Details for: ATP6V0B

Gene ID: 533

Symbol: ATP6V0B

Ensembl ID: ENSG00000117410

Description: ATPase H+ transporting V0 subunit b

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.67
    Marker Score: 205325
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.59
    Marker Score: 9627
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.54
    Marker Score: 5877
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.47
    Marker Score: 8754
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.44
    Marker Score: 1837
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.22
    Marker Score: 3683
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.17
    Marker Score: 3830
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.06
    Marker Score: 35517.5
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.03
    Marker Score: 6155
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.99
    Marker Score: 2818.5
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.96
    Marker Score: 5768
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.88
    Marker Score: 3057
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.82
    Marker Score: 72283
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.8
    Marker Score: 2836
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.79
    Marker Score: 3950
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.79
    Marker Score: 2788
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.76
    Marker Score: 13555
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.74
    Marker Score: 95082
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.68
    Marker Score: 10340
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.64
    Marker Score: 1077
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.58
    Marker Score: 87719
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.54
    Marker Score: 5791
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.51
    Marker Score: 1048
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.5
    Marker Score: 2806
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.49
    Marker Score: 33412
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.49
    Marker Score: 6440.5
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.47
    Marker Score: 6155
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 2.47
    Marker Score: 829
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.46
    Marker Score: 1430
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.44
    Marker Score: 6972
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.42
    Marker Score: 14676
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.39
    Marker Score: 2788.5
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.38
    Marker Score: 5746
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.36
    Marker Score: 840
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.35
    Marker Score: 2100
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.35
    Marker Score: 811
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.34
    Marker Score: 3719
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.33
    Marker Score: 1981
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 2.32
    Marker Score: 1426
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.32
    Marker Score: 1828
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.31
    Marker Score: 14764
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.31
    Marker Score: 15031
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.31
    Marker Score: 23361
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.3
    Marker Score: 4207
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.3
    Marker Score: 684
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.26
    Marker Score: 19458
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.25
    Marker Score: 3610
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 2.24
    Marker Score: 1159
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 2.24
    Marker Score: 967
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.23
    Marker Score: 533
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.22
    Marker Score: 1055
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.22
    Marker Score: 7893.5
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.22
    Marker Score: 1223
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.22
    Marker Score: 9088
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 2.22
    Marker Score: 1352
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.22
    Marker Score: 6966
  • Cell Name: PP cell (CL0000696)
    Fold Change: 2.21
    Marker Score: 498
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2.21
    Marker Score: 823
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.21
    Marker Score: 16429
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.2
    Marker Score: 1461
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.19
    Marker Score: 3220
  • Cell Name: basophil (CL0000767)
    Fold Change: 2.18
    Marker Score: 1038
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.17
    Marker Score: 3844
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.17
    Marker Score: 5296
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 2.16
    Marker Score: 1022
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.16
    Marker Score: 16886.5
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.14
    Marker Score: 1273
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.12
    Marker Score: 1418
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.11
    Marker Score: 714
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.11
    Marker Score: 1436
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 2.09
    Marker Score: 843.5
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.09
    Marker Score: 4368
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.09
    Marker Score: 976.5
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.07
    Marker Score: 3616
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 2.07
    Marker Score: 2755
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.06
    Marker Score: 1976
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.06
    Marker Score: 13123
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 2.04
    Marker Score: 1289
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 2.04
    Marker Score: 8480
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.03
    Marker Score: 2624
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.03
    Marker Score: 3697
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.03
    Marker Score: 8746
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 2.03
    Marker Score: 537
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.02
    Marker Score: 1269
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 2.02
    Marker Score: 523
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.01
    Marker Score: 19951
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 2
    Marker Score: 526.5
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2
    Marker Score: 4536
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.99
    Marker Score: 576
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.99
    Marker Score: 3268
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.99
    Marker Score: 1363
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.98
    Marker Score: 1163
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.98
    Marker Score: 684
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.98
    Marker Score: 2094
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.98
    Marker Score: 9493
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.97
    Marker Score: 2328
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.97
    Marker Score: 7747
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.97
    Marker Score: 980
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.97
    Marker Score: 1185
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.96
    Marker Score: 2067

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** - ATP6V0B is a protein of the ATP6 family of ATPases. - It is expressed in a variety of cell types, including monocytes, macrophages, and neurons. - It is a multi-functional protein that can be involved in both macroautophagy and other cellular processes. **Pathways and functions:** - ATP6V0B is involved in the regulation of macroautophagy by binding to the AMP-activated protein kinase (AMPK) complex. - When AMPK is activated, it phosphorylates and inhibits ATPS4A, an enzyme that is involved in the initiation of macroautophagy. - By inhibiting ATPS4A, ATP6V0B helps to promote macroautophagy. - In addition to its role in macroautophagy, ATP6V0B is also involved in other cellular processes, including cell cycle regulation, apoptosis, and inflammation. **Clinical significance:** - Mutations in ATP6V0B have been linked to several human diseases, including cancer and neurodegenerative disorders. - These mutations can disrupt the normal function of ATP6V0B, leading to the accumulation of damaged proteins and organelles and the development of disease symptoms. - Thus, ATP6V0B is a promising target for the development of new therapies for these diseases.

Genular Protein ID: 3206085998

Symbol: VATO_HUMAN

Name: hATPL

UniProtKB Accession Codes:

Q99437 D3DPY5 Q6IB32

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChiTaRS 1 ComplexPortal 4 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 9 EMDB 6 Ensembl 3 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 6 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 5 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9653649

Title: Identification and characterization of the gene encoding a second proteolipid subunit of human vacuolar H(+)-ATPase (ATP6F).

PubMed ID: 9653649

DOI: 10.1006/geno.1998.5310

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 33065002

Title: Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly.

PubMed ID: 33065002

DOI: 10.1016/j.molcel.2020.09.029

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 205
  • Mass: 21406
  • Checksum: F17C688D068A2785
  • Sequence:
    • MTGLALLYSG VFVAFWACAL AVGVCYTIFD LGFRFDVAWF LTETSPFMWS NLGIGLAISL 
SVVGAAWGIY ITGSSIIGGG VKAPRIKTKN LVSIIFCEAV AIYGIIMAIV ISNMAEPFSA 
TDPKAIGHRN YHAGYSMFGA GLTVGLSNLF CGVCVGIVGS GAALADAQNP SLFVKILIVE 
IFGSAIGLFG VIVAILQTSR VKMGD

Genular Protein ID: 598873252

Symbol: E9PNL3_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PNL3

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 2 PhylomeDB 1 Proteomes 2 RefSeq 1 RuleBase 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 261
  • Mass: 27677
  • Checksum: 424FA9E80FF3722D
  • Sequence:
    • MTGLALLYSG VFVAFWACAL AVGVCYTIFD LGFRFDVAWF LTETSPFMWS NLGIGLAISL 
SVVGAAWGIY ITGSSIIGGG VKAPRIKTKN LVSIIFCEAV AIYGIIMAIV ISNMAEPFSA 
TDPKAIGHRN YHAGYSMFGA GLTVGLSNLF CGVCVGIVGS GAALADAQNP SLFVKILIVE 
IFGSAIGLFG VIVAILQVMN PLGKPLCPCP QPSLTLLLEK LKCSPSLPIT IDSPKQLPPP 
HFHLLVFSYR GSLFLSLIWC H

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.