Details for: ATP5ME

Gene ID: 521

Symbol: ATP5ME

Ensembl ID: ENSG00000169020

Description: ATP synthase membrane subunit e

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 333.9260
    Cell Significance Index: -137.5600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 290.4965
    Cell Significance Index: -137.1500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 284.9919
    Cell Significance Index: -115.7800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 259.6692
    Cell Significance Index: -133.5700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 205.3136
    Cell Significance Index: -137.7700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 122.5670
    Cell Significance Index: -117.0200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 41.8107
    Cell Significance Index: -112.0100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 31.0407
    Cell Significance Index: -95.3400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 15.9326
    Cell Significance Index: -34.8700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 4.8487
    Cell Significance Index: 874.0600
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 4.8368
    Cell Significance Index: 51.3900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 4.7064
    Cell Significance Index: 578.6900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 4.4143
    Cell Significance Index: 40.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.9650
    Cell Significance Index: 184.8700
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.6127
    Cell Significance Index: 28.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.5749
    Cell Significance Index: 490.9300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.5398
    Cell Significance Index: 93.0800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.3217
    Cell Significance Index: 1814.0500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.0129
    Cell Significance Index: 158.1900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.9373
    Cell Significance Index: 207.7400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.9110
    Cell Significance Index: 1287.0200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.6262
    Cell Significance Index: 336.6600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 2.5890
    Cell Significance Index: 256.1100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.5292
    Cell Significance Index: 52.9400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.4936
    Cell Significance Index: 172.4500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.3483
    Cell Significance Index: 276.9400
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.3362
    Cell Significance Index: 63.5900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.1941
    Cell Significance Index: 26.1600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.0146
    Cell Significance Index: 150.1500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.8248
    Cell Significance Index: 95.0500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.8209
    Cell Significance Index: 85.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.7064
    Cell Significance Index: 220.4600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.2359
    Cell Significance Index: 14.0400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1165
    Cell Significance Index: 58.0000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.0526
    Cell Significance Index: 66.3400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.9357
    Cell Significance Index: 185.7000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6809
    Cell Significance Index: 110.7400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.6016
    Cell Significance Index: 6.5400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.5855
    Cell Significance Index: 37.7800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.5553
    Cell Significance Index: 420.2900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5495
    Cell Significance Index: 104.5700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.5118
    Cell Significance Index: 9.4600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.4372
    Cell Significance Index: 6.6400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.4216
    Cell Significance Index: 309.1500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4067
    Cell Significance Index: 81.5800
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2309
    Cell Significance Index: 3.4600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.1813
    Cell Significance Index: 14.3600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1538
    Cell Significance Index: 5.4100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0860
    Cell Significance Index: 30.8600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0707
    Cell Significance Index: 63.8600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0188
    Cell Significance Index: 0.3200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0197
    Cell Significance Index: -0.5600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0259
    Cell Significance Index: -48.7000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0543
    Cell Significance Index: -1.4500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0701
    Cell Significance Index: -1.9600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0766
    Cell Significance Index: -141.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0854
    Cell Significance Index: -14.5900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0908
    Cell Significance Index: -139.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1117
    Cell Significance Index: -151.9200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1161
    Cell Significance Index: -11.8600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1239
    Cell Significance Index: -91.7700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1339
    Cell Significance Index: -6.7700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1396
    Cell Significance Index: -88.6600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1940
    Cell Significance Index: -88.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.2044
    Cell Significance Index: -115.2700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2334
    Cell Significance Index: -9.5600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2496
    Cell Significance Index: -155.8700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.4025
    Cell Significance Index: -115.8000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5089
    Cell Significance Index: -58.3000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.5962
    Cell Significance Index: -19.1000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6170
    Cell Significance Index: -18.1200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6301
    Cell Significance Index: -38.7300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.7121
    Cell Significance Index: -150.0000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.7199
    Cell Significance Index: -83.9000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.7228
    Cell Significance Index: -105.0700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.8272
    Cell Significance Index: -17.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.0839
    Cell Significance Index: -83.1800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.1892
    Cell Significance Index: -30.3800
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.2168
    Cell Significance Index: -55.1600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -1.2234
    Cell Significance Index: -9.4300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.2627
    Cell Significance Index: -131.4800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.3197
    Cell Significance Index: -45.8600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.4741
    Cell Significance Index: -26.0500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.7273
    Cell Significance Index: -103.7000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.7862
    Cell Significance Index: -109.5100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.8747
    Cell Significance Index: -105.2000
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.8869
    Cell Significance Index: -31.7900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.9005
    Cell Significance Index: -25.9300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -1.9505
    Cell Significance Index: -24.9800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -2.0426
    Cell Significance Index: -51.0600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -2.0691
    Cell Significance Index: -17.3800
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -2.2003
    Cell Significance Index: -37.9300
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -2.4236
    Cell Significance Index: -33.9700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -2.4311
    Cell Significance Index: -70.0500
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.7154
    Cell Significance Index: -79.9800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.8529
    Cell Significance Index: -126.1900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.9715
    Cell Significance Index: -109.0800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -3.0876
    Cell Significance Index: -31.9600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -3.0953
    Cell Significance Index: -53.0500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -3.1076
    Cell Significance Index: -79.8800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Subunit of ATP synthase**: ATP5ME is a membrane subunit of the ATP synthase complex, which is a crucial enzyme in the mitochondrial inner membrane. 2. **N-terminally processed**: The protein is processed at the N-terminus, indicating that it undergoes post-translational modifications to acquire its functional form. 3. **Conserved across species**: The ATP5ME gene is conserved across various species, suggesting its essential role in mitochondrial function and energy production. 4. **Highly expressed in energy-demanding tissues**: ATP5ME is significantly expressed in cells that require high energy production, such as skeletal muscle, cardiac muscle, and pancreatic acinar cells. **Pathways and Functions:** 1. **Chemiosmotic coupling**: ATP5ME participates in the chemiosmotic coupling process, where the proton gradient across the mitochondrial inner membrane drives the synthesis of ATP. 2. **Mitochondrial biogenesis and maintenance**: ATP5ME is involved in the regulation of mitochondrial biogenesis and maintenance, ensuring the proper functioning and structure of mitochondria. 3. **Proton transport**: ATP5ME plays a critical role in proton transport across the mitochondrial inner membrane, contributing to the generation of the proton gradient. 4. **Regulation of energy metabolism**: ATP5ME is involved in the regulation of energy metabolism, ensuring that energy production is balanced with energy demand. **Clinical Significance:** 1. **Mitochondrial disorders**: Mutations in the ATP5ME gene have been linked to mitochondrial disorders, such as mitochondrial myopathies and neuropathies. 2. **Energy metabolism dysregulation**: Alterations in ATP5ME expression or function can lead to energy metabolism dysregulation, contributing to various diseases, including cancer and metabolic disorders. 3. **Cardiovascular diseases**: ATP5ME has been implicated in the pathogenesis of cardiovascular diseases, including hypertension and cardiac arrhythmias. 4. **Cancer therapy**: Targeting ATP5ME has been explored as a potential therapeutic strategy for cancer treatment, as it is involved in energy metabolism and tumor growth. In conclusion, ATP5ME is a critical component of the mitochondrial ATP synthase complex, playing a pivotal role in energy production and regulation. Its dysregulation has been linked to various diseases, highlighting the importance of understanding its functions and clinical significance. Further research is necessary to elucidate the mechanisms underlying ATP5ME's role in energy metabolism and disease pathogenesis.

Genular Protein ID: 1791130665

Symbol: ATP5I_HUMAN

Name: ATP synthase subunit e, mitochondrial, N-terminally processed

UniProtKB Accession Codes:

P56385 Q0D2L9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 4 EMDB 10 Ensembl 1 GO 8 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 10 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19892738

Title: Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini.

PubMed ID: 19892738

DOI: 10.1073/pnas.0908958106

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 69
  • Mass: 7933
  • Checksum: E4FF2B855F4535DC
  • Sequence:
    • MVPPVQVSPL IKLGRYSALF LGVAYGATRY NYLKPRAEEE RRIAAEEKKK QDELKRIARE 
LAEDDSILK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.