Details for: Bok

Gene ID: 51800

Symbol: Bok

Ensembl ID: ENSMUSG00000026278

Description: BCL2-related ovarian killer

Associated with

  • Activation of cysteine-type endopeptidase activity involved in apoptotic process
    (GO:0006919)
  • Activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
    (GO:0008635)
  • Apoptotic process
    (GO:0006915)
  • Bh domain binding
    (GO:0051400)
  • Cellular component disassembly involved in execution phase of apoptosis
    (GO:0006921)
  • Channel activity
    (GO:0015267)
  • Cis-golgi network membrane
    (GO:0033106)
  • Cytoplasm
    (GO:0005737)
  • Early endosome membrane
    (GO:0031901)
  • Endoplasmic reticulum
    (GO:0005783)
  • Endoplasmic reticulum membrane
    (GO:0005789)
  • Extrinsic apoptotic signaling pathway in absence of ligand
    (GO:0097192)
  • Golgi apparatus
    (GO:0005794)
  • Intrinsic apoptotic signaling pathway by p53 class mediator
    (GO:0072332)
  • Intrinsic apoptotic signaling pathway in response to dna damage
    (GO:0008630)
  • Male gonad development
    (GO:0008584)
  • Membrane
    (GO:0016020)
  • Mitochondrial inner membrane
    (GO:0005743)
  • Mitochondrial membrane
    (GO:0031966)
  • Mitochondrial outer membrane
    (GO:0005741)
  • Mitochondrion
    (GO:0005739)
  • Negative regulation of mitochondrial depolarization
    (GO:0051902)
  • Negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
    (GO:1901029)
  • Negative regulation of necroptotic process
    (GO:0060546)
  • Negative regulation of neuron apoptotic process
    (GO:0043524)
  • Neuron apoptotic process
    (GO:0051402)
  • Nuclear outer membrane
    (GO:0005640)
  • Nucleus
    (GO:0005634)
  • Oligodendrocyte differentiation
    (GO:0048709)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
    (GO:1902237)
  • Positive regulation of execution phase of apoptosis
    (GO:1900119)
  • Positive regulation of intrinsic apoptotic signaling pathway
    (GO:2001244)
  • Positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
    (GO:1901030)
  • Positive regulation of perk-mediated unfolded protein response
    (GO:1903899)
  • Protein-containing complex binding
    (GO:0044877)
  • Protein binding
    (GO:0005515)
  • Protein complex oligomerization
    (GO:0051259)
  • Protein dimerization activity
    (GO:0046983)
  • Protein heterodimerization activity
    (GO:0046982)
  • Protein homodimerization activity
    (GO:0042803)
  • Recycling endosome membrane
    (GO:0055038)
  • Regulation of autophagy
    (GO:0010506)
  • Regulation of chorionic trophoblast cell proliferation
    (GO:1901382)
  • Regulation of cytosolic calcium ion concentration
    (GO:0051480)
  • Regulation of granulosa cell apoptotic process
    (GO:1904708)
  • Release of cytochrome c from mitochondria
    (GO:0001836)
  • Signaling receptor binding
    (GO:0005102)
  • Trans-golgi network membrane
    (GO:0032588)
  • Ubiquitin protein ligase binding
    (GO:0031625)

Other Information

Genular Protein ID: 3599436213

Symbol: BOK_MOUSE

Name: Apoptosis activator Mtd

UniProtKB Accession Codes:

O35425

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 43 Gene3D 1 GeneTree 1 HOGENOM 1 InParanoid 1 InterPro 4 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 9535847

Title: Mtd, a novel Bcl-2 family member activates apoptosis in the absence of heterodimerization with Bcl-2 and Bcl-XL.

PubMed ID: 9535847

DOI: 10.1074/jbc.273.15.8705

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23429263

Title: Intracellular localization of the BCL-2 family member BOK and functional implications.

PubMed ID: 23429263

DOI: 10.1038/cdd.2013.10

PubMed ID: 23884412

Title: The Bcl-2 protein family member Bok binds to the coupling domain of inositol 1,4,5-trisphosphate receptors and protects them from proteolytic cleavage.

PubMed ID: 23884412

DOI: 10.1074/jbc.m113.496570

PubMed ID: 26015568

Title: BCL-2 family member BOK promotes apoptosis in response to endoplasmic reticulum stress.

PubMed ID: 26015568

DOI: 10.1073/pnas.1421063112

PubMed ID: 26949185

Title: BOK Is a Non-canonical BCL-2 Family Effector of Apoptosis Regulated by ER-Associated Degradation.

PubMed ID: 26949185

DOI: 10.1016/j.cell.2016.02.026

PubMed ID: 27053113

Title: The Stability and Expression Level of Bok Are Governed by Binding to Inositol 1,4,5-Trisphosphate Receptors.

PubMed ID: 27053113

DOI: 10.1074/jbc.m115.711242

PubMed ID: 27098698

Title: Bok Is Not Pro-Apoptotic But Suppresses Poly ADP-Ribose Polymerase-Dependent Cell Death Pathways and Protects against Excitotoxic and Seizure-Induced Neuronal Injury.

PubMed ID: 27098698

DOI: 10.1523/jneurosci.3780-15.2016

Sequence Information:

  • Length: 213
  • Mass: 23456
  • Checksum: F8755C45CB05D626
  • Sequence:
    • MEVLRRSSVF AAEIMDAFDR SPTDKELVAQ AKALGREYVH ARLLRAGLSW SAPERASPAP 
GGRLAEVCTV LLRLGDELEQ IRPSVYRNVA RQLHIPLQSE PVVTDAFLAV AGHIFSAGIT 
WGKVVSLYSV AAGLAVDCVR QAQPAMVHAL VDCLGEFVRK TLATWLRRRG GWTDVLKCVV 
STDPGFRSHW LVATLCSFGR FLKAAFFLLL PER

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.