Details for: ATP5PF

Gene ID: 522

Symbol: ATP5PF

Ensembl ID: ENSG00000154723

Description: ATP synthase peripheral stalk subunit F6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 315.0643
    Cell Significance Index: -129.7900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 272.5614
    Cell Significance Index: -110.7300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 266.9222
    Cell Significance Index: -126.0200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 238.5566
    Cell Significance Index: -122.7100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 188.3619
    Cell Significance Index: -126.4000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 117.1205
    Cell Significance Index: -111.8200
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 30.3151
    Cell Significance Index: -81.2100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 26.9872
    Cell Significance Index: -82.8900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 17.1755
    Cell Significance Index: -37.5900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 8.2345
    Cell Significance Index: 138.7100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 5.3470
    Cell Significance Index: 140.6000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 4.2292
    Cell Significance Index: 222.0500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.9379
    Cell Significance Index: 183.6100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.6538
    Cell Significance Index: 76.4800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.4945
    Cell Significance Index: 629.9600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.4827
    Cell Significance Index: 478.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.2685
    Cell Significance Index: 401.9000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 3.1081
    Cell Significance Index: 219.8200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.0398
    Cell Significance Index: 1660.1300
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.0385
    Cell Significance Index: 24.2600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.8930
    Cell Significance Index: 341.1700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.7710
    Cell Significance Index: 31.4800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.6226
    Cell Significance Index: 1159.5200
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.5902
    Cell Significance Index: 90.0100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.3165
    Cell Significance Index: 172.6500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.1067
    Cell Significance Index: 135.9200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.9331
    Cell Significance Index: 247.8100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.8553
    Cell Significance Index: 20.1700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.7847
    Cell Significance Index: 16.4400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.6982
    Cell Significance Index: 219.4000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.6239
    Cell Significance Index: 44.2000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.4600
    Cell Significance Index: 76.0500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.4314
    Cell Significance Index: 41.2400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.2425
    Cell Significance Index: 36.4900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1889
    Cell Significance Index: 53.8900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.1634
    Cell Significance Index: 54.6800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 1.0672
    Cell Significance Index: 84.5200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.8629
    Cell Significance Index: 59.6800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.8135
    Cell Significance Index: 596.4800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7666
    Cell Significance Index: 75.8300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7265
    Cell Significance Index: 145.7400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7059
    Cell Significance Index: 44.4900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6949
    Cell Significance Index: 36.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5818
    Cell Significance Index: 115.4700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4494
    Cell Significance Index: 85.5200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2723
    Cell Significance Index: 206.1200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2439
    Cell Significance Index: 39.6800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.2301
    Cell Significance Index: 82.5300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0919
    Cell Significance Index: 3.2300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0483
    Cell Significance Index: 1.2900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0131
    Cell Significance Index: 0.2200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0110
    Cell Significance Index: -0.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0179
    Cell Significance Index: -33.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0562
    Cell Significance Index: -5.7400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0657
    Cell Significance Index: -121.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0849
    Cell Significance Index: -130.6600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0931
    Cell Significance Index: -15.9000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1050
    Cell Significance Index: -142.7400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1158
    Cell Significance Index: -85.8200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1231
    Cell Significance Index: -78.1500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1426
    Cell Significance Index: -7.2100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1749
    Cell Significance Index: -5.0200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1840
    Cell Significance Index: -83.5100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1862
    Cell Significance Index: -21.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1914
    Cell Significance Index: -107.9700
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2339
    Cell Significance Index: -2.9900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2555
    Cell Significance Index: -159.5600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2701
    Cell Significance Index: -16.6000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2732
    Cell Significance Index: -5.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3502
    Cell Significance Index: -40.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.3608
    Cell Significance Index: -103.8200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.4861
    Cell Significance Index: -37.3000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.5898
    Cell Significance Index: -24.1700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5997
    Cell Significance Index: -15.3200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.6263
    Cell Significance Index: -91.0500
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.6391
    Cell Significance Index: -134.6100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.8101
    Cell Significance Index: -17.5500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8496
    Cell Significance Index: -27.2100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.8781
    Cell Significance Index: -24.5400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.9210
    Cell Significance Index: -13.8000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.1484
    Cell Significance Index: -19.6800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.1688
    Cell Significance Index: -121.7000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.2105
    Cell Significance Index: -72.6700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.4158
    Cell Significance Index: -79.4500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.5788
    Cell Significance Index: -18.8200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.7777
    Cell Significance Index: -26.2500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.0631
    Cell Significance Index: -126.4900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -2.0739
    Cell Significance Index: -17.4200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -2.2311
    Cell Significance Index: -30.4400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -2.2976
    Cell Significance Index: -17.7100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.3192
    Cell Significance Index: -68.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.4770
    Cell Significance Index: -109.5700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -2.5711
    Cell Significance Index: -66.0900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -2.7538
    Cell Significance Index: -67.1900
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -2.8965
    Cell Significance Index: -24.8900
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.9543
    Cell Significance Index: -108.4500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.9751
    Cell Significance Index: -17.9800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -2.9849
    Cell Significance Index: -30.9000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -3.0295
    Cell Significance Index: -114.7200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -3.1979
    Cell Significance Index: -112.0300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location:** The ATP5PF gene is located on chromosome 17q24.3. 2. **Protein structure:** The ATP5PF protein is a peripheral stalk subunit of the ATP synthase enzyme complex, consisting of six subunits (F1, F2, F3, F4, F5, and F6). 3. **Function:** The ATP5PF protein plays a critical role in the production of ATP through chemiosmotic coupling, generating a proton motive force that drives the synthesis of ATP. 4. **Expression:** The ATP5PF gene is expressed in various cell types, including skeletal muscle satellite cells, pancreatic acinar cells, and myeloid dendritic cells. **Pathways and Functions:** 1. **Cristae formation:** The ATP5PF protein is involved in the formation of cristae, the infoldings of the mitochondrial inner membrane that increase the surface area for ATP production. 2. **ATP synthesis by chemiosmotic coupling:** The ATP5PF protein plays a crucial role in the production of ATP through chemiosmotic coupling, harnessing the energy generated by the respiratory electron transport chain to drive the synthesis of ATP. 3. **Mitochondrial biogenesis:** The ATP5PF protein is involved in the regulation of mitochondrial biogenesis, ensuring the proper formation and function of mitochondria. 4. **Proton motive force-driven atp synthesis:** The ATP5PF protein generates a proton motive force that drives the synthesis of ATP, highlighting its importance in maintaining cellular energy homeostasis. **Clinical Significance:** 1. **Mitochondrial disorders:** Mutations in the ATP5PF gene have been associated with mitochondrial disorders, including neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. 2. **Cancer:** The ATP5PF protein has been implicated in cancer development and progression, with altered expression levels observed in various types of cancer, including breast and lung cancer. 3. **Metabolic disorders:** The ATP5PF protein plays a crucial role in regulating energy metabolism, and alterations in its expression have been linked to metabolic disorders, including type 2 diabetes and obesity. 4. **Neurological disorders:** The ATP5PF protein has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. In conclusion, the ATP5PF gene encodes for a critical component of the mitochondrial inner membrane, playing a pivotal role in the production of ATP through chemiosmotic coupling. Its expression in various cell types highlights its importance in maintaining cellular homeostasis and energy production. Alterations in its expression have been linked to various diseases, including mitochondrial disorders, cancer, metabolic disorders, and neurological disorders.

Genular Protein ID: 1682714000

Symbol: ATP5J_HUMAN

Name: N/A

UniProtKB Accession Codes:

P18859 J3KQ83

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 9 Ensembl 6 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 7 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1825642

Title: Human mitochondrial ATP synthase: cloning cDNA for the nuclear-encoded precursor of coupling factor 6.

PubMed ID: 1825642

DOI: 10.1016/0378-1119(91)90068-m

PubMed ID: 1830479

Title: Molecular cloning of cDNA for the import precursor of human coupling factor 6 of H(+)-ATP synthase in mitochondria.

PubMed ID: 1830479

DOI: 10.1016/0006-291x(91)90178-a

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 17213182

Title: Identification of genes related to Parkinson's disease using expressed sequence tags.

PubMed ID: 17213182

DOI: 10.1093/dnares/dsl016

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1286669

Title: Human liver protein map: a reference database established by microsequencing and gel comparison.

PubMed ID: 1286669

DOI: 10.1002/elps.11501301201

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29961568

Title: De Novo Truncating Mutations in WASF1 Cause Intellectual Disability with Seizures.

PubMed ID: 29961568

DOI: 10.1016/j.ajhg.2018.06.001

Sequence Information:

  • Length: 108
  • Mass: 12588
  • Checksum: EDC1A14F01A10F17
  • Sequence:
    • MILQRLFRFS SVIRSAVSVH LRRNIGVTAV AFNKELDPIQ KLFVDKIREY KSKRQTSGGP 
VDASSEYQQE LERELFKLKQ MFGNADMNTF PTFKFEDPKF EVIEKPQA

Genular Protein ID: 1572421572

Symbol: Q6NZ59_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6NZ59

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 5 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 108
  • Mass: 12628
  • Checksum: EDD2CDCF01A10F17
  • Sequence:
    • MILQRLFRFS SVIRSAVSVH LRRNIGVTAV AFNKELDPIQ KLFVDKIREY KSKRQTSGGP 
VDASSEYQQE LERELFKLKQ MFGNADMNTF HTFKFEDPKF EVIEKPQA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.