Details for: ATP5PF

Gene ID: 522

Symbol: ATP5PF

Ensembl ID: ENSG00000154723

Description: ATP synthase peripheral stalk subunit F6

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 6.65
    Marker Score: 4,450
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 5.02
    Marker Score: 10,599
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 4.16
    Marker Score: 1,218
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 4.03
    Marker Score: 2,445
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 3.91
    Marker Score: 2,018
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 3.9
    Marker Score: 51,911
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 3.86
    Marker Score: 3,023
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 3.83
    Marker Score: 5,890
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.82
    Marker Score: 10,230
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 3.78
    Marker Score: 2,668
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.7
    Marker Score: 1,971
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 3.69
    Marker Score: 2,785
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 3.65
    Marker Score: 3,957
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.65
    Marker Score: 3,258
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 3.58
    Marker Score: 1,485
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 3.54
    Marker Score: 1,973
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 3.45
    Marker Score: 2,926
  • Cell Name: fetal cardiomyocyte (CL0002495)
    Fold Change: 3.37
    Marker Score: 1,108
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 3.36
    Marker Score: 11,942
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 3.35
    Marker Score: 44,225
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.31
    Marker Score: 3,450
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 3.29
    Marker Score: 1,213
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.28
    Marker Score: 5,437
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 3.2
    Marker Score: 10,045
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.17
    Marker Score: 8,003
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.14
    Marker Score: 3,795
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 3.04
    Marker Score: 5,705
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 3.03
    Marker Score: 2,860
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 3.02
    Marker Score: 12,555
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 3.02
    Marker Score: 3,934
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 3.01
    Marker Score: 14,442
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3
    Marker Score: 29,681
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.99
    Marker Score: 2,671
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.99
    Marker Score: 23,355
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.97
    Marker Score: 102,825
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.95
    Marker Score: 34,290
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.93
    Marker Score: 3,542
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.92
    Marker Score: 3,099
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.9
    Marker Score: 2,897
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.89
    Marker Score: 2,935
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 2.89
    Marker Score: 3,084
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 2.89
    Marker Score: 1,899
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 2.88
    Marker Score: 920
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 2.86
    Marker Score: 1,524
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.86
    Marker Score: 6,520
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 2.86
    Marker Score: 1,286
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 2.86
    Marker Score: 3,960
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.83
    Marker Score: 18,395
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 2.82
    Marker Score: 2,930
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.81
    Marker Score: 6,866
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.79
    Marker Score: 5,679
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.79
    Marker Score: 7,957
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 2.77
    Marker Score: 1,973
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.75
    Marker Score: 20,437
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.73
    Marker Score: 3,867
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 2.73
    Marker Score: 3,861
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.73
    Marker Score: 7,530
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 2.72
    Marker Score: 1,545
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.71
    Marker Score: 10,457
  • Cell Name: serous secreting cell (CL0000313)
    Fold Change: 2.71
    Marker Score: 1,081
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.71
    Marker Score: 23,319
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.7
    Marker Score: 14,210
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.67
    Marker Score: 4,251
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.67
    Marker Score: 920
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.67
    Marker Score: 23,179
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.67
    Marker Score: 1,675
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.66
    Marker Score: 636
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.66
    Marker Score: 17,350
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.65
    Marker Score: 4,267
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.65
    Marker Score: 2,980
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.64
    Marker Score: 10,825
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.64
    Marker Score: 29,712
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.64
    Marker Score: 5,503
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.62
    Marker Score: 26,367
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.61
    Marker Score: 11,259
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.61
    Marker Score: 35,057
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 2.61
    Marker Score: 5,209
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 2.61
    Marker Score: 2,805
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.6
    Marker Score: 16,617
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.6
    Marker Score: 4,262
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 2.6
    Marker Score: 145,249
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.59
    Marker Score: 2,482
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.57
    Marker Score: 3,535
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.57
    Marker Score: 825
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.57
    Marker Score: 87,379
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.56
    Marker Score: 2,018
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.56
    Marker Score: 1,215
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.56
    Marker Score: 65,562
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.55
    Marker Score: 7,567
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.55
    Marker Score: 3,924
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.54
    Marker Score: 1,435
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.54
    Marker Score: 6,903
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 2.52
    Marker Score: 1,303
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.51
    Marker Score: 1,668
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.51
    Marker Score: 2,137
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.51
    Marker Score: 5,693
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 2.5
    Marker Score: 1,296
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.5
    Marker Score: 2,859
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.49
    Marker Score: 1,283
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.48
    Marker Score: 5,830

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Location:** The ATP5PF gene is located on chromosome 17q24.3. 2. **Protein structure:** The ATP5PF protein is a peripheral stalk subunit of the ATP synthase enzyme complex, consisting of six subunits (F1, F2, F3, F4, F5, and F6). 3. **Function:** The ATP5PF protein plays a critical role in the production of ATP through chemiosmotic coupling, generating a proton motive force that drives the synthesis of ATP. 4. **Expression:** The ATP5PF gene is expressed in various cell types, including skeletal muscle satellite cells, pancreatic acinar cells, and myeloid dendritic cells. **Pathways and Functions:** 1. **Cristae formation:** The ATP5PF protein is involved in the formation of cristae, the infoldings of the mitochondrial inner membrane that increase the surface area for ATP production. 2. **ATP synthesis by chemiosmotic coupling:** The ATP5PF protein plays a crucial role in the production of ATP through chemiosmotic coupling, harnessing the energy generated by the respiratory electron transport chain to drive the synthesis of ATP. 3. **Mitochondrial biogenesis:** The ATP5PF protein is involved in the regulation of mitochondrial biogenesis, ensuring the proper formation and function of mitochondria. 4. **Proton motive force-driven atp synthesis:** The ATP5PF protein generates a proton motive force that drives the synthesis of ATP, highlighting its importance in maintaining cellular energy homeostasis. **Clinical Significance:** 1. **Mitochondrial disorders:** Mutations in the ATP5PF gene have been associated with mitochondrial disorders, including neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease. 2. **Cancer:** The ATP5PF protein has been implicated in cancer development and progression, with altered expression levels observed in various types of cancer, including breast and lung cancer. 3. **Metabolic disorders:** The ATP5PF protein plays a crucial role in regulating energy metabolism, and alterations in its expression have been linked to metabolic disorders, including type 2 diabetes and obesity. 4. **Neurological disorders:** The ATP5PF protein has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. In conclusion, the ATP5PF gene encodes for a critical component of the mitochondrial inner membrane, playing a pivotal role in the production of ATP through chemiosmotic coupling. Its expression in various cell types highlights its importance in maintaining cellular homeostasis and energy production. Alterations in its expression have been linked to various diseases, including mitochondrial disorders, cancer, metabolic disorders, and neurological disorders.

Genular Protein ID: 1682714000

Symbol: ATP5J_HUMAN

Name: N/A

UniProtKB Accession Codes:

P18859 J3KQ83

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 8 EPD 1 Ensembl 6 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 8 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 2 RefSeq 7 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SWISS-2DPAGE 1 SignaLink 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1825642

Title: Human mitochondrial ATP synthase: cloning cDNA for the nuclear-encoded precursor of coupling factor 6.

PubMed ID: 1825642

DOI: 10.1016/0378-1119(91)90068-m

PubMed ID: 1830479

Title: Molecular cloning of cDNA for the import precursor of human coupling factor 6 of H(+)-ATP synthase in mitochondria.

PubMed ID: 1830479

DOI: 10.1016/0006-291x(91)90178-a

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 17213182

Title: Identification of genes related to Parkinson's disease using expressed sequence tags.

PubMed ID: 17213182

DOI: 10.1093/dnares/dsl016

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1286669

Title: Human liver protein map: a reference database established by microsequencing and gel comparison.

PubMed ID: 1286669

DOI: 10.1002/elps.11501301201

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29961568

Title: De Novo Truncating Mutations in WASF1 Cause Intellectual Disability with Seizures.

PubMed ID: 29961568

DOI: 10.1016/j.ajhg.2018.06.001

Sequence Information:

  • Length: 108
  • Mass: 12588
  • Checksum: EDC1A14F01A10F17
  • Sequence:
    • MILQRLFRFS SVIRSAVSVH LRRNIGVTAV AFNKELDPIQ KLFVDKIREY KSKRQTSGGP 
VDASSEYQQE LERELFKLKQ MFGNADMNTF PTFKFEDPKF EVIEKPQA

Genular Protein ID: 1572421572

Symbol: Q6NZ59_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6NZ59

Database IDs:

ARBA 11 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 3 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRNR 1 PIRSF 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 5 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 108
  • Mass: 12628
  • Checksum: EDD2CDCF01A10F17
  • Sequence:
    • MILQRLFRFS SVIRSAVSVH LRRNIGVTAV AFNKELDPIQ KLFVDKIREY KSKRQTSGGP 
VDASSEYQQE LERELFKLKQ MFGNADMNTF HTFKFEDPKF EVIEKPQA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.