Insm1 | ENSMUSG00000068154 | NCBI 53626

Details for: Insm1

Gene ID: 53626

Symbol: Insm1

Ensembl ID: ENSMUSG00000068154

Description: insulinoma-associated 1

Associated with

Adrenal chromaffin cell differentiation
(GO:0061104)
Cell migration
(GO:0016477)
Cell population proliferation
(GO:0008283)
Chromatin dna binding
(GO:0031490)
Cyclin binding
(GO:0030332)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription repressor activity, rna polymerase ii-specific
(GO:0001227)
Endocrine pancreas development
(GO:0031018)
Endocrine system development
(GO:0035270)
Histone deacetylase binding
(GO:0042826)
Metal ion binding
(GO:0046872)
Molecular adaptor activity
(GO:0060090)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of protein phosphorylation
(GO:0001933)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Neuron differentiation
(GO:0030182)
Noradrenergic neuron development
(GO:0003358)
Norepinephrine biosynthetic process
(GO:0042421)
Nucleus
(GO:0005634)
Pancreatic a cell differentiation
(GO:0003310)
Positive regulation of cell differentiation
(GO:0045597)
Positive regulation of cell migration
(GO:0030335)
Positive regulation of cell population proliferation
(GO:0008284)
Positive regulation of neural precursor cell proliferation
(GO:2000179)
Protein binding
(GO:0005515)
Regulation of cell cycle
(GO:0051726)
Regulation of cell cycle process
(GO:0010564)
Regulation of gene expression
(GO:0010468)
Regulation of protein-containing complex assembly
(GO:0043254)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sympathetic ganglion development
(GO:0061549)
Transcription repressor complex
(GO:0017053)
Transdifferentiation
(GO:0060290)
Type b pancreatic cell development
(GO:0003323)
Type b pancreatic cell differentiation
(GO:0003309)

Other Information

Proteins

Insulinoma-associated protein 1

Genular Protein ID: 1777842648

Symbol: INSM1_MOUSE

Name: Insulinoma-associated protein 1

UniProtKB Accession Codes:

Q63ZV0 Q9Z113

Database IDs:

Citations:

PubMed ID: 12079283

Title: The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein.

PubMed ID: 12079283

DOI: 10.1006/geno.2002.6800

PubMed ID: 12890672

Title: NeuroD1/E47 regulates the E-box element of a novel zinc finger transcription factor, IA-1, in developing nervous system.

PubMed ID: 12890672

DOI: 10.1074/jbc.m306795200

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16511571

Title: IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas.

PubMed ID: 16511571

DOI: 10.1038/sj.emboj.7601011

PubMed ID: 16951258

Title: The zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells.

PubMed ID: 16951258

DOI: 10.1101/gad.381806

PubMed ID: 18094025

Title: Insm1 (IA-1) is a crucial component of the transcriptional network that controls differentiation of the sympatho-adrenal lineage.

PubMed ID: 18094025

DOI: 10.1242/dev.011783

PubMed ID: 18940587

Title: Insulinoma-associated 1 has a panneurogenic role and promotes the generation and expansion of basal progenitors in the developing mouse neocortex.

PubMed ID: 18940587

DOI: 10.1016/j.neuron.2008.09.020

PubMed ID: 24227653

Title: Insm1 controls development of pituitary endocrine cells and requires a SNAG domain for function and for recruitment of histone-modifying factors.

PubMed ID: 24227653

DOI: 10.1242/dev.097642

Sequence Information:

Length: 521
Mass: 54050
Checksum: 84D0D8E64504D351
Sequence:

MPRGFLVKRS KKSTPVSYRV RGGEDSDRAL LLSPGCGGAR AEPPVPSPGP LPPPPPPALA 
ERAHAALAAA LACAPGPPPP PPPGPRAAHF GNPEAAHPAP LYSPTRPVSR EHEKHKYFER 
SFNLGSPVSA ESFPTPAALL AGGGSGANGA GGGGGGTCGG DALLFAPAEL KMGTAFSAGA 
EAARGPGTGP PLSPAAALRP PGKRPAPPAA VATEPPAKAA KAPSAKKPKA IRKLHFEDEV 
TTSPVLGLKI KEGPVEAPRG RAGGATRPLG EFICQLCKEE YADPFALAQH KCSRIVRVEY 
RCPECAKVFS CPANLASHRR WHKPRPVPAA ARAPEPEAAT RAEAREAAGG GSSDRDTPSP 
GGVSESGSED GLYECHHCAK KFRRQAYLRK HLLAHHQALQ AKGAPPPPPP PPPPAEDILA 
FYAGPDEKAP QEASGDGEAA GVLGLSATAQ CHLCPVCGET FPSKGAQERH LRLLHAAQVF 
PCKYCPATFY SSPGLTRHIN KCHPSENRQV ILLQVPVRPA C

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Insm1

Associated with

Other Information

The zinc-finger transcription factor INSM1 is expressed during embryo development and interacts with the Cbl-associated protein. PubMed ID: 12079283

NeuroD1/E47 regulates the E-box element of a novel zinc finger transcription factor, IA-1, in developing nervous system. PubMed ID: 12890672

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

IA1 is NGN3-dependent and essential for differentiation of the endocrine pancreas. PubMed ID: 16511571

The zinc-finger factor Insm1 (IA-1) is essential for the development of pancreatic beta cells and intestinal endocrine cells. PubMed ID: 16951258

Insm1 (IA-1) is a crucial component of the transcriptional network that controls differentiation of the sympatho-adrenal lineage. PubMed ID: 18094025

Insulinoma-associated 1 has a panneurogenic role and promotes the generation and expansion of basal progenitors in the developing mouse neocortex. PubMed ID: 18940587

Insm1 controls development of pituitary endocrine cells and requires a SNAG domain for function and for recruitment of histone-modifying factors. PubMed ID: 24227653