Details for: ATP6V1G2

Gene ID: 534

Symbol: ATP6V1G2

Ensembl ID: ENSG00000213760

Description: ATPase H+ transporting V1 subunit G2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 43.3314
    Cell Significance Index: -6.7400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 25.2323
    Cell Significance Index: -6.4000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 15.5044
    Cell Significance Index: -7.3200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 5.9379
    Cell Significance Index: 311.7600
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 5.4584
    Cell Significance Index: -6.7300
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 3.9187
    Cell Significance Index: 30.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 3.0783
    Cell Significance Index: 188.7300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.9400
    Cell Significance Index: -9.0300
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.7594
    Cell Significance Index: 56.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.9426
    Cell Significance Index: 189.0800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.7667
    Cell Significance Index: 48.3200
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.6471
    Cell Significance Index: 5.7000
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.6273
    Cell Significance Index: 7.7800
  • Cell Name: parasol ganglion cell of retina (CL4023189)
    Fold Change: 0.5963
    Cell Significance Index: 1.9100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5120
    Cell Significance Index: 50.6500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4686
    Cell Significance Index: 423.1400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.4595
    Cell Significance Index: 9.7900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3880
    Cell Significance Index: 139.1700
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.3441
    Cell Significance Index: 2.4900
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3265
    Cell Significance Index: 35.5200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2992
    Cell Significance Index: 17.9600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2837
    Cell Significance Index: 46.1500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2517
    Cell Significance Index: 3.0000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1823
    Cell Significance Index: 12.6100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1646
    Cell Significance Index: 31.3200
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.1409
    Cell Significance Index: 1.1000
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.1105
    Cell Significance Index: 0.8500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0865
    Cell Significance Index: 3.9200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.0581
    Cell Significance Index: 2.5700
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0517
    Cell Significance Index: 0.8300
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: 0.0497
    Cell Significance Index: 0.2600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0461
    Cell Significance Index: 0.9900
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 0.0393
    Cell Significance Index: 0.6800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.0359
    Cell Significance Index: 1.3600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0271
    Cell Significance Index: 0.7800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0270
    Cell Significance Index: 0.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0241
    Cell Significance Index: 3.3100
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.0168
    Cell Significance Index: 0.1900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0127
    Cell Significance Index: 0.2800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0072
    Cell Significance Index: 0.1800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0071
    Cell Significance Index: 0.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0062
    Cell Significance Index: 1.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0001
    Cell Significance Index: 0.1700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0000
    Cell Significance Index: 0.0600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0015
    Cell Significance Index: -2.3500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0019
    Cell Significance Index: -3.5900
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0043
    Cell Significance Index: -1.9200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0058
    Cell Significance Index: -4.2700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0062
    Cell Significance Index: -0.3500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0076
    Cell Significance Index: -4.8300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0079
    Cell Significance Index: -5.8800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0086
    Cell Significance Index: -6.5300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0086
    Cell Significance Index: -4.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0094
    Cell Significance Index: -1.7000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0101
    Cell Significance Index: -1.1800
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.0109
    Cell Significance Index: -0.0900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0110
    Cell Significance Index: -0.4500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0116
    Cell Significance Index: -5.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0116
    Cell Significance Index: -6.3300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0128
    Cell Significance Index: -0.3300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0134
    Cell Significance Index: -8.3500
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: -0.0138
    Cell Significance Index: -0.0900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0168
    Cell Significance Index: -0.4700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0228
    Cell Significance Index: -3.3100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0232
    Cell Significance Index: -0.3500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0238
    Cell Significance Index: -6.8400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.0240
    Cell Significance Index: -0.5000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0270
    Cell Significance Index: -1.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0290
    Cell Significance Index: -3.5700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0334
    Cell Significance Index: -7.0300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0373
    Cell Significance Index: -4.4000
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0398
    Cell Significance Index: -0.5700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0402
    Cell Significance Index: -5.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0436
    Cell Significance Index: -7.4400
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0454
    Cell Significance Index: -0.9800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0467
    Cell Significance Index: -1.5300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0487
    Cell Significance Index: -5.5800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0510
    Cell Significance Index: -6.5900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0514
    Cell Significance Index: -1.0900
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.0522
    Cell Significance Index: -0.3100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0540
    Cell Significance Index: -1.1200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0586
    Cell Significance Index: -5.9900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0590
    Cell Significance Index: -0.6700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0611
    Cell Significance Index: -4.6900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0643
    Cell Significance Index: -6.6900
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.0653
    Cell Significance Index: -0.6800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0670
    Cell Significance Index: -2.1400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0693
    Cell Significance Index: -1.3700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0749
    Cell Significance Index: -5.9300
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0757
    Cell Significance Index: -1.5200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0782
    Cell Significance Index: -4.0600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0791
    Cell Significance Index: -5.1000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0827
    Cell Significance Index: -0.5600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0840
    Cell Significance Index: -6.2600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0845
    Cell Significance Index: -1.4200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0859
    Cell Significance Index: -3.0100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0904
    Cell Significance Index: -3.1400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1017
    Cell Significance Index: -4.7400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1051
    Cell Significance Index: -7.4300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1117
    Cell Significance Index: -3.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The ATP6V1G2 gene exhibits the following key characteristics: 1. **Proton-pumping activity**: The ATP6V1G2 gene encodes for a subunit of the V-type ATPase complex, which is responsible for pumping protons across cellular membranes, thereby regulating pH and ion homeostasis. 2. **Subunit specificity**: The G2 subunit is a unique component of the V-type ATPase complex, which is involved in regulating the activity of the enzyme. 3. **Expression patterns**: The ATP6V1G2 gene is highly expressed in various tissues, including the nervous system, kidney, and intestinal epithelial cells. 4. **Regulation of immune responses**: The ATP6V1G2 gene is involved in regulating immune responses, including the activation of macrophages and the production of reactive oxygen species (ROS). **Pathways and Functions** The ATP6V1G2 gene is involved in various cellular pathways, including: 1. **Ion homeostasis**: The ATP6V1G2 gene plays a crucial role in regulating ion homeostasis, particularly in the nervous system and kidney. 2. **Acidification of vesicles**: The ATP6V1G2 gene is involved in acidifying vesicles, such as synaptic vesicles and melanosomes, which is essential for neurotransmitter release and melanin synthesis. 3. **Immune responses**: The ATP6V1G2 gene is involved in regulating immune responses, including the activation of macrophages and the production of ROS. 4. **Autophagy**: The ATP6V1G2 gene is involved in regulating autophagy, a cellular process that involves the degradation and recycling of cellular components. **Clinical Significance** The ATP6V1G2 gene has significant clinical implications, particularly in the context of neurological and immunological disorders. Some potential clinical applications of the ATP6V1G2 gene include: 1. **Neurological disorders**: Mutations in the ATP6V1G2 gene have been implicated in various neurological disorders, including Parkinson's disease and Alzheimer's disease. 2. **Immunological disorders**: The ATP6V1G2 gene is involved in regulating immune responses, and mutations in this gene may contribute to immunological disorders, such as autoimmune diseases. 3. **Cancer**: The ATP6V1G2 gene is involved in regulating autophagy, and alterations in this gene may contribute to cancer development and progression. 4. **Personalized medicine**: The ATP6V1G2 gene may be used as a biomarker for personalized medicine, allowing for targeted therapies and interventions based on individual genetic profiles. In conclusion, the ATP6V1G2 gene plays a crucial role in various cellular processes, including ion homeostasis, acidification of vesicles, and regulation of immune responses. Its involvement in neurological and immunological disorders highlights the potential for this gene to be used as a biomarker for personalized medicine and targeted therapies.

Genular Protein ID: 2817612062

Symbol: VATG2_HUMAN

Name: V-type proton ATPase subunit G 2

UniProtKB Accession Codes:

O95670 B5MEF0 Q2L6F8 Q5HYU8 Q5RJ63

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CTD 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 23 Ensembl 15 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 RNAct 1 Reactome 5 RefSeq 3 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10202016

Title: A new member of the Ig superfamily and a V-ATPase G subunit are among the predicted products of novel genes close to the TNF locus in the human MHC.

PubMed ID: 10202016

PubMed ID: 14574404

Title: The DNA sequence and analysis of human chromosome 6.

PubMed ID: 14574404

DOI: 10.1038/nature02055

PubMed ID: 16702430

Title: Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity.

PubMed ID: 16702430

DOI: 10.1534/genetics.106.057034

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12384298

Title: Molecular cloning and characterization of novel tissue-specific isoforms of the human vacuolar H(+)-ATPase C, G and d subunits, and their evaluation in autosomal recessive distal renal tubular acidosis.

PubMed ID: 12384298

DOI: 10.1016/s0378-1119(02)00884-3

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

Sequence Information:

  • Length: 118
  • Mass: 13604
  • Checksum: 5D46EEE0C8D7657D
  • Sequence:
    • MASQSQGIQQ LLQAEKRAAE KVADARKRKA RRLKQAKEEA QMEVEQYRRE REHEFQSKQQ 
AAMGSQGNLS AEVEQATRRQ VQGMQSSQQR NRERVLAQLL GMVCDVRPQV HPNYRISA

Genular Protein ID: 3070814051

Symbol: Q6NVJ2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6NVJ2

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 2 Gene3D 1 InterPro 1 KEGG 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 RefSeq 3 RuleBase 1 SAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 109
  • Mass: 12673
  • Checksum: B36570AA79D43477
  • Sequence:
    • QLLQAEKRAA EKVADARKRK ARRLKQAKEE AQMEVEQYRR EREHEFQSKQ QAAMGSQGNL 
SAEVEQATRR QVQGMQSSQQ RNRERVLAQL LGMVCDVRPQ VHPNYRISA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.