Slc46a1 | ENSMUSG00000020829 | NCBI 52466

Details for: Slc46a1

Gene ID: 52466

Symbol: Slc46a1

Ensembl ID: ENSMUSG00000020829

Description: solute carrier family 46, member 1

Associated with

Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Heme signaling
(R-MMU-9707616)
Iron uptake and transport
(R-MMU-917937)
Metabolism
(R-MMU-1430728)
Metabolism of folate and pterines
(R-MMU-196757)
Metabolism of vitamins and cofactors
(R-MMU-196854)
Metabolism of water-soluble vitamins and cofactors
(R-MMU-196849)
Transport of small molecules
(R-MMU-382551)
Apical plasma membrane
(GO:0016324)
Basolateral plasma membrane
(GO:0016323)
Brush border membrane
(GO:0031526)
Cytoplasm
(GO:0005737)
Endosome
(GO:0005768)
Endosome membrane
(GO:0010008)
Folate import across plasma membrane
(GO:1904447)
Folate transmembrane transport
(GO:0098838)
Folic acid:proton symporter activity
(GO:0140211)
Folic acid binding
(GO:0005542)
Folic acid transmembrane transporter activity
(GO:0008517)
Folic acid transport
(GO:0015884)
Heme transmembrane transporter activity
(GO:0015232)
Heme transport
(GO:0015886)
Methotrexate transmembrane transporter activity
(GO:0015350)
Methotrexate transport
(GO:0051958)
Plasma membrane
(GO:0005886)
Proton transmembrane transport
(GO:1902600)
Proton transmembrane transporter activity
(GO:0015078)
Symporter activity
(GO:0015293)
Transmembrane transport
(GO:0055085)
Transmembrane transporter activity
(GO:0022857)

Other Information

Proteins

PCFT_MOUSE

Genular Protein ID: 1136044445

Symbol: PCFT_MOUSE

Name: N/A

UniProtKB Accession Codes:

Q6PEM8 Q571I8 Q5SYG0 Q8R1H7 Q9D1P1

Database IDs:

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16143108

Title: Identification of an intestinal heme transporter.

PubMed ID: 16143108

DOI: 10.1016/j.cell.2005.06.025

PubMed ID: 17962486

Title: Cloning and functional characterization of the proton-coupled electrogenic folate transporter and analysis of its expression in retinal cell types.

PubMed ID: 17962486

DOI: 10.1167/iovs.07-0288

PubMed ID: 19144319

Title: The phagosomal proteome in interferon-gamma-activated macrophages.

PubMed ID: 19144319

DOI: 10.1016/j.immuni.2008.11.006

PubMed ID: 19074442

Title: A role for the proton-coupled folate transporter (PCFT-SLC46A1) in folate receptor-mediated endocytosis.

PubMed ID: 19074442

DOI: 10.1074/jbc.m807665200

PubMed ID: 19349973

Title: Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.

PubMed ID: 19349973

DOI: 10.1038/nbt.1532

PubMed ID: 21346251

Title: A mouse model of hereditary folate malabsorption: deletion of the PCFT gene leads to systemic folate deficiency.

PubMed ID: 21346251

DOI: 10.1182/blood-2010-04-279653

PubMed ID: 22058337

Title: Polarized distribution of heme transporters in retinal pigment epithelium and their regulation in the iron-overload disease hemochromatosis.

PubMed ID: 22058337

DOI: 10.1167/iovs.11-8264

Sequence Information:

Length: 459
Mass: 50089
Checksum: A251124B3B9846AF
Sequence:

MEGRVSSVGS PHSFLNAPVL FRGPVEPLVF LANFALVLQG PLTTQYLWHR FSTELGYNGT 
RHRENCGNQS ADPLMKEVET LTSHWTLYMN VGGFLVGLFW STLLGAWSDR VGRRPLLVLA 
SLGLLLQAVV SIFVVQLELH VGFFVLGRAL CALLGDFNGL LAASFASVAD VSSNHSRTFR 
MALLEACIGV AGTLASLLGG HWLRAQGYAN PFWLALALLI VMALYAAFCF GETVKEPKST 
RLFTLRHHRS IARLYVVPAP EKSRMHLALY SLAIFVVVTV HFGAQDILTL YELSAPLCWD 
SKLIGYGSAA QHLPYLTSLL GLRLLQFCLA DTWVAEIGLA FNILGMVVFA FATITPLMFT 
GYGLLFLSLV TTPVIRAKLS KLVSESEQGA LFSAVACVNS LAMLMASGIF NSIYPATLNF 
MKGFPFLLGA GLLFIPAILI GVLEKVNPHP EFQQFPQSP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Slc46a1

Associated with

Other Information

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Identification of an intestinal heme transporter. PubMed ID: 16143108

Cloning and functional characterization of the proton-coupled electrogenic folate transporter and analysis of its expression in retinal cell types. PubMed ID: 17962486

The phagosomal proteome in interferon-gamma-activated macrophages. PubMed ID: 19144319

A role for the proton-coupled folate transporter (PCFT-SLC46A1) in folate receptor-mediated endocytosis. PubMed ID: 19074442

Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins. PubMed ID: 19349973

A mouse model of hereditary folate malabsorption: deletion of the PCFT gene leads to systemic folate deficiency. PubMed ID: 21346251

Polarized distribution of heme transporters in retinal pigment epithelium and their regulation in the iron-overload disease hemochromatosis. PubMed ID: 22058337