Tuba8 | ENSMUSG00000030137 | NCBI 53857

Details for: Tuba8

Gene ID: 53857

Symbol: Tuba8

Ensembl ID: ENSMUSG00000030137

Description: tubulin, alpha 8

Associated with

Adaptive immune system
(R-MMU-1280218)
Aggrephagy
(R-MMU-9646399)
Antiviral mechanism by ifn-stimulated genes
(R-MMU-1169410)
Asparagine n-linked glycosylation
(R-MMU-446203)
Autophagy
(R-MMU-9612973)
Axon guidance
(R-MMU-422475)
Carboxyterminal post-translational modifications of tubulin
(R-MMU-8955332)
Cell cycle
(R-MMU-1640170)
Cell cycle, mitotic
(R-MMU-69278)
Cellular responses to stimuli
(R-MMU-8953897)
Cellular responses to stress
(R-MMU-2262752)
Cilium assembly
(R-MMU-5617833)
Copi-dependent golgi-to-er retrograde traffic
(R-MMU-6811434)
Copi-independent golgi-to-er retrograde traffic
(R-MMU-6811436)
Copi-mediated anterograde transport
(R-MMU-6807878)
Cytokine signaling in immune system
(R-MMU-1280215)
Developmental biology
(R-MMU-1266738)
Eml4 and nudc in mitotic spindle formation
(R-MMU-9648025)
Er to golgi anterograde transport
(R-MMU-199977)
Factors involved in megakaryocyte development and platelet production
(R-MMU-983231)
G2/m transition
(R-MMU-69275)
Gap junction assembly
(R-MMU-190861)
Gap junction trafficking
(R-MMU-190828)
Gap junction trafficking and regulation
(R-MMU-157858)
Golgi-to-er retrograde transport
(R-MMU-8856688)
Hemostasis
(R-MMU-109582)
Hsp90 chaperone cycle for steroid hormone receptors (shr) in the presence of ligand
(R-MMU-3371497)
Immune system
(R-MMU-168256)
Interferon signaling
(R-MMU-913531)
Intra-golgi and retrograde golgi-to-er traffic
(R-MMU-6811442)
Kinesins
(R-MMU-983189)
L1cam interactions
(R-MMU-373760)
Macroautophagy
(R-MMU-1632852)
Membrane trafficking
(R-MMU-199991)
Metabolism of proteins
(R-MMU-392499)
Mhc class ii antigen presentation
(R-MMU-2132295)
Microtubule-dependent trafficking of connexons from golgi to the plasma membrane
(R-MMU-190840)
Mitotic anaphase
(R-MMU-68882)
Mitotic g2-g2/m phases
(R-MMU-453274)
Mitotic metaphase and anaphase
(R-MMU-2555396)
Mitotic prometaphase
(R-MMU-68877)
M phase
(R-MMU-68886)
Nervous system development
(R-MMU-9675108)
Nuclear envelope (ne) reassembly
(R-MMU-2995410)
Organelle biogenesis and maintenance
(R-MMU-1852241)
Pkr-mediated signaling
(R-MMU-9833482)
Post-translational protein modification
(R-MMU-597592)
Recruitment of numa to mitotic centrosomes
(R-MMU-380320)
Recycling pathway of l1
(R-MMU-437239)
Resolution of sister chromatid cohesion
(R-MMU-2500257)
Rho gtpase effectors
(R-MMU-195258)
Rho gtpases activate formins
(R-MMU-5663220)
Rho gtpases activate iqgaps
(R-MMU-5626467)
Sealing of the nuclear envelope (ne) by escrt-iii
(R-MMU-9668328)
Selective autophagy
(R-MMU-9663891)
Separation of sister chromatids
(R-MMU-2467813)
Signaling by rho gtpases
(R-MMU-194315)
Signaling by rho gtpases, miro gtpases and rhobtb3
(R-MMU-9716542)
Signal transduction
(R-MMU-162582)
The role of gtse1 in g2/m progression after g2 checkpoint
(R-MMU-8852276)
Transport of connexons to the plasma membrane
(R-MMU-190872)
Transport to the golgi and subsequent modification
(R-MMU-948021)
Vesicle-mediated transport
(R-MMU-5653656)
Acrosomal vesicle
(GO:0001669)
Cytoplasm
(GO:0005737)
Cytoskeleton
(GO:0005856)
Cytoskeleton organization
(GO:0007010)
Gtp binding
(GO:0005525)
Hydrolase activity
(GO:0016787)
Metal ion binding
(GO:0046872)
Microtubule
(GO:0005874)
Microtubule-based process
(GO:0007017)
Microtubule cytoskeleton
(GO:0015630)
Microtubule cytoskeleton organization
(GO:0000226)
Mitotic cell cycle
(GO:0000278)
Nucleotide binding
(GO:0000166)
Spermatid development
(GO:0007286)
Spermatogenesis
(GO:0007283)
Structural constituent of cytoskeleton
(GO:0005200)

Other Information

Proteins

Tubulin alpha-8 chain

Genular Protein ID: 4252934761

Symbol: TBA8_MOUSE

Name: Tubulin alpha-8 chain

UniProtKB Accession Codes:

Q9JJZ2 D4P911 Q9CV57

Database IDs:

Citations:

PubMed ID: 10772959

Title: TUBA8: a new tissue-specific isoform of alpha-tubulin that is highly conserved in human and mouse.

PubMed ID: 10772959

DOI: 10.1006/bbrc.2000.2571

PubMed ID: 20466094

Title: Tuba8 is expressed at low levels in the developing mouse and human brain.

PubMed ID: 20466094

DOI: 10.1016/j.ajhg.2010.03.019

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15890843

Title: Tubulin polyglutamylase enzymes are members of the TTL domain protein family.

PubMed ID: 15890843

DOI: 10.1126/science.1113010

PubMed ID: 19896110

Title: Mutation of the variant alpha-tubulin TUBA8 results in polymicrogyria with optic nerve hypoplasia.

PubMed ID: 19896110

DOI: 10.1016/j.ajhg.2009.10.007

PubMed ID: 19524510

Title: Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation.

PubMed ID: 19524510

DOI: 10.1016/j.cell.2009.05.020

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 23897886

Title: Tubulin glycylases and glutamylases have distinct functions in stabilization and motility of ependymal cilia.

PubMed ID: 23897886

DOI: 10.1083/jcb.201305041

PubMed ID: 33414192

Title: Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility.

PubMed ID: 33414192

DOI: 10.1126/science.abd4914

Sequence Information:

Length: 449
Mass: 50052
Checksum: AA979E2DB21FC5DD
Sequence:

MRECISVHVG QAGVQIGNAC WELFCLEHGI QADGTFGTQA SKINDDDSFT TFFSETGNGK 
HVPRAVMVDL EPTVVDEVRA GTYRQLFHPE QLITGKEDAA NNYARGHYTV GKESIDLVLD 
RIRKLTDACS GLQGFLIFHS FGGGTGSGFT SLLMERLSLD YGKKSKLEFA IYPAPQVSTA 
VVEPYNSILT THTTLEHSDC AFMVDNEAIY DICRRNLDIE RPTYTNLNRL ISQIVSSITA 
SLRFDGALNV DLTEFQTNLV PYPRIHFPLV TYAPIISAEK AYHEQLSVAE ITSSCFEPNS 
QMVKCDPRHG KYMACCMLYR GDVVPKDVNV AIAAIKTKRT IQFVDWCPTG FKVGINYQPP 
TVVPGGDLAK VQRAVCMLSN TTAIAEAWAR LDHKFDLMYA KRAFVHWYVG EGMEEGEFSE 
AREDLAALEK DYEEVGTDSF EEENEGEEF

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Tuba8

Associated with

Other Information

TUBA8: a new tissue-specific isoform of alpha-tubulin that is highly conserved in human and mouse. PubMed ID: 10772959

Tuba8 is expressed at low levels in the developing mouse and human brain. PubMed ID: 20466094

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Tubulin polyglutamylase enzymes are members of the TTL domain protein family. PubMed ID: 15890843

Mutation of the variant alpha-tubulin TUBA8 results in polymicrogyria with optic nerve hypoplasia. PubMed ID: 19896110

Evolutionary divergence of enzymatic mechanisms for posttranslational polyglycylation. PubMed ID: 19524510

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Tubulin glycylases and glutamylases have distinct functions in stabilization and motility of ependymal cilia. PubMed ID: 23897886

Tubulin glycylation controls axonemal dynein activity, flagellar beat, and male fertility. PubMed ID: 33414192