Details for: ATP5ME

Gene ID: 521

Symbol: ATP5ME

Ensembl ID: ENSG00000169020

Description: ATP synthase membrane subunit e

Associated with

  • Cristae formation
    (R-HSA-8949613)
  • Formation of atp by chemiosmotic coupling
    (R-HSA-163210)
  • Metabolism
    (R-HSA-1430728)
  • Mitochondrial biogenesis
    (R-HSA-1592230)
  • Organelle biogenesis and maintenance
    (R-HSA-1852241)
  • Respiratory electron transport, atp synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
    (R-HSA-163200)
  • The citric acid (tca) cycle and respiratory electron transport
    (R-HSA-1428517)
  • Mitochondrial inner membrane
    (GO:0005743)
  • Mitochondrial proton-transporting atp synthase complex
    (GO:0005753)
  • Mitochondrial proton-transporting atp synthase complex, coupling factor f(o)
    (GO:0000276)
  • Mitochondrion
    (GO:0005739)
  • Protein binding
    (GO:0005515)
  • Proton-transporting atp synthase activity, rotational mechanism
    (GO:0046933)
  • Proton motive force-driven atp synthesis
    (GO:0015986)
  • Proton motive force-driven mitochondrial atp synthesis
    (GO:0042776)
  • Proton transmembrane transport
    (GO:1902600)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 6.19
    Marker Score: 4141
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 5.37
    Marker Score: 11329
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 4.44
    Marker Score: 4806.5
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 4.08
    Marker Score: 1195
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 3.91
    Marker Score: 2184
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 3.84
    Marker Score: 2895
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.8
    Marker Score: 10184
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 3.8
    Marker Score: 1575
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 3.79
    Marker Score: 24199
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 3.79
    Marker Score: 15743
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.77
    Marker Score: 5804.5
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 3.72
    Marker Score: 1920.5
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 3.63
    Marker Score: 4726
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 3.63
    Marker Score: 3078
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.54
    Marker Score: 12562
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 3.53
    Marker Score: 1302
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.53
    Marker Score: 3146
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.44
    Marker Score: 3588.5
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 3.4
    Marker Score: 16341
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 3.33
    Marker Score: 20261
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.3
    Marker Score: 5466
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 3.28
    Marker Score: 2331
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.27
    Marker Score: 10264
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.25
    Marker Score: 6100
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.25
    Marker Score: 9260
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.22
    Marker Score: 1061
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.19
    Marker Score: 7276
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.19
    Marker Score: 8819
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 3.18
    Marker Score: 1098
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 3.18
    Marker Score: 7218
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 3.12
    Marker Score: 2990
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.1
    Marker Score: 107406
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 3.06
    Marker Score: 26561
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 3.04
    Marker Score: 3045
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.04
    Marker Score: 30144
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3.04
    Marker Score: 3674
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 3.03
    Marker Score: 2704.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.02
    Marker Score: 168906
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 3.02
    Marker Score: 23561
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.01
    Marker Score: 2356
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.01
    Marker Score: 34939
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 3
    Marker Score: 19527
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3
    Marker Score: 39514
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 2.99
    Marker Score: 1596.5
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.99
    Marker Score: 7544
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.99
    Marker Score: 4140
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.96
    Marker Score: 3005
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.92
    Marker Score: 4698
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.92
    Marker Score: 15340
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 2.91
    Marker Score: 1772.5
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.91
    Marker Score: 1936
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 2.9
    Marker Score: 929
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.9
    Marker Score: 21590
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.88
    Marker Score: 4078
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.87
    Marker Score: 3467
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.85
    Marker Score: 4530
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.84
    Marker Score: 38205.5
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 2.84
    Marker Score: 1725
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.83
    Marker Score: 3001.5
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.82
    Marker Score: 2401
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.81
    Marker Score: 2999
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.79
    Marker Score: 1115
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.79
    Marker Score: 1255
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.79
    Marker Score: 666
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.77
    Marker Score: 94127
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 2.76
    Marker Score: 3062
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.75
    Marker Score: 6710
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.75
    Marker Score: 2590
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.74
    Marker Score: 5480
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 2.74
    Marker Score: 1459
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2.73
    Marker Score: 2834
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 2.72
    Marker Score: 1498.5
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 2.71
    Marker Score: 1402
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 2.68
    Marker Score: 848
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.67
    Marker Score: 23011
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.67
    Marker Score: 3054
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.67
    Marker Score: 4112
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 2.65
    Marker Score: 1111
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.65
    Marker Score: 5541
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.65
    Marker Score: 1322
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 2.62
    Marker Score: 1852
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.61
    Marker Score: 29390
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.6
    Marker Score: 2922.5
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.6
    Marker Score: 16914
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.6
    Marker Score: 1708
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.58
    Marker Score: 9942
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.57
    Marker Score: 5229.5
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.57
    Marker Score: 3641
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.56
    Marker Score: 11022
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.55
    Marker Score: 1310.5
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.54
    Marker Score: 65167
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.54
    Marker Score: 1205
  • Cell Name: tracheobronchial serous cell (CL0019001)
    Fold Change: 2.54
    Marker Score: 927
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.51
    Marker Score: 748
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 2.5
    Marker Score: 1141
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 2.48
    Marker Score: 678
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.47
    Marker Score: 4305
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.47
    Marker Score: 4195.5
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 2.47
    Marker Score: 928
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 2.47
    Marker Score: 653

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Other Information

**Key characteristics:** - ATP5ME is a highly conserved protein that is found in all eukaryotic cells. - It is a transmembrane protein that spans the mitochondrial inner membrane. - It is responsible for the insertion and translocation of protons across the mitochondrial inner membrane, which is essential for the proton-transporting ATP synthase complex to function. **Pathways and functions:** - ATP5ME is involved in the citric acid (tca) cycle and respiratory electron transport. - It is responsible for the synthesis of ATP through chemiosmosis. - It is also involved in the regulation of mitochondrial biogenesis, as it is expressed in cells that are responsible for the differentiation of muscle and fat cells. **Clinical significance:** - Mutations in ATP5ME have been linked to several human diseases, including mitochondrial myopathy, lactic acidosis, and type 2 diabetes. - These diseases are characterized by a decrease in ATP5ME protein levels or activity. - Targeting ATP5ME has been investigated as a therapeutic strategy for these diseases. **Additional information:** - ATP5ME is a highly regulated protein that is controlled by a number of factors, including calcium, AMP-activated protein kinase (AMPK), and the mitochondrial matrix protein mitofusin. - It is a key regulator of mitochondrial energy production and respiration. - Mutations in ATP5ME have been shown to have a significant impact on mitochondrial function and cell survival.

Genular Protein ID: 1791130665

Symbol: ATP5I_HUMAN

Name: ATP synthase subunit e, mitochondrial, N-terminally processed

UniProtKB Accession Codes:

P56385 Q0D2L9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 4 EMDB 8 EPD 1 Ensembl 1 GO 7 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 8 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19892738

Title: Global profiling of protease cleavage sites by chemoselective labeling of protein N-termini.

PubMed ID: 19892738

DOI: 10.1073/pnas.0908958106

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

Sequence Information:

  • Length: 69
  • Mass: 7933
  • Checksum: E4FF2B855F4535DC
  • Sequence:
    • MVPPVQVSPL IKLGRYSALF LGVAYGATRY NYLKPRAEEE RRIAAEEKKK QDELKRIARE 
LAEDDSILK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.