Details for: ACP1

Gene ID: 52

Symbol: ACP1

Ensembl ID: ENSG00000143727

Description: acid phosphatase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 199.7811
    Cell Significance Index: -31.0800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 154.4294
    Cell Significance Index: -39.1700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 139.7993
    Cell Significance Index: -57.5900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 124.2809
    Cell Significance Index: -50.4900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 123.2201
    Cell Significance Index: -58.1800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 110.7050
    Cell Significance Index: -56.9500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 86.6886
    Cell Significance Index: -58.1700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 52.9776
    Cell Significance Index: -50.5800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 33.8212
    Cell Significance Index: -41.7000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 15.1856
    Cell Significance Index: -40.6800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 14.4778
    Cell Significance Index: -57.1300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 11.8771
    Cell Significance Index: -36.4800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 7.1187
    Cell Significance Index: -15.5800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.1099
    Cell Significance Index: 24.8300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.8948
    Cell Significance Index: 31.4700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.4420
    Cell Significance Index: 84.8600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.4102
    Cell Significance Index: 50.4500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.1067
    Cell Significance Index: 1150.5100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.9590
    Cell Significance Index: 91.3400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.9133
    Cell Significance Index: 123.4400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.8923
    Cell Significance Index: 88.9400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.8038
    Cell Significance Index: 47.4300
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 1.5276
    Cell Significance Index: 16.2300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4835
    Cell Significance Index: 1339.5100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.4408
    Cell Significance Index: 169.9100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.3683
    Cell Significance Index: 12.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.3171
    Cell Significance Index: 180.8700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.3110
    Cell Significance Index: 169.3800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.2706
    Cell Significance Index: 34.0500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2539
    Cell Significance Index: 34.1300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.2016
    Cell Significance Index: 35.2900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.1929
    Cell Significance Index: 215.0400
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.1613
    Cell Significance Index: 26.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.1371
    Cell Significance Index: 139.8200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.1001
    Cell Significance Index: 57.7600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.0495
    Cell Significance Index: 78.2200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9905
    Cell Significance Index: 70.0500
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9559
    Cell Significance Index: 189.7100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9399
    Cell Significance Index: 415.5400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9315
    Cell Significance Index: 48.3900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8443
    Cell Significance Index: 58.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.7097
    Cell Significance Index: 204.2100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.6778
    Cell Significance Index: 42.7200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.6704
    Cell Significance Index: 17.9000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.5947
    Cell Significance Index: 119.3000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5796
    Cell Significance Index: 26.2700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5626
    Cell Significance Index: 72.1200
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.5310
    Cell Significance Index: 6.8000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.4799
    Cell Significance Index: 81.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3882
    Cell Significance Index: 11.1900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.3429
    Cell Significance Index: 2.8800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2744
    Cell Significance Index: 98.4200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2103
    Cell Significance Index: 34.2000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2056
    Cell Significance Index: 39.1200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1280
    Cell Significance Index: 96.9000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1039
    Cell Significance Index: 1.1800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0789
    Cell Significance Index: 1.3200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0473
    Cell Significance Index: 4.6800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0257
    Cell Significance Index: 18.8100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0110
    Cell Significance Index: 20.7500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0067
    Cell Significance Index: -12.3700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0135
    Cell Significance Index: -9.9700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0168
    Cell Significance Index: -25.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0343
    Cell Significance Index: -46.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0345
    Cell Significance Index: -3.5200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0382
    Cell Significance Index: -24.2300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0397
    Cell Significance Index: -24.8200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0507
    Cell Significance Index: -1.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0654
    Cell Significance Index: -36.9000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0744
    Cell Significance Index: -33.7700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0846
    Cell Significance Index: -5.2000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0890
    Cell Significance Index: -18.7500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0915
    Cell Significance Index: -2.9300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1742
    Cell Significance Index: -4.6600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1756
    Cell Significance Index: -20.1200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1757
    Cell Significance Index: -9.8600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2356
    Cell Significance Index: -6.0200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2493
    Cell Significance Index: -29.0500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2635
    Cell Significance Index: -38.3000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2644
    Cell Significance Index: -7.3900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2794
    Cell Significance Index: -8.0100
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2826
    Cell Significance Index: -32.2600
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.3656
    Cell Significance Index: -2.2500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3743
    Cell Significance Index: -8.1100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3754
    Cell Significance Index: -28.8100
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.4233
    Cell Significance Index: -2.6500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.4471
    Cell Significance Index: -6.7000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4471
    Cell Significance Index: -6.1000
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.4542
    Cell Significance Index: -35.9700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5206
    Cell Significance Index: -54.2100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5745
    Cell Significance Index: -38.6300
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: -0.6726
    Cell Significance Index: -4.3900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.6834
    Cell Significance Index: -20.1300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.7388
    Cell Significance Index: -13.6600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7473
    Cell Significance Index: -4.5100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.7641
    Cell Significance Index: -7.9100
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.7937
    Cell Significance Index: -14.0300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.8029
    Cell Significance Index: -41.8200
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.8681
    Cell Significance Index: -6.5600
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.8687
    Cell Significance Index: -10.3600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The ACP1 gene is a single nucleotide gene that encodes for a protein with a molecular weight of approximately 30 kDa. It is primarily expressed in various cell types, including epithelial cells, mesenchymal cells, and hematopoietic cells. The ACP1 protein exhibits acid phosphatase activity, which is essential for the regulation of cellular processes, such as cell signaling, proliferation, and differentiation. **Pathways and Functions:** The ACP1 protein is involved in several cellular pathways, including: 1. **Acid Phosphatase Activity:** ACP1 mediates the dephosphorylation of tyrosine residues on proteins, which plays a crucial role in regulating cellular signaling pathways. 2. **Protein Binding:** ACP1 interacts with various proteins, including those involved in cell adhesion, migration, and proliferation. 3. **Non-membrane Spanning Protein Tyrosine Phosphatase Activity:** ACP1 exhibits phosphatase activity on tyrosine residues, regulating protein-protein interactions and signaling pathways. The ACP1 protein also plays a role in various cellular processes, including: 1. **Cell Signaling:** ACP1 regulates cell signaling pathways, including those involved in proliferation, differentiation, and survival. 2. **Cell Adhesion:** ACP1 interacts with cell adhesion molecules, regulating cell migration and invasion. 3. **Immune Response:** ACP1 is expressed on the surface of immune cells, including T cells and dendritic cells, and plays a role in regulating immune responses. **Clinical Significance:** The ACP1 gene has been implicated in various diseases, including: 1. **Cancer:** ACP1 expression is often upregulated in cancer cells, where it contributes to tumor progression and metastasis. 2. **Autoimmune Diseases:** ACP1 has been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where it regulates immune responses and tissue damage. 3. **Neurological Disorders:** ACP1 expression is altered in neurological disorders, including Alzheimer's disease and Parkinson's disease, where it contributes to neuronal dysfunction and degeneration. In conclusion, the ACP1 gene is a complex gene with multiple functions and implications in various diseases. Further research is needed to fully understand the mechanisms of ACP1 and its potential applications in immunology and disease diagnosis.

Genular Protein ID: 247282862

Symbol: PPAC_HUMAN

Name: Adipocyte acid phosphatase

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 1939112

Title: Human red cell acid phosphatase (ACP1). The amino acid sequence of the two isozymes Bf and Bs encoded by the ACP1*B allele.

PubMed ID: 1939112

DOI: 10.1016/s0021-9258(18)54754-2

PubMed ID: 1627603

Title: Human red cell acid phosphatase (ACP1): the primary structure of the two pairs of isozymes encoded by the ACP1*A and ACP1*C alleles.

PubMed ID: 1627603

DOI: 10.1016/0167-4838(92)90155-7

PubMed ID: 1587862

Title: Sequencing, cloning, and expression of human red cell-type acid phosphatase, a cytoplasmic phosphotyrosyl protein phosphatase.

PubMed ID: 1587862

DOI: 10.1016/s0021-9258(19)50097-7

PubMed ID: 8586411

Title: Gene structure, sequence, and chromosomal localization of the human red cell-type low-molecular-weight acid phosphotyrosyl phosphatase gene, ACP1.

PubMed ID: 8586411

DOI: 10.1006/geno.1995.9893

PubMed ID: 1304913

Title: Identification of the adipocyte acid phosphatase as a PAO-sensitive tyrosyl phosphatase.

PubMed ID: 1304913

DOI: 10.1002/pro.5560010603

PubMed ID: 9038134

Title: Regulation of the low molecular weight phosphotyrosine phosphatase by phosphorylation at tyrosines 131 and 132.

PubMed ID: 9038134

DOI: 10.1074/jbc.272.9.5371

PubMed ID: 10336608

Title: A novel isoform of the low molecular weight phosphotyrosine phosphatase, LMPTP-C, arising from alternative mRNA splicing.

PubMed ID: 10336608

DOI: 10.1046/j.1432-1327.1999.00353.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16344560

Title: Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.

PubMed ID: 16344560

DOI: 10.1101/gr.4039406

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8364553

Title: A TaqI site identifies the *A allele at the ACP1 locus.

PubMed ID: 8364553

DOI: 10.1093/hmg/2.7.1079-a

PubMed ID: 9499402

Title: Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses.

PubMed ID: 9499402

DOI: 10.1101/gad.12.5.667

PubMed ID: 12167657

Title: Regulation of the EphA2 kinase by the low molecular weight tyrosine phosphatase induces transformation.

PubMed ID: 12167657

DOI: 10.1074/jbc.m207127200

PubMed ID: 11971983

Title: Tyrosine phosphorylation regulates alpha II spectrin cleavage by calpain.

PubMed ID: 11971983

DOI: 10.1128/mcb.22.10.3527-3536.2002

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 9705307

Title: Crystal structure of a human low molecular weight phosphotyrosyl phosphatase. Implications for substrate specificity.

PubMed ID: 9705307

DOI: 10.1074/jbc.273.34.21714

Sequence Information:

  • Length: 158
  • Mass: 18042
  • Checksum: 46617BD799313EED
  • Sequence:
  • MAEQATKSVL FVCLGNICRS PIAEAVFRKL VTDQNISENW RVDSAATSGY EIGNPPDYRG 
    QSCMKRHGIP MSHVARQITK EDFATFDYIL CMDESNLRDL NRKSNQVKTC KAKIELLGSY 
    DPQKQLIIED PYYGNDSDFE TVYQQCVRCC RAFLEKAH

Genular Protein ID: 381261049

Symbol: A0A140VK37_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 112
  • Mass: 12230
  • Checksum: 805DBFA90F43D732
  • Sequence:
  • MAEQATKSVL FVCLGNICRS PIAEAVFRKL VTDQNISENW RVDSAATSGY EIGNPPDYRG 
    QSCMKRHGIP MSHVARQVPS LDLKLCVLCF SGSLTAVLFL TGTWAGPQTQ EL

Genular Protein ID: 4132645691

Symbol: Q59EH3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 165
  • Mass: 18698
  • Checksum: E896DF024F52C29A
  • Sequence:
  • GASARGKMAE QATKSVLFVC LGNICRSPIA EAVFRKLVTD QNISENWRVD SAATSGYEIG 
    NPPDYRGQSC MKRHGIPMSH VARQITKEDF ATFDYILCMD ESNLRDLNRK SNRVKTCKAK 
    IELLGSYDPQ KQLIIEDPYY GNDSDFETVY QQCVRCCRAF LEKAH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.