Details for: ATP6V1A
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 287.2476
Cell Significance Index: -44.6800 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 180.9627
Cell Significance Index: -45.9000 - Cell Name: embryonic stem cell (CL0002322)
Fold Change: 109.6984
Cell Significance Index: -45.1900 - Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 104.9939
Cell Significance Index: -49.5700 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 104.3182
Cell Significance Index: -42.3800 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 90.0492
Cell Significance Index: -46.3200 - Cell Name: ileal goblet cell (CL1000326)
Fold Change: 73.9171
Cell Significance Index: -49.6000 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 38.9552
Cell Significance Index: -48.0300 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 17.5410
Cell Significance Index: -46.9900 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 12.4745
Cell Significance Index: -49.2300 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 9.2251
Cell Significance Index: -20.1900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 6.2241
Cell Significance Index: 1790.8500 - Cell Name: columnar/cuboidal epithelial cell (CL0000075)
Fold Change: 4.7375
Cell Significance Index: 18.1400 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: 2.9881
Cell Significance Index: 348.2300 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.3621
Cell Significance Index: 473.8300 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 1.7441
Cell Significance Index: 625.5800 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 1.4679
Cell Significance Index: 98.7000 - Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 1.3488
Cell Significance Index: 38.4900 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: 1.2482
Cell Significance Index: 17.0300 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 1.2014
Cell Significance Index: 130.6800 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 1.0315
Cell Significance Index: 27.6400 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.9286
Cell Significance Index: 184.2900 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: 0.9175
Cell Significance Index: 48.1700 - Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.8151
Cell Significance Index: 10.1100 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.8005
Cell Significance Index: 437.1600 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.7414
Cell Significance Index: 120.5900 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.7232
Cell Significance Index: 130.3800 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 0.6771
Cell Significance Index: 25.6400 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 0.6752
Cell Significance Index: 29.8700 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.6724
Cell Significance Index: 465.0800 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.6592
Cell Significance Index: 125.4500 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.6322
Cell Significance Index: 77.7400 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.5797
Cell Significance Index: 27.0300 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 0.5493
Cell Significance Index: 33.7600 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.5241
Cell Significance Index: 40.2200 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.2812
Cell Significance Index: 124.3400 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.2727
Cell Significance Index: 513.4300 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: 0.2569
Cell Significance Index: 16.1900 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.2316
Cell Significance Index: 4.2800 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.2143
Cell Significance Index: 193.5000 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.2018
Cell Significance Index: 19.9600 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.1823
Cell Significance Index: 3.9500 - Cell Name: cerebellar granule cell (CL0001031)
Fold Change: 0.1511
Cell Significance Index: 2.5900 - Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.1489
Cell Significance Index: 3.2600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1151
Cell Significance Index: 3.3200 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1144
Cell Significance Index: 15.7100 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 0.1074
Cell Significance Index: 6.0300 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0986
Cell Significance Index: 16.8400 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: 0.0773
Cell Significance Index: 56.6500 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0646
Cell Significance Index: 7.6200 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0497
Cell Significance Index: 31.5600 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.0428
Cell Significance Index: 19.4300 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.0340
Cell Significance Index: 0.9500 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: 0.0332
Cell Significance Index: 45.1600 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0155
Cell Significance Index: 23.8100 - Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0130
Cell Significance Index: 23.9200 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.0013
Cell Significance Index: 0.0700 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.0079
Cell Significance Index: -0.2100 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0111
Cell Significance Index: -8.2500 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0148
Cell Significance Index: -9.2700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.0195
Cell Significance Index: -0.6900 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0267
Cell Significance Index: -20.1800 - Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.0275
Cell Significance Index: -0.3000 - Cell Name: cortical interneuron (CL0008031)
Fold Change: -0.0363
Cell Significance Index: -0.8700 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0400
Cell Significance Index: -5.8200 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0657
Cell Significance Index: -37.0500 - Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0863
Cell Significance Index: -8.8200 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1233
Cell Significance Index: -25.9700 - Cell Name: odontoblast (CL0000060)
Fold Change: -0.1287
Cell Significance Index: -16.5000 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.1302
Cell Significance Index: -16.8300 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.1859
Cell Significance Index: -21.2200 - Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.1902
Cell Significance Index: -4.8900 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1938
Cell Significance Index: -20.1800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.1955
Cell Significance Index: -9.1900 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: -0.2072
Cell Significance Index: -9.3900 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.2215
Cell Significance Index: -2.6400 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.2323
Cell Significance Index: -16.4300 - Cell Name: cone retinal bipolar cell (CL0000752)
Fold Change: -0.2439
Cell Significance Index: -1.8800 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.2447
Cell Significance Index: -18.2400 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.2681
Cell Significance Index: -30.7200 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.3087
Cell Significance Index: -19.9200 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.3091
Cell Significance Index: -24.4800 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.3400
Cell Significance Index: -7.2400 - Cell Name: decidual cell (CL2000002)
Fold Change: -0.3478
Cell Significance Index: -5.5800 - Cell Name: leptomeningeal cell (CL0000708)
Fold Change: -0.3965
Cell Significance Index: -8.4800 - Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -0.4437
Cell Significance Index: -12.7200 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.4855
Cell Significance Index: -15.5500 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.4975
Cell Significance Index: -10.3200 - Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: -0.5053
Cell Significance Index: -6.7400 - Cell Name: medium spiny neuron (CL1001474)
Fold Change: -0.5765
Cell Significance Index: -7.7800 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.6152
Cell Significance Index: -37.7200 - Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.6276
Cell Significance Index: -13.3200 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.7640
Cell Significance Index: -7.0400 - Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.7792
Cell Significance Index: -25.5100 - Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.7817
Cell Significance Index: -24.9000 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.7925
Cell Significance Index: -41.2800 - Cell Name: OFF midget ganglion cell (CL4033047)
Fold Change: -0.8452
Cell Significance Index: -10.5400 - Cell Name: peg cell (CL4033014)
Fold Change: -0.8475
Cell Significance Index: -19.5800 - Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: -0.8568
Cell Significance Index: -16.9400 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -0.8596
Cell Significance Index: -29.8700
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 3942827416
Symbol: VATA_HUMAN
Name: V-type proton ATPase catalytic subunit A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8463241
Title: Identification of two subunit A isoforms of the vacuolar H(+)-ATPase in human osteoclastoma.
PubMed ID: 8463241
PubMed ID: 10931946
Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.
PubMed ID: 10931946
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16641997
Title: The DNA sequence, annotation and analysis of human chromosome 3.
PubMed ID: 16641997
DOI: 10.1038/nature04728
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23035048
Title: Vacuolar-type H+-ATPase V1A subunit is a molecular partner of Wolfram syndrome 1 (WFS1) protein, which regulates its expression and stability.
PubMed ID: 23035048
DOI: 10.1093/hmg/dds400
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 28065471
Title: Mutations in ATP6V1E1 or ATP6V1A cause autosomal-recessive cutis laxa.
PubMed ID: 28065471
PubMed ID: 28296633
Title: The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1alpha prolyl hydroxylation by regulating cellular iron levels.
PubMed ID: 28296633
DOI: 10.7554/elife.22693
PubMed ID: 29668857
Title: De novo mutations of the ATP6V1A gene cause developmental encephalopathy with epilepsy.
PubMed ID: 29668857
DOI: 10.1093/brain/awy092
PubMed ID: 31786107
Title: Heat shock factor 4 regulates lysosome activity by modulating the alphaB-crystallin-ATP6V1A-mTOR complex in ocular lens.
PubMed ID: 31786107
PubMed ID: 33208464
Title: The ATPase ATP6V1A facilitates rabies virus replication by promoting virion uncoating and interacting with the viral matrix protein.
PubMed ID: 33208464
PubMed ID: 32001091
PubMed ID: 33065002
Title: Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly.
PubMed ID: 33065002
Sequence Information:
- Length: 617
- Mass: 68304
- Checksum: DB409A8731D772CB
- Sequence:
MDFSKLPKIL DEDKESTFGY VHGVSGPVVT ACDMAGAAMY ELVRVGHSEL VGEIIRLEGD MATIQVYEET SGVSVGDPVL RTGKPLSVEL GPGIMGAIFD GIQRPLSDIS SQTQSIYIPR GVNVSALSRD IKWDFTPCKN LRVGSHITGG DIYGIVSENS LIKHKIMLPP RNRGTVTYIA PPGNYDTSDV VLELEFEGVK EKFTMVQVWP VRQVRPVTEK LPANHPLLTG QRVLDALFPC VQGGTTAIPG AFGCGKTVIS QSLSKYSNSD VIIYVGCGER GNEMSEVLRD FPELTMEVDG KVESIMKRTA LVANTSNMPV AAREASIYTG ITLSEYFRDM GYHVSMMADS TSRWAEALRE ISGRLAEMPA DSGYPAYLGA RLASFYERAG RVKCLGNPER EGSVSIVGAV SPPGGDFSDP VTSATLGIVQ VFWGLDKKLA QRKHFPSVNW LISYSKYMRA LDEYYDKHFT EFVPLRTKAK EILQEEEDLA EIVQLVGKAS LAETDKITLE VAKLIKDDFL QQNGYTPYDR FCPFYKTVGM LSNMIAFYDM ARRAVETTAQ SDNKITWSII REHMGDILYK LSSMKFKDPL KDGEAKIKSD YAQLLEDMQN AFRSLED
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.