Details for: ATP5ME

Gene ID: 521

Symbol: ATP5ME

Ensembl ID: ENSG00000169020

Description: ATP synthase membrane subunit e

Associated with

  • Cristae formation
    (R-HSA-8949613)
  • Formation of atp by chemiosmotic coupling
    (R-HSA-163210)
  • Metabolism
    (R-HSA-1430728)
  • Mitochondrial biogenesis
    (R-HSA-1592230)
  • Organelle biogenesis and maintenance
    (R-HSA-1852241)
  • Respiratory electron transport, atp synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    (R-HSA-163200)
  • The citric acid (tca) cycle and respiratory electron transport
    (R-HSA-1428517)
  • Mitochondrial inner membrane
    (GO:0005743)
  • Mitochondrial proton-transporting atp synthase complex
    (GO:0005753)
  • Mitochondrial proton-transporting atp synthase complex, coupling factor f(o)
    (GO:0000276)
  • Mitochondrion
    (GO:0005739)
  • Protein binding
    (GO:0005515)
  • Proton-transporting atp synthase activity, rotational mechanism
    (GO:0046933)
  • Proton motive force-driven atp synthesis
    (GO:0015986)
  • Proton motive force-driven mitochondrial atp synthesis
    (GO:0042776)
  • Proton transmembrane transport
    (GO:1902600)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 6.19
    Marker Score: 4,141
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 5.37
    Marker Score: 11,329
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 4.44
    Marker Score: 4,807
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 4.08
    Marker Score: 1,195
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 3.91
    Marker Score: 2,184
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 3.84
    Marker Score: 2,895
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.8
    Marker Score: 10,184
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 3.8
    Marker Score: 1,575
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3.79
    Marker Score: 24,199
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 3.79
    Marker Score: 15,743
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.77
    Marker Score: 5,805
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 3.72
    Marker Score: 1,921
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 3.63
    Marker Score: 4,726
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 3.63
    Marker Score: 3,078
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.54
    Marker Score: 12,562
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 3.53
    Marker Score: 1,302
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.53
    Marker Score: 3,146
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.44
    Marker Score: 3,589
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 3.4
    Marker Score: 16,341
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 3.33
    Marker Score: 20,261
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.3
    Marker Score: 5,466
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 3.28
    Marker Score: 2,331
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.27
    Marker Score: 10,264
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.25
    Marker Score: 6,100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.25
    Marker Score: 9,260
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.22
    Marker Score: 1,061
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.19
    Marker Score: 7,276
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.19
    Marker Score: 8,819
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 3.18
    Marker Score: 1,098
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.18
    Marker Score: 7,218
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 3.12
    Marker Score: 2,990
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.1
    Marker Score: 107,406
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.06
    Marker Score: 26,561
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 3.04
    Marker Score: 3,045
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.04
    Marker Score: 30,144
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3.04
    Marker Score: 3,674
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.03
    Marker Score: 2,705
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.02
    Marker Score: 168,906
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.02
    Marker Score: 23,561
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.01
    Marker Score: 2,356
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.01
    Marker Score: 34,939
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3
    Marker Score: 19,527
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3
    Marker Score: 39,514
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 2.99
    Marker Score: 1,597
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.99
    Marker Score: 7,544
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.99
    Marker Score: 4,140
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.96
    Marker Score: 3,005
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.92
    Marker Score: 4,698
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.92
    Marker Score: 15,340
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.91
    Marker Score: 1,773
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.91
    Marker Score: 1,936
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 2.9
    Marker Score: 929
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.9
    Marker Score: 21,590
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.88
    Marker Score: 4,078
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.87
    Marker Score: 3,467
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.85
    Marker Score: 4,530
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.84
    Marker Score: 38,206
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 2.84
    Marker Score: 1,725
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.83
    Marker Score: 3,002
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.82
    Marker Score: 2,401
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.81
    Marker Score: 2,999
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.79
    Marker Score: 1,115
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.79
    Marker Score: 1,255
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.79
    Marker Score: 666
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.77
    Marker Score: 94,127
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.76
    Marker Score: 3,062
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.75
    Marker Score: 6,710
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.75
    Marker Score: 2,590
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.74
    Marker Score: 5,480
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 2.74
    Marker Score: 1,459
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2.73
    Marker Score: 2,834
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 2.72
    Marker Score: 1,499
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 2.71
    Marker Score: 1,402
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.68
    Marker Score: 848
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.67
    Marker Score: 23,011
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.67
    Marker Score: 3,054
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.67
    Marker Score: 4,112
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 2.65
    Marker Score: 1,111
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.65
    Marker Score: 5,541
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.65
    Marker Score: 1,322
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.62
    Marker Score: 1,852
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.61
    Marker Score: 29,390
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.6
    Marker Score: 2,923
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.6
    Marker Score: 16,914
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.6
    Marker Score: 1,708
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.58
    Marker Score: 9,942
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.57
    Marker Score: 5,230
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.57
    Marker Score: 3,641
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.56
    Marker Score: 11,022
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.55
    Marker Score: 1,311
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.54
    Marker Score: 65,167
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.54
    Marker Score: 1,205
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 2.54
    Marker Score: 927
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.51
    Marker Score: 748
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 2.5
    Marker Score: 1,141
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 2.48
    Marker Score: 678
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.47
    Marker Score: 4,305
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.47
    Marker Score: 4,196
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 2.47
    Marker Score: 928
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 2.47
    Marker Score: 653

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit of ATP synthase**: ATP5ME is a membrane subunit of the ATP synthase complex, which is a crucial enzyme in the mitochondrial inner membrane. 2. **N-terminally processed**: The protein is processed at the N-terminus, indicating that it undergoes post-translational modifications to acquire its functional form. 3. **Conserved across species**: The ATP5ME gene is conserved across various species, suggesting its essential role in mitochondrial function and energy production. 4. **Highly expressed in energy-demanding tissues**: ATP5ME is significantly expressed in cells that require high energy production, such as skeletal muscle, cardiac muscle, and pancreatic acinar cells. **Pathways and Functions:** 1. **Chemiosmotic coupling**: ATP5ME participates in the chemiosmotic coupling process, where the proton gradient across the mitochondrial inner membrane drives the synthesis of ATP. 2. **Mitochondrial biogenesis and maintenance**: ATP5ME is involved in the regulation of mitochondrial biogenesis and maintenance, ensuring the proper functioning and structure of mitochondria. 3. **Proton transport**: ATP5ME plays a critical role in proton transport across the mitochondrial inner membrane, contributing to the generation of the proton gradient. 4. **Regulation of energy metabolism**: ATP5ME is involved in the regulation of energy metabolism, ensuring that energy production is balanced with energy demand. **Clinical Significance:** 1. **Mitochondrial disorders**: Mutations in the ATP5ME gene have been linked to mitochondrial disorders, such as mitochondrial myopathies and neuropathies. 2. **Energy metabolism dysregulation**: Alterations in ATP5ME expression or function can lead to energy metabolism dysregulation, contributing to various diseases, including cancer and metabolic disorders. 3. **Cardiovascular diseases**: ATP5ME has been implicated in the pathogenesis of cardiovascular diseases, including hypertension and cardiac arrhythmias. 4. **Cancer therapy**: Targeting ATP5ME has been explored as a potential therapeutic strategy for cancer treatment, as it is involved in energy metabolism and tumor growth. In conclusion, ATP5ME is a critical component of the mitochondrial ATP synthase complex, playing a pivotal role in energy production and regulation. Its dysregulation has been linked to various diseases, highlighting the importance of understanding its functions and clinical significance. Further research is necessary to elucidate the mechanisms underlying ATP5ME's role in energy metabolism and disease pathogenesis.

Genular Protein ID: 1791130665

Symbol: ATP5I_HUMAN

Name: ATP synthase subunit e, mitochondrial, N-terminally processed

UniProtKB Accession Codes:

P56385 Q0D2L9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 4 EMDB 8 EPD 1 Ensembl 1 GO 7 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 8 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19892738

Title: Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini.

PubMed ID: 19892738

DOI: 10.1073/pnas.0908958106

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 69
  • Mass: 7933
  • Checksum: E4FF2B855F4535DC
  • Sequence:
    • MVPPVQVSPL IKLGRYSALF LGVAYGATRY NYLKPRAEEE RRIAAEEKKK QDELKRIARE 
LAEDDSILK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.