Details for: ATP6V0B

Gene ID: 533

Symbol: ATP6V0B

Ensembl ID: ENSG00000117410

Description: ATPase H+ transporting V0 subunit b

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.67
    Marker Score: 205,325
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 3.59
    Marker Score: 9,627
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 3.54
    Marker Score: 5,877
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 3.47
    Marker Score: 8,754
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 3.44
    Marker Score: 1,837
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.22
    Marker Score: 3,683
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 3.17
    Marker Score: 3,830
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.06
    Marker Score: 35,518
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.03
    Marker Score: 6,155
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.99
    Marker Score: 2,819
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.96
    Marker Score: 5,768
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.88
    Marker Score: 3,057
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.82
    Marker Score: 72,283
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.8
    Marker Score: 2,836
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.79
    Marker Score: 3,950
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.79
    Marker Score: 2,788
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 2.76
    Marker Score: 13,555
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.74
    Marker Score: 95,082
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.68
    Marker Score: 10,340
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.64
    Marker Score: 1,077
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 2.58
    Marker Score: 87,719
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 2.54
    Marker Score: 5,791
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.51
    Marker Score: 1,048
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.5
    Marker Score: 2,806
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.49
    Marker Score: 33,412
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.49
    Marker Score: 6,441
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 2.47
    Marker Score: 6,155
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 2.47
    Marker Score: 829
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.46
    Marker Score: 1,430
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 2.44
    Marker Score: 6,972
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.42
    Marker Score: 14,676
  • Cell Name: club cell (CL0000158)
    Fold Change: 2.39
    Marker Score: 2,789
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 2.38
    Marker Score: 5,746
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.36
    Marker Score: 840
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.35
    Marker Score: 2,100
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.35
    Marker Score: 811
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.34
    Marker Score: 3,719
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.33
    Marker Score: 1,981
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 2.32
    Marker Score: 1,426
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.32
    Marker Score: 1,828
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.31
    Marker Score: 14,764
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.31
    Marker Score: 15,031
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.31
    Marker Score: 23,361
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 2.3
    Marker Score: 4,207
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.3
    Marker Score: 684
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.26
    Marker Score: 19,458
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.25
    Marker Score: 3,610
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 2.24
    Marker Score: 1,159
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 2.24
    Marker Score: 967
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.23
    Marker Score: 533
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.22
    Marker Score: 1,055
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.22
    Marker Score: 7,894
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 2.22
    Marker Score: 1,223
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.22
    Marker Score: 9,088
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 2.22
    Marker Score: 1,352
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.22
    Marker Score: 6,966
  • Cell Name: PP cell (CL0000696)
    Fold Change: 2.21
    Marker Score: 498
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 2.21
    Marker Score: 823
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.21
    Marker Score: 16,429
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 2.2
    Marker Score: 1,461
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.19
    Marker Score: 3,220
  • Cell Name: basophil (CL0000767)
    Fold Change: 2.18
    Marker Score: 1,038
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.17
    Marker Score: 3,844
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.17
    Marker Score: 5,296
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 2.16
    Marker Score: 1,022
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.16
    Marker Score: 16,887
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.14
    Marker Score: 1,273
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 2.12
    Marker Score: 1,418
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.11
    Marker Score: 714
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 2.11
    Marker Score: 1,436
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 2.09
    Marker Score: 844
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.09
    Marker Score: 4,368
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 2.09
    Marker Score: 977
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.07
    Marker Score: 3,616
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 2.07
    Marker Score: 2,755
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 2.06
    Marker Score: 1,976
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 2.06
    Marker Score: 13,123
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 2.04
    Marker Score: 1,289
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 2.04
    Marker Score: 8,480
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.03
    Marker Score: 2,624
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 2.03
    Marker Score: 3,697
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.03
    Marker Score: 8,746
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 2.03
    Marker Score: 537
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 2.02
    Marker Score: 1,269
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 2.02
    Marker Score: 523
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.01
    Marker Score: 19,951
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 2
    Marker Score: 527
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2
    Marker Score: 4,536
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.99
    Marker Score: 576
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.99
    Marker Score: 3,268
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 1.99
    Marker Score: 1,363
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.98
    Marker Score: 1,163
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.98
    Marker Score: 684
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.98
    Marker Score: 2,094
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.98
    Marker Score: 9,493
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.97
    Marker Score: 2,328
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.97
    Marker Score: 7,747
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.97
    Marker Score: 980
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.97
    Marker Score: 1,185
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.96
    Marker Score: 2,067

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Proton Transport**: The primary function of ATP6V0B is to facilitate proton transport across cellular membranes, which is essential for maintaining cellular homeostasis and regulating various cellular processes. 2. **V-Type ATPase Complex**: The V0 subunit b is a component of the proton-transporting V-type ATPase complex, which is characterized by its rotational mechanism of proton transport. 3. **Cellular Localization**: ATP6V0B is significantly expressed in various cell types, including immune cells, epithelial cells, and neurons, highlighting its importance in multiple cellular processes. **Pathways and Functions** 1. **Immune Response**: ATP6V0B plays a crucial role in the regulation of immune responses, particularly in the context of phagocytic vesicle membrane and lysosomal lumen acidification. This gene is significantly expressed in lung macrophages, where it contributes to the regulation of phagocytic function and lysosomal acidification. 2. **Cellular Signaling**: The V0 subunit b of the proton-transporting V-type ATPase complex is involved in cellular signaling pathways, including the regulation of macroautophagy and the production of ROS and RNS in phagocytes. 3. **Protein Transport**: ATP6V0B is also involved in the transport of small molecules across cellular membranes, highlighting its role in regulating various cellular processes. **Clinical Significance** 1. **Immune-Related Disorders**: Alterations in ATP6V0B expression have been implicated in various immune-related disorders, including autoimmune diseases and immunodeficiency syndromes. 2. **Cancer**: The V0 subunit b of the proton-transporting V-type ATPase complex has been shown to play a role in cancer progression, particularly in the context of tumor cell migration and invasion. 3. **Neurological Disorders**: ATP6V0B has been implicated in various neurological disorders, including Parkinson's disease and Alzheimer's disease, where it contributes to the regulation of mitochondrial function and cellular homeostasis. In conclusion, ATP6V0B is a critical gene that plays a pivotal role in various cellular processes, including immune response, cellular signaling, and protein transport. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the function and clinical significance of this gene.

Genular Protein ID: 3206085998

Symbol: VATO_HUMAN

Name: hATPL

UniProtKB Accession Codes:

Q99437 D3DPY5 Q6IB32

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChiTaRS 1 ComplexPortal 4 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 9 EMDB 6 Ensembl 3 ExpressionAtlas 1 GO 18 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 6 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 5 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9653649

Title: Identification and characterization of the gene encoding a second proteolipid subunit of human vacuolar H(+)-ATPase (ATP6F).

PubMed ID: 9653649

DOI: 10.1006/geno.1998.5310

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 33065002

Title: Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly.

PubMed ID: 33065002

DOI: 10.1016/j.molcel.2020.09.029

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 205
  • Mass: 21406
  • Checksum: F17C688D068A2785
  • Sequence:
    • MTGLALLYSG VFVAFWACAL AVGVCYTIFD LGFRFDVAWF LTETSPFMWS NLGIGLAISL 
SVVGAAWGIY ITGSSIIGGG VKAPRIKTKN LVSIIFCEAV AIYGIIMAIV ISNMAEPFSA 
TDPKAIGHRN YHAGYSMFGA GLTVGLSNLF CGVCVGIVGS GAALADAQNP SLFVKILIVE 
IFGSAIGLFG VIVAILQTSR VKMGD

Genular Protein ID: 598873252

Symbol: E9PNL3_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PNL3

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 2 PhylomeDB 1 Proteomes 2 RefSeq 1 RuleBase 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 261
  • Mass: 27677
  • Checksum: 424FA9E80FF3722D
  • Sequence:
    • MTGLALLYSG VFVAFWACAL AVGVCYTIFD LGFRFDVAWF LTETSPFMWS NLGIGLAISL 
SVVGAAWGIY ITGSSIIGGG VKAPRIKTKN LVSIIFCEAV AIYGIIMAIV ISNMAEPFSA 
TDPKAIGHRN YHAGYSMFGA GLTVGLSNLF CGVCVGIVGS GAALADAQNP SLFVKILIVE 
IFGSAIGLFG VIVAILQVMN PLGKPLCPCP QPSLTLLLEK LKCSPSLPIT IDSPKQLPPP 
HFHLLVFSYR GSLFLSLIWC H

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.