TRIM34 | ENSG00000258659 | NCBI 53840

Details for: TRIM34

Gene ID: 53840

Symbol: TRIM34

Ensembl ID: ENSG00000258659

Description: tripartite motif containing 34

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Immune system
(R-HSA-168256)
Interferon gamma signaling
(R-HSA-877300)
Interferon signaling
(R-HSA-913531)
Cytoplasm
(GO:0005737)
Cytosol
(GO:0005829)
Defense response to virus
(GO:0051607)
Identical protein binding
(GO:0042802)
Innate immune response
(GO:0045087)
Mitochondrion
(GO:0005739)
Molecular_function
(GO:0003674)
Nucleoplasm
(GO:0005654)
Positive regulation of autophagy
(GO:0010508)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of dna-binding transcription factor activity
(GO:0051091)
Positive regulation of nf-kappab transcription factor activity
(GO:0051092)
Protein homodimerization activity
(GO:0042803)
Protein kinase binding
(GO:0019901)
Protein polyubiquitination
(GO:0000209)
Regulation of protein localization
(GO:0032880)
Regulation of viral entry into host cell
(GO:0046596)
Ubiquitin protein ligase activity
(GO:0061630)
Zinc ion binding
(GO:0008270)

Other Information

Proteins

E3 ubiquitin-protein ligase TRIM34

Genular Protein ID: 3067524904

Symbol: TRI34_HUMAN

Name: E3 ubiquitin-protein ligase TRIM34

UniProtKB Accession Codes:

Q9BYJ4 D3DQS7 Q9C016 Q9HCR0 Q9HCR1 Q9HCR2

Database IDs:

Citations:

PubMed ID: 11013086

Title: Molecular cloning of ring finger protein 21 (RNF21)/interferon-responsive finger protein (ifp1), which possesses two RING-B box-coiled coil domains in tandem.

PubMed ID: 11013086

DOI: 10.1006/geno.2000.6318

PubMed ID: 11331580

Title: The tripartite motif family identifies cell compartments.

PubMed ID: 11331580

DOI: 10.1093/emboj/20.9.2140

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 17156811

Title: Unique features of TRIM5alpha among closely related human TRIM family members.

PubMed ID: 17156811

DOI: 10.1016/j.virol.2006.10.035

PubMed ID: 21680743

Title: Determinants of the higher order association of the restriction factor TRIM5alpha and other tripartite motif (TRIM) proteins.

PubMed ID: 21680743

DOI: 10.1074/jbc.m111.260406

PubMed ID: 31487507

Title: TRIM34 facilitates the formation of multinucleated giant cells by enhancing cell fusion and phagocytosis in epithelial cells.

PubMed ID: 31487507

DOI: 10.1016/j.yexcr.2019.111594

PubMed ID: 32282853

Title: TRIM34 restricts HIV-1 and SIV capsids in a TRIM5alpha-dependent manner.

PubMed ID: 32282853

DOI: 10.1371/journal.ppat.1008507

PubMed ID: 31956709

Title: TRIM34 localizes to the mitochondria and mediates apoptosis through the mitochondrial pathway in HEK293T cells.

PubMed ID: 31956709

DOI: 10.1016/j.heliyon.2019.e03115

PubMed ID: 35065966

Title: TRIM34 modulates influenza virus-activated programmed cell death by targeting Z-DNA-binding protein 1 for K63-linked polyubiquitination.

PubMed ID: 35065966

DOI: 10.1016/j.jbc.2022.101611

Sequence Information:

Length: 488
Mass: 56864
Checksum: F2D60A16576187A0
Sequence:

MASKILLNVQ EEVTCPICLE LLTEPLSLDC GHSLCRACIT VSNKEAVTSM GGKSSCPVCG 
ISYSFEHLQA NQHLANIVER LKEVKLSPDN GKKRDLCDHH GEKLLLFCKE DRKVICWLCE 
RSQEHRGHHT VLTEEVFKEC QEKLQAVLKR LKKEEEEAEK LEADIREEKT SWKYQVQTER 
QRIQTEFDQL RSILNNEEQR ELQRLEEEEK KTLDKFAEAE DELVQQKQLV RELISDVECR 
SQWSTMELLQ DMSGIMKWSE IWRLKKPKMV SKKLKTVFHA PDLSRMLQMF RELTAVRCYW 
VDVTLNSVNL NLNLVLSEDQ RQVISVPIWP FQCYNYGVLG SQYFSSGKHY WEVDVSKKTA 
WILGVYCRTY SRHMKYVVRR CANRQNLYTK YRPLFGYWVI GLQNKCKYGV FEESLSSDPE 
VLTLSMAVPP CRVGVFLDYE AGIVSFFNVT SHGSLIYKFS KCCFSQPVYP YFNPWNCPAP 
MTLCPPSS

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: TRIM34

Associated with

Other Information

Molecular cloning of ring finger protein 21 (RNF21)/interferon-responsive finger protein (ifp1), which possesses two RING-B box-coiled coil domains in tandem. PubMed ID: 11013086

The tripartite motif family identifies cell compartments. PubMed ID: 11331580

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

Unique features of TRIM5alpha among closely related human TRIM family members. PubMed ID: 17156811

Determinants of the higher order association of the restriction factor TRIM5alpha and other tripartite motif (TRIM) proteins. PubMed ID: 21680743

TRIM34 facilitates the formation of multinucleated giant cells by enhancing cell fusion and phagocytosis in epithelial cells. PubMed ID: 31487507

TRIM34 restricts HIV-1 and SIV capsids in a TRIM5alpha-dependent manner. PubMed ID: 32282853

TRIM34 localizes to the mitochondria and mediates apoptosis through the mitochondrial pathway in HEK293T cells. PubMed ID: 31956709

TRIM34 modulates influenza virus-activated programmed cell death by targeting Z-DNA-binding protein 1 for K63-linked polyubiquitination. PubMed ID: 35065966