Details for: ACP1

Gene ID: 52

Symbol: ACP1

Ensembl ID: ENSG00000143727

Description: acid phosphatase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.51
    Marker Score: 86888
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.44
    Marker Score: 32224
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.28
    Marker Score: 4755
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.26
    Marker Score: 2359
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.13
    Marker Score: 3421
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.12
    Marker Score: 3008
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.07
    Marker Score: 2085
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.06
    Marker Score: 2199
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.06
    Marker Score: 3494
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.03
    Marker Score: 2149
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 2.03
    Marker Score: 2434
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.01
    Marker Score: 20340.5
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.01
    Marker Score: 7886
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.99
    Marker Score: 8148.5
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.98
    Marker Score: 1319
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.97
    Marker Score: 1856.5
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.97
    Marker Score: 5371
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.95
    Marker Score: 4591
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.95
    Marker Score: 3448
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.94
    Marker Score: 714
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.93
    Marker Score: 2075
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.92
    Marker Score: 22359
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.91
    Marker Score: 4535
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.91
    Marker Score: 2025
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.89
    Marker Score: 5138
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.89
    Marker Score: 12265
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.86
    Marker Score: 14538.5
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.85
    Marker Score: 2851
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.85
    Marker Score: 2941
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.84
    Marker Score: 1156
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.84
    Marker Score: 15835
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.83
    Marker Score: 1333
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.82
    Marker Score: 2047
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.82
    Marker Score: 2610
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.81
    Marker Score: 6685
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.8
    Marker Score: 2396.5
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.8
    Marker Score: 4101
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.8
    Marker Score: 2120
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.79
    Marker Score: 8594.5
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.79
    Marker Score: 5311
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.78
    Marker Score: 11622
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.78
    Marker Score: 1587
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.76
    Marker Score: 1108
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.75
    Marker Score: 965.5
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.75
    Marker Score: 2581
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.74
    Marker Score: 3541
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.73
    Marker Score: 4228.5
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.71
    Marker Score: 10941
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.71
    Marker Score: 2982
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.71
    Marker Score: 574
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.69
    Marker Score: 6522.5
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.68
    Marker Score: 2790
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.67
    Marker Score: 3790
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.66
    Marker Score: 1727
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.65
    Marker Score: 371
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.65
    Marker Score: 781
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.64
    Marker Score: 392
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.64
    Marker Score: 22030
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.62
    Marker Score: 4483
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.62
    Marker Score: 1559
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.61
    Marker Score: 85196
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 1.61
    Marker Score: 864
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.61
    Marker Score: 16157
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.6
    Marker Score: 1261
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.59
    Marker Score: 2849
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.59
    Marker Score: 1566
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.59
    Marker Score: 15701.5
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.58
    Marker Score: 6835
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.58
    Marker Score: 682
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 1.58
    Marker Score: 710
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.58
    Marker Score: 1487
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.57
    Marker Score: 1973
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.57
    Marker Score: 1518
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.56
    Marker Score: 1889
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.56
    Marker Score: 555
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.56
    Marker Score: 501
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.56
    Marker Score: 857
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.55
    Marker Score: 651
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.55
    Marker Score: 800
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.55
    Marker Score: 2835
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.55
    Marker Score: 364
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.55
    Marker Score: 5488
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.54
    Marker Score: 3024
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.54
    Marker Score: 580
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.53
    Marker Score: 1444.5
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.53
    Marker Score: 4840
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.53
    Marker Score: 4815
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.53
    Marker Score: 723
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.53
    Marker Score: 536
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.53
    Marker Score: 754
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.52
    Marker Score: 747
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.52
    Marker Score: 811
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.52
    Marker Score: 1103
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.52
    Marker Score: 4078
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.51
    Marker Score: 1265
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.51
    Marker Score: 435
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 1.5
    Marker Score: 481
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.5
    Marker Score: 329
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.49
    Marker Score: 1013.5
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.49
    Marker Score: 1511

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Other Information

**Key characteristics:** * The ACP1 gene is located on chromosome 17p13.1. * It is a single-exon gene that encodes for a protein of approximately 450 amino acids. * The protein is a transmembrane protein that is expressed on the surface of cells. * It is a pleiotropic protein that can have different effects on cell behavior depending on the cellular context. **Pathways and functions:** * ACP1 is a key regulator of cell signaling. It is a negative regulator of the MAPK signaling pathway, which is involved in cell growth, differentiation, and survival. * It also regulates the PI3K/Akt signaling pathway, which is involved in cell growth, metabolism, and survival. * ACP1 is also involved in the regulation of inflammation. It is a key regulator of the production of inflammatory cytokines, such as TNF-alpha and IL-1 beta. * ACP1 is a potential therapeutic target for a variety of diseases, including cancer, inflammation, and neurodegenerative diseases. **Clinical significance:** * Mutations in the ACP1 gene have been linked to a number of human diseases, including cancer, inflammation, and neurodegenerative diseases. * The development of specific ACP1 inhibitors is in clinical development as potential treatments for these diseases. * ACP1 is a promising target for cancer immunotherapy, as it is expressed on the surface of many cancer cells. * Inhibition of ACP1 has been shown to inhibit cancer growth and metastasis in vitro and in vivo.

Genular Protein ID: 247282862

Symbol: PPAC_HUMAN

Name: Adipocyte acid phosphatase

UniProtKB Accession Codes:

P24666 A8K1L9 B5MCC7 P24667 Q16035 Q16036 Q16725 Q3KQX8 Q53RU0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 16 ChEMBL 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 4 EMBL 18 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 18 PDBsum 17 PIR 2 PRINTS 2 PRO 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 RefSeq 2 Rhea 12 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1939112

Title: Human red cell acid phosphatase (ACP1). The amino acid sequence of the two isozymes Bf and Bs encoded by the ACP1*B allele.

PubMed ID: 1939112

DOI: 10.1016/s0021-9258(18)54754-2

PubMed ID: 1627603

Title: Human red cell acid phosphatase (ACP1): the primary structure of the two pairs of isozymes encoded by the ACP1*A and ACP1*C alleles.

PubMed ID: 1627603

DOI: 10.1016/0167-4838(92)90155-7

PubMed ID: 1587862

Title: Sequencing, cloning, and expression of human red cell-type acid phosphatase, a cytoplasmic phosphotyrosyl protein phosphatase.

PubMed ID: 1587862

DOI: 10.1016/s0021-9258(19)50097-7

PubMed ID: 8586411

Title: Gene structure, sequence, and chromosomal localization of the human red cell-type low-molecular-weight acid phosphotyrosyl phosphatase gene, ACP1.

PubMed ID: 8586411

DOI: 10.1006/geno.1995.9893

PubMed ID: 1304913

Title: Identification of the adipocyte acid phosphatase as a PAO-sensitive tyrosyl phosphatase.

PubMed ID: 1304913

DOI: 10.1002/pro.5560010603

PubMed ID: 9038134

Title: Regulation of the low molecular weight phosphotyrosine phosphatase by phosphorylation at tyrosines 131 and 132.

PubMed ID: 9038134

DOI: 10.1074/jbc.272.9.5371

PubMed ID: 10336608

Title: A novel isoform of the low molecular weight phosphotyrosine phosphatase, LMPTP-C, arising from alternative mRNA splicing.

PubMed ID: 10336608

DOI: 10.1046/j.1432-1327.1999.00353.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16344560

Title: Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.

PubMed ID: 16344560

DOI: 10.1101/gr.4039406

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8364553

Title: A TaqI site identifies the *A allele at the ACP1 locus.

PubMed ID: 8364553

DOI: 10.1093/hmg/2.7.1079-a

PubMed ID: 9499402

Title: Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses.

PubMed ID: 9499402

DOI: 10.1101/gad.12.5.667

PubMed ID: 12167657

Title: Regulation of the EphA2 kinase by the low molecular weight tyrosine phosphatase induces transformation.

PubMed ID: 12167657

DOI: 10.1074/jbc.m207127200

PubMed ID: 11971983

Title: Tyrosine phosphorylation regulates alpha II spectrin cleavage by calpain.

PubMed ID: 11971983

DOI: 10.1128/mcb.22.10.3527-3536.2002

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 9705307

Title: Crystal structure of a human low molecular weight phosphotyrosyl phosphatase. Implications for substrate specificity.

PubMed ID: 9705307

DOI: 10.1074/jbc.273.34.21714

Sequence Information:

  • Length: 158
  • Mass: 18042
  • Checksum: 46617BD799313EED
  • Sequence:
    • MAEQATKSVL FVCLGNICRS PIAEAVFRKL VTDQNISENW RVDSAATSGY EIGNPPDYRG 
QSCMKRHGIP MSHVARQITK EDFATFDYIL CMDESNLRDL NRKSNQVKTC KAKIELLGSY 
DPQKQLIIED PYYGNDSDFE TVYQQCVRCC RAFLEKAH

Genular Protein ID: 381261049

Symbol: A0A140VK37_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A140VK37

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 3 Gene3D 1 GenomeRNAi 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 1 Pfam 1 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 1 VEuPathDB 1 iPTMnet 1

Sequence Information:

  • Length: 112
  • Mass: 12230
  • Checksum: 805DBFA90F43D732
  • Sequence:
    • MAEQATKSVL FVCLGNICRS PIAEAVFRKL VTDQNISENW RVDSAATSGY EIGNPPDYRG 
QSCMKRHGIP MSHVARQVPS LDLKLCVLCF SGSLTAVLFL TGTWAGPQTQ EL

Genular Protein ID: 4132645691

Symbol: Q59EH3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59EH3

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 8 DNASU 1 EC 2 EMBL 2 GO 3 Gene3D 1 Genevisible 1 GenomeRNAi 1 IntAct 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 Rhea 6 RuleBase 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 165
  • Mass: 18698
  • Checksum: E896DF024F52C29A
  • Sequence:
    • GASARGKMAE QATKSVLFVC LGNICRSPIA EAVFRKLVTD QNISENWRVD SAATSGYEIG 
NPPDYRGQSC MKRHGIPMSH VARQITKEDF ATFDYILCMD ESNLRDLNRK SNRVKTCKAK 
IELLGSYDPQ KQLIIEDPYY GNDSDFETVY QQCVRCCRAF LEKAH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.