Details for: Nphp1

Gene ID: 53885

Symbol: Nphp1

Ensembl ID: ENSMUSG00000027378

Description: nephronophthisis 1 (juvenile) homolog (human)

Associated with

Other Information

Genular Protein ID: 1415433260

Symbol: NPHP1_MOUSE

Name: Nephrocystin-1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10665934

Title: Nephrocystin: gene expression and sequence conservation between human, mouse, and Caenorhabditis elegans.

PubMed ID: 10665934

DOI: 10.1681/asn.v112270

PubMed ID: 10739664

Title: Crk-associated substrate p130(Cas) interacts with nephrocystin and both proteins localize to cell-cell contacts of polarized epithelial cells.

PubMed ID: 10739664

DOI: 10.1006/excr.2000.4822

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 11493697

Title: Nephrocystin interacts with Pyk2, p130(Cas), and tensin and triggers phosphorylation of Pyk2.

PubMed ID: 11493697

DOI: 10.1073/pnas.171269898

PubMed ID: 12006559

Title: Nephrocystin-conserved domains involved in targeting to epithelial cell-cell junctions, interaction with filamins, and establishing cell polarity.

PubMed ID: 12006559

DOI: 10.1074/jbc.m111697200

PubMed ID: 16885411

Title: Nephrocystin specifically localizes to the transition zone of renal and respiratory cilia and photoreceptor connecting cilia.

PubMed ID: 16885411

DOI: 10.1681/asn.2005121351

PubMed ID: 18477472

Title: Nephrocystin-1 interacts directly with Ack1 and is expressed in human collecting duct.

PubMed ID: 18477472

DOI: 10.1016/j.bbrc.2008.05.016

PubMed ID: 18684731

Title: Targeted disruption of Nphp1 causes male infertility due to defects in the later steps of sperm morphogenesis in mice.

PubMed ID: 18684731

DOI: 10.1093/hmg/ddn231

PubMed ID: 19208653

Title: Essential role of nephrocystin in photoreceptor intraflagellar transport in mouse.

PubMed ID: 19208653

DOI: 10.1093/hmg/ddp068

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 20856870

Title: Nephrocystin-1 forms a complex with polycystin-1 via a polyproline motif/SH3 domain interaction and regulates the apoptotic response in mammals.

PubMed ID: 20856870

DOI: 10.1371/journal.pone.0012719

PubMed ID: 21565611

Title: Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.

PubMed ID: 21565611

DOI: 10.1016/j.cell.2011.04.019

PubMed ID: 25671767

Title: Anks3 interacts with nephronophthisis proteins and is required for normal renal development.

PubMed ID: 25671767

DOI: 10.1038/ki.2015.17

PubMed ID: 29899041

Title: SPATA7 maintains a novel photoreceptor-specific zone in the distal connecting cilium.

PubMed ID: 29899041

DOI: 10.1083/jcb.201712117

Sequence Information:

  • Length: 687
  • Mass: 77035
  • Checksum: FAA10B044F5CE678
  • Sequence:
  • MLARRPRDPL QALRRRGQEL KLQVDSLVTE SQLTGALEPS KRREIYQRCI QLKQAVDENK 
    NTLQKLNKAD EAAPVGNYEQ RKEEEHSLLE KLACQLQELA VSISRKDALK VEAHSDKEED 
    DTTEDDEEET GGEEEESEGD GEGKQEQASP KQAETETVTY IALGDFAAQQ TGDLTFKKGD 
    VLHIIEKKPD GWWLAKDAEG VEGLIPRTYL EPYNKEDKLE SSEGSEEGGE EDGEEDVEVV 
    DETADGAQVK QRTDSHWSAV RKAISEQINT VDVLATMGAI PAGFRPSTLS QLLDEAGNQF 
    RASYFLQPEL TTSQLAFRDL TWDAKAGTIM SRPSRVSLIL TLWSCKMIPL PGTSIQVLSR 
    HIRLCLFDGS KVLSNIHTVR AVWQPKKPKT WTFSPQVTGI LPCLLDGDCF IRSNSSTPDL 
    GILFELGISY IRNSTGERGE LSCGWVFLKL FDASGVPIPA KTYELFLNGG TPYEKGVEVD 
    PSVSRRAQGS VFRQMISVRR QPQLLVKLRS LNRRSRAMLS LLPETLVGSM CSAHLLIFYR 
    QILGDVLLRD RTNLQSADLI SHPVLATFPL LLEQPDVMDA LRSSWSEKES TLKRAEKRDK 
    ELLKAEFLLV YHDCVLPLLH STLLPPFRWA EEETEAARWK AIADFLKQSR ENEGSLKALL 
    SPDGVHKPFD LSEQTFDFLG EIRKNSG

Genular Protein ID: 970209290

Symbol: Q3TWM5_MOUSE

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10349636

Title: High-efficiency full-length cDNA cloning.

PubMed ID: 10349636

DOI: 10.1016/S0076-6879(99)03004-9

PubMed ID: 11042159

Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.

PubMed ID: 11042159

DOI: 10.1101/gr.145100

PubMed ID: 11076861

Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.

PubMed ID: 11076861

DOI: 10.1101/gr.152600

PubMed ID: 11217851

Title: Functional annotation of a full-length mouse cDNA collection.

PubMed ID: 11217851

DOI: 10.1038/35055500

PubMed ID: 12466851

Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.

PubMed ID: 12466851

DOI: 10.1038/nature01266

PubMed ID: 16141073

Title: Antisense Transcription in the Mammalian Transcriptome.

PubMed ID: 16141073

DOI: 10.1126/science.1112009

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 690
  • Mass: 77394
  • Checksum: E5201D4C7FE19854
  • Sequence:
  • MLARRPRDPL QALRRRGQEL KLQVDSLVTE SQLTGALEPS KRREIYQRCI QLKQAVDENK 
    NTLQKLNKAD EAAPVGNYEQ RKEEEHSLLE KLACQLQELA VSISRKDALK VEAHSDKEED 
    DTTEDDEEET GGEEEESEGD GEGKQEQASP KQAETETVTY IALGDFAAQQ TGDLTFKKGD 
    VLHIIEKKPD GWWLAKDAEG VEGLIPRTYL EPYNKEDKLE SSEGSEEGGE EDGEEDGEED 
    VEVVDETADG AQVKQRTDSH WSAVRKAISE QINTVDVLAT MGAIPAGFRP STLSQLLDEG 
    NQFRASYFLQ PELTTSQLAF RDLTWDAKAG TIMSRPSRVS LILTLWSCKM IPLPGTSIQV 
    LSRHIRLCLF DGSKVLSNIH TVRAVWQPKK PKTWTFSPQV TGILPCLLDG DCFIRSNSST 
    PDLGILFELG ISYIRNSTGE RGELSCGWVF LKLFDASGVP IPAKTYELFL NGGTPYEKGV 
    EVDPSVSRRA QGSVFRQMIS VRRQPQLLVK LRSLNRRSRA MLSLLPETLV GSMCSAHLLI 
    FYRQILGDVL LRDRTNLQSA DLISHPVLAT FPLLLEQPDV MDALRSSWSE KESTLKRAEK 
    RDKELLKAEF LLVYHDCVLP LLHSTLLPPF RWAEEETEAA RWKAIADFLK QSRENEGSLK 
    ALLSPDGVHK PFDLSEQTFD FLGEIRKNSG

Genular Protein ID: 2469687947

Symbol: A2APS1_MOUSE

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

Sequence Information:

  • Length: 691
  • Mass: 77466
  • Checksum: DF41AD8C464A16A6
  • Sequence:
  • MLARRPRDPL QALRRRGQEL KLQVDSLVTE SQLTGALEPS KRREIYQRCI QLKQAVDENK 
    NTLQKLNKAD EAAPVGNYEQ RKEEEHSLLE KLACQLQELA VSISRKDALK VEAHSDKEED 
    DTTEDDEEET GGEEEESEGD GEGKQEQASP KQAETETVTY IALGDFAAQQ TGDLTFKKGD 
    VLHIIEKKPD GWWLAKDAEG VEGLIPRTYL EPYNKEDKLE SSEGSEEGGE EDGEEDGEED 
    VEVVDETADG AQVKQRTDSH WSAVRKAISE QINTVDVLAT MGAIPAGFRP STLSQLLDEA 
    GNQFRASYFL QPELTTSQLA FRDLTWDAKA GTIMSRPSRV SLILTLWSCK MIPLPGTSIQ 
    VLSRHIRLCL FDGSKVLSNI HTVRAVWQPK KPKTWTFSPQ VTGILPCLLD GDCFIRSNSS 
    TPDLGILFEL GISYIRNSTG ERGELSCGWV FLKLFDASGV PIPAKTYELF LNGGTPYEKG 
    VEVDPSVSRR AQGSVFRQMI SVRRQPQLLV KLRSLNRRSR AMLSLLPETL VGSMCSAHLL 
    IFYRQILGDV LLRDRTNLQS ADLISHPVLA TFPLLLEQPD VMDALRSSWS EKESTLKRAE 
    KRDKELLKAE FLLVYHDCVL PLLHSTLLPP FRWAEEETEA ARWKAIADFL KQSRENEGSL 
    KALLSPDGVH KPFDLSEQTF DFLGEIRKNS G

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.