Details for: ATP6V1C1

Gene ID: 528

Symbol: ATP6V1C1

Ensembl ID: ENSG00000155097

Description: ATPase H+ transporting V1 subunit C1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 235.2370
    Cell Significance Index: -36.5900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 154.2323
    Cell Significance Index: -39.1200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 99.3573
    Cell Significance Index: -40.9300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 87.5196
    Cell Significance Index: -41.3200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 83.3955
    Cell Significance Index: -33.8800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 75.6631
    Cell Significance Index: -38.9200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 35.7426
    Cell Significance Index: -34.1300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 32.3694
    Cell Significance Index: -39.9100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 13.8174
    Cell Significance Index: -37.0200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.3369
    Cell Significance Index: -40.7900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 8.1788
    Cell Significance Index: -17.9000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.8872
    Cell Significance Index: 378.5800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.4801
    Cell Significance Index: 172.4900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.4118
    Cell Significance Index: 40.4700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2622
    Cell Significance Index: 250.4900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.0913
    Cell Significance Index: 29.1400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0023
    Cell Significance Index: 109.0300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9836
    Cell Significance Index: 352.8100
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.9394
    Cell Significance Index: 7.6600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.7848
    Cell Significance Index: 127.6500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.7455
    Cell Significance Index: 50.1300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.6259
    Cell Significance Index: 8.5400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.5750
    Cell Significance Index: 30.1900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.4282
    Cell Significance Index: 77.2000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.4068
    Cell Significance Index: 11.6100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3744
    Cell Significance Index: 16.5600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3714
    Cell Significance Index: 202.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3657
    Cell Significance Index: 13.8500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.3626
    Cell Significance Index: 44.5800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3600
    Cell Significance Index: 22.1300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3421
    Cell Significance Index: 33.8500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.3186
    Cell Significance Index: 220.3400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2415
    Cell Significance Index: 33.1700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2276
    Cell Significance Index: 4.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.2204
    Cell Significance Index: 16.9100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1975
    Cell Significance Index: 8.9500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.1759
    Cell Significance Index: 331.1800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1663
    Cell Significance Index: 4.7900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1562
    Cell Significance Index: 10.8000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1473
    Cell Significance Index: 28.0400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1454
    Cell Significance Index: 17.1500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.1387
    Cell Significance Index: 8.7400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1311
    Cell Significance Index: 57.9600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0733
    Cell Significance Index: 135.2200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0694
    Cell Significance Index: 3.6200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0491
    Cell Significance Index: 31.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0455
    Cell Significance Index: 2.1200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0453
    Cell Significance Index: 5.8100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0410
    Cell Significance Index: 2.3000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0402
    Cell Significance Index: 2.0900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0349
    Cell Significance Index: 2.6000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0323
    Cell Significance Index: 0.6300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0296
    Cell Significance Index: 45.5700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0215
    Cell Significance Index: 29.2900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0209
    Cell Significance Index: 0.5700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0199
    Cell Significance Index: 0.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0100
    Cell Significance Index: 1.7100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0061
    Cell Significance Index: 2.7700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0121
    Cell Significance Index: -8.9800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0167
    Cell Significance Index: -12.2700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0229
    Cell Significance Index: -2.6300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0246
    Cell Significance Index: -2.8100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0279
    Cell Significance Index: -4.0600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0290
    Cell Significance Index: -18.1000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0300
    Cell Significance Index: -16.9100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0324
    Cell Significance Index: -24.5400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0395
    Cell Significance Index: -4.0300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.0404
    Cell Significance Index: -0.9700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0623
    Cell Significance Index: -2.9300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1022
    Cell Significance Index: -21.5200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1137
    Cell Significance Index: -32.7300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1165
    Cell Significance Index: -15.0500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1252
    Cell Significance Index: -3.5000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1582
    Cell Significance Index: -4.2400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1657
    Cell Significance Index: -2.8400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1878
    Cell Significance Index: -4.0000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2262
    Cell Significance Index: -23.5500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2472
    Cell Significance Index: -15.9500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3259
    Cell Significance Index: -23.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3690
    Cell Significance Index: -11.8200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.3708
    Cell Significance Index: -4.4200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3734
    Cell Significance Index: -29.5700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3739
    Cell Significance Index: -6.9100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.3866
    Cell Significance Index: -4.8000
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4674
    Cell Significance Index: -9.9200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.5265
    Cell Significance Index: -11.2600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5772
    Cell Significance Index: -15.4400
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.5852
    Cell Significance Index: -35.8800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5874
    Cell Significance Index: -9.8300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6217
    Cell Significance Index: -15.9800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6284
    Cell Significance Index: -21.8400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.6321
    Cell Significance Index: -13.8400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6614
    Cell Significance Index: -19.4300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6670
    Cell Significance Index: -17.5400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.6889
    Cell Significance Index: -21.9400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.6933
    Cell Significance Index: -22.7000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.7326
    Cell Significance Index: -14.4900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.7464
    Cell Significance Index: -37.7200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.7626
    Cell Significance Index: -15.3100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8213
    Cell Significance Index: -24.1900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Proton-transporting V-ATPase subunit**: The ATP6V1C1 gene encodes for a subunit of the V-ATPase, a proton-pumping enzyme that plays a crucial role in acidification and transport of small molecules across cellular membranes. 2. **Significantly expressed in various cell types**: The ATP6V1C1 gene is expressed in a wide range of cell types, including fibroblasts of mammary glands, osteoclasts, and neurons, indicating its importance in different tissues and developmental stages. 3. **Involved in multiple signaling pathways**: The ATP6V1C1 gene is involved in various signaling pathways, including those related to amino acid metabolism, insulin signaling, and immune responses. 4. **Regulation of macroautophagy**: The ATP6V1C1 gene is involved in the regulation of macroautophagy, a process by which cells recycle damaged or dysfunctional components. **Pathways and Functions** 1. **Amino acid metabolism**: The ATP6V1C1 gene is involved in the regulation of amino acid metabolism, including the regulation of mTORC1, a critical regulator of protein synthesis and cell growth. 2. **Insulin signaling**: The ATP6V1C1 gene is involved in insulin signaling, including the regulation of insulin receptor recycling and signaling by insulin receptor tyrosine kinases. 3. **Immune responses**: The ATP6V1C1 gene is involved in immune responses, including the regulation of macroautophagy and the production of ROS and RNS in phagocytes. 4. **Transport of small molecules**: The ATP6V1C1 gene is involved in the transport of small molecules across cellular membranes, including the acidification of synaptic vesicle lumen. 5. **Regulation of macroautophagy**: The ATP6V1C1 gene is involved in the regulation of macroautophagy, a process by which cells recycle damaged or dysfunctional components. **Clinical Significance** 1. **Neurological disorders**: Alterations in the ATP6V1C1 gene have been implicated in various neurological disorders, including Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis. 2. **Cancer**: The ATP6V1C1 gene is overexpressed in certain types of cancer, including osteosarcoma and breast cancer, suggesting its potential role in tumorigenesis. 3. **Autoimmune diseases**: The ATP6V1C1 gene is involved in the regulation of immune responses, including the production of ROS and RNS in phagocytes, which may contribute to the development of autoimmune diseases. 4. **Metabolic disorders**: Alterations in the ATP6V1C1 gene have been implicated in various metabolic disorders, including insulin resistance and type 2 diabetes. In conclusion, the ATP6V1C1 gene plays a crucial role in various cellular processes, including acidification, transport of small molecules, and regulation of immune responses. Its significance in different tissues and developmental stages, as well as its involvement in multiple signaling pathways, highlights its importance in maintaining cellular homeostasis and overall health. Further studies are needed to fully elucidate the functions and clinical significance of the ATP6V1C1 gene.

Genular Protein ID: 2066094745

Symbol: VATC1_HUMAN

Name: V-type proton ATPase subunit C 1

UniProtKB Accession Codes:

P21283

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 4 EMDB 5 Ensembl 2 ExpressionAtlas 1 GO 13 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 5 PDBsum 5 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 6 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8250920

Title: Cloning and tissue distribution of subunits C, D, and E of the human vacuolar H(+)-ATPase.

PubMed ID: 8250920

DOI: 10.1006/bbrc.1993.2434

PubMed ID: 11707601

Title: BAALC, the human member of a novel mammalian neuroectoderm gene lineage, is implicated in hematopoiesis and acute leukemia.

PubMed ID: 11707601

DOI: 10.1073/pnas.241525498

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2147024

Title: Molecular cloning of cDNA encoding the C subunit of H(+)-ATPase from bovine chromaffin granules.

PubMed ID: 2147024

DOI: 10.1016/s0021-9258(17)30516-1

PubMed ID: 12384298

Title: Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis.

PubMed ID: 12384298

DOI: 10.1016/s0378-1119(02)00884-3

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 33065002

Title: Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly.

PubMed ID: 33065002

DOI: 10.1016/j.molcel.2020.09.029

Sequence Information:

  • Length: 382
  • Mass: 43942
  • Checksum: 5626E2AB2BD66BA7
  • Sequence:
    • MTEFWLISAP GEKTCQQTWE KLHAATSKNN NLAVTSKFNI PDLKVGTLDV LVGLSDELAK 
LDAFVEGVVK KVAQYMADVL EDSKDKVQEN LLANGVDLVT YITRFQWDMA KYPIKQSLKN 
ISEIIAKGVT QIDNDLKSRA SAYNNLKGNL QNLERKNAGS LLTRSLAEIV KKDDFVLDSE 
YLVTLLVVVP KLNHNDWIKQ YETLAEMVVP RSSNVLSEDQ DSYLCNVTLF RKAVDDFRHK 
ARENKFIVRD FQYNEEEMKA DKEEMNRLST DKKKQFGPLV RWLKVNFSEA FIAWIHVKAL 
RVFVESVLRY GLPVNFQAML LQPNKKTLKK LREVLHELYK HLDSSAAAII DAPMDIPGLN 
LSQQEYYPYV YYKIDCNLLE FK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.