ATP6V1B2 | ENSG00000147416 | NCBI 526

Details for: ATP6V1B2

Associated with

Amino acids regulate mtorc1
(R-HSA-9639288)
Cellular responses to stimuli
(R-HSA-8953897)
Cellular responses to stress
(R-HSA-2262752)
Cellular response to starvation
(R-HSA-9711097)
Developmental biology
(R-HSA-1266738)
Immune system
(R-HSA-168256)
Innate immune system
(R-HSA-168249)
Insulin receptor recycling
(R-HSA-77387)
Ion channel transport
(R-HSA-983712)
Iron uptake and transport
(R-HSA-917937)
Mitf-m-dependent gene expression
(R-HSA-9856651)
Mitf-m-regulated melanocyte development
(R-HSA-9730414)
Regulation of mitf-m-dependent genes involved in lysosome biogenesis and autophagy
(R-HSA-9857377)
Ros and rns production in phagocytes
(R-HSA-1222556)
Signaling by insulin receptor
(R-HSA-74752)
Signaling by receptor tyrosine kinases
(R-HSA-9006934)
Signal transduction
(R-HSA-162582)
Transferrin endocytosis and recycling
(R-HSA-917977)
Transport of small molecules
(R-HSA-382551)
Apical plasma membrane
(GO:0016324)
Atp binding
(GO:0005524)
Atp metabolic process
(GO:0046034)
Clathrin-coated vesicle membrane
(GO:0030665)
Cytosol
(GO:0005829)
Extracellular exosome
(GO:0070062)
Extrinsic component of synaptic vesicle membrane
(GO:0098850)
Intracellular membrane-bounded organelle
(GO:0043231)
Lysosomal membrane
(GO:0005765)
Melanosome
(GO:0042470)
Microvillus
(GO:0005902)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Proton-transporting atpase activity, rotational mechanism
(GO:0046961)
Proton transmembrane transport
(GO:1902600)
Proton transmembrane transporter activity
(GO:0015078)
Regulation of macroautophagy
(GO:0016241)
Ruffle
(GO:0001726)
Synaptic vesicle lumen acidification
(GO:0097401)
Vacuolar acidification
(GO:0007035)
Vacuolar proton-transporting v-type atpase, v1 domain
(GO:0000221)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

elicited macrophage CL0000861

CSI 38.43

rCSI 35.28%

PRS 55.92
melanocyte of skin CL1000458

CSI 21.97

rCSI 29.95%

PRS 24.56
amacrine cell CL0000561

CSI 20.13

rCSI 58.33%

PRS 39.31
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 19.18

rCSI 23.24%

PRS 41.55
basal cell of epidermis CL0002187

CSI 17.11

rCSI 30.32%

PRS 29.02
CD14-low, CD16-positive monocyte CL0002396

CSI 17.03

rCSI 13.12%

PRS 47.17
megakaryocyte-erythroid progenitor cell CL0000050

CSI 16.5

rCSI 14.9%

PRS 44.84
melanocyte CL0000148

CSI 16.15

rCSI 11.96%

PRS 41.63
Hofbauer cell CL3000001

CSI 15.49

rCSI 29.25%

PRS 58.6
promonocyte CL0000559

CSI 15.35

rCSI 26.29%

PRS 57.6
blood vessel endothelial cell CL0000071

CSI 9.82

rCSI 20.38%

PRS 46.08
early lymphoid progenitor CL0000936

CSI 9.49

rCSI 8.34%

PRS 53.34
retinal ganglion cell CL0000740

CSI 9.38

rCSI 20.72%

PRS 36.09
lung neuroendocrine cell CL1000223

CSI 9.33

rCSI 13.8%

PRS 53.4
L2/3 intratelencephalic projecting glutamatergic neuron CL4030059

CSI 8

rCSI 17.36%

PRS 38.01
colon macrophage CL0009038

CSI 7.92

rCSI 36.59%

PRS 70.09
mesenchymal cell CL0008019

CSI 7.82

rCSI 19.85%

PRS 43.71
myeloid leukocyte CL0000766

CSI 7.72

rCSI 7.12%

PRS 48.92
helper T cell CL0000912

CSI 7.58

rCSI 10.72%

PRS 56.12
vascular associated smooth muscle cell CL0000359

CSI 7.08

rCSI 22.96%

PRS 50.68
hematopoietic stem cell CL0000037

CSI 6.57

rCSI 4.37%

PRS 51.83
pancreatic D cell CL0000173

CSI 6.37

rCSI 6.26%

PRS 50.78
cytotoxic T cell CL0000910

CSI 6.18

rCSI 35.4%

PRS 59.67
alternatively activated macrophage CL0000890

CSI 6.15

rCSI 7.74%

PRS 61.63
cerebral cortex endothelial cell CL1001602

CSI 6.09

rCSI 10.54%

PRS 38.86
chondrocyte CL0000138

CSI 5.84

rCSI 9.29%

PRS 41.07
CD1c-positive myeloid dendritic cell CL0002399

CSI 5.78

rCSI 6.98%

PRS 56.24
suprabasal keratinocyte CL4033013

CSI 5.75

rCSI 9.39%

PRS 25.35
cerebral cortex neuron CL0010012

CSI 5.72

rCSI 23.32%

PRS 44.99
bronchus fibroblast of lung CL2000093

CSI 5.42

rCSI 4.4%

PRS 48.83
conventional dendritic cell CL0000990

CSI 5.37

rCSI 4.48%

PRS 66.93
OFF-bipolar cell CL0000750

CSI 5.18

rCSI 7.08%

PRS 57.59
pulmonary capillary endothelial cell CL4028001

CSI 5.03

rCSI 9.59%

PRS 65.11
dendritic cell CL0000451

CSI 5.01

rCSI 6.18%

PRS 69.91
ciliated epithelial cell CL0000067

CSI 4.9

rCSI 4.31%

PRS 37.18
interneuron CL0000099

CSI 4.85

rCSI 9.73%

PRS 37.92
astrocyte of the cerebral cortex CL0002605

CSI 4.61

rCSI 10.33%

PRS 32.81
goblet cell CL0000160

CSI 4.61

rCSI 4.35%

PRS 48.9
platelet CL0000233

CSI 4.36

rCSI 18.1%

PRS 56.9
retinal cone cell CL0000573

CSI 4.35

rCSI 7%

PRS 38.74
neutrophil CL0000775

CSI 4.27

rCSI 23.88%

PRS 59.45
inflammatory macrophage CL0000863

CSI 4.2

rCSI 7.17%

PRS 74.32
myofibroblast cell CL0000186

CSI 4.18

rCSI 5.79%

PRS 52.5
skin fibroblast CL0002620

CSI 4.07

rCSI 3.51%

PRS 56.21
CD14-positive, CD16-positive monocyte CL0002397

CSI 4.05

rCSI 5.3%

PRS 61.5
radial glial cell CL0000681

CSI 4.02

rCSI 5.58%

PRS 47.58
retinal rod cell CL0000604

CSI 4

rCSI 7.05%

PRS 46.17
CD8-positive, alpha-beta cytotoxic T cell CL0000794

CSI 3.81

rCSI 4.55%

PRS 68.5
enteroendocrine cell CL0000164

CSI 3.8

rCSI 5.19%

PRS 50.68
double negative thymocyte CL0002489

CSI 3.76

rCSI 2.61%

PRS 57.34
renal principal cell CL0005009

CSI 3.7

rCSI 9.61%

PRS 53.06
tracheobronchial smooth muscle cell CL0019019

CSI 3.64

rCSI 6.41%

PRS 56.45
alveolar type 1 fibroblast cell CL4028004

CSI 3.62

rCSI 3.97%

PRS 52.09
intermediate monocyte CL0002393

CSI 3.52

rCSI 5.31%

PRS 50.52
non-classical monocyte CL0000875

CSI 3.48

rCSI 5.58%

PRS 75.34
glioblast CL0000030

CSI 3.41

rCSI 5.45%

PRS 41.86
macrophage CL0000235

CSI 3.41

rCSI 6.2%

PRS 74.19
alveolar macrophage CL0000583

CSI 3.37

rCSI 5.55%

PRS 53.72
effector CD8-positive, alpha-beta T cell CL0001050

CSI 3.32

rCSI 2.53%

PRS 59.89
fibroblast of lung CL0002553

CSI 3.25

rCSI 3.02%

PRS 47.86
monocyte CL0000576

CSI 3.24

rCSI 5.85%

PRS 68.47
Kupffer cell CL0000091

CSI 3.21

rCSI 7.34%

PRS 47.56
stem cell CL0000034

CSI 3.2

rCSI 3.09%

PRS 38.87
enterocyte CL0000584

CSI 3.16

rCSI 5.1%

PRS 55.93
dendritic cell, human CL0001056

CSI 3.14

rCSI 4.82%

PRS 55.5
pancreatic PP cell CL0002275

CSI 3.13

rCSI 12.46%

PRS 63.61
mature B cell CL0000785

CSI 3.11

rCSI 2.7%

PRS 57.9
lung interstitial macrophage CL4033043

CSI 3.05

rCSI 6.86%

PRS 67.75
duct epithelial cell CL0000068

CSI 2.96

rCSI 4.32%

PRS 51.5
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 2.88

rCSI 7.01%

PRS 31.05
pancreatic ductal cell CL0002079

CSI 2.87

rCSI 5.59%

PRS 50.37
CD14-positive monocyte CL0001054

CSI 2.87

rCSI 3.58%

PRS 59.5
mononuclear phagocyte CL0000113

CSI 2.86

rCSI 6.3%

PRS 52.28
extravillous trophoblast CL0008036

CSI 2.83

rCSI 3.5%

PRS 44.01
keratinocyte CL0000312

CSI 2.68

rCSI 2.25%

PRS 53.04
naive T cell CL0000898

CSI 2.63

rCSI 1.83%

PRS 61.38
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 2.62

rCSI 1.76%

PRS 59.2
epithelial cell of proximal tubule CL0002306

CSI 2.61

rCSI 6.38%

PRS 43.65
epithelial cell of lower respiratory tract CL0002632

CSI 2.61

rCSI 2.02%

PRS 48.86
colonocyte CL1000347

CSI 2.57

rCSI 3.69%

PRS 54.66
pulmonary ionocyte CL0017000

CSI 2.56

rCSI 3.11%

PRS 55.92
hepatic stellate cell CL0000632

CSI 2.55

rCSI 9.55%

PRS 41.07
neuroblast (sensu Vertebrata) CL0000031

CSI 2.53

rCSI 3.25%

PRS 46.13
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 2.51

rCSI 4.43%

PRS 31.05
syncytiotrophoblast cell CL0000525

CSI 2.5

rCSI 7.21%

PRS 65.26
mucus secreting cell CL0000319

CSI 2.5

rCSI 3.97%

PRS 59.15
placental villous trophoblast CL2000060

CSI 2.45

rCSI 3.78%

PRS 45.91
cerebral cortex GABAergic interneuron CL0010011

CSI 2.42

rCSI 7.14%

PRS 52.14
ON-bipolar cell CL0000749

CSI 2.41

rCSI 3.59%

PRS 50.36
perivascular cell CL4033054

CSI 2.41

rCSI 3.29%

PRS 53.23
cerebellar granule cell CL0001031

CSI 2.4

rCSI 3.52%

PRS 43.39
plasmacytoid dendritic cell, human CL0001058

CSI 2.35

rCSI 1.64%

PRS 50.12
CD4-positive helper T cell CL0000492

CSI 2.3

rCSI 1.74%

PRS 61
activated type II NK T cell CL0000931

CSI 2.29

rCSI 2.58%

PRS 64.74
neural crest cell CL0011012

CSI 2.29

rCSI 1.81%

PRS 35.82
pancreatic A cell CL0000171

CSI 2.22

rCSI 2.33%

PRS 51.36
colon epithelial cell CL0011108

CSI 2.22

rCSI 2.33%

PRS 45.18
innate lymphoid cell CL0001065

CSI 2.22

rCSI 4.58%

PRS 53.37
Mueller cell CL0000636

CSI 2.2

rCSI 5.03%

PRS 41.39
kidney interstitial alternatively activated macrophage CL1000695

CSI 2.19

rCSI 5.72%

PRS 47.41

OFF midget ganglion cell CL4033047

CSI 0.2

rCSI 4.7%

PRS 41.6%
ON midget ganglion cell CL4033046

CSI 0.2

rCSI 4.7%

PRS 40.4%
metallothionein-positive alveolar macrophage CL4033042

CSI 0.3

rCSI 3.2%

PRS 76.5%
ON parasol ganglion cell CL4033052

CSI 0.3

rCSI 4.3%

PRS 40.3%
P/D1 enteroendocrine cell CL0002268

CSI 0.3

rCSI 1.7%

PRS 69.6%
kidney connecting tubule epithelial cell CL1000768

CSI 0.4

rCSI 0.9%

PRS 38.5%
eosinophil CL0000771

CSI 0.4

rCSI 2.5%

PRS 78.5%
H2 horizontal cell CL0004218

CSI 0.5

rCSI 2.6%

PRS 47.3%
central nervous system neuron CL2000029

CSI 0.6

rCSI 4.0%

PRS 36.1%
enteroendocrine cell of colon CL0009042

CSI 0.6

rCSI 2.7%

PRS 72.4%
indirect pathway medium spiny neuron CL4023029

CSI 0.6

rCSI 14.0%

PRS 32.4%
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 0.6

rCSI 3.6%

PRS 71.8%
GABAergic amacrine cell CL4030027

CSI 0.6

rCSI 2.1%

PRS 39.1%
direct pathway medium spiny neuron CL4023026

CSI 0.6

rCSI 15.0%

PRS 31.5%
pancreatic stellate cell CL0002410

CSI 0.7

rCSI 4.0%

PRS 58.8%
near-projecting glutamatergic cortical neuron CL4023012

CSI 0.7

rCSI 2.6%

PRS 32.9%
eye photoreceptor cell CL0000287

CSI 0.7

rCSI 7.9%

PRS 71.7%
type EC enteroendocrine cell CL0000577

CSI 0.7

rCSI 2.6%

PRS 60.4%
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 0.7

rCSI 2.4%

PRS 36.7%
myeloid dendritic cell, human CL0001057

CSI 0.8

rCSI 4.3%

PRS 78.0%
neural progenitor cell CL0011020

CSI 0.8

rCSI 3.6%

PRS 41.2%
pancreatic epsilon cell CL0005019

CSI 0.8

rCSI 3.9%

PRS 70.2%
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 0.9

rCSI 2.7%

PRS 35.7%
L6b glutamatergic cortical neuron CL4023038

CSI 0.9

rCSI 2.7%

PRS 33.3%
tissue-resident macrophage CL0000864

CSI 0.9

rCSI 4.2%

PRS 66.0%
type B pancreatic cell CL0000169

CSI 0.9

rCSI 2.0%

PRS 45.7%
H1 horizontal cell CL0004217

CSI 0.9

rCSI 3.6%

PRS 49.8%
lung ciliated cell CL1000271

CSI 0.9

rCSI 1.1%

PRS 38.3%
megakaryocyte CL0000556

CSI 1.0

rCSI 4.2%

PRS 63.6%
retinal bipolar neuron CL0000748

CSI 1.1

rCSI 2.1%

PRS 37.7%
cardiac muscle cell CL0000746

CSI 1.1

rCSI 1.6%

PRS 39.2%
alveolar adventitial fibroblast CL4028006

CSI 1.1

rCSI 1.8%

PRS 49.3%
promyelocyte CL0000836

CSI 1.2

rCSI 1.7%

PRS 58.1%
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 1.2

rCSI 6.9%

PRS 33.4%
sncg GABAergic cortical interneuron CL4023015

CSI 1.2

rCSI 2.0%

PRS 34.2%
lamp5 GABAergic cortical interneuron CL4023011

CSI 1.2

rCSI 2.1%

PRS 32.0%
conjunctival epithelial cell CL1000432

CSI 1.2

rCSI 1.9%

PRS 48.7%
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 1.3

rCSI 4.5%

PRS 30.9%
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 1.3

rCSI 3.1%

PRS 37.2%
paneth cell CL0000510

CSI 1.3

rCSI 1.9%

PRS 65.7%
enteroendocrine cell of small intestine CL0009006

CSI 1.3

rCSI 2.8%

PRS 63.0%
granulocyte CL0000094

CSI 1.3

rCSI 2.0%

PRS 57.5%
multi-ciliated epithelial cell CL0005012

CSI 1.3

rCSI 1.3%

PRS 42.3%
retinal blood vessel endothelial cell CL0002585

CSI 1.3

rCSI 2.1%

PRS 52.2%
professional antigen presenting cell CL0000145

CSI 1.3

rCSI 4.5%

PRS 78.2%
erythrocyte CL0000232

CSI 1.3

rCSI 3.0%

PRS 53.4%
club cell CL0000158

CSI 1.4

rCSI 2.0%

PRS 46.9%
podocyte CL0000653

CSI 1.4

rCSI 6.0%

PRS 47.0%
mature alpha-beta T cell CL0000791

CSI 1.4

rCSI 4.9%

PRS 67.6%
VIP GABAergic cortical interneuron CL4023016

CSI 1.4

rCSI 1.6%

PRS 31.9%
CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920

CSI 1.4

rCSI 2.8%

PRS 66.2%
hepatocyte CL0000182

CSI 1.4

rCSI 2.5%

PRS 46.7%
retinal pigment epithelial cell CL0002586

CSI 1.4

rCSI 2.8%

PRS 47.1%
peripheral nervous system neuron CL2000032

CSI 1.5

rCSI 2.0%

PRS 41.2%
choroid plexus epithelial cell CL0000706

CSI 1.5

rCSI 2.4%

PRS 38.6%
pancreatic acinar cell CL0002064

CSI 1.5

rCSI 1.9%

PRS 53.3%
pvalb GABAergic cortical interneuron CL4023018

CSI 1.5

rCSI 1.8%

PRS 30.4%
muscle cell CL0000187

CSI 1.5

rCSI 3.1%

PRS 69.7%
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 1.6

rCSI 8.2%

PRS 59.5%
Langerhans cell CL0000453

CSI 1.6

rCSI 2.5%

PRS 65.3%
sst GABAergic cortical interneuron CL4023017

CSI 1.7

rCSI 2.2%

PRS 33.0%
type L enteroendocrine cell CL0002279

CSI 1.7

rCSI 3.2%

PRS 67.1%
squamous epithelial cell CL0000076

CSI 1.7

rCSI 4.1%

PRS 53.7%
vascular leptomeningeal cell CL4023051

CSI 1.8

rCSI 3.1%

PRS 40.5%
intestinal epithelial cell CL0002563

CSI 1.8

rCSI 1.9%

PRS 47.4%
myeloid dendritic cell CL0000782

CSI 1.9

rCSI 2.7%

PRS 64.6%
transit amplifying cell of colon CL0009011

CSI 1.9

rCSI 2.2%

PRS 51.5%
neuroblast (sensu Nematoda and Protostomia) CL0000338

CSI 1.9

rCSI 2.2%

PRS 42.3%
retina horizontal cell CL0000745

CSI 1.9

rCSI 2.9%

PRS 44.7%
neuron CL0000540

CSI 1.9

rCSI 5.0%

PRS 39.8%
pro-B cell CL0000826

CSI 1.9

rCSI 1.6%

PRS 49.4%
granulocyte monocyte progenitor cell CL0000557

CSI 1.9

rCSI 1.7%

PRS 52.2%
rod bipolar cell CL0000751

CSI 1.9

rCSI 3.5%

PRS 41.5%
epithelial cell of lung CL0000082

CSI 2.0

rCSI 1.7%

PRS 46.8%
intestinal tuft cell CL0019032

CSI 2.0

rCSI 3.1%

PRS 53.0%
inhibitory interneuron CL0000498

CSI 2.1

rCSI 4.9%

PRS 39.3%
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 2.1

rCSI 3.0%

PRS 45.0%
lung macrophage CL1001603

CSI 2.2

rCSI 4.8%

PRS 54.9%
common myeloid progenitor CL0000049

CSI 2.2

rCSI 1.8%

PRS 48.9%
intestine goblet cell CL0019031

CSI 2.2

rCSI 1.9%

PRS 47.0%
kidney interstitial alternatively activated macrophage CL1000695

CSI 2.2

rCSI 5.7%

PRS 47.4%
Mueller cell CL0000636

CSI 2.2

rCSI 5.0%

PRS 41.4%
innate lymphoid cell CL0001065

CSI 2.2

rCSI 4.6%

PRS 53.4%
colon epithelial cell CL0011108

CSI 2.2

rCSI 2.3%

PRS 45.2%
pancreatic A cell CL0000171

CSI 2.2

rCSI 2.3%

PRS 51.4%
neural crest cell CL0011012

CSI 2.3

rCSI 1.8%

PRS 35.8%
activated type II NK T cell CL0000931

CSI 2.3

rCSI 2.6%

PRS 64.7%
CD4-positive helper T cell CL0000492

CSI 2.3

rCSI 1.7%

PRS 61.0%
plasmacytoid dendritic cell, human CL0001058

CSI 2.4

rCSI 1.6%

PRS 50.1%
cerebellar granule cell CL0001031

CSI 2.4

rCSI 3.5%

PRS 43.4%
perivascular cell CL4033054

CSI 2.4

rCSI 3.3%

PRS 53.2%
ON-bipolar cell CL0000749

CSI 2.4

rCSI 3.6%

PRS 50.4%
cerebral cortex GABAergic interneuron CL0010011

CSI 2.4

rCSI 7.1%

PRS 52.1%
placental villous trophoblast CL2000060

CSI 2.5

rCSI 3.8%

PRS 45.9%
mucus secreting cell CL0000319

CSI 2.5

rCSI 4.0%

PRS 59.2%
syncytiotrophoblast cell CL0000525

CSI 2.5

rCSI 7.2%

PRS 65.3%
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 2.5

rCSI 4.4%

PRS 31.1%
neuroblast (sensu Vertebrata) CL0000031

CSI 2.5

rCSI 3.3%

PRS 46.1%
hepatic stellate cell CL0000632

CSI 2.6

rCSI 9.6%

PRS 41.1%
pulmonary ionocyte CL0017000

CSI 2.6

rCSI 3.1%

PRS 55.9%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

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Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary Analyzed for its expression specificity (CSI Z-SCORE), **[ATP6V1B2](/details-gene/526)** is identified not as a cell-type-specific marker but as a broadly expressed and functionally essential component of the vacuolar H+-ATPase (V-ATPase) proton pump. Its consistent expression across a diverse range of cell types, including immune, neuronal, and epithelial lineages, underscores its fundamental role in core cellular processes such as organelle acidification, protein trafficking, and autophagy. This profile suggests that while its function is critical, it is not uniquely enriched to define any single cell type, but rather serves as a vital 'housekeeping' gene involved in maintaining cellular homeostasis. Genetic mutations in [ATP6V1B2](/details-gene/526) are linked to rare developmental disorders, including deafness-onychodystrophy syndrome ([124480](https://omim.org/entry/124480)), confirming its non-redundant role in human physiology. ## Cellular Roles and Expression Landscape The expression profile of [ATP6V1B2](/details-gene/526), when assessed for specificity, reveals its widespread importance across numerous cell lineages rather than a role as a distinguishing marker. In the **Overall** context, the CSI (Z-SCORE) is 0.00 for all top-expressing cells, and the percentile rank scores (PRS) are moderate (ranging from ~24% to ~59%). This pattern indicates that while [ATP6V1B2](/details-gene/526) is abundantly expressed in these cells, its expression is not sufficiently unique to differentiate them from other cell types. The maximal effect size (deltaVal: 1.00) across these cells suggests that its expression is consistently elevated above a baseline, but this pattern is shared by many cells, thus resulting in low specificity. This broad expression pattern spans functionally distinct cell types, highlighting its conserved role: * **Immune Cells:** High expression is noted in myeloid cells such as [elicited macrophage](/details-cell/CL0000861), [Hofbauer cell](/details-cell/CL3000001), and [promonocyte](/details-cell/CL0000559). This is consistent with the critical function of V-ATPases in acidifying phagosomes and lysosomes, a key step in antigen processing and pathogen clearance. * **Pigment Cells:** Expression in [melanocyte of skin](/details-cell/CL1000458) aligns with literature demonstrating the role of V-ATPases in acidifying melanosomes, which is essential for melanin synthesis and maturation ([PubMed: 12643545](https://pubmed.ncbi.nlm.nih.gov/12643545)). * **Nervous System:** Presence in neuronal types like [amacrine cell](/details-cell/CL0000561), [retinal ganglion cell](/details-cell/CL0000740), and [L2/3 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4030059) points to its role in synaptic vesicle acidification ([GO:0097401](https://www.ebi.ac.uk/QuickGO/term/GO:0097401)), a prerequisite for neurotransmitter loading and signaling. * **Epithelial and Progenitor Cells:** Expression in [basal cell of epidermis](/details-cell/CL0002187) and [megakaryocyte-erythroid progenitor cell](/details-cell/CL0000050) suggests a foundational role in cellular maintenance, trafficking, and developmental processes. In summary, the lack of specificity (low Z-score) combined with broad, consistent expression across diverse lineages solidifies the role of [ATP6V1B2](/details-gene/526) as a ubiquitous and essential component of cellular machinery. ## Pathways and Molecular Function The functional annotations for [ATP6V1B2](/details-gene/526) strongly corroborate its observed expression pattern as a fundamental cellular workhorse. As a subunit of the V-ATPase complex, its primary molecular functions involve '[Proton transmembrane transporter activity](/details-go/GO:0015078)' and '[Proton-transporting atpase activity, rotational mechanism](/details-go/GO:0046961)'. These activities are integral to the biological process of '[Proton transmembrane transport](/details-go/GO:1902600)', which is essential for acidifying various intracellular compartments. This core function supports a wide array of cellular pathways: * **Organelle Homeostasis:** The gene is crucial for '[Vacuolar acidification](/details-go/GO:0007035)' and is a key component of the '[Lysosomal membrane](/details-go/GO:0005765)'. This acidification is vital for the activity of lysosomal hydrolases and for processes like '[Regulation of macroautophagy](/details-go/GO:0016241)' and receptor-mediated endocytosis, such as '[Transferrin endocytosis and recycling](/details-reactome/R-HSA-917977)'. * **Immune Function:** Its involvement in the '[Innate immune system](/details-reactome/R-HSA-168249)' pathway is directly linked to the requirement for phagolysosomal acidification in macrophages and other phagocytes to destroy pathogens and process antigens. * **Metabolic Regulation:** Reactome pathways such as '[Amino acids regulate mtorc1](/details-reactome/R-HSA-9639288)' and '[Cellular response to starvation](/details-reactome/R-HSA-9711097)' highlight a role for V-ATPase in nutrient sensing. Lysosomal acidification is a critical upstream signal for the mTORC1 complex, linking cellular catabolism to growth signals. * **Specialized Cellular Functions:** Pathways like '[Mitf-m-regulated melanocyte development](/details-reactome/R-HSA-9730414)' explain its role in melanocytes, where melanosome pH is critical. Similarly, its role in '[Synaptic vesicle lumen acidification](/details-go/GO:0097401)' is central to its function in neurons. The extensive involvement of [ATP6V1B2](/details-gene/526) in these foundational pathways explains why it is broadly expressed and why its disruption leads to systemic disease, as seen in Zimmermann-Laband syndrome ([PubMed: 25915598](https://pubmed.ncbi.nlm.nih.gov/25915598)). ## Research Directions Despite its well-established core function, the widespread expression of [ATP6V1B2](/details-gene/526) across diverse cell types raises questions about its cell-context-specific regulation and interacting partners. Understanding these nuances could provide insights into disease mechanisms and therapeutic opportunities. ### Testable Hypotheses 1. **Hypothesis:** The functional activity of the ATP6V1B2-containing V-ATPase complex in neurons is modulated by cell-type-specific interacting proteins that couple synaptic activity to autophagic flux. Dysregulation of these interactions in cells like the [amacrine cell](/details-cell/CL0000561) may contribute to retinal neurodegenerative disorders. * **Experimental Approach:** Perform immunoprecipitation of ATP6V1B2 from isolated retinal amacrine cells followed by mass spectrometry (IP-MS) to identify unique binding partners. Subsequently, use proximity ligation assays (PLA) to validate these interactions in situ and utilize siRNA-mediated knockdown of candidate interactors to assess changes in autophagic markers (e.g., LC3-II/p62 ratio) under conditions of stimulated synaptic activity. 2. **Hypothesis:** During the differentiation of a [promonocyte](/details-cell/CL0000559) into a mature [elicited macrophage](/details-cell/CL0000861), the subcellular localization of ATP6V1B2 is dynamically regulated, shifting from predominantly Golgi/ER localization to plasma membrane and phagosomal membranes to support mature phagocytic function. * **Experimental Approach:** Induce differentiation of a human monocyte cell line (e.g., THP-1). Use super-resolution microscopy and immunofluorescence to track the subcellular localization of endogenous ATP6V1B2 at different time points of differentiation. Cell surface biotinylation assays could be used to quantify its translocation to the plasma membrane. 3. **Hypothesis:** In [melanocyte of skin](/details-cell/CL1000458), the transcriptional expression of [ATP6V1B2](/details-gene/526) is directly co-regulated with key melanogenesis enzymes (e.g., TYR, TYRP1) by the master regulator MITF, and this co-regulation is essential for coordinating melanosome acidification with melanin synthesis. * **Experimental Approach:** Use CRISPRi to knockdown MITF in a human melanocyte cell line and perform qPCR and Western blot to quantify concomitant changes in [ATP6V1B2](/details-gene/526), TYR, and TYRP1 expression. Furthermore, use chromatin immunoprecipitation sequencing (ChIP-seq) for MITF to determine if it directly binds to regulatory regions of the [ATP6V1B2](/details-gene/526) gene. ### Therapeutic Potential Given its ubiquitous and essential nature, [ATP6V1B2](/details-gene/526) itself is a challenging therapeutic target for systemic inhibition. However, its role in specific cellular contexts presents opportunities. For instance, V-ATPase inhibitors are known to disrupt lysosomal function and are explored in oncology to sensitize cancer cells to stress. Understanding how to selectively modulate ATP6V1B2 activity or its specific protein-protein interactions in target cells, such as malignant melanocytes or hyper-activated macrophages, could offer a more nuanced therapeutic window, potentially avoiding the toxicity associated with systemic V-ATPase inhibition. For the associated genetic disorders, gene therapy represents a potential long-term corrective strategy.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

V-type proton ATPase subunit B, brain isoform

Genular Protein ID: 2685274077

Symbol: VATB2_HUMAN

Name: V-type proton ATPase subunit B, brain isoform

UniProtKB Accession Codes:

P21281 B2R5Z3 D3DSQ5 Q14544 Q15859 Q96IR0

Database IDs:

Citations:

PubMed ID: 1373501

Title: Selectively amplified expression of an isoform of the vacuolar H(+)-ATPase 56-kilodalton subunit in renal intercalated cells.

PubMed ID: 1373501

DOI: 10.1073/pnas.89.8.3541

PubMed ID: 7945239

Title: Heterogeneity of vacuolar H(+)-ATPase: differential expression of two human subunit B isoforms.

PubMed ID: 7945239

DOI: 10.1042/bj3030191

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 7706273

Title: Transcriptional regulation of the vacuolar H(+)-ATPase B2 subunit gene in differentiating THP-1 cells.

PubMed ID: 7706273

DOI: 10.1074/jbc.270.13.7320

PubMed ID: 2145275

Title: An mRNA from human brain encodes an isoform of the B subunit of the vacuolar H(+)-ATPase.

PubMed ID: 2145275

DOI: 10.1016/s0021-9258(18)38179-1

PubMed ID: 12643545

Title: Proteomic analysis of early melanosomes: identification of novel melanosomal proteins.

PubMed ID: 12643545

DOI: 10.1021/pr025562r

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24913193

Title: De novo mutation in ATP6V1B2 impairs lysosome acidification and causes dominant deafness-onychodystrophy syndrome.

PubMed ID: 24913193

DOI: 10.1038/cr.2014.77

PubMed ID: 25915598

Title: Mutations in KCNH1 and ATP6V1B2 cause Zimmermann-Laband syndrome.

PubMed ID: 25915598

DOI: 10.1038/ng.3282

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29993276

Title: H+-ATPase B1 subunit localizes to thick ascending limb and distal convoluted tubule of rodent and human kidney.

PubMed ID: 29993276

DOI: 10.1152/ajprenal.00539.2017

PubMed ID: 32001091

Title: Structure and Roles of V-type ATPases.

PubMed ID: 32001091

DOI: 10.1016/j.tibs.2019.12.007

PubMed ID: 33065002

Title: Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly.

PubMed ID: 33065002

DOI: 10.1016/j.molcel.2020.09.029

Sequence Information:

Length: 511
Mass: 56501
Checksum: E01E85BBA36E5DED
Sequence:

MALRAMRGIV NGAAPELPVP TGGPAVGARE QALAVSRNYL SQPRLTYKTV SGVNGPLVIL 
DHVKFPRYAE IVHLTLPDGT KRSGQVLEVS GSKAVVQVFE GTSGIDAKKT SCEFTGDILR 
TPVSEDMLGR VFNGSGKPID RGPVVLAEDF LDIMGQPINP QCRIYPEEMI QTGISAIDGM 
NSIARGQKIP IFSAAGLPHN EIAAQICRQA GLVKKSKDVV DYSEENFAIV FAAMGVNMET 
ARFFKSDFEE NGSMDNVCLF LNLANDPTIE RIITPRLALT TAEFLAYQCE KHVLVILTDM 
SSYAEALREV SAAREEVPGR RGFPGYMYTD LATIYERAGR VEGRNGSITQ IPILTMPNDD 
ITHPIPDLTG YITEGQIYVD RQLHNRQIYP PINVLPSLSR LMKSAIGEGM TRKDHADVSN 
QLYACYAIGK DVQAMKAVVG EEALTSDDLL YLEFLQKFER NFIAQGPYEN RTVFETLDIG 
WQLLRIFPKE MLKRIPQSTL SEFYPRDSAK H

	Overall overall
	Acute kidney failure MONDO0002492
	Adrenal gland UBERON0002369
	Alzheimer disease MONDO0004975
	Amyotrophic lateral sclerosis MONDO0004976
	Ascending colon UBERON0001156
	Basal cell carcinoma MONDO0020804
	Bipolar disorder MONDO0004985
	Bipolar I disorder MONDO0001866
	Blood UBERON0000178
	\|— Blood COVID-19 UBERON0000178_MONDO0100096
	\|— Blood Cytomegalovirus infection UBERON0000178_MONDO0005132
	\|— Blood Healthy UBERON0000178_PATO0000461
	Body of stomach UBERON0001161
	Bone marrow UBERON0002371
	\|— Bone marrow Healthy UBERON0002371_PATO0000461
	Brain UBERON0000955
	Breast UBERON0000310
	\|— Breast Healthy UBERON0000310_PATO0000461
	\|— Breast cancer MONDO0007254
	Bronchus UBERON0002185
	Caecum UBERON0001153
	Caudate lobe of liver UBERON0001117
	Cerebellum UBERON0002037
	Cerebral cortex UBERON0000956
	\|— Cerebral cortex Healthy UBERON0000956_PATO0000461
	Cerebrospinal fluid UBERON0001359
	Choroid plexus UBERON0001886
	Colon UBERON0001155
	\|— Colon Healthy UBERON0001155_PATO0000461
	\|— Colonic epithelium UBERON0000397
	Colorectal cancer MONDO0005575
	Cortex of kidney UBERON0001225
	\|— Cortex of kidney Healthy UBERON0001225_PATO0000461
	COVID-19 MONDO0100096
	Crohn disease MONDO0005011
	Cytomegalovirus infection MONDO0005132
	Dementia MONDO0001627
	Dorsolateral prefrontal cortex UBERON0009834
	\|— Dorsolateral prefrontal cortex Bipolar disorder UBERON0009834_MONDO0004985
	\|— Dorsolateral prefrontal cortex Bipolar I disorder UBERON0009834_MONDO0001866
	\|— Dorsolateral prefrontal cortex Dementia UBERON0009834_MONDO0001627
	\|— Dorsolateral prefrontal cortex Healthy UBERON0009834_PATO0000461
	\|— Dorsolateral prefrontal cortex Schizophrenia UBERON0009834_MONDO0005090
	\|— Dorsolateral prefrontal cortex Vascular dementia UBERON0009834_MONDO0004648
	Duodenum UBERON0002114
	\|— Duodenum Healthy UBERON0002114_PATO0000461
	Fovea centralis UBERON0001786
	\|— Fovea centralis Healthy UBERON0001786_PATO0000461
	Frontal cortex UBERON0001870
	Glioblastoma MONDO0018177
	Healthy PATO0000461
	Heart left ventricle UBERON0002084
	\|— Heart left ventricle Healthy UBERON0002084_PATO0000461
	Heart right ventricle UBERON0002080
	\|— Heart right ventricle Healthy UBERON0002080_PATO0000461
	Hippocampal formation UBERON0002421
	\|— Hippocampal formation Healthy UBERON0002421_PATO0000461
	Hypothalamus UBERON0001898
	\|— Hypothalamus Healthy UBERON0001898_PATO0000461
	Ileum UBERON0002116
	\|— Ileum Healthy UBERON0002116_PATO0000461
	\|— Ileum lamina propria UBERON8600035
	Interventricular septum UBERON0002094
	Islet of Langerhans UBERON0000006
	Isolated focal cortical dysplasia type II MONDO0011818
	Kidney UBERON0002113
	\|— Kidney Healthy UBERON0002113_PATO0000461
	Leukoencephalopathy, diffuse hereditary, with spheroids 1 MONDO0800027
	Liver UBERON0002107
	\|— Liver Healthy UBERON0002107_PATO0000461
	Lung UBERON0002048
	\|— Lung Healthy UBERON0002048_PATO0000461
	\|— Lung Renal cell carcinoma UBERON0002048_MONDO0005086
	\|— Lung adenocarcinoma MONDO0005061
	Lymph node UBERON0000029
	\|— Lymph node Metastatic melanoma UBERON0000029_MONDO0005191
	Malignant ovarian serous tumor MONDO0024885
	Medial orbital frontal cortex UBERON0022352
	Mesenteric lymph node UBERON0002509
	\|— Mesenteric lymph node Healthy UBERON0002509_PATO0000461
	Metastatic melanoma MONDO0005191
	Midbrain UBERON0001891
	\|— Midbrain Healthy UBERON0001891_PATO0000461
	Nasopharynx UBERON0001728
	Neocortex UBERON0001950
	\|— Neocortex Healthy UBERON0001950_PATO0000461
	Neuroblastoma MONDO0005072
	Occipital cortex UBERON0016540
	Parkinson disease MONDO0005180
	Peripheral region of retina UBERON0013682
	\|— Peripheral region of retina Healthy UBERON0013682_PATO0000461
	Placenta UBERON0001987
	\|— Placenta Healthy UBERON0001987_PATO0000461
	Pleural effusion UBERON0000175
	Pons UBERON0000988
	\|— Pons Healthy UBERON0000988_PATO0000461
	Prefrontal cortex UBERON0000451
	Primary motor cortex UBERON0001384
	Primary visual cortex UBERON0002436
	Renal cell carcinoma MONDO0005086
	Renal medulla UBERON0000362
	\|— Renal medulla Healthy UBERON0000362_PATO0000461
	Respiratory airway UBERON0001005
	\|— Respiratory airway COVID-19 UBERON0001005_MONDO0100096
	Retina UBERON0000966
	\|— Retina Healthy UBERON0000966_PATO0000461
	Right atrium auricular region UBERON0006631
	Schizophrenia MONDO0005090
	Sigmoid colon UBERON0001159
	Skin of body UBERON0002097
	\|— Skin of body Healthy UBERON0002097_PATO0000461
	Small cell lung carcinoma MONDO0008433
	Spleen UBERON0002106
	\|— Spleen Healthy UBERON0002106_PATO0000461
	Substantia nigra pars compacta UBERON0001965
	Telencephalon UBERON0001893
	\|— Telencephalon Healthy UBERON0001893_PATO0000461
	Thalamic complex UBERON0010225
	\|— Thalamic complex Healthy UBERON0010225_PATO0000461
	Thymus UBERON0002370
	\|— Thymus Healthy UBERON0002370_PATO0000461
	Trachea UBERON0003126
	UBERON0005290 UBERON0005290
	\|— UBERON0005290 Healthy UBERON0005290_PATO0000461
	UBERON8440012 UBERON8440012
	\|— UBERON8440012 Healthy UBERON8440012_PATO0000461
	Upper lobe of left lung UBERON0008952
	Vascular dementia MONDO0004648

Details for: ATP6V1B2

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Selectively amplified expression of an isoform of the vacuolar H(+)-ATPase 56-kilodalton subunit in renal intercalated cells. PubMed ID: 1373501

Heterogeneity of vacuolar H(+)-ATPase: differential expression of two human subunit B isoforms. PubMed ID: 7945239

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Transcriptional regulation of the vacuolar H(+)-ATPase B2 subunit gene in differentiating THP-1 cells. PubMed ID: 7706273

An mRNA from human brain encodes an isoform of the B subunit of the vacuolar H(+)-ATPase. PubMed ID: 2145275

Proteomic analysis of early melanosomes: identification of novel melanosomal proteins. PubMed ID: 12643545

Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes. PubMed ID: 17081065

Initial characterization of the human central proteome. PubMed ID: 21269460

De novo mutation in ATP6V1B2 impairs lysosome acidification and causes dominant deafness-onychodystrophy syndrome. PubMed ID: 24913193

Mutations in KCNH1 and ATP6V1B2 cause Zimmermann-Laband syndrome. PubMed ID: 25915598

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

H+-ATPase B1 subunit localizes to thick ascending limb and distal convoluted tubule of rodent and human kidney. PubMed ID: 29993276

Structure and Roles of V-type ATPases. PubMed ID: 32001091

Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly. PubMed ID: 33065002