ATP6V1A | ENSG00000114573 | NCBI 523

Details for: ATP6V1A

Gene ID: 523

Symbol: ATP6V1A

Ensembl ID: ENSG00000114573

Description: ATPase H+ transporting V1 subunit A

Associated with

Amino acids regulate mtorc1
(R-HSA-9639288)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Insulin receptor recycling
(R-HSA-77387)
Ion channel transport
(R-HSA-983712)
Iron uptake and transport
(R-HSA-917937)
Ros and rns production in phagocytes
(R-HSA-1222556)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Transferrin endocytosis and recycling
(R-HSA-917977)
Transport of small molecules
(R-HSA-382551)
Apical plasma membrane
(GO:0016324)
Atp binding
(GO:0005524)
Atp hydrolysis activity
(GO:0016887)
Cellular response to increased oxygen levels
(GO:0036295)
Clathrin-coated vesicle membrane
(GO:0030665)
Cytosol
(GO:0005829)
Endosomal lumen acidification
(GO:0048388)
Endosome membrane
(GO:0010008)
Extracellular exosome
(GO:0070062)
Extrinsic component of synaptic vesicle membrane
(GO:0098850)
Golgi lumen acidification
(GO:0061795)
Golgi membrane
(GO:0000139)
Intracellular iron ion homeostasis
(GO:0006879)
Intracellular membrane-bounded organelle
(GO:0043231)
Intracellular ph reduction
(GO:0051452)
Lysosomal lumen acidification
(GO:0007042)
Lysosomal membrane
(GO:0005765)
Membrane
(GO:0016020)
Microvillus
(GO:0005902)
Nucleoplasm
(GO:0005654)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Proton-transporting atpase activity, rotational mechanism
(GO:0046961)
Proton-transporting atp synthase activity, rotational mechanism
(GO:0046933)
Proton-transporting two-sector atpase complex
(GO:0016469)
Proton-transporting v-type atpase complex
(GO:0033176)
Proton motive force-driven atp synthesis
(GO:0015986)
Proton transmembrane transport
(GO:1902600)
Regulation of macroautophagy
(GO:0016241)
Secretory granule
(GO:0030141)
Synaptic vesicle lumen acidification
(GO:0097401)
Transmembrane transporter complex
(GO:1902495)
Vacuolar acidification
(GO:0007035)
Vacuolar proton-transporting v-type atpase, v1 domain
(GO:0000221)

Other Information

Proteins

V-type proton ATPase catalytic subunit A

Genular Protein ID: 3942827416

Symbol: VATA_HUMAN

Name: V-type proton ATPase catalytic subunit A

UniProtKB Accession Codes:

P38606 B2RBR8 B7Z1R5 D3DN75 Q53YD9 Q96DY6 Q9UHY3

Database IDs:

Citations:

PubMed ID: 8463241

Title: Identification of two subunit A isoforms of the vacuolar H(+)-ATPase in human osteoclastoma.

PubMed ID: 8463241

DOI: 10.1016/s0021-9258(18)53147-1

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23035048

Title: Vacuolar-type H+-ATPase V1A subunit is a molecular partner of Wolfram syndrome 1 (WFS1) protein, which regulates its expression and stability.

PubMed ID: 23035048

DOI: 10.1093/hmg/dds400

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28065471

Title: Mutations in ATP6V1E1 or ATP6V1A cause autosomal-recessive cutis laxa.

PubMed ID: 28065471

DOI: 10.1016/j.ajhg.2016.12.010

PubMed ID: 28296633

Title: The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1alpha prolyl hydroxylation by regulating cellular iron levels.

PubMed ID: 28296633

DOI: 10.7554/elife.22693

PubMed ID: 29668857

Title: De novo mutations of the ATP6V1A gene cause developmental encephalopathy with epilepsy.

PubMed ID: 29668857

DOI: 10.1093/brain/awy092

PubMed ID: 31786107

Title: Heat shock factor 4 regulates lysosome activity by modulating the alphaB-crystallin-ATP6V1A-mTOR complex in ocular lens.

PubMed ID: 31786107

DOI: 10.1016/j.bbagen.2019.129496

PubMed ID: 33208464

Title: The ATPase ATP6V1A facilitates rabies virus replication by promoting virion uncoating and interacting with the viral matrix protein.

PubMed ID: 33208464

DOI: 10.1074/jbc.ra120.014190

PubMed ID: 32001091

Title: Structure and Roles of V-type ATPases.

PubMed ID: 32001091

DOI: 10.1016/j.tibs.2019.12.007

PubMed ID: 33065002

Title: Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly.

PubMed ID: 33065002

DOI: 10.1016/j.molcel.2020.09.029

Sequence Information:

Length: 617
Mass: 68304
Checksum: DB409A8731D772CB
Sequence:

MDFSKLPKIL DEDKESTFGY VHGVSGPVVT ACDMAGAAMY ELVRVGHSEL VGEIIRLEGD 
MATIQVYEET SGVSVGDPVL RTGKPLSVEL GPGIMGAIFD GIQRPLSDIS SQTQSIYIPR 
GVNVSALSRD IKWDFTPCKN LRVGSHITGG DIYGIVSENS LIKHKIMLPP RNRGTVTYIA 
PPGNYDTSDV VLELEFEGVK EKFTMVQVWP VRQVRPVTEK LPANHPLLTG QRVLDALFPC 
VQGGTTAIPG AFGCGKTVIS QSLSKYSNSD VIIYVGCGER GNEMSEVLRD FPELTMEVDG 
KVESIMKRTA LVANTSNMPV AAREASIYTG ITLSEYFRDM GYHVSMMADS TSRWAEALRE 
ISGRLAEMPA DSGYPAYLGA RLASFYERAG RVKCLGNPER EGSVSIVGAV SPPGGDFSDP 
VTSATLGIVQ VFWGLDKKLA QRKHFPSVNW LISYSKYMRA LDEYYDKHFT EFVPLRTKAK 
EILQEEEDLA EIVQLVGKAS LAETDKITLE VAKLIKDDFL QQNGYTPYDR FCPFYKTVGM 
LSNMIAFYDM ARRAVETTAQ SDNKITWSII REHMGDILYK LSSMKFKDPL KDGEAKIKSD 
YAQLLEDMQN AFRSLED

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ATP6V1A

Associated with

Other Information

Identification of two subunit A isoforms of the vacuolar H(+)-ATPase in human osteoclastoma. PubMed ID: 8463241

Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. PubMed ID: 10931946

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence, annotation and analysis of human chromosome 3. PubMed ID: 16641997

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Initial characterization of the human central proteome. PubMed ID: 21269460

N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB. PubMed ID: 22814378

Vacuolar-type H+-ATPase V1A subunit is a molecular partner of Wolfram syndrome 1 (WFS1) protein, which regulates its expression and stability. PubMed ID: 23035048

Toward a comprehensive characterization of a human cancer cell phosphoproteome. PubMed ID: 23186163

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Mutations in ATP6V1E1 or ATP6V1A cause autosomal-recessive cutis laxa. PubMed ID: 28065471

The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1alpha prolyl hydroxylation by regulating cellular iron levels. PubMed ID: 28296633

De novo mutations of the ATP6V1A gene cause developmental encephalopathy with epilepsy. PubMed ID: 29668857

Heat shock factor 4 regulates lysosome activity by modulating the alphaB-crystallin-ATP6V1A-mTOR complex in ocular lens. PubMed ID: 31786107

The ATPase ATP6V1A facilitates rabies virus replication by promoting virion uncoating and interacting with the viral matrix protein. PubMed ID: 33208464

Structure and Roles of V-type ATPases. PubMed ID: 32001091

Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly. PubMed ID: 33065002