Myd88-independent tlr4 cascade
(R-MMU-166166)
Negative regulation of fgfr1 signaling
(R-MMU-5654726)
Negative regulation of fgfr2 signaling
(R-MMU-5654727)
Negative regulation of fgfr3 signaling
(R-MMU-5654732)
Negative regulation of fgfr4 signaling
(R-MMU-5654733)
Negative regulation of mapk pathway
(R-MMU-5675221)
Negative regulation of the pi3k/akt network
(R-MMU-199418)
Nonsense-mediated decay (nmd)
(R-MMU-927802)
Nonsense mediated decay (nmd) enhanced by the exon junction complex (ejc)
(R-MMU-975957)
Nuclear events (kinase and transcription factor activation)
(R-MMU-198725)
Opioid signalling
(R-MMU-111885)
Organelle biogenesis and maintenance
(R-MMU-1852241)
Pi5p, pp2a and ier3 regulate pi3k/akt signaling
(R-MMU-6811558)
Pip3 activates akt signaling
(R-MMU-1257604)
Platelet homeostasis
(R-MMU-418346)
Platelet sensitization by ldl
(R-MMU-432142)
Raf/map kinase cascade
(R-MMU-5673001)
Raf activation
(R-MMU-5673000)
Recruitment of numa to mitotic centrosomes
(R-MMU-380320)
Regulation of plk1 activity at g2/m transition
(R-MMU-2565942)
Regulation of tp53 activity
(R-MMU-5633007)
Resolution of sister chromatid cohesion
(R-MMU-2500257)
Response of endothelial cells to shear stress
(R-MMU-9860931)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate formins
(R-MMU-5663220)
Rna polymerase ii transcription
(R-MMU-73857)
Signaling by fgfr
(R-MMU-190236)
Signaling by fgfr1
(R-MMU-5654736)
Signaling by fgfr2
(R-MMU-5654738)
Signaling by fgfr3
(R-MMU-5654741)
Signaling by fgfr4
(R-MMU-5654743)
Signaling by gpcr
(R-MMU-372790)
Signaling by interleukins
(R-MMU-449147)
Signaling by ntrk1 (trka)
(R-MMU-187037)
Signaling by ntrks
(R-MMU-166520)
Signaling by receptor tyrosine kinases
(R-MMU-9006934)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signaling by wnt
(R-MMU-195721)
Signal transduction
(R-MMU-162582)
Tcf dependent signaling in response to wnt
(R-MMU-201681)
Toll-like receptor cascades
(R-MMU-168898)
Toll like receptor 2 (tlr2) cascade
(R-MMU-181438)
Toll like receptor 3 (tlr3) cascade
(R-MMU-168164)
Toll like receptor 4 (tlr4) cascade
(R-MMU-166016)
Toll like receptor 5 (tlr5) cascade
(R-MMU-168176)
Toll like receptor 7/8 (tlr7/8) cascade
(R-MMU-168181)
Toll like receptor 9 (tlr9) cascade
(R-MMU-168138)
Toll like receptor 10 (tlr10) cascade
(R-MMU-168142)
Toll like receptor tlr1:tlr2 cascade
(R-MMU-168179)
Toll like receptor tlr6:tlr2 cascade
(R-MMU-168188)
Transcriptional regulation by tp53
(R-MMU-3700989)
Turbulent (oscillatory, disturbed) flow shear stress activates signaling by piezo1 and integrins in endothelial cells
(R-MMU-9860927)

Other Information

Proteins

Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

Genular Protein ID: 3858194555

Symbol: 2AAA_MOUSE

Name: Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

UniProtKB Accession Codes:

Q76MZ3

Database IDs:

Citations:

PubMed ID: 10100624

Title: Alpha4 protein as a common regulator of type 2A-related serine/threonine protein phosphatases.

PubMed ID: 10100624

DOI: 10.1016/s0014-5793(99)00189-1

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16258073

Title: A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A.

PubMed ID: 16258073

DOI: 10.1124/mol.105.018275

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22417654

Title: The B55alpha-containing PP2A holoenzyme dephosphorylates FOXO1 in islet beta-cells under oxidative stress.

PubMed ID: 22417654

DOI: 10.1042/bj20111606

PubMed ID: 23806337

Title: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.

PubMed ID: 23806337

DOI: 10.1016/j.molcel.2013.06.001

PubMed ID: 26974206

Title: Phosphatase PP2A is requisite for the function of regulatory T cells.

PubMed ID: 26974206

DOI: 10.1038/ni.3390

PubMed ID: 30611118

Title: Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment.

PubMed ID: 30611118

DOI: 10.1016/j.isci.2018.12.012

PubMed ID: 33505023

Title: AIM2 in regulatory T cells restrains autoimmune diseases.

PubMed ID: 33505023

DOI: 10.1038/s41586-021-03231-w

Sequence Information:

Length: 589
Mass: 65323
Checksum: 5175409E4D50A366
Sequence:

MAAADGDDSL YPIAVLIDEL RNEDVQLRLN SIKKLSTIAL ALGVERTRSE LLPFLTDTIY 
DEDEVLLALA EQLGTFTTLV GGPEYVHCLL PPLESLATVE ETVVRDKAVE SLRAISHEHS 
PSDLEAHFVP LVKRLAGGDW FTSRTSACGL FSVCYPRVSS AVKAELRQYF RNLCSDDTPM 
VRRAAASKLG EFAKVLELDN VKSEIIPMFS NLASDEQDSV RLLAVEACVN IAQLLPQEDL 
EALVMPTLRQ AAEDKSWRVR YMVADKFTEL QKAVGPEITK TDLVPAFQNL MKDCEAEVRA 
AASHKVKEFC ENLSADCREN VIMTQILPCI KELVSDANQH VKSALASVIM GLSPILGKDN 
TIEHLLPLFL AQLKDECPEV RLNIISNLDC VNEVIGIRQL SQSLLPAIVE LAEDAKWRVR 
LAIIEYMPLL AGQLGVEFFD EKLNSLCMAW LVDHVYAIRE AATSNLKKLV EKFGKEWAHA 
TIIPKVLAMS GDPNYLHRMT TLFCINVLSE VCGQDITTKH MLPTVLRMAG DPVANVRFNV 
AKSLQKIGPI LDNSTLQSEV KPILEKLTQD QDVDVKYFAQ EALTVLSLA

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Ppp2r1a

Associated with

Other Information

Alpha4 protein as a common regulator of type 2A-related serine/threonine protein phosphatases. PubMed ID: 10100624

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

A direct interaction between the N terminus of adenylyl cyclase AC8 and the catalytic subunit of protein phosphatase 2A. PubMed ID: 16258073

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

The B55alpha-containing PP2A holoenzyme dephosphorylates FOXO1 in islet beta-cells under oxidative stress. PubMed ID: 22417654

SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. PubMed ID: 23806337

Phosphatase PP2A is requisite for the function of regulatory T cells. PubMed ID: 26974206

Mitogenic Signals Stimulate the CREB Coactivator CRTC3 through PP2A Recruitment. PubMed ID: 30611118

AIM2 in regulatory T cells restrains autoimmune diseases. PubMed ID: 33505023