Details for: ACP1

Gene ID: 52

Symbol: ACP1

Ensembl ID: ENSG00000143727

Description: acid phosphatase 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.51
    Marker Score: 86,888
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 2.44
    Marker Score: 32,224
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.28
    Marker Score: 4,755
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 2.26
    Marker Score: 2,359
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.13
    Marker Score: 3,421
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.12
    Marker Score: 3,008
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.07
    Marker Score: 2,085
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.06
    Marker Score: 2,199
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.06
    Marker Score: 3,494
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 2.03
    Marker Score: 2,149
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 2.03
    Marker Score: 2,434
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.01
    Marker Score: 20,341
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.01
    Marker Score: 7,886
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.99
    Marker Score: 8,149
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.98
    Marker Score: 1,319
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 1.97
    Marker Score: 1,857
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.97
    Marker Score: 5,371
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.95
    Marker Score: 4,591
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.95
    Marker Score: 3,448
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 1.94
    Marker Score: 714
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.93
    Marker Score: 2,075
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.92
    Marker Score: 22,359
  • Cell Name: stem cell (CL0000034)
    Fold Change: 1.91
    Marker Score: 4,535
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.91
    Marker Score: 2,025
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 1.89
    Marker Score: 5,138
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.89
    Marker Score: 12,265
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 1.86
    Marker Score: 14,539
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.85
    Marker Score: 2,851
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.85
    Marker Score: 2,941
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1.84
    Marker Score: 1,156
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.84
    Marker Score: 15,835
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.83
    Marker Score: 1,333
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.82
    Marker Score: 2,047
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.82
    Marker Score: 2,610
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.81
    Marker Score: 6,685
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.8
    Marker Score: 2,397
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.8
    Marker Score: 4,101
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.8
    Marker Score: 2,120
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.79
    Marker Score: 8,595
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.79
    Marker Score: 5,311
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.78
    Marker Score: 11,622
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.78
    Marker Score: 1,587
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.76
    Marker Score: 1,108
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.75
    Marker Score: 966
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.75
    Marker Score: 2,581
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.74
    Marker Score: 3,541
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.73
    Marker Score: 4,229
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.71
    Marker Score: 10,941
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.71
    Marker Score: 2,982
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.71
    Marker Score: 574
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.69
    Marker Score: 6,523
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.68
    Marker Score: 2,790
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 1.67
    Marker Score: 3,790
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.66
    Marker Score: 1,727
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.65
    Marker Score: 371
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.65
    Marker Score: 781
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.64
    Marker Score: 392
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 1.64
    Marker Score: 22,030
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.62
    Marker Score: 4,483
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.62
    Marker Score: 1,559
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.61
    Marker Score: 85,196
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 1.61
    Marker Score: 864
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.61
    Marker Score: 16,157
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 1.6
    Marker Score: 1,261
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.59
    Marker Score: 2,849
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.59
    Marker Score: 1,566
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 1.59
    Marker Score: 15,702
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.58
    Marker Score: 6,835
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.58
    Marker Score: 682
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 1.58
    Marker Score: 710
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.58
    Marker Score: 1,487
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.57
    Marker Score: 1,973
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 1.57
    Marker Score: 1,518
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.56
    Marker Score: 1,889
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 1.56
    Marker Score: 555
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.56
    Marker Score: 501
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.56
    Marker Score: 857
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.55
    Marker Score: 651
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 1.55
    Marker Score: 800
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 1.55
    Marker Score: 2,835
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.55
    Marker Score: 364
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.55
    Marker Score: 5,488
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 1.54
    Marker Score: 3,024
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.54
    Marker Score: 580
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.53
    Marker Score: 1,445
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 1.53
    Marker Score: 4,840
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.53
    Marker Score: 4,815
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.53
    Marker Score: 723
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.53
    Marker Score: 536
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.53
    Marker Score: 754
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 1.52
    Marker Score: 747
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.52
    Marker Score: 811
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.52
    Marker Score: 1,103
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.52
    Marker Score: 4,078
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.51
    Marker Score: 1,265
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.51
    Marker Score: 435
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 1.5
    Marker Score: 481
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.5
    Marker Score: 329
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.49
    Marker Score: 1,014
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.49
    Marker Score: 1,511

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** The ACP1 gene is a single nucleotide gene that encodes for a protein with a molecular weight of approximately 30 kDa. It is primarily expressed in various cell types, including epithelial cells, mesenchymal cells, and hematopoietic cells. The ACP1 protein exhibits acid phosphatase activity, which is essential for the regulation of cellular processes, such as cell signaling, proliferation, and differentiation. **Pathways and Functions:** The ACP1 protein is involved in several cellular pathways, including: 1. **Acid Phosphatase Activity:** ACP1 mediates the dephosphorylation of tyrosine residues on proteins, which plays a crucial role in regulating cellular signaling pathways. 2. **Protein Binding:** ACP1 interacts with various proteins, including those involved in cell adhesion, migration, and proliferation. 3. **Non-membrane Spanning Protein Tyrosine Phosphatase Activity:** ACP1 exhibits phosphatase activity on tyrosine residues, regulating protein-protein interactions and signaling pathways. The ACP1 protein also plays a role in various cellular processes, including: 1. **Cell Signaling:** ACP1 regulates cell signaling pathways, including those involved in proliferation, differentiation, and survival. 2. **Cell Adhesion:** ACP1 interacts with cell adhesion molecules, regulating cell migration and invasion. 3. **Immune Response:** ACP1 is expressed on the surface of immune cells, including T cells and dendritic cells, and plays a role in regulating immune responses. **Clinical Significance:** The ACP1 gene has been implicated in various diseases, including: 1. **Cancer:** ACP1 expression is often upregulated in cancer cells, where it contributes to tumor progression and metastasis. 2. **Autoimmune Diseases:** ACP1 has been linked to autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where it regulates immune responses and tissue damage. 3. **Neurological Disorders:** ACP1 expression is altered in neurological disorders, including Alzheimer's disease and Parkinson's disease, where it contributes to neuronal dysfunction and degeneration. In conclusion, the ACP1 gene is a complex gene with multiple functions and implications in various diseases. Further research is needed to fully understand the mechanisms of ACP1 and its potential applications in immunology and disease diagnosis.

Genular Protein ID: 247282862

Symbol: PPAC_HUMAN

Name: Adipocyte acid phosphatase

UniProtKB Accession Codes:

P24666 A8K1L9 B5MCC7 P24667 Q16035 Q16036 Q16725 Q3KQX8 Q53RU0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CTD 1 ChEBI 16 ChEMBL 1 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EC 4 EMBL 18 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 18 PDBsum 17 PIR 2 PRINTS 2 PRO 1 PathwayCommons 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 RefSeq 2 Rhea 12 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1939112

Title: Human red cell acid phosphatase (ACP1). The amino acid sequence of the two isozymes Bf and Bs encoded by the ACP1*B allele.

PubMed ID: 1939112

DOI: 10.1016/s0021-9258(18)54754-2

PubMed ID: 1627603

Title: Human red cell acid phosphatase (ACP1): the primary structure of the two pairs of isozymes encoded by the ACP1*A and ACP1*C alleles.

PubMed ID: 1627603

DOI: 10.1016/0167-4838(92)90155-7

PubMed ID: 1587862

Title: Sequencing, cloning, and expression of human red cell-type acid phosphatase, a cytoplasmic phosphotyrosyl protein phosphatase.

PubMed ID: 1587862

DOI: 10.1016/s0021-9258(19)50097-7

PubMed ID: 8586411

Title: Gene structure, sequence, and chromosomal localization of the human red cell-type low-molecular-weight acid phosphotyrosyl phosphatase gene, ACP1.

PubMed ID: 8586411

DOI: 10.1006/geno.1995.9893

PubMed ID: 1304913

Title: Identification of the adipocyte acid phosphatase as a PAO-sensitive tyrosyl phosphatase.

PubMed ID: 1304913

DOI: 10.1002/pro.5560010603

PubMed ID: 9038134

Title: Regulation of the low molecular weight phosphotyrosine phosphatase by phosphorylation at tyrosines 131 and 132.

PubMed ID: 9038134

DOI: 10.1074/jbc.272.9.5371

PubMed ID: 10336608

Title: A novel isoform of the low molecular weight phosphotyrosine phosphatase, LMPTP-C, arising from alternative mRNA splicing.

PubMed ID: 10336608

DOI: 10.1046/j.1432-1327.1999.00353.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16344560

Title: Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.

PubMed ID: 16344560

DOI: 10.1101/gr.4039406

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8364553

Title: A TaqI site identifies the *A allele at the ACP1 locus.

PubMed ID: 8364553

DOI: 10.1093/hmg/2.7.1079-a

PubMed ID: 9499402

Title: Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses.

PubMed ID: 9499402

DOI: 10.1101/gad.12.5.667

PubMed ID: 12167657

Title: Regulation of the EphA2 kinase by the low molecular weight tyrosine phosphatase induces transformation.

PubMed ID: 12167657

DOI: 10.1074/jbc.m207127200

PubMed ID: 11971983

Title: Tyrosine phosphorylation regulates alpha II spectrin cleavage by calpain.

PubMed ID: 11971983

DOI: 10.1128/mcb.22.10.3527-3536.2002

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 9705307

Title: Crystal structure of a human low molecular weight phosphotyrosyl phosphatase. Implications for substrate specificity.

PubMed ID: 9705307

DOI: 10.1074/jbc.273.34.21714

Sequence Information:

  • Length: 158
  • Mass: 18042
  • Checksum: 46617BD799313EED
  • Sequence:
    • MAEQATKSVL FVCLGNICRS PIAEAVFRKL VTDQNISENW RVDSAATSGY EIGNPPDYRG 
QSCMKRHGIP MSHVARQITK EDFATFDYIL CMDESNLRDL NRKSNQVKTC KAKIELLGSY 
DPQKQLIIED PYYGNDSDFE TVYQQCVRCC RAFLEKAH

Genular Protein ID: 381261049

Symbol: A0A140VK37_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A140VK37

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 EMBL 2 ExpressionAtlas 1 GO 3 Gene3D 1 GenomeRNAi 1 InterPro 3 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 1 Pfam 1 RefSeq 1 SAM 1 SMART 2 SMR 1 SUPFAM 1 VEuPathDB 1 iPTMnet 1

Sequence Information:

  • Length: 112
  • Mass: 12230
  • Checksum: 805DBFA90F43D732
  • Sequence:
    • MAEQATKSVL FVCLGNICRS PIAEAVFRKL VTDQNISENW RVDSAATSGY EIGNPPDYRG 
QSCMKRHGIP MSHVARQVPS LDLKLCVLCF SGSLTAVLFL TGTWAGPQTQ EL

Genular Protein ID: 4132645691

Symbol: Q59EH3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59EH3

Database IDs:

ARBA 10 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 8 DNASU 1 EC 2 EMBL 2 GO 3 Gene3D 1 Genevisible 1 GenomeRNAi 1 IntAct 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 Rhea 6 RuleBase 1 SMART 2 SUPFAM 1

Sequence Information:

  • Length: 165
  • Mass: 18698
  • Checksum: E896DF024F52C29A
  • Sequence:
    • GASARGKMAE QATKSVLFVC LGNICRSPIA EAVFRKLVTD QNISENWRVD SAATSGYEIG 
NPPDYRGQSC MKRHGIPMSH VARQITKEDF ATFDYILCMD ESNLRDLNRK SNRVKTCKAK 
IELLGSYDPQ KQLIIEDPYY GNDSDFETVY QQCVRCCRAF LEKAH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.