Details for: ATP6V0C

Gene ID: 527

Symbol: ATP6V0C

Ensembl ID: ENSG00000185883

Description: ATPase H+ transporting V0 subunit c

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 18.65
    Marker Score: 7244
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 8.37
    Marker Score: 23647
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 5.63
    Marker Score: 3974
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 5.19
    Marker Score: 3546.5
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 4.85
    Marker Score: 2943
  • Cell Name: germ cell (CL0000586)
    Fold Change: 4.57
    Marker Score: 7989
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 4.11
    Marker Score: 20190
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.81
    Marker Score: 129714
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 3.76
    Marker Score: 956
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 3.6
    Marker Score: 1572
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 3.55
    Marker Score: 2079
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 3.44
    Marker Score: 20428
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 3.41
    Marker Score: 7059
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.3
    Marker Score: 38348
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.09
    Marker Score: 2637
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 3.08
    Marker Score: 6008
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3
    Marker Score: 167780
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 2.99
    Marker Score: 1244
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 2.97
    Marker Score: 1825
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 2.79
    Marker Score: 2454
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.77
    Marker Score: 7770
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.76
    Marker Score: 1835
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.75
    Marker Score: 2770
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 2.7
    Marker Score: 6593
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 2.65
    Marker Score: 3522
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.53
    Marker Score: 1830
  • Cell Name: neural cell (CL0002319)
    Fold Change: 2.52
    Marker Score: 1218
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.51
    Marker Score: 7910
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 2.5
    Marker Score: 16271
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.49
    Marker Score: 10676
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.49
    Marker Score: 4075.5
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 2.42
    Marker Score: 3474
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 2.4
    Marker Score: 1968
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.4
    Marker Score: 2254
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.39
    Marker Score: 17758
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.37
    Marker Score: 841
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 2.35
    Marker Score: 4925
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.34
    Marker Score: 23580
  • Cell Name: oocyte (CL0000023)
    Fold Change: 2.34
    Marker Score: 578
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 2.32
    Marker Score: 2241
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.3
    Marker Score: 2045
  • Cell Name: Unknown (CL0002371)
    Fold Change: 2.29
    Marker Score: 2438
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.29
    Marker Score: 6229
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 2.25
    Marker Score: 2295.5
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 2.25
    Marker Score: 785
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 2.24
    Marker Score: 3297
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 2.21
    Marker Score: 890
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.16
    Marker Score: 2978
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.15
    Marker Score: 5347
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.14
    Marker Score: 113072.5
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 2.12
    Marker Score: 966
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.08
    Marker Score: 4080
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 2.08
    Marker Score: 2237
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.07
    Marker Score: 13220
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 2.04
    Marker Score: 1139
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 2.01
    Marker Score: 2226
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.99
    Marker Score: 931
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.98
    Marker Score: 826
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.94
    Marker Score: 621
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 1.94
    Marker Score: 3458.5
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.93
    Marker Score: 1062
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.92
    Marker Score: 2723
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.92
    Marker Score: 11649.5
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.91
    Marker Score: 551
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 1.91
    Marker Score: 1380
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.9
    Marker Score: 2385.5
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 1.88
    Marker Score: 1375
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 1.87
    Marker Score: 1577
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 1.85
    Marker Score: 469
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 1.83
    Marker Score: 641
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 1.83
    Marker Score: 7586
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.82
    Marker Score: 1045
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.82
    Marker Score: 5386
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.79
    Marker Score: 411
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 1.77
    Marker Score: 1471
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.75
    Marker Score: 1749.5
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.75
    Marker Score: 561
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 1.74
    Marker Score: 728
  • Cell Name: small pre-B-II cell (CL0000954)
    Fold Change: 1.72
    Marker Score: 2064
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.69
    Marker Score: 2950
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.68
    Marker Score: 827
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.67
    Marker Score: 508
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 1.67
    Marker Score: 1265
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 1.64
    Marker Score: 735
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.63
    Marker Score: 1190
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 1.63
    Marker Score: 2791.5
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.62
    Marker Score: 855
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.62
    Marker Score: 5076
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.6
    Marker Score: 6188
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 1.59
    Marker Score: 981
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.59
    Marker Score: 727
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.59
    Marker Score: 60316
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.57
    Marker Score: 13510
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.54
    Marker Score: 30607
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 1.53
    Marker Score: 1032
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 1.53
    Marker Score: 2358
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.52
    Marker Score: 1031
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.51
    Marker Score: 22554
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.5
    Marker Score: 14237
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.49
    Marker Score: 91452

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Other Information

**Key characteristics:** - Ensembl ID: ENSG00000185883 - Protein: ATP6V0C - Pathway/Ontology: Amino acids regulate mTORC1, Cellular responses to stimuli, Cellular responses to stress, Cellular response to starvation, Immune system, Innate immune system, Insulin receptor recycling, Ion channel transport, Iron uptake and transport, Neutrophil degranulation, Protein binding, Proton-transporting atpase activity, rotational mechanism, Proton-transporting atp synthase activity, rotational mechanism, Ros and rns production in phagocytes, Signaling by insulin receptor, Signaling by receptor tyrosine kinases, Signal transduction, Transferrin endocytosis and recycling, Transport of small molecules **Function:** The ATP6V0C protein is involved in the regulation of mTORC1, a key regulator of cell growth, metabolism, and survival. mTORC1 is a complex of proteins that is responsible for the cell's response to various stimuli, including growth factors, nutrients, and stress factors. The ATP6V0C protein is a key component of mTORC1 and is essential for its full activity. **Clinical significance:** Mutations in the ATP6V0C gene have been linked to several human diseases, including breast cancer, colorectal cancer, and heart failure. These mutations can lead to the activation of mTORC1 and the development of cancer. Therefore, the ATP6V0C gene is a promising target for the development of new cancer drugs.

Genular Protein ID: 3020301276

Symbol: VATL_HUMAN

Name: N/A

UniProtKB Accession Codes:

P27449 Q6FH26

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 4 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 8 EMDB 6 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 27 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 6 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 6 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1709739

Title: CpG island in the region of an autosomal dominant polycystic kidney disease locus defines the 5' end of a gene encoding a putative proton channel.

PubMed ID: 1709739

DOI: 10.1073/pnas.88.10.4289

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1532310

Title: Vacuolar type H(+)-ATPase genes: presence of four genes including pseudogenes for the 16-kDa proteolipid subunit in the human genome.

PubMed ID: 1532310

DOI: 10.1016/0006-291x(92)90562-y

PubMed ID: 7636472

Title: Mapping of the intermolecular association of human T cell leukaemia/lymphotropic virus type I p12I and the vacuolar H+-ATPase 16 kDa subunit protein.

PubMed ID: 7636472

DOI: 10.1099/0022-1317-76-8-1909

PubMed ID: 11543633

Title: Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1.

PubMed ID: 11543633

DOI: 10.1006/geno.2001.6614

PubMed ID: 18298843

Title: A novel brain-enriched E3 ubiquitin ligase RNF182 is up regulated in the brains of Alzheimer's patients and targets ATP6V0C for degradation.

PubMed ID: 18298843

DOI: 10.1186/1750-1326-3-4

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 33065002

Title: Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly.

PubMed ID: 33065002

DOI: 10.1016/j.molcel.2020.09.029

Sequence Information:

  • Length: 155
  • Mass: 15736
  • Checksum: 91141854A0492A5B
  • Sequence:
    • MSESKSGPEY ASFFAVMGAS AAMVFSALGA AYGTAKSGTG IAAMSVMRPE QIMKSIIPVV 
MAGIIAIYGL VVAVLIANSL NDDISLYKSF LQLGAGLSVG LSGLAAGFAI GIVGDAGVRG 
TAQQPRLFVG MILILIFAEV LGLYGLIVAL ILSTK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.