Details for: E2f7

Gene ID: 52679

Symbol: E2f7

Ensembl ID: ENSMUSG00000020185

Description: E2F transcription factor 7

Associated with

  • Gene expression (transcription)
    (R-MMU-74160)
  • Generic transcription pathway
    (R-MMU-212436)
  • Rna polymerase ii transcription
    (R-MMU-73857)
  • Tp53 regulates transcription of cell cycle genes
    (R-MMU-6791312)
  • Tp53 regulates transcription of genes involved in g1 cell cycle arrest
    (R-MMU-6804116)
  • Transcriptional regulation by tp53
    (R-MMU-3700989)
  • Chorionic trophoblast cell differentiation
    (GO:0060718)
  • Cis-regulatory region sequence-specific dna binding
    (GO:0000987)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity
    (GO:0001217)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
    (GO:0006977)
  • Hepatocyte differentiation
    (GO:0070365)
  • Identical protein binding
    (GO:0042802)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of cytokinesis
    (GO:0032466)
  • Negative regulation of g1/s transition of mitotic cell cycle
    (GO:2000134)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nuclear speck
    (GO:0016607)
  • Nucleus
    (GO:0005634)
  • Placenta development
    (GO:0001890)
  • Positive regulation of dna endoreduplication
    (GO:0032877)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of dna-templated transcription
    (GO:0006355)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulator complex
    (GO:0090575)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Sprouting angiogenesis
    (GO:0002040)
  • Transcription regulator complex
    (GO:0005667)
  • Trophoblast giant cell differentiation
    (GO:0060707)

Other Information

Genular Protein ID: 1729622712

Symbol: E2F7_MOUSE

Name: Transcription factor E2F7

UniProtKB Accession Codes:

Q6S7F2 B2RWZ8 Q8BRE2 Q8BSQ3 Q8C9R3

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 8 Ensembl 2 ExpressionAtlas 1 GO 24 Gene3D 1 GeneTree 1 HOGENOM 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MGI 1 MINT 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRO 1 PaxDb 1 Pfam 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 2 VEuPathDB 1 eggNOG 1 iPTMnet 1

Citations:

PubMed ID: 12893818

Title: Identification and characterization of E2F7, a novel mammalian E2F family member capable of blocking cellular proliferation.

PubMed ID: 12893818

DOI: 10.1074/jbc.m308105200

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 18194653

Title: Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development.

PubMed ID: 18194653

DOI: 10.1016/j.devcel.2007.10.017

PubMed ID: 22903062

Title: E2F7 and E2F8 promote angiogenesis through transcriptional activation of VEGFA in cooperation with HIF1.

PubMed ID: 22903062

DOI: 10.1038/emboj.2012.231

PubMed ID: 22516201

Title: Atypical E2F repressors and activators coordinate placental development.

PubMed ID: 22516201

DOI: 10.1016/j.devcel.2012.01.013

PubMed ID: 22802529

Title: The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence.

PubMed ID: 22802529

DOI: 10.1101/gad.196238.112

PubMed ID: 23064264

Title: E2F8 is essential for polyploidization in mammalian cells.

PubMed ID: 23064264

DOI: 10.1038/ncb2585

PubMed ID: 23064266

Title: Canonical and atypical E2Fs regulate the mammalian endocycle.

PubMed ID: 23064266

DOI: 10.1038/ncb2595

PubMed ID: 22180533

Title: E2F7 represses a network of oscillating cell cycle genes to control S-phase progression.

PubMed ID: 22180533

DOI: 10.1093/nar/gkr1203

Sequence Information:

  • Length: 904
  • Mass: 99535
  • Checksum: 1EABCD1805FF80D2
  • Sequence:
    • MEVNCLTLKD LISPRQTRLD FAIEDAENAQ KENIFVDRSR MTPKTPMKNE PIDLSKQRIF 
TPDRNPITPV KPVDRQPQVE PWTPTANLKM LISAASPDIR DREKKKELFR PIENKEDAFV 
NSLQLDVAGD GAVDEYEKQR PSRKQKSLGL LCQKFLARYP SYPLSTEKTT ISLDEVAVSL 
GVERRRIYDI VNVLESLHLV SRVAKNQYGW HGRHSLPKTL RTLQRLGEEQ KYEEQMACLQ 
QKELDLMGYR FGERRKDGSP DPRDPHLLDF SEADYPSSSA NSRKDKSLRI MSQKFVMLFL 
VSKTKIVTLD VAAKILIEES QDTPDHSKFK TKVRRLYDIA NVLTSLALIK KVHVTEERGR 
KPAFKWIGPV DFSSIDEELL DVSASILPEL KKEAYGQIRV CAKERLVRYG SFNTVHTSEK 
IQRKVSSEPS SPQGERQGSA YSLEIGSLAA IYRQKVEDNS QEEAFVSNTA VPPASILDPA 
LSMDSEYCVK PLAQPVFSVA QTDLPAFSAQ NGPSGQVGVP VPSAASDTEN LKPALLAGQP 
LVYVPSTQLF MLYGSVQEGL SPESRSEEDG GGSDVPADLS VTPSAQKRLC EERDPQEEED 
EPAMKRQSQE FEDSPLSLVM PKKPSSSTDL ACPVTMGNGS SPPLEDACVK GQLPAAEEVT 
GKAAPNCYVA SECGNPARNP DTEKPSNENE ITKDPSLMQY LYVQSPAGLN GFNMVLPGTQ 
TPHTVAPSPA QLPSFGVPCM FLQSPGLGPF PVLYSPAIPG PISSAPGTHP NPGPMNFGLS 
TLASASHLLI SPAAMVNPKP STLPCTDPQL RCQPSLNLNP VMPGSHGVIH PESPCYVRHP 
VSMVKAEQSP APATPKSIQR RHRETFFKTP GSLGDPVFRR KERNQSRNTS SAQRRLEISS 
SGPD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.