Details for: ATP6V0B

Gene ID: 533

Symbol: ATP6V0B

Ensembl ID: ENSG00000117410

Description: ATPase H+ transporting V0 subunit b

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 532.4496
    Cell Significance Index: -82.8200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 341.4637
    Cell Significance Index: -86.6100
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 258.4431
    Cell Significance Index: -106.4700
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 227.5468
    Cell Significance Index: -107.4300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 199.2476
    Cell Significance Index: -102.4900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 160.2630
    Cell Significance Index: -107.5400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 78.7376
    Cell Significance Index: -97.0800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 30.2647
    Cell Significance Index: -81.0800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 26.4826
    Cell Significance Index: -81.3400
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 26.2541
    Cell Significance Index: -103.6000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.4125
    Cell Significance Index: -20.6000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 8.6900
    Cell Significance Index: 1012.7200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 6.0343
    Cell Significance Index: 111.5300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 5.4066
    Cell Significance Index: 283.8700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 4.1390
    Cell Significance Index: 192.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 3.6391
    Cell Significance Index: 1047.0700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 2.9357
    Cell Significance Index: 137.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.6538
    Cell Significance Index: 197.7900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.4902
    Cell Significance Index: 1359.9700
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 2.2846
    Cell Significance Index: 14.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.0315
    Cell Significance Index: 131.0600
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.0128
    Cell Significance Index: 18.5400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.8905
    Cell Significance Index: 340.7900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.6928
    Cell Significance Index: 49.7200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.4831
    Cell Significance Index: 182.3600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.2694
    Cell Significance Index: 163.9900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1621
    Cell Significance Index: 159.5900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1382
    Cell Significance Index: 503.2200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.1061
    Cell Significance Index: 130.4400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.0102
    Cell Significance Index: 28.9600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9746
    Cell Significance Index: 195.5100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.9546
    Cell Significance Index: 94.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.8944
    Cell Significance Index: 46.4600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.8366
    Cell Significance Index: 52.7300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.7820
    Cell Significance Index: 20.8800
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.7065
    Cell Significance Index: 24.5500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5925
    Cell Significance Index: 75.9600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.5630
    Cell Significance Index: 39.8200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.5254
    Cell Significance Index: 14.3000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.4405
    Cell Significance Index: 158.0100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.4183
    Cell Significance Index: 306.6700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3574
    Cell Significance Index: 61.0300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3368
    Cell Significance Index: 9.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2957
    Cell Significance Index: 56.2800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.2928
    Cell Significance Index: 7.7000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2863
    Cell Significance Index: 56.8100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.1373
    Cell Significance Index: 1.5600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1173
    Cell Significance Index: 88.7600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0928
    Cell Significance Index: 64.2100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0003
    Cell Significance Index: -0.0300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0283
    Cell Significance Index: -20.9500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0331
    Cell Significance Index: -62.3600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0650
    Cell Significance Index: -119.9200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0775
    Cell Significance Index: -119.2700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0869
    Cell Significance Index: -118.1900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.0895
    Cell Significance Index: -0.6900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1048
    Cell Significance Index: -2.9300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1105
    Cell Significance Index: -70.1900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1343
    Cell Significance Index: -75.7200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1363
    Cell Significance Index: -22.1800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1386
    Cell Significance Index: -86.5600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1775
    Cell Significance Index: -80.5700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3002
    Cell Significance Index: -34.3900
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.3210
    Cell Significance Index: -4.8100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3476
    Cell Significance Index: -73.2200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.3662
    Cell Significance Index: -6.2800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.4371
    Cell Significance Index: -9.3100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.5509
    Cell Significance Index: -9.2200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.5749
    Cell Significance Index: -4.5900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5809
    Cell Significance Index: -13.4200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.6030
    Cell Significance Index: -87.6600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6138
    Cell Significance Index: -19.6600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.6244
    Cell Significance Index: -38.3800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.7034
    Cell Significance Index: -17.9700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.8958
    Cell Significance Index: -60.2400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.9677
    Cell Significance Index: -110.4600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.9741
    Cell Significance Index: -101.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.9746
    Cell Significance Index: -54.6900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.0222
    Cell Significance Index: -22.1500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.0432
    Cell Significance Index: -82.6200
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.0497
    Cell Significance Index: -12.5100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.1601
    Cell Significance Index: -89.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -1.1900
    Cell Significance Index: -53.9400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.2015
    Cell Significance Index: -32.2000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.3300
    Cell Significance Index: -27.8400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.3581
    Cell Significance Index: -18.5300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.4157
    Cell Significance Index: -37.8700
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -1.5560
    Cell Significance Index: -21.8100
  • Cell Name: columnar/cuboidal epithelial cell (CL0000075)
    Fold Change: -1.6009
    Cell Significance Index: -6.1300
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -1.6931
    Cell Significance Index: -21.0000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.7129
    Cell Significance Index: -105.0200
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.8902
    Cell Significance Index: -11.4200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.9223
    Cell Significance Index: -56.6200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -2.0836
    Cell Significance Index: -59.4600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.2312
    Cell Significance Index: -98.6900
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -2.3116
    Cell Significance Index: -18.8500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -2.3866
    Cell Significance Index: -42.1800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.3939
    Cell Significance Index: -87.8800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -2.4046
    Cell Significance Index: -58.6700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -2.4352
    Cell Significance Index: -85.3100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Proton Transport**: The primary function of ATP6V0B is to facilitate proton transport across cellular membranes, which is essential for maintaining cellular homeostasis and regulating various cellular processes. 2. **V-Type ATPase Complex**: The V0 subunit b is a component of the proton-transporting V-type ATPase complex, which is characterized by its rotational mechanism of proton transport. 3. **Cellular Localization**: ATP6V0B is significantly expressed in various cell types, including immune cells, epithelial cells, and neurons, highlighting its importance in multiple cellular processes. **Pathways and Functions** 1. **Immune Response**: ATP6V0B plays a crucial role in the regulation of immune responses, particularly in the context of phagocytic vesicle membrane and lysosomal lumen acidification. This gene is significantly expressed in lung macrophages, where it contributes to the regulation of phagocytic function and lysosomal acidification. 2. **Cellular Signaling**: The V0 subunit b of the proton-transporting V-type ATPase complex is involved in cellular signaling pathways, including the regulation of macroautophagy and the production of ROS and RNS in phagocytes. 3. **Protein Transport**: ATP6V0B is also involved in the transport of small molecules across cellular membranes, highlighting its role in regulating various cellular processes. **Clinical Significance** 1. **Immune-Related Disorders**: Alterations in ATP6V0B expression have been implicated in various immune-related disorders, including autoimmune diseases and immunodeficiency syndromes. 2. **Cancer**: The V0 subunit b of the proton-transporting V-type ATPase complex has been shown to play a role in cancer progression, particularly in the context of tumor cell migration and invasion. 3. **Neurological Disorders**: ATP6V0B has been implicated in various neurological disorders, including Parkinson's disease and Alzheimer's disease, where it contributes to the regulation of mitochondrial function and cellular homeostasis. In conclusion, ATP6V0B is a critical gene that plays a pivotal role in various cellular processes, including immune response, cellular signaling, and protein transport. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the function and clinical significance of this gene.

Genular Protein ID: 3206085998

Symbol: VATO_HUMAN

Name: hATPL

UniProtKB Accession Codes:

Q99437 D3DPY5 Q6IB32

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChiTaRS 1 ComplexPortal 4 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 9 EMDB 6 Ensembl 3 ExpressionAtlas 1 GO 17 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 6 RefSeq 2 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 9653649

Title: Identification and characterization of the gene encoding a second proteolipid subunit of human vacuolar H(+)-ATPase (ATP6F).

PubMed ID: 9653649

DOI: 10.1006/geno.1998.5310

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 33065002

Title: Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly.

PubMed ID: 33065002

DOI: 10.1016/j.molcel.2020.09.029

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 205
  • Mass: 21406
  • Checksum: F17C688D068A2785
  • Sequence:
    • MTGLALLYSG VFVAFWACAL AVGVCYTIFD LGFRFDVAWF LTETSPFMWS NLGIGLAISL 
SVVGAAWGIY ITGSSIIGGG VKAPRIKTKN LVSIIFCEAV AIYGIIMAIV ISNMAEPFSA 
TDPKAIGHRN YHAGYSMFGA GLTVGLSNLF CGVCVGIVGS GAALADAQNP SLFVKILIVE 
IFGSAIGLFG VIVAILQTSR VKMGD

Genular Protein ID: 598873252

Symbol: E9PNL3_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PNL3

Database IDs:

ARBA 8 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 2 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 3 Gene3D 1 GeneTree 1 HGNC 1 InterPro 3 MassIVE 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PeptideAtlas 1 Pfam 2 PhylomeDB 1 Proteomes 2 RefSeq 1 RuleBase 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

Sequence Information:

  • Length: 261
  • Mass: 27677
  • Checksum: 424FA9E80FF3722D
  • Sequence:
    • MTGLALLYSG VFVAFWACAL AVGVCYTIFD LGFRFDVAWF LTETSPFMWS NLGIGLAISL 
SVVGAAWGIY ITGSSIIGGG VKAPRIKTKN LVSIIFCEAV AIYGIIMAIV ISNMAEPFSA 
TDPKAIGHRN YHAGYSMFGA GLTVGLSNLF CGVCVGIVGS GAALADAQNP SLFVKILIVE 
IFGSAIGLFG VIVAILQVMN PLGKPLCPCP QPSLTLLLEK LKCSPSLPIT IDSPKQLPPP 
HFHLLVFSYR GSLFLSLIWC H

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.