Details for: Tet1

Gene ID: 52463

Symbol: Tet1

Ensembl ID: ENSMUSG00000047146

Description: tet methylcytosine dioxygenase 1

Associated with

  • 5-methylcytosine dioxygenase activity
    (GO:0070579)
  • Cellular response to reactive oxygen species
    (GO:0034614)
  • Chromatin remodeling
    (GO:0006338)
  • Chromosomal 5-methylcytosine dna demethylation pathway
    (GO:0141166)
  • Dendrite morphogenesis
    (GO:0048813)
  • Dna binding
    (GO:0003677)
  • Epigenetic programing of male pronucleus
    (GO:0044727)
  • Inner cell mass cell differentiation
    (GO:0001826)
  • Iron ion binding
    (GO:0005506)
  • Methyl-cpg binding
    (GO:0008327)
  • Negative regulation of cell migration
    (GO:0030336)
  • Negative regulation of stem cell population maintenance
    (GO:1902455)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Negative regulation of transforming growth factor beta receptor signaling pathway
    (GO:0030512)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of gene expression via chromosomal cpg island demethylation
    (GO:0044029)
  • Positive regulation of stem cell population maintenance
    (GO:1902459)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Protein o-linked glycosylation
    (GO:0006493)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sin3-type complex
    (GO:0070822)
  • Stem cell population maintenance
    (GO:0019827)
  • Zinc ion binding
    (GO:0008270)

Other Information

Genular Protein ID: 1374459498

Symbol: TET1_MOUSE

Name: Methylcytosine dioxygenase TET1

UniProtKB Accession Codes:

Q3URK3 D0VLQ4 E9Q9Y4 Q6ZPK2 Q9CY36

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChEBI 49 ChiTaRS 1 ComplexPortal 1 EC 3 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 25 GeneTree 1 GlyGen 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MGI 1 MINT 1 NCBI Taxonomy 1 PANTHER 2 PRO 1 PROSITE 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 2 Rhea 9 SMART 1 SMR 1 STRING 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 20639862

Title: Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification.

PubMed ID: 20639862

DOI: 10.1038/nature09303

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 14621295

Title: Prediction of the coding sequences of mouse homologues of KIAA gene: III. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.

PubMed ID: 14621295

DOI: 10.1093/dnares/10.4.167

PubMed ID: 21496894

Title: Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain.

PubMed ID: 21496894

DOI: 10.1016/j.cell.2011.03.022

PubMed ID: 21816367

Title: Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development.

PubMed ID: 21816367

DOI: 10.1016/j.stem.2011.07.010

PubMed ID: 21514197

Title: Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells.

PubMed ID: 21514197

DOI: 10.1016/j.molcel.2011.04.005

PubMed ID: 21490601

Title: TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity.

PubMed ID: 21490601

DOI: 10.1038/nature10066

PubMed ID: 21451524

Title: Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells.

PubMed ID: 21451524

DOI: 10.1038/nature09934

PubMed ID: 21778364

Title: Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine.

PubMed ID: 21778364

DOI: 10.1126/science.1210597

PubMed ID: 23151479

Title: Tet1 controls meiosis by regulating meiotic gene expression.

PubMed ID: 23151479

DOI: 10.1038/nature11709

PubMed ID: 23352810

Title: Combined deficiency of tet1 and tet2 causes epigenetic abnormalities but is compatible with postnatal development.

PubMed ID: 23352810

DOI: 10.1016/j.devcel.2012.12.015

PubMed ID: 23352454

Title: Tet proteins connect the O-linked N-acetylglucosamine transferase Ogt to chromatin in embryonic stem cells.

PubMed ID: 23352454

DOI: 10.1016/j.molcel.2012.12.019

PubMed ID: 24357321

Title: CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins.

PubMed ID: 24357321

DOI: 10.1126/science.1244587

PubMed ID: 25284789

Title: 5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex.

PubMed ID: 25284789

DOI: 10.1016/j.celrep.2014.08.071

PubMed ID: 25557551

Title: CRL4(VprBP) E3 ligase promotes monoubiquitylation and chromatin binding of TET dioxygenases.

PubMed ID: 25557551

DOI: 10.1016/j.molcel.2014.12.002

PubMed ID: 27916660

Title: Isoform switch of TET1 regulates DNA demethylation and mouse development.

PubMed ID: 27916660

DOI: 10.1016/j.molcel.2016.10.030

PubMed ID: 28554894

Title: Fam60a defines a variant Sin3a-Hdac complex in embryonic stem cells required for self-renewal.

PubMed ID: 28554894

DOI: 10.15252/embj.201696307

PubMed ID: 28504700

Title: Lineage-specific functions of TET1 in the postimplantation mouse embryo.

PubMed ID: 28504700

DOI: 10.1038/ng.3868

PubMed ID: 28531272

Title: A novel isoform of TET1 that lacks a CXXC domain is overexpressed in cancer.

PubMed ID: 28531272

DOI: 10.1093/nar/gkx435

PubMed ID: 28855337

Title: An epigenetic switch repressing Tet1 in gonadotropes activates the reproductive axis.

PubMed ID: 28855337

DOI: 10.1073/pnas.1704393114

PubMed ID: 31089182

Title: TET1 contributes to allergic airway inflammation and regulates interferon and aryl hydrocarbon receptor signaling pathways in bronchial epithelial cells.

PubMed ID: 31089182

DOI: 10.1038/s41598-019-43767-6

PubMed ID: 32855402

Title: TET1 is a beige adipocyte-selective epigenetic suppressor of thermogenesis.

PubMed ID: 32855402

DOI: 10.1038/s41467-020-18054-y

PubMed ID: 32286661

Title: Nono deficiency compromises TET1 chromatin association and impedes neuronal differentiation of mouse embryonic stem cells.

PubMed ID: 32286661

DOI: 10.1093/nar/gkaa213

PubMed ID: 33895792

Title: RNF217 regulates iron homeostasis through its E3 ubiquitin ligase activity by modulating ferroportin degradation.

PubMed ID: 33895792

DOI: 10.1182/blood.2020008986

PubMed ID: 33262245

Title: Tet1 Isoforms Differentially Regulate Gene Expression, Synaptic Transmission, and Memory in the Mammalian Brain.

PubMed ID: 33262245

DOI: 10.1523/jneurosci.1821-20.2020

PubMed ID: 34166371

Title: Tet1 regulates epigenetic remodeling of the pericentromeric heterochromatin and chromocenter organization in DNA hypomethylated cells.

PubMed ID: 34166371

DOI: 10.1371/journal.pgen.1009646

PubMed ID: 36056023

Title: Isoform-specific and ubiquitination dependent recruitment of Tet1 to replicating heterochromatin modulates methylcytosine oxidation.

PubMed ID: 36056023

DOI: 10.1038/s41467-022-32799-8

Sequence Information:

  • Length: 2039
  • Mass: 222945
  • Checksum: 0E6E066F803ADFB1
  • Sequence:
    • MSRSRPAKPS KSVKTKLQKK KDIQMKTKTS KQAVRHGASA KAVNPGKPKQ LIKRRDGKKE 
TEDKTPTPAP SFLTRAGAAR MNRDRNQVLF QNPDSLTCNG FTMALRRTSL SWRLSQRPVV 
TPKPKKVPPS KKQCTHNIQD EPGVKHSEND SVPSQHATVS PGTENGEQNR CLVEGESQEI 
TQSCPVFEER IEDTQSCISA SGNLEAEISW PLEGTHCEEL LSHQTSDNEC TSPQECAPLP 
QRSTSEVTSQ KNTSNQLADL SSQVESIKLS DPSPNPTGSD HNGFPDSSFR IVPELDLKTC 
MPLDESVYPT ALIRFILAGS QPDVFDTKPQ EKTLITTPEQ VGSHPNQVLD ATSVLGQAFS 
TLPLQWGFSG ANLVQVEALG KGSDSPEDLG AITMLNQQET VAMDMDRNAT PDLPIFLPKP 
PNTVATYSSP LLGPEPHSST SCGLEVQGAT PILTLDSGHT PQLPPNPESS SVPLVIAANG 
TRAEKQFGTS LFPAVPQGFT VAAENEVQHA PLDLTQGSQA APSKLEGEIS RVSITGSADV 
KATAMSMPVT QASTSSPPCN STPPMVERRK RKACGVCEPC QQKANCGECT YCKNRKNSHQ 
ICKKRKCEVL KKKPEATSQA QVTKENKRPQ REKKPKVLKT DFNNKPVNGP KSESMDCSRR 
GHGEEEQRLD LITHPLENVR KNAGGMTGIE VEKWAPNKKS HLAEGQVKGS CDANLTGVEN 
PQPSEDDKQQ TNPSPTFAQT IRNGMKNVHC LPTDTHLPLN KLNHEEFSKA LGNNSSKLLT 
DPSNCKDAMS VTTSGGECDH LKGPRNTLLF QKPGLNCRSG AEPTIFNNHP NTHSAGSRPH 
PPEKVPNKEP KDGSPVQPSL LSLMKDRRLT LEQVVAIEAL TQLSEAPSES SSPSKPEKDE 
EAHQKTASLL NSCKAILHSV RKDLQDPNVQ GKGLHHDTVV FNGQNRTFKS PDSFATNQAL 
IKSQGYPSSP TAEKKGAAGG RAPFDGFENS HPLPIESHNL ENCSQVLSCD QNLSSHDPSC 
QDAPYSQIEE DVAAQLTQLA STINHINAEV RNAESTPESL VAKNTKQKHS QEKRMVHQKP 
PSSTQTKPSV PSAKPKKAQK KARATPHANK RKKKPPARSS QENDQKKQEQ LAIEYSKMHD 
IWMSSKFQRF GQSSPRSFPV LLRNIPVFNQ ILKPVTQSKT PSQHNELFPP INQIKFTRNP 
ELAKEKVKVE PSDSLPTCQF KTESGGQTFA EPADNSQGQP MVSVNQEAHP LPQSPPSNQC 
ANIMAGAAQT QFHLGAQENL VHQIPPPTLP GTSPDTLLPD PASILRKGKV LHFDGITVVT 
EKREAQTSSN GPLGPTTDSA QSEFKESIMD LLSKPAKNLI AGLKEQEAAP CDCDGGTQKE 
KGPYYTHLGA GPSVAAVREL METRFGQKGK AIRIEKIVFT GKEGKSSQGC PVAKWVIRRS 
GPEEKLICLV RERVDHHCST AVIVVLILLW EGIPRLMADR LYKELTENLR SYSGHPTDRR 
CTLNKKRTCT CQGIDPKTCG ASFSFGCSWS MYFNGCKFGR SENPRKFRLA PNYPLHNYYK 
RITGMSSEGS DVKTGWIIPD RKTLISREEK QLEKNLQELA TVLAPLYKQM APVAYQNQVE 
YEEVAGDCRL GNEEGRPFSG VTCCMDFCAH SHKDIHNMHN GSTVVCTLIR ADGRDTNCPE 
DEQLHVLPLY RLADTDEFGS VEGMKAKIKS GAIQVNGPTR KRRLRFTEPV PRCGKRAKMK 
QNHNKSGSHN TKSFSSASST SHLVKDESTD FCPLQASSAE TSTCTYSKTA SGGFAETSSI 
LHCTMPSGAH SGANAAAGEC TGTVQPAEVA AHPHQSLPTA DSPVHAEPLT SPSEQLTSNQ 
SNQQLPLLSN SQKLASCQVE DERHPEADEP QHPEDDNLPQ LDEFWSDSEE IYADPSFGGV 
AIAPIHGSVL IECARKELHA TTSLRSPKRG VPFRVSLVFY QHKSLNKPNH GFDINKIKCK 
CKKVTKKKPA DRECPDVSPE ANLSHQIPSR VASTLTRDNV VTVSPYSLTH VAGPYNRWV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.