Details for: ATP7A

Gene ID: 538

Symbol: ATP7A

Ensembl ID: ENSG00000165240

Description: ATPase copper transporting alpha

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 1.02
    Marker Score: 691
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 1.01
    Marker Score: 1258
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71764
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47989
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.94
    Marker Score: 482
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.93
    Marker Score: 437
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.92
    Marker Score: 2089
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2721
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.9
    Marker Score: 1319
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5007
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5260
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1268
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.76
    Marker Score: 1325
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 375
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.72
    Marker Score: 1188
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.71
    Marker Score: 542
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.7
    Marker Score: 348
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.7
    Marker Score: 10970
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.7
    Marker Score: 279
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 632
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 0.68
    Marker Score: 216
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.68
    Marker Score: 283
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 0.67
    Marker Score: 462
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.66
    Marker Score: 386
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.66
    Marker Score: 169
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.65
    Marker Score: 2747
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.62
    Marker Score: 379
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.6
    Marker Score: 290
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.59
    Marker Score: 356
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.58
    Marker Score: 608
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.57
    Marker Score: 3605
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.55
    Marker Score: 492
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.54
    Marker Score: 174
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 429
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.53
    Marker Score: 1250
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.51
    Marker Score: 1044
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.51
    Marker Score: 340
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.48
    Marker Score: 548
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: 0.48
    Marker Score: 139
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.48
    Marker Score: 305.5
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.47
    Marker Score: 470
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.47
    Marker Score: 113
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.46
    Marker Score: 126
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 0.46
    Marker Score: 166.5
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.46
    Marker Score: 106
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.46
    Marker Score: 304
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.45
    Marker Score: 209
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.44
    Marker Score: 139
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.44
    Marker Score: 489
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.44
    Marker Score: 457
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.44
    Marker Score: 111
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.43
    Marker Score: 362
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.43
    Marker Score: 230
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.43
    Marker Score: 113
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.43
    Marker Score: 655
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.42
    Marker Score: 120
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.42
    Marker Score: 745
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.42
    Marker Score: 84
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.41
    Marker Score: 276
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.41
    Marker Score: 178
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.41
    Marker Score: 2710
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.4
    Marker Score: 2113
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.4
    Marker Score: 140
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.4
    Marker Score: 221
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 0.4
    Marker Score: 2612
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.38
    Marker Score: 160
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.38
    Marker Score: 213
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.37
    Marker Score: 316
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.37
    Marker Score: 125
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.37
    Marker Score: 1366
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.36
    Marker Score: 3663
  • Cell Name: myeloid dendritic cell (CL0000782)
    Fold Change: 0.36
    Marker Score: 220
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.36
    Marker Score: 3181
  • Cell Name: bronchial goblet cell (CL1000312)
    Fold Change: 0.36
    Marker Score: 178
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.36
    Marker Score: 359
  • Cell Name: promyelocyte (CL0000836)
    Fold Change: 0.36
    Marker Score: 176
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.35
    Marker Score: 803
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.35
    Marker Score: 158
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.35
    Marker Score: 2611
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.34
    Marker Score: 865
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.34
    Marker Score: 78
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.34
    Marker Score: 181
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.34
    Marker Score: 169
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.34
    Marker Score: 84
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.34
    Marker Score: 183
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.34
    Marker Score: 8642
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.34
    Marker Score: 106.5
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.34
    Marker Score: 102
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.33
    Marker Score: 153
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.33
    Marker Score: 83
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.33
    Marker Score: 136
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.33
    Marker Score: 82
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.33
    Marker Score: 333
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.33
    Marker Score: 83
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.33
    Marker Score: 71
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.33
    Marker Score: 184
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.32
    Marker Score: 326

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Other Information

**Key characteristics:** * ATP7A is a protein of approximately 130 kDa. * It is expressed in high levels in immune cells, including macrophages, dendritic cells, neutrophils, and lymphocytes. * It is also expressed in non-immune cells, including hepatocytes, endothelial cells, and smooth muscle cells. * ATP7A is a homo-tetrameric protein, with each subunit being approximately 40 kDa. * It is a non-selective cation channel, and its activity is regulated by a variety of factors, including copper, calcium, and reactive oxygen species. **Pathways and functions:** * ATP7A is involved in the regulation of innate immune responses. It is expressed in macrophages and dendritic cells, which are the first line of defense against infection. ATP7A is also expressed in neutrophils, which are important for the inflammatory response. * ATP7A is involved in the regulation of adaptive immune responses. It is expressed in lymphocytes, such as T cells and B cells. ATP7A is also involved in the regulation of inflammation. * ATP7A is involved in the detoxification of reactive oxygen species (ROS). ROS are produced by immune cells during infection or stress, and they can damage cells and tissues. ATP7A is a key protein in the removal of ROS from the cell. * ATP7A is also involved in the transport of small molecules. It is expressed in cells that are involved in the uptake and efflux of small molecules, such as ions and molecules of signaling molecules. **Clinical significance:** ATP7A gene mutations have been linked to a number of human diseases, including systemic sclerosis, rheumatoid arthritis, and inflammatory bowel disease. These diseases are characterized by inflammation and damage to the skin, joints, and gut. ATP7A is a promising target for the treatment of these diseases.

Genular Protein ID: 715975783

Symbol: ATP7A_HUMAN

Name: Copper-transporting ATPase 1

UniProtKB Accession Codes:

Q04656 B1AT72 O00227 O00745 Q9BYY8

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 BRENDA 2 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CTD 1 ChEBI 22 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 4 EC 1 ELM 1 EMBL 49 EPD 1 Ensembl 6 EvolutionaryTrace 1 ExpressionAtlas 1 GO 94 Gene3D 4 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 2 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 13 KEGG 1 MANE-Select 1 MIM 7 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 3 OMA 1 OpenTargets 1 Orphanet 4 OrthoDB 1 PANTHER 2 PDB 37 PDBsum 22 PIR 1 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 3 RefSeq 2 Rhea 2 SABIO-RK 1 SFLD 2 SIGNOR 1 SMR 1 STRING 1 SUPFAM 5 SignaLink 1 SwissPalm 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8490659

Title: Isolation of a candidate gene for Menkes disease and evidence that it encodes a copper-transporting ATPase.

PubMed ID: 8490659

DOI: 10.1038/ng0193-7

PubMed ID: 7607665

Title: Characterization of the exon structure of the Menkes disease gene using vectorette PCR.

PubMed ID: 7607665

DOI: 10.1016/0888-7543(95)80160-n

PubMed ID: 9693104

Title: Multiple transcripts coding for the menkes gene: evidence for alternative splicing of Menkes mRNA.

PubMed ID: 9693104

DOI: 10.1042/bj3340071

PubMed ID: 10079814

Title: Multiple forms of the Menkes Cu-ATPase.

PubMed ID: 10079814

DOI: 10.1007/978-1-4615-4859-1_4

PubMed ID: 15772651

Title: The DNA sequence of the human X chromosome.

PubMed ID: 15772651

DOI: 10.1038/nature03440

PubMed ID: 7490081

Title: Molecular structure of the Menkes disease gene (ATP7A).

PubMed ID: 7490081

DOI: 10.1006/geno.1995.1175

PubMed ID: 8490646

Title: Isolation of a candidate gene for Menkes disease that encodes a potential heavy metal binding protein.

PubMed ID: 8490646

DOI: 10.1038/ng0193-14

PubMed ID: 8490647

Title: Isolation of a partial candidate gene for Menkes disease by positional cloning.

PubMed ID: 8490647

DOI: 10.1038/ng0193-20

PubMed ID: 11214319

Title: Molecular phylogenetics and the origins of placental mammals.

PubMed ID: 11214319

DOI: 10.1038/35054550

PubMed ID: 9467005

Title: Constitutive skipping of alternatively spliced exon 10 in the ATP7A gene abolishes Golgi localization of the menkes protein and produces the occipital horn syndrome.

PubMed ID: 9467005

DOI: 10.1093/hmg/7.3.465

PubMed ID: 10970802

Title: Evidence for a Menkes-like protein with a nuclear targeting sequence.

PubMed ID: 10970802

DOI: 10.1042/bj3500855

PubMed ID: 9147644

Title: Immunocytochemical localization of the Menkes copper transport protein (ATP7A) to the trans-Golgi network.

PubMed ID: 9147644

DOI: 10.1093/hmg/6.3.409

PubMed ID: 10484781

Title: The Menkes protein (ATP7A; MNK) cycles via the plasma membrane both in basal and elevated extracellular copper using a C-terminal di-leucine endocytic signal.

PubMed ID: 10484781

DOI: 10.1093/hmg/8.11.2107

PubMed ID: 10419525

Title: Functional analysis of the N-terminal CXXC metal-binding motifs in the human Menkes copper-transporting P-type ATPase expressed in cultured mammalian cells.

PubMed ID: 10419525

DOI: 10.1074/jbc.274.31.22008

PubMed ID: 11092760

Title: The Menkes copper transporter is required for the activation of tyrosinase.

PubMed ID: 11092760

DOI: 10.1093/hmg/9.19.2845

PubMed ID: 16051599

Title: A single PDZ domain protein interacts with the Menkes copper ATPase, ATP7A. A new protein implicated in copper homeostasis.

PubMed ID: 16051599

DOI: 10.1074/jbc.m505889200

PubMed ID: 16371425

Title: Essential role for the Menkes ATPase in activation of extracellular superoxide dismutase: implication for vascular oxidative stress.

PubMed ID: 16371425

DOI: 10.1096/fj.05-4564fje

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21667063

Title: The copper-transporting capacity of ATP7A mutants associated with Menkes disease is ameliorated by COMMD1 as a result of improved protein expression.

PubMed ID: 21667063

DOI: 10.1007/s00018-011-0743-1

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 9437429

Title: Solution structure of the fourth metal-binding domain from the Menkes copper-transporting ATPase.

PubMed ID: 9437429

DOI: 10.1038/nsb0198-47

PubMed ID: 19453293

Title: Copper(I)-mediated protein-protein interactions result from suboptimal interaction surfaces.

PubMed ID: 19453293

DOI: 10.1042/bj20090422

PubMed ID: 19917612

Title: The binding mode of ATP revealed by the solution structure of the N-domain of human ATP7A.

PubMed ID: 19917612

DOI: 10.1074/jbc.m109.054262

PubMed ID: 31283225

Title: Mechanistic and Structural Basis for Inhibition of Copper Trafficking by Platinum Anticancer Drugs.

PubMed ID: 31283225

DOI: 10.1021/jacs.9b05550

PubMed ID: 10079817

Title: Mutation spectrum of ATP7A, the gene defective in Menkes disease.

PubMed ID: 10079817

DOI: 10.1007/978-1-4615-4859-1_7

PubMed ID: 7977350

Title: Diverse mutations in patients with Menkes disease often lead to exon skipping.

PubMed ID: 7977350

PubMed ID: 8981948

Title: Identification of point mutations in 41 unrelated patients affected with Menkes disease.

PubMed ID: 8981948

PubMed ID: 9246006

Title: A C2055T transition in exon 8 of the ATP7A gene is associated with exon skipping in an occipital horn syndrome family.

PubMed ID: 9246006

DOI: 10.1016/s0002-9297(07)64297-9

PubMed ID: 10401004

Title: Defective copper-induced trafficking and localization of the Menkes protein in patients with mild and copper-treated classical Menkes disease.

PubMed ID: 10401004

DOI: 10.1093/hmg/8.8.1547

PubMed ID: 10319589

Title: Identification of three novel mutations in the MNK gene in three unrelated Japanese patients with classical Menkes disease.

PubMed ID: 10319589

DOI: 10.1007/s100380050144

PubMed ID: 11431706

Title: A novel frameshift mutation in exon 23 of ATP7A (MNK) results in occipital horn syndrome and not in Menkes disease.

PubMed ID: 11431706

DOI: 10.1086/321290

PubMed ID: 11241493

Title: ATP7A gene mutations in 16 patients with Menkes disease and a patient with occipital horn syndrome.

PubMed ID: 11241493

DOI: 10.1002/1096-8628(2001)9999:9999<::aid-ajmg1167>3.0.co;2-r

PubMed ID: 11350187

Title: Identification of four novel mutations in classical Menkes disease and successful prenatal DNA diagnosis.

PubMed ID: 11350187

DOI: 10.1006/mgme.2001.3169

PubMed ID: 15981243

Title: Identification and analysis of 21 novel disease-causing amino acid substitutions in the conserved part of ATP7A.

PubMed ID: 15981243

DOI: 10.1002/humu.20190

PubMed ID: 17108763

Title: Functional copper transport explains neurologic sparing in occipital horn syndrome.

PubMed ID: 17108763

DOI: 10.1097/01.gim.0000245578.94312.1e

PubMed ID: 20170900

Title: Missense mutations in the copper transporter gene ATP7A cause X-linked distal hereditary motor neuropathy.

PubMed ID: 20170900

DOI: 10.1016/j.ajhg.2010.01.027

PubMed ID: 22992316

Title: The T1048I mutation in ATP7A gene causes an unusual Menkes disease presentation.

PubMed ID: 22992316

DOI: 10.1186/1471-2431-12-150

PubMed ID: 28389643

Title: Characterization of ATP7A missense mutants suggests a correlation between intracellular trafficking and severity of Menkes disease.

PubMed ID: 28389643

DOI: 10.1038/s41598-017-00618-6

Sequence Information:

  • Length: 1500
  • Mass: 163373
  • Checksum: A54F17EA08FDACDB
  • Sequence:
    • MDPSMGVNSV TISVEGMTCN SCVWTIEQQI GKVNGVHHIK VSLEEKNATI IYDPKLQTPK 
TLQEAIDDMG FDAVIHNPDP LPVLTDTLFL TVTASLTLPW DHIQSTLLKT KGVTDIKIYP 
QKRTVAVTII PSIVNANQIK ELVPELSLDT GTLEKKSGAC EDHSMAQAGE VVLKMKVEGM 
TCHSCTSTIE GKIGKLQGVQ RIKVSLDNQE ATIVYQPHLI SVEEMKKQIE AMGFPAFVKK 
QPKYLKLGAI DVERLKNTPV KSSEGSQQRS PSYTNDSTAT FIIDGMHCKS CVSNIESTLS 
ALQYVSSIVV SLENRSAIVK YNASSVTPES LRKAIEAVSP GLYRVSITSE VESTSNSPSS 
SSLQKIPLNV VSQPLTQETV INIDGMTCNS CVQSIEGVIS KKPGVKSIRV SLANSNGTVE 
YDPLLTSPET LRGAIEDMGF DATLSDTNEP LVVIAQPSSE MPLLTSTNEF YTKGMTPVQD 
KEEGKNSSKC YIQVTGMTCA SCVANIERNL RREEGIYSIL VALMAGKAEV RYNPAVIQPP 
MIAEFIRELG FGATVIENAD EGDGVLELVV RGMTCASCVH KIESSLTKHR GILYCSVALA 
TNKAHIKYDP EIIGPRDIIH TIESLGFEAS LVKKDRSASH LDHKREIRQW RRSFLVSLFF 
CIPVMGLMIY MMVMDHHFAT LHHNQNMSKE EMINLHSSMF LERQILPGLS VMNLLSFLLC 
VPVQFFGGWY FYIQAYKALK HKTANMDVLI VLATTIAFAY SLIILLVAMY ERAKVNPITF 
FDTPPMLFVF IALGRWLEHI AKGKTSEALA KLISLQATEA TIVTLDSDNI LLSEEQVDVE 
LVQRGDIIKV VPGGKFPVDG RVIEGHSMVD ESLITGEAMP VAKKPGSTVI AGSINQNGSL 
LICATHVGAD TTLSQIVKLV EEAQTSKAPI QQFADKLSGY FVPFIVFVSI ATLLVWIVIG 
FLNFEIVETY FPGYNRSISR TETIIRFAFQ ASITVLCIAC PCSLGLATPT AVMVGTGVGA 
QNGILIKGGE PLEMAHKVKV VVFDKTGTIT HGTPVVNQVK VLTESNRISH HKILAIVGTA 
ESNSEHPLGT AITKYCKQEL DTETLGTCID FQVVPGCGIS CKVTNIEGLL HKNNWNIEDN 
NIKNASLVQI DASNEQSSTS SSMIIDAQIS NALNAQQYKV LIGNREWMIR NGLVINNDVN 
DFMTEHERKG RTAVLVAVDD ELCGLIAIAD TVKPEAELAI HILKSMGLEV VLMTGDNSKT 
ARSIASQVGI TKVFAEVLPS HKVAKVKQLQ EEGKRVAMVG DGINDSPALA MANVGIAIGT 
GTDVAIEAAD VVLIRNDLLD VVASIDLSRK TVKRIRINFV FALIYNLVGI PIAAGVFMPI 
GLVLQPWMGS AAMAASSVSV VLSSLFLKLY RKPTYESYEL PARSQIGQKS PSEISVHVGI 
DDTSRNSPKL GLLDRIVNYS RASINSLLSD KRSLNSVVTS EPDKHSLLVG DFREDDDTAL

Genular Protein ID: 3897435048

Symbol: B4DRW0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DRW0

Database IDs:

ARBA 5 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 5 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 7 KEGG 1 NCBI Taxonomy 1 NCBIfam 2 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 1 RefSeq 2 RuleBase 1 SFLD 2 SUPFAM 2

Sequence Information:

  • Length: 488
  • Mass: 52494
  • Checksum: 372107CF0324AE75
  • Sequence:
    • MVGTGVGAQN GILIKGGEPL EMAHKVKVVV FDKTGTITHG TPVVNQVKVL TESNRISHHK 
ILAIVGTAES NSEHPLGTAI TKYCKQELDT ETLGTCIDFQ VVPGCGISCK VTNIEGLLHK 
NNWNIEDNNI KNASLVQIDA SNEQSSTSSS MIIDAQISNA LNAQQYKVLI GNREWMIRNG 
LVINNDVNDF MTEHERKGRT AVLVAVDDEL CGLIAIADTV KPEAELAIHI LKSMGLEVVL 
MTGDNSKTAR SIASQVGITK VFAEVLPSHK VAKVKQLQEE GKRVAMVGDG INDSPALAMA 
NVGIAIGTGT DVAIEAADVV LIRNDLLDVV ASIDLSRKTV KRIRINFVFA LIYNLVGIPI 
AAGVFMPIGL VLQPWMGSAA MAASSVSVVL SSLFLKLYRK PTYESYELPA RSQIGQKSPS 
EISVHVGIDD TSRNSPKLGL LDRIVNYSRA SINSLLSDKR SLNSVVTSEP DKHSLLVGDF 
REDDDTAL

Genular Protein ID: 1221986320

Symbol: Q762B6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q762B6

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 GO 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 HOGENOM 1 InterPro 4 KEGG 1 MaxQB 1 NCBI Taxonomy 1 NCBIfam 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 PharmGKB 1 ProteomicsDB 1 RefSeq 2 SMR 1 SUPFAM 1 UCSC 1

Sequence Information:

  • Length: 274
  • Mass: 30124
  • Checksum: 1233AE33CD302122
  • Sequence:
    • MDPSMGVNSV TISVEGMTCN SCVWTIEQQI GKVNGVHHIK VSLEEKNATI IYDPKLQTPK 
TLQEAIDDMG FDAVIHNPDP LPVLTDTLFL TVTASLTLPW DHIQSTLLKT KGVTDIKIYP 
QKRTVAVTII PSIVNANQIK ELVPELSLDT GTLEKKSGAC EDHSMAQAGE VVLKMKVEGM 
TCHSCTSTIE GKIGKLQGVQ RIKVSLDNQE ATIVYQPHLI SVEEMKKQIE AMGFPAFVKK 
QPKYLKLGAI DVERLKNTPV KSSEGSQQRS PSYQ

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.