Hif3a | ENSMUSG00000004328 | NCBI 53417

Details for: Hif3a

Gene ID: 53417

Symbol: Hif3a

Ensembl ID: ENSMUSG00000004328

Description: hypoxia inducible factor 3, alpha subunit

Associated with

Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Metabolism of proteins
(R-MMU-392499)
Neddylation
(R-MMU-8951664)
Oxygen-dependent proline hydroxylation of hypoxia-inducible factor alpha
(R-MMU-1234176)
Post-translational protein modification
(R-MMU-597592)
Regulation of gene expression by hypoxia-inducible factor
(R-MMU-1234158)
Angiogenesis
(GO:0001525)
Apoptotic process
(GO:0006915)
Cellular response to hypoxia
(GO:0071456)
Chromatin
(GO:0000785)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Mitochondrion
(GO:0005739)
Nuclear speck
(GO:0016607)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to hypoxia
(GO:0001666)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Rna polymerase ii transcription regulatory region sequence-specific dna binding
(GO:0000977)
Transcription by rna polymerase ii
(GO:0006366)

Other Information

Proteins

Basic-helix-loop-helix-PAS protein MOP7

Genular Protein ID: 2908393821

Symbol: HIF3A_MOUSE

Name: Basic-helix-loop-helix-PAS protein MOP7

UniProtKB Accession Codes:

Q0VBL6 A1IM61 E9QLB1 Q3UN40 Q8VHR1 Q9QX54 Q9Z2I5

Database IDs:

Citations:

PubMed ID: 9840812

Title: Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha.

PubMed ID: 9840812

PubMed ID: 11734856

Title: Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression.

PubMed ID: 11734856

DOI: 10.1038/35107085

PubMed ID: 18070924

Title: Abnormal heart development and lung remodeling in mice lacking the hypoxia-inducible factor-related basic helix-loop-helix PAS protein NEPAS.

PubMed ID: 18070924

DOI: 10.1128/mcb.01332-07

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 12119283

Title: Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus.

PubMed ID: 12119283

DOI: 10.1074/jbc.c200328200

PubMed ID: 17355974

Title: Transcriptional up-regulation of inhibitory PAS domain protein gene expression by hypoxia-inducible factor 1 (HIF-1): a negative feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells.

PubMed ID: 17355974

DOI: 10.1074/jbc.m700732200

PubMed ID: 21546903

Title: Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins.

PubMed ID: 21546903

DOI: 10.1038/cdd.2011.47

PubMed ID: 24092767

Title: Nucleocytoplasmic shuttling of IPAS by its unique nuclear import and export signals unshared with other HIF-3alpha splice variants.

PubMed ID: 24092767

DOI: 10.1093/jb/mvt088

Sequence Information:

Length: 662
Mass: 73044
Checksum: D05E2B9CB2B63E4E
Sequence:

MDWDQDRSNT ELRKEKSRDA ARSRRSQETE VLYQLAHTLP FARGVSAHLD KASIMRLTIS 
YLRMHRLCAA GEWNQVEKGG EPLDACYLKA LEGFVMVLTA EGDMAYLSEN VSKHLGLSQL 
ELIGHSIFDF IHPCDQEELQ DALTPRPNLS KKKLEAPTER HFSLRMKSTL TSRGRTLNLK 
AATWKVLHCS GHMRAYKPPA QTSPAGSPRS EPPLQCLVLI CEAIPHPASL EPPLGRGAFL 
SRHSLDMKFT YCDERIAEVA GYSPDDLIGC SAYEYIHALD SDAVSRSIHT LLSKGQAVTG 
QYRFLARTGG YLWTQTQATV VSGGRGPQSE SIICVHFLIS RVEETGVVLS LEQTEQHTRR 
PPRLSASSQK GIPGNSVDSP APRILAFLHP PALSEASLAA DPRRFCSPDL RRLMAPILDG 
PPPAATPSTP QATRRPQSPL PADLPDKLTV GLENAHRLST AQKNKTVETD LDIAQDPDTL 
DLEMLAPYIS MDDDFQLNSS EQLPKVHRRP PRVARRPRAR SFHGLSPPIP EPSLLPRWGS 
DPRLNCSSPS RGDRPTASLM PGTRKRALAQ SSEDKGLELL ETKPPKRSPR LEPGSFLLPP 
LSLSFLLQGR QLPGNQQDPR APLVHSHEPL GLAPSLLSLC QHEETVQPRN RFPPAAGLGQ 
TH

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Hif3a

Associated with

Other Information

Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha. PubMed ID: 9840812

Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. PubMed ID: 11734856

Abnormal heart development and lung remodeling in mice lacking the hypoxia-inducible factor-related basic helix-loop-helix PAS protein NEPAS. PubMed ID: 18070924

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus. PubMed ID: 12119283

Transcriptional up-regulation of inhibitory PAS domain protein gene expression by hypoxia-inducible factor 1 (HIF-1): a negative feedback regulatory circuit in HIF-1-mediated signaling in hypoxic cells. PubMed ID: 17355974

Pro-apoptotic activity of inhibitory PAS domain protein (IPAS), a negative regulator of HIF-1, through binding to pro-survival Bcl-2 family proteins. PubMed ID: 21546903

Nucleocytoplasmic shuttling of IPAS by its unique nuclear import and export signals unshared with other HIF-3alpha splice variants. PubMed ID: 24092767