Details for: ATP6AP1

Gene ID: 537

Symbol: ATP6AP1

Ensembl ID: ENSG00000071553

Description: ATPase H+ transporting accessory protein 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 3.54
    Marker Score: 2146
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 3.2
    Marker Score: 2855
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 3.13
    Marker Score: 2208
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.42
    Marker Score: 4007
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.4
    Marker Score: 61401
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.33
    Marker Score: 5875
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 2.25
    Marker Score: 9347
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.19
    Marker Score: 4447.5
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 2.09
    Marker Score: 1399
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.03
    Marker Score: 2326
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.98
    Marker Score: 5304
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.94
    Marker Score: 1068
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.92
    Marker Score: 7550
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.87
    Marker Score: 2264
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 1.85
    Marker Score: 744.5
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.81
    Marker Score: 1814
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.81
    Marker Score: 2669
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 1.78
    Marker Score: 1675
  • Cell Name: blood cell (CL0000081)
    Fold Change: 1.75
    Marker Score: 20305
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 1.74
    Marker Score: 10577
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 1.71
    Marker Score: 2477
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 1.7
    Marker Score: 710
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.69
    Marker Score: 94678
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 1.68
    Marker Score: 14631
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.68
    Marker Score: 58240
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.67
    Marker Score: 831
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.66
    Marker Score: 3792
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.66
    Marker Score: 1757
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 1.65
    Marker Score: 784
  • Cell Name: PP cell (CL0000696)
    Fold Change: 1.65
    Marker Score: 372
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.63
    Marker Score: 2308
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.62
    Marker Score: 1078
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 1.6
    Marker Score: 3125
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 1.6
    Marker Score: 3987.5
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 1.6
    Marker Score: 2301
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 1.6
    Marker Score: 538
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 1.6
    Marker Score: 596
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 1.58
    Marker Score: 464
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 1.56
    Marker Score: 860
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.55
    Marker Score: 4017
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.54
    Marker Score: 812
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 1.54
    Marker Score: 628
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.54
    Marker Score: 11439
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.53
    Marker Score: 1547
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 1.52
    Marker Score: 13109
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.51
    Marker Score: 5838
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 1.51
    Marker Score: 1003.5
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 1.48
    Marker Score: 348
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.47
    Marker Score: 3074.5
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 1.46
    Marker Score: 504
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 1.46
    Marker Score: 975
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 1.45
    Marker Score: 1215
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 1.45
    Marker Score: 1052
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.45
    Marker Score: 1368
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.42
    Marker Score: 14275
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.42
    Marker Score: 1528
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 1.4
    Marker Score: 748.5
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.37
    Marker Score: 8907
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.37
    Marker Score: 1451
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 1.36
    Marker Score: 1380
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.35
    Marker Score: 2574
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 1.35
    Marker Score: 630
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1.34
    Marker Score: 3658
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 1.34
    Marker Score: 1780
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.33
    Marker Score: 775
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 1.33
    Marker Score: 688
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 1.33
    Marker Score: 6982
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.33
    Marker Score: 5726
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 1.32
    Marker Score: 382
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 1.32
    Marker Score: 1371
  • Cell Name: oocyte (CL0000023)
    Fold Change: 1.31
    Marker Score: 323
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 1.31
    Marker Score: 801
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 1.3
    Marker Score: 741
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 1.3
    Marker Score: 332
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 1.29
    Marker Score: 253
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 1.28
    Marker Score: 363
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 1.28
    Marker Score: 409
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.27
    Marker Score: 866
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 1.27
    Marker Score: 709
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 1.27
    Marker Score: 1129
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.26
    Marker Score: 312
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 1.25
    Marker Score: 2050.5
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 1.24
    Marker Score: 428
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 1.23
    Marker Score: 2183
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 1.21
    Marker Score: 720
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 1.21
    Marker Score: 644
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.2
    Marker Score: 12200
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.19
    Marker Score: 3104
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 1.18
    Marker Score: 558
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.18
    Marker Score: 1003
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.18
    Marker Score: 666
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 1.18
    Marker Score: 1419
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.17
    Marker Score: 3668
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 1.16
    Marker Score: 576
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.16
    Marker Score: 5577
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.16
    Marker Score: 486
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 1.15
    Marker Score: 1219
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 1.15
    Marker Score: 397
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 1.15
    Marker Score: 1828
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.15
    Marker Score: 1232.5

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * ATP6AP1 is a large protein with a molecular weight of approximately 150 kDa. * It is a member of the ATPase H+ transporting accessory protein family. * It is involved in the regulation of cellular pH through the control of protein binding and transport. **Pathways and functions:** * ATP6AP1 is involved in the regulation of insulin receptor recycling. * It is also involved in the maintenance of intracellular iron ion homeostasis. * It is involved in the transport of small molecules, including ions and proteins. **Clinical significance:** * Mutations in ATP6AP1 have been linked to several human diseases, including diabetes, cancer, and heart disease. * Studies of ATP6AP1 have potential implications for the development of new therapeutic strategies for these diseases. **Additional notes:** * ATP6AP1 is a highly conserved protein, with a similar sequence found in organisms from yeast to humans. * It is a well-established regulator of cellular pH and has been extensively studied for its role in various cellular processes.

Genular Protein ID: 1590030885

Symbol: VAS1_HUMAN

Name: V-type proton ATPase subunit S1

UniProtKB Accession Codes:

Q15904 A6ZKI4 Q8NBT4 Q9H0C7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 4 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 10 EMDB 6 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 26 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 6 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 2 SIGNOR 1 SMR 1 STRING 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 3 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8733135

Title: Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci.

PubMed ID: 8733135

DOI: 10.1093/hmg/5.5.659

PubMed ID: 11230166

Title: Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.

PubMed ID: 11230166

DOI: 10.1101/gr.gr1547r

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16303743

Title: Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.

PubMed ID: 16303743

DOI: 10.1093/dnares/12.2.117

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8034313

Title: Isolation of expressed sequences encoded by the human Xq terminal portion using microclone probes generated by laser microdissection.

PubMed ID: 8034313

DOI: 10.1006/geno.1994.1194

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 26212330

Title: RNASEK Is a V-ATPase-Associated Factor Required for Endocytosis and the Replication of Rhinovirus, Influenza A Virus, and Dengue Virus.

PubMed ID: 26212330

DOI: 10.1016/j.celrep.2015.06.076

PubMed ID: 27231034

Title: ATP6AP1 deficiency causes an immunodeficiency with hepatopathy, cognitive impairment and abnormal protein glycosylation.

PubMed ID: 27231034

DOI: 10.1038/ncomms11600

PubMed ID: 28296633

Title: The vacuolar-ATPase complex and assembly factors, TMEM199 and CCDC115, control HIF1alpha prolyl hydroxylation by regulating cellular iron levels.

PubMed ID: 28296633

DOI: 10.7554/elife.22693

PubMed ID: 29127204

Title: Mutations in the X-linked ATP6AP2 cause a glycosylation disorder with autophagic defects.

PubMed ID: 29127204

DOI: 10.1084/jem.20170453

PubMed ID: 28728022

Title: Loss of TMEM106B ameliorates lysosomal and frontotemporal dementia-related phenotypes in progranulin-deficient mice.

PubMed ID: 28728022

DOI: 10.1016/j.neuron.2017.06.026

PubMed ID: 33065002

Title: Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly.

PubMed ID: 33065002

DOI: 10.1016/j.molcel.2020.09.029

Sequence Information:

  • Length: 470
  • Mass: 52026
  • Checksum: A71C7EF0E90D0652
  • Sequence:
    • MMAAMATARV RMGPRCAQAL WRMPWLPVFL SLAAAAAAAA AEQQVPLVLW SSDRDLWAPA 
ADTHEGHITS DLQLSTYLDP ALELGPRNVL LFLQDKLSIE DFTAYGGVFG NKQDSAFSNL 
ENALDLAPSS LVLPAVDWYA VSTLTTYLQE KLGASPLHVD LATLRELKLN ASLPALLLIR 
LPYTASSGLM APREVLTGND EVIGQVLSTL KSEDVPYTAA LTAVRPSRVA RDVAVVAGGL 
GRQLLQKQPV SPVIHPPVSY NDTAPRILFW AQNFSVAYKD QWEDLTPLTF GVQELNLTGS 
FWNDSFARLS LTYERLFGTT VTFKFILANR LYPVSARHWF TMERLEVHSN GSVAYFNASQ 
VTGPSIYSFH CEYVSSLSKK GSLLVARTQP SPWQMMLQDF QIQAFNVMGE QFSYASDCAS 
FFSPGIWMGL LTSLFMLFIF TYGLHMILSL KTMDRFDDHK GPTISLTQIV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.