Details for: Mfhas1

Gene ID: 52065

Symbol: Mfhas1

Ensembl ID: ENSMUSG00000070056

Description: malignant fibrous histiocytoma amplified sequence 1

Associated with

  • Cytoplasm
    (GO:0005737)
  • Defense response
    (GO:0006952)
  • Erythrocyte differentiation
    (GO:0030218)
  • Gtp binding
    (GO:0005525)
  • Inflammatory response
    (GO:0006954)
  • Innate immune response
    (GO:0045087)
  • Intracellular signal transduction
    (GO:0035556)
  • Negative regulation of inflammatory response
    (GO:0050728)
  • Negative regulation of protein localization to nucleus
    (GO:1900181)
  • Negative regulation of toll-like receptor 2 signaling pathway
    (GO:0034136)
  • Negative regulation of toll-like receptor 4 signaling pathway
    (GO:0034144)
  • Positive regulation of erk1 and erk2 cascade
    (GO:0070374)
  • Positive regulation of jnk cascade
    (GO:0046330)
  • Positive regulation of p38mapk cascade
    (GO:1900745)
  • Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
    (GO:0051897)
  • Positive regulation of toll-like receptor 2 signaling pathway
    (GO:0034137)
  • Protein phosphatase 2a binding
    (GO:0051721)
  • Regulation of macrophage activation
    (GO:0043030)
  • Regulation of toll-like receptor signaling pathway
    (GO:0034121)
  • Ubiquitin protein ligase binding
    (GO:0031625)

Other Information

Genular Protein ID: 2254242934

Symbol: MFHA1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q3V1N1 Q3TAN2 Q8C4N5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChiTaRS 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 21 Gene3D 3 GeneTree 1 HOGENOM 1 InParanoid 1 InterPro 6 KEGG 1 MGI 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PRO 1 PROSITE 2 PaxDb 1 Pfam 3 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 20616063

Title: Human leucine-rich repeat proteins: a genome-wide bioinformatic categorization and functional analysis in innate immunity.

PubMed ID: 20616063

DOI: 10.1073/pnas.1000093107

PubMed ID: 26599367

Title: MFHAS1 is associated with sepsis and stimulates TLR2/NF-kappaB signaling pathway following negative regulation.

PubMed ID: 26599367

DOI: 10.1371/journal.pone.0143662

PubMed ID: 28609714

Title: MFHAS1 suppresses TLR4 signaling pathway via induction of PP2A C subunit cytoplasm translocation and inhibition of c-Jun dephosphorylation at Thr239.

PubMed ID: 28609714

DOI: 10.1016/j.molimm.2017.06.017

Sequence Information:

  • Length: 1048
  • Mass: 116599
  • Checksum: 9FE71A05E80544C0
  • Sequence:
    • MAGQDSGNLK TVRLWRDAAL RARKLRSNLR QLTLSCPGAG GDPLESPDAP QLVLPANIGD 
IEVLNLGNNG LEDVPEGLGS ALGSLRVLVL RRNRFARLPP AVAELGHHLT ELDVSHNRLT 
ILGAEVVSAL RELRKLNLSH NQLPALPAQL GALAHLEELD VSFNRLAHLP DSFSCLNHLR 
TLDVDHNQLT AFPQQLLQLA ALEELDVSSN RLRGLPEDIS ALRALKILWL SGAELGTLPR 
GFCELASLES LMLDNNGLQA LPDEFSRLQR LKMLNLSSNL FEEFPAALLP LAGLEELYLS 
RNQLTSVPSL IAGLGRLLTL WLDNNRIRYL PDSIVELTGL EELVLQGNQI AVLPDNFGQL 
SRVGLWKIKD NPLIQPPYEV CMKGIPYIAA YQKELAHSQP AVQPRLKLLL MGHKAAGKTL 
LRHCLTEDKV EGGQGGGDKE KSYLPFPPLG SKGIEVTSWT ADASRGLRFI VYDLAGDESY 
EVIQPFFLSP GALYVLVVNL ATYEPRCFPT TVGSFLHRVG ARVPHAVVCI VGTHADLCGE 
RELEEKCLDI HRQIALQEKN DAEGLSHLAK VVDEALARDF ELRSASPHAA YYGVSDKNLR 
RRKAHFQYLL NHRLQILSPV LPVSCRDPLQ LQRLRDKLLS VAEHREIFPN LHRVLPRSWQ 
VLEELHFQPP QAQRLWLSWW DSARLGLQAG LTEDRLQSAL SYLHESGKLL YFEDSPALKE 
HVFHNLTRLI DILNVFFQRD ASLLLHKLLL GTNGEGEGEG ESFPTIAVPS PGQDPLRATQ 
LHHYVEGFLL HGLLPAHIIR LLLKPHVQAQ QDLQLLLELL EKMGLCYCLN KPKGKPLNGS 
AAWYKFPCYV QNEVPHAEAW INGTNLAGQS FVAEQLQIEY SFPFTFPPGL FARYSVQINS 
HVVHRSDGKF QIFAYRGKVP VVVSYRPAKG VLQPDTLSIA SHASLPNIWT AWQAITPLVE 
ELNVLLQEWP GLHYTVHILC SKCLKRGSPN PHAFPGELLS QPRPEGVAEI ICPKNGSERV 
NVALVYPPTP TVISPCSKKN VGEKHRNQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.