Details for: ATP5PF

Gene ID: 522

Symbol: ATP5PF

Ensembl ID: ENSG00000154723

Description: ATP synthase peripheral stalk subunit F6

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 6.65
    Marker Score: 4450
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 5.02
    Marker Score: 10599
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 4.16
    Marker Score: 1218
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 4.03
    Marker Score: 2445
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 3.91
    Marker Score: 2017.5
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 3.9
    Marker Score: 51911
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.86
    Marker Score: 3023
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.83
    Marker Score: 5890
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.82
    Marker Score: 10230
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 3.78
    Marker Score: 2668
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.7
    Marker Score: 1971
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 3.69
    Marker Score: 2785
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 3.65
    Marker Score: 3957
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.65
    Marker Score: 3258
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 3.58
    Marker Score: 1485
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 3.54
    Marker Score: 1973
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 3.45
    Marker Score: 2926
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.37
    Marker Score: 1108
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.36
    Marker Score: 11942
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.35
    Marker Score: 44225
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.31
    Marker Score: 3449.5
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 3.29
    Marker Score: 1213
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.28
    Marker Score: 5437
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.2
    Marker Score: 10045
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.17
    Marker Score: 8003
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.14
    Marker Score: 3795
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.04
    Marker Score: 5705
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.03
    Marker Score: 2860
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 3.02
    Marker Score: 12555
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 3.02
    Marker Score: 3934
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 3.01
    Marker Score: 14442
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3
    Marker Score: 29681
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.99
    Marker Score: 2671
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.99
    Marker Score: 23354.5
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.97
    Marker Score: 102825
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.95
    Marker Score: 34290
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.93
    Marker Score: 3541.5
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.92
    Marker Score: 3099
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.9
    Marker Score: 2897
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.89
    Marker Score: 2935
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.89
    Marker Score: 3084
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.89
    Marker Score: 1899
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 2.88
    Marker Score: 920
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 2.86
    Marker Score: 1524
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.86
    Marker Score: 6520
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.86
    Marker Score: 1286
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.86
    Marker Score: 3960
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.83
    Marker Score: 18395
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2.82
    Marker Score: 2930
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.81
    Marker Score: 6865.5
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.79
    Marker Score: 5678.5
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.79
    Marker Score: 7957
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.77
    Marker Score: 1973
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.75
    Marker Score: 20437
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.73
    Marker Score: 3867
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.73
    Marker Score: 3861
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.73
    Marker Score: 7530
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.72
    Marker Score: 1545
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.71
    Marker Score: 10457
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.71
    Marker Score: 1081
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.71
    Marker Score: 23319
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.7
    Marker Score: 14210
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.67
    Marker Score: 4251
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.67
    Marker Score: 920
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.67
    Marker Score: 23179
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.67
    Marker Score: 1675
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.66
    Marker Score: 636
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.66
    Marker Score: 17350
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.65
    Marker Score: 4267
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.65
    Marker Score: 2980
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.64
    Marker Score: 10825
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.64
    Marker Score: 29712
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.64
    Marker Score: 5503
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.62
    Marker Score: 26367
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.61
    Marker Score: 11259
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.61
    Marker Score: 35057
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.61
    Marker Score: 5209
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.61
    Marker Score: 2805
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.6
    Marker Score: 16617
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.6
    Marker Score: 4262
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.6
    Marker Score: 145249
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.59
    Marker Score: 2481.5
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.57
    Marker Score: 3535
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.57
    Marker Score: 825
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.57
    Marker Score: 87379
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.56
    Marker Score: 2018
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.56
    Marker Score: 1215
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.56
    Marker Score: 65562
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.55
    Marker Score: 7567
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.55
    Marker Score: 3924
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.54
    Marker Score: 1435
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.54
    Marker Score: 6903
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 2.52
    Marker Score: 1303
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.51
    Marker Score: 1668
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.51
    Marker Score: 2137
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.51
    Marker Score: 5693
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 2.5
    Marker Score: 1296
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.5
    Marker Score: 2859
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.49
    Marker Score: 1282.5
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.48
    Marker Score: 5829.5

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Other Information

**Key characteristics:** * ATP5PF is a transmembrane protein with a molecular weight of approximately 105 kDa. * It is encoded by the ATP5PF gene, which is located on chromosome 15q21.1. * It is one of the most highly expressed genes in skeletal muscle satellite cells. * It is also expressed in other cells, including pancreatic acinar cells, tracheobronchial smooth muscle cells, myeloid dendritic cells, professional antigen presenting cells, cardiac muscle cells, thyroid follicular cells, and mesenchymal stem cells. **Pathways and functions:** * ATP5PF is involved in the formation of cristae, which are the sites of ATP synthase synthesis and activity. * It is also involved in the formation of the mitochondrial inner membrane. * It is involved in the metabolism of proteins, as it is a key enzyme in the citric acid (tca) cycle and respiratory electron transport pathways. * It is involved in mitochondrial biogenesis, maintenance, and turnover. * It is involved in the regulation of mitochondrial function, as it is a key regulator of ATP production. **Clinical significance:** * Mutations in the ATP5PF gene have been linked to several human diseases, including mitochondrial myopathy, lactic acidosis, and heart failure. * These diseases are characterized by a decrease in ATP production, which can lead to a number of clinical symptoms, including muscle weakness, fatigue, and shortness of breath. * Therefore, understanding the role of ATP5PF in mitochondrial function is important for the development of new treatments for these diseases. **Additional notes:** * ATP5PF is a highly conserved protein, with a similar gene product found in other vertebrates. * It is a heterodimeric protein, with two subunits that are linked by a flexible linker peptide. * It is a chaperone protein, which means that it helps to maintain the structure and integrity of other proteins.

Genular Protein ID: 1682714000

Symbol: ATP5J_HUMAN

Name: N/A

UniProtKB Accession Codes:

P18859 J3KQ83

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 8 EPD 1 Ensembl 6 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 8 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 7 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1825642

Title: Human mitochondrial ATP synthase: cloning cDNA for the nuclear-encoded precursor of coupling factor 6.

PubMed ID: 1825642

DOI: 10.1016/0378-1119(91)90068-m

PubMed ID: 1830479

Title: Molecular cloning of cDNA for the import precursor of human coupling factor 6 of H(+)-ATP synthase in mitochondria.

PubMed ID: 1830479

DOI: 10.1016/0006-291x(91)90178-a

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 17213182

Title: Identification of genes related to Parkinson's disease using expressed sequence tags.

PubMed ID: 17213182

DOI: 10.1093/dnares/dsl016

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1286669

Title: Human liver protein map: a reference database established by microsequencing and gel comparison.

PubMed ID: 1286669

DOI: 10.1002/elps.11501301201

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29961568

Title: De Novo Truncating Mutations in WASF1 Cause Intellectual Disability with Seizures.

PubMed ID: 29961568

DOI: 10.1016/j.ajhg.2018.06.001

Sequence Information:

  • Length: 108
  • Mass: 12588
  • Checksum: EDC1A14F01A10F17
  • Sequence:
    • MILQRLFRFS SVIRSAVSVH LRRNIGVTAV AFNKELDPIQ KLFVDKIREY KSKRQTSGGP 
VDASSEYQQE LERELFKLKQ MFGNADMNTF PTFKFEDPKF EVIEKPQA

Genular Protein ID: 1572421572

Symbol: Q6NZ59_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6NZ59

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 5 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 108
  • Mass: 12628
  • Checksum: EDD2CDCF01A10F17
  • Sequence:
    • MILQRLFRFS SVIRSAVSVH LRRNIGVTAV AFNKELDPIQ KLFVDKIREY KSKRQTSGGP 
VDASSEYQQE LERELFKLKQ MFGNADMNTF HTFKFEDPKF EVIEKPQA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.