Stk39 | ENSMUSG00000027030 | NCBI 53416

Details for: Stk39

Gene ID: 53416

Symbol: Stk39

Ensembl ID: ENSMUSG00000027030

Description: serine/threonine kinase 39

Associated with

Apical plasma membrane
(GO:0016324)
Atp binding
(GO:0005524)
Basolateral plasma membrane
(GO:0016323)
Cell body
(GO:0044297)
Cell cortex
(GO:0005938)
Cellular hyperosmotic response
(GO:0071474)
Cellular hypotonic response
(GO:0071476)
Cellular response to chemokine
(GO:1990869)
Cellular response to potassium ion
(GO:0035865)
Cell volume homeostasis
(GO:0006884)
Chemokine (c-x-c motif) ligand 12 signaling pathway
(GO:0038146)
Chromatin remodeling
(GO:0006338)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Histone h2as1 kinase activity
(GO:0044024)
Inflammatory response
(GO:0006954)
Intracellular chloride ion homeostasis
(GO:0030644)
Intracellular membrane-bounded organelle
(GO:0043231)
Intracellular signal transduction
(GO:0035556)
Kinase activity
(GO:0016301)
Macrophage activation
(GO:0042116)
Maintenance of lens transparency
(GO:0036438)
Membrane
(GO:0016020)
Monoatomic ion homeostasis
(GO:0050801)
Negative regulation of creatine transmembrane transporter activity
(GO:1905408)
Negative regulation of pancreatic juice secretion
(GO:0090188)
Negative regulation of potassium ion transmembrane transport
(GO:1901380)
Negative regulation of potassium ion transmembrane transporter activity
(GO:1901017)
Negative regulation of sodium ion transmembrane transporter activity
(GO:2000650)
Nucleoplasm
(GO:0005654)
Peptidyl-serine phosphorylation
(GO:0018105)
Peptidyl-threonine phosphorylation
(GO:0018107)
Positive regulation of ion transmembrane transporter activity
(GO:0032414)
Positive regulation of p38mapk cascade
(GO:1900745)
Positive regulation of potassium ion transport
(GO:0043268)
Positive regulation of t cell chemotaxis
(GO:0010820)
Protein autophosphorylation
(GO:0046777)
Protein binding
(GO:0005515)
Protein kinase binding
(GO:0019901)
Protein phosphorylation
(GO:0006468)
Protein serine/threonine kinase activity
(GO:0004674)
Protein serine kinase activity
(GO:0106310)
Regulation of blood pressure
(GO:0008217)
Regulation of inflammatory response
(GO:0050727)
Renal sodium ion absorption
(GO:0070294)
Response to aldosterone
(GO:1904044)
Response to dietary excess
(GO:0002021)
Signal transduction
(GO:0007165)
Sodium ion transmembrane transport
(GO:0035725)

Other Information

Proteins

STE20/SPS1-related proline-alanine-rich protein kinase

Genular Protein ID: 2253546498

Symbol: STK39_MOUSE

Name: STE20/SPS1-related proline-alanine-rich protein kinase

UniProtKB Accession Codes:

Q9Z1W9 Q80W13

Database IDs:

Citations:

PubMed ID: 10980603

Title: SPAK, a STE20/SPS1-related kinase that activates the p38 pathway.

PubMed ID: 10980603

DOI: 10.1038/sj.onc.1203784

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14563843

Title: Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a scaffolding role of the kinase.

PubMed ID: 14563843

DOI: 10.1074/jbc.m309436200

PubMed ID: 16530727

Title: The TNF receptor, RELT, binds SPAK and uses it to mediate p38 and JNK activation.

PubMed ID: 16530727

DOI: 10.1016/j.bbrc.2006.02.125

PubMed ID: 16382158

Title: Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter.

PubMed ID: 16382158

DOI: 10.1128/mcb.26.2.689-698.2006

PubMed ID: 17488636

Title: Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model.

PubMed ID: 17488636

DOI: 10.1016/j.cmet.2007.03.009

PubMed ID: 19633012

Title: Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure.

PubMed ID: 19633012

DOI: 10.1093/hmg/ddp344

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20385770

Title: SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na(+)-K(+)-Cl(-) cotransporter 2.

PubMed ID: 20385770

DOI: 10.1128/mcb.01560-09

PubMed ID: 21733846

Title: WNK2 is a novel regulator of essential neuronal cation-chloride cotransporters.

PubMed ID: 21733846

DOI: 10.1074/jbc.m111.222893

PubMed ID: 21486947

Title: Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade.

PubMed ID: 21486947

DOI: 10.1242/jcs.084111

PubMed ID: 21317537

Title: IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway.

PubMed ID: 21317537

DOI: 10.1172/jci43475

PubMed ID: 23542070

Title: Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice.

PubMed ID: 23542070

DOI: 10.1053/j.gastro.2013.03.047

Sequence Information:

Length: 556
Mass: 60320
Checksum: 66085A90554311D8
Sequence:

MAEPSGSPVH VQLSQQAAPV TAAAATAPAA ATSAPAPAPA PAPAASAAPA PAPAAAPAPA 
PAAQAVGWPI CRDAYELQEV IGSGATAVVQ AALCKPRQER VAIKRINLEK CQTSMDELLK 
EIQAMSQCSH PNVVTYYTSF VVKDELWLVM KLLSGGSMLD IIKYIVNRGE HKNGVLEEAI 
IATILKEVLE GLDYLHRNGQ IHRDLKAGNI LLGEDGSVQI ADFGVSAFLA TGGDVTRNKV 
RKTFVGTPCW MAPEVMEQVR GYDFKADMWS FGITAIELAT GAAPYHKYPP MKVLMLTLQN 
DPPTLETGVE DKEMMKKYGK SFRKLLSLCL QKDPSKRPTA AELLKCKFFQ KAKNREYLIE 
KLLTRTPDIA QRAKKVRRVP GSSGHLHKTE DGDWEWSDDE MDEKSEEGKA AASQEKSRRV 
KEENSEISVN AGGIPEQIQS LSVHDSQAQP NANEDYREGP CAVNLVLRLR NSRKELNDIR 
FEFTPGRDTA DGVSQELFSA GLVDGHDVVI VAANLQKIVD DPKALKTLTF KLASGCDGSE 
IPDEVKLIGF AQLSVS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Stk39

Associated with

Other Information

SPAK, a STE20/SPS1-related kinase that activates the p38 pathway. PubMed ID: 10980603

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Characterization of the interaction of the stress kinase SPAK with the Na+-K+-2Cl- cotransporter in the nervous system: evidence for a scaffolding role of the kinase. PubMed ID: 14563843

The TNF receptor, RELT, binds SPAK and uses it to mediate p38 and JNK activation. PubMed ID: 16530727

Characterization of SPAK and OSR1, regulatory kinases of the Na-K-2Cl cotransporter. PubMed ID: 16382158

Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model. PubMed ID: 17488636

Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure. PubMed ID: 19633012

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

SORLA/SORL1 functionally interacts with SPAK to control renal activation of Na(+)-K(+)-Cl(-) cotransporter 2. PubMed ID: 20385770

WNK2 is a novel regulator of essential neuronal cation-chloride cotransporters. PubMed ID: 21733846

Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade. PubMed ID: 21486947

IRBIT governs epithelial secretion in mice by antagonizing the WNK/SPAK kinase pathway. PubMed ID: 21317537

Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice. PubMed ID: 23542070