Details for: ATP6V1C1

Gene ID: 528

Symbol: ATP6V1C1

Ensembl ID: ENSG00000155097

Description: ATPase H+ transporting V1 subunit C1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.85
    Marker Score: 63013
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.74
    Marker Score: 867
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.68
    Marker Score: 103112.5
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.63
    Marker Score: 6836
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 1.57
    Marker Score: 3195
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.57
    Marker Score: 14889
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.56
    Marker Score: 13431
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.56
    Marker Score: 16095.5
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.52
    Marker Score: 30254
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.5
    Marker Score: 14132.5
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.49
    Marker Score: 5766
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 1.48
    Marker Score: 56277
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.48
    Marker Score: 816
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.42
    Marker Score: 52550
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.4
    Marker Score: 2155
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 1.37
    Marker Score: 10524
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.35
    Marker Score: 5493
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 1.32
    Marker Score: 416
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 1.31
    Marker Score: 377
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 1.3
    Marker Score: 19460.5
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 1.29
    Marker Score: 1553
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 1.24
    Marker Score: 1663
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 1.22
    Marker Score: 26003.5
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.2
    Marker Score: 4962
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.18
    Marker Score: 292
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.16
    Marker Score: 4103
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.09
    Marker Score: 1093
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.07
    Marker Score: 725
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.05
    Marker Score: 613
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.04
    Marker Score: 2458
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 1.03
    Marker Score: 26385.5
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.02
    Marker Score: 16017.5
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 1.02
    Marker Score: 354
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.01
    Marker Score: 2060
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.01
    Marker Score: 1063
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.01
    Marker Score: 2511
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71661
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 0.99
    Marker Score: 47885
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.99
    Marker Score: 1199
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.99
    Marker Score: 404
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.99
    Marker Score: 1134
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30384
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.98
    Marker Score: 286
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.98
    Marker Score: 1079
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.97
    Marker Score: 1219
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.97
    Marker Score: 911
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.96
    Marker Score: 1039
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2390
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.93
    Marker Score: 5652
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.93
    Marker Score: 477
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.91
    Marker Score: 2006
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2693
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.9
    Marker Score: 950
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.89
    Marker Score: 1313
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.88
    Marker Score: 2217
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.88
    Marker Score: 807.5
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.88
    Marker Score: 3445
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.87
    Marker Score: 4283
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 0.87
    Marker Score: 4020
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.86
    Marker Score: 989
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.86
    Marker Score: 426
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.85
    Marker Score: 564
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.85
    Marker Score: 354.5
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.84
    Marker Score: 522
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.84
    Marker Score: 413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.83
    Marker Score: 4757
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.83
    Marker Score: 722
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.83
    Marker Score: 926
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.83
    Marker Score: 346
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.83
    Marker Score: 495
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.83
    Marker Score: 472
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.83
    Marker Score: 2215
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.83
    Marker Score: 1186.5
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.82
    Marker Score: 547
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.82
    Marker Score: 328
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.82
    Marker Score: 1450
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.81
    Marker Score: 1475
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.81
    Marker Score: 1342
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.81
    Marker Score: 819
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.81
    Marker Score: 255
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.8
    Marker Score: 1037
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.8
    Marker Score: 489
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.8
    Marker Score: 3329
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.8
    Marker Score: 294
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.79
    Marker Score: 1528
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 605
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.79
    Marker Score: 273
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.78
    Marker Score: 43884.5
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.78
    Marker Score: 1106
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.78
    Marker Score: 183
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.77
    Marker Score: 799
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.77
    Marker Score: 928
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.76
    Marker Score: 682
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.76
    Marker Score: 260
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.76
    Marker Score: 1477
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.76
    Marker Score: 790

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Other Information

**Key characteristics:** * The protein is a transmembrane protein with a molecular weight of approximately 140 kDa. * It is a V-type proton ATPase, which means that it transports protons across the plasma membrane from an area of higher concentration (inside the cell) to an area of lower concentration (outside the cell). * The protein is involved in a variety of cellular processes, including energy production, calcium signaling, and apoptosis. * It is a key regulator of cellular metabolism and growth. **Pathways and functions:** * The ATP6V1C1 gene is involved in the regulation of mTORC1 (mammalian target of rapamycin complex 1), a key regulator of cell growth, proliferation, and metabolism. * It is also involved in cellular responses to stimuli, stress, and starvation. * It is involved in the regulation of inflammation and immune responses. * It is a key regulator of macroautophagy, a process by which the body breaks down and recycles damaged or unnecessary cellular components. * It is also involved in the production of ROS (reactive oxygen species) and rNS (reactive nitrogen species) in phagocytes. * It regulates the signaling by the insulin receptor. **Clinical significance:** * Mutations in the ATP6V1C1 gene have been linked to several human diseases, including breast cancer, colon cancer, and diabetes. * Studies of these mutations have led to the development of new drugs that target the ATP6V1C1 protein, which have shown promise in treating these diseases.

Genular Protein ID: 2066094745

Symbol: VATC1_HUMAN

Name: V-type proton ATPase subunit C 1

UniProtKB Accession Codes:

P21283

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 4 EMDB 5 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 14 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 10 PDBsum 5 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 5 RefSeq 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8250920

Title: Cloning and tissue distribution of subunits C, D, and E of the human vacuolar H(+)-ATPase.

PubMed ID: 8250920

DOI: 10.1006/bbrc.1993.2434

PubMed ID: 11707601

Title: BAALC, the human member of a novel mammalian neuroectoderm gene lineage, is implicated in hematopoiesis and acute leukemia.

PubMed ID: 11707601

DOI: 10.1073/pnas.241525498

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2147024

Title: Molecular cloning of cDNA encoding the C subunit of H(+)-ATPase from bovine chromaffin granules.

PubMed ID: 2147024

DOI: 10.1016/s0021-9258(17)30516-1

PubMed ID: 12384298

Title: Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis.

PubMed ID: 12384298

DOI: 10.1016/s0378-1119(02)00884-3

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 33065002

Title: Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly.

PubMed ID: 33065002

DOI: 10.1016/j.molcel.2020.09.029

Sequence Information:

  • Length: 382
  • Mass: 43942
  • Checksum: 5626E2AB2BD66BA7
  • Sequence:
    • MTEFWLISAP GEKTCQQTWE KLHAATSKNN NLAVTSKFNI PDLKVGTLDV LVGLSDELAK 
LDAFVEGVVK KVAQYMADVL EDSKDKVQEN LLANGVDLVT YITRFQWDMA KYPIKQSLKN 
ISEIIAKGVT QIDNDLKSRA SAYNNLKGNL QNLERKNAGS LLTRSLAEIV KKDDFVLDSE 
YLVTLLVVVP KLNHNDWIKQ YETLAEMVVP RSSNVLSEDQ DSYLCNVTLF RKAVDDFRHK 
ARENKFIVRD FQYNEEEMKA DKEEMNRLST DKKKQFGPLV RWLKVNFSEA FIAWIHVKAL 
RVFVESVLRY GLPVNFQAML LQPNKKTLKK LREVLHELYK HLDSSAAAII DAPMDIPGLN 
LSQQEYYPYV YYKIDCNLLE FK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.