Gene ATP5PO - ENSG00000241837 | NCBI Gene ID: 539

Details for: ATP5PO

Gene ID: 539

Symbol: ATP5PO

Ensembl ID: ENSG00000241837

Description: ATP synthase peripheral stalk subunit OSCP

Associated with

Cristae formation
(R-HSA-8949613)
Formation of atp by chemiosmotic coupling
(R-HSA-163210)
Metabolism
(R-HSA-1430728)
Metabolism of proteins
(R-HSA-392499)
Mitochondrial biogenesis
(R-HSA-1592230)
Mitochondrial protein degradation
(R-HSA-9837999)
Organelle biogenesis and maintenance
(R-HSA-1852241)
Respiratory electron transport, atp synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
(R-HSA-163200)
The citric acid (tca) cycle and respiratory electron transport
(R-HSA-1428517)
Atp biosynthetic process
(GO:0006754)
Mitochondrial inner membrane
(GO:0005743)
Mitochondrial proton-transporting atp synthase, stator stalk
(GO:0000274)
Mitochondrial proton-transporting atp synthase complex
(GO:0005753)
Mitochondrion
(GO:0005739)
Nucleus
(GO:0005634)
Plasma membrane
(GO:0005886)
Protein binding
(GO:0005515)
Proton-transporting atp synthase activity, rotational mechanism
(GO:0046933)
Proton-transporting atp synthase complex, catalytic core f(1)
(GO:0045261)
Proton motive force-driven atp synthesis
(GO:0015986)
Proton motive force-driven mitochondrial atp synthesis
(GO:0042776)
Proton transmembrane transport
(GO:1902600)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: follicular B cell (CL0000843)
Fold Change: 5.29
Marker Score: 5735
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 4.66
Marker Score: 9846.5
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: 4.36
Marker Score: 3077.5
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: 4.05
Marker Score: 2460
Cell Name: professional antigen presenting cell (CL0000145)
Fold Change: 3.91
Marker Score: 2017
Cell Name: cord blood hematopoietic stem cell (CL2000095)
Fold Change: 3.88
Marker Score: 2925
Cell Name: renal intercalated cell (CL0005010)
Fold Change: 3.74
Marker Score: 1992
Cell Name: erythroid progenitor cell (CL0000038)
Fold Change: 3.65
Marker Score: 3810
Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 3.59
Marker Score: 3201.5
Cell Name: tracheobronchial smooth muscle cell (CL0019019)
Fold Change: 3.44
Marker Score: 1008.5
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 3.33
Marker Score: 12888
Cell Name: fetal cardiomyocyte (CL0002495)
Fold Change: 3.27
Marker Score: 1075
Cell Name: ventricular cardiac muscle cell (CL2000046)
Fold Change: 3.27
Marker Score: 1355
Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
Fold Change: 3.16
Marker Score: 2686
Cell Name: mesenchymal stem cell (CL0000134)
Fold Change: 3.16
Marker Score: 4864
Cell Name: Kupffer cell (CL0000091)
Fold Change: 3.16
Marker Score: 3159
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 2.99
Marker Score: 12482
Cell Name: enteric neuron (CL0007011)
Fold Change: 2.97
Marker Score: 1579
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 2.94
Marker Score: 1640
Cell Name: radial glial cell (CL0000681)
Fold Change: 2.93
Marker Score: 1080.5
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: 2.88
Marker Score: 22513
Cell Name: malignant cell (CL0001064)
Fold Change: 2.87
Marker Score: 38521
Cell Name: kidney collecting duct intercalated cell (CL1001432)
Fold Change: 2.79
Marker Score: 4627
Cell Name: enteric smooth muscle cell (CL0002504)
Fold Change: 2.79
Marker Score: 6564
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 2.79
Marker Score: 6811.5
Cell Name: lung secretory cell (CL1000272)
Fold Change: 2.78
Marker Score: 2479
Cell Name: epithelial cell of esophagus (CL0002252)
Fold Change: 2.76
Marker Score: 23766.5
Cell Name: enterocyte (CL0000584)
Fold Change: 2.75
Marker Score: 13217
Cell Name: glycinergic neuron (CL1001509)
Fold Change: 2.75
Marker Score: 3323
Cell Name: mucous neck cell (CL0000651)
Fold Change: 2.75
Marker Score: 6242
Cell Name: thyroid follicular cell (CL0002258)
Fold Change: 2.72
Marker Score: 2130
Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
Fold Change: 2.71
Marker Score: 7266.5
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 2.69
Marker Score: 10390
Cell Name: epithelial cell of urethra (CL1000296)
Fold Change: 2.68
Marker Score: 2115
Cell Name: pro-T cell (CL0000827)
Fold Change: 2.67
Marker Score: 10935.5
Cell Name: serous secreting cell (CL0000313)
Fold Change: 2.67
Marker Score: 1065.5
Cell Name: embryonic stem cell (CL0002322)
Fold Change: 2.66
Marker Score: 851
Cell Name: glycinergic amacrine cell (CL4030028)
Fold Change: 2.63
Marker Score: 2482
Cell Name: skeletal muscle satellite stem cell (CL0008011)
Fold Change: 2.62
Marker Score: 2801
Cell Name: epithelial cell of nephron (CL1000449)
Fold Change: 2.62
Marker Score: 5471.5
Cell Name: peripheral nervous system neuron (CL2000032)
Fold Change: 2.61
Marker Score: 2933
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 2.61
Marker Score: 5938
Cell Name: cell in vitro (CL0001034)
Fold Change: 2.59
Marker Score: 89826
Cell Name: neural crest cell (CL0011012)
Fold Change: 2.59
Marker Score: 2768
Cell Name: decidual cell (CL2000002)
Fold Change: 2.59
Marker Score: 11150.5
Cell Name: DN3 thymocyte (CL0000807)
Fold Change: 2.56
Marker Score: 1280
Cell Name: foveolar cell of stomach (CL0002179)
Fold Change: 2.54
Marker Score: 16203
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 2.54
Marker Score: 5155
Cell Name: chondrocyte (CL0000138)
Fold Change: 2.53
Marker Score: 1140
Cell Name: germinal center B cell (CL0000844)
Fold Change: 2.5
Marker Score: 1524
Cell Name: pneumocyte (CL0000322)
Fold Change: 2.5
Marker Score: 4015
Cell Name: theca cell (CL0000503)
Fold Change: 2.46
Marker Score: 1766
Cell Name: smooth muscle cell (CL0000192)
Fold Change: 2.44
Marker Score: 1604
Cell Name: IgG memory B cell (CL0000979)
Fold Change: 2.43
Marker Score: 1463.5
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 2.43
Marker Score: 15526
Cell Name: luminal epithelial cell of mammary gland (CL0002326)
Fold Change: 2.42
Marker Score: 4293
Cell Name: IgG-negative class switched memory B cell (CL0002117)
Fold Change: 2.42
Marker Score: 2385
Cell Name: early pro-B cell (CL0002046)
Fold Change: 2.41
Marker Score: 24407.5
Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
Fold Change: 2.4
Marker Score: 579
Cell Name: mesodermal cell (CL0000222)
Fold Change: 2.4
Marker Score: 31625
Cell Name: Mueller cell (CL0000636)
Fold Change: 2.38
Marker Score: 3303
Cell Name: endocardial cell (CL0002350)
Fold Change: 2.38
Marker Score: 1344
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 2.37
Marker Score: 26638
Cell Name: retinal rod cell (CL0000604)
Fold Change: 2.36
Marker Score: 6744
Cell Name: supporting cell (CL0000630)
Fold Change: 2.35
Marker Score: 4414
Cell Name: smooth muscle cell of large intestine (CL1000279)
Fold Change: 2.35
Marker Score: 888.5
Cell Name: skeletal muscle satellite cell (CL0000594)
Fold Change: 2.32
Marker Score: 1555
Cell Name: kidney cell (CL1000497)
Fold Change: 2.32
Marker Score: 1547
Cell Name: decidual natural killer cell, human (CL0002343)
Fold Change: 2.31
Marker Score: 6388.5
Cell Name: uterine smooth muscle cell (CL0002601)
Fold Change: 2.3
Marker Score: 3001
Cell Name: migratory enteric neural crest cell (CL0002607)
Fold Change: 2.3
Marker Score: 2162
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: 2.29
Marker Score: 2421
Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
Fold Change: 2.29
Marker Score: 2321
Cell Name: enterocyte of colon (CL1000347)
Fold Change: 2.28
Marker Score: 3519
Cell Name: hematopoietic cell (CL0000988)
Fold Change: 2.28
Marker Score: 1516.5
Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
Fold Change: 2.28
Marker Score: 1650
Cell Name: mesenchymal cell (CL0008019)
Fold Change: 2.27
Marker Score: 3864
Cell Name: glandular cell of esophagus (CL0002657)
Fold Change: 2.26
Marker Score: 715
Cell Name: intestine goblet cell (CL0019031)
Fold Change: 2.25
Marker Score: 2157
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 2.25
Marker Score: 8843
Cell Name: endothelial cell of uterus (CL0009095)
Fold Change: 2.24
Marker Score: 4469
Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
Fold Change: 2.23
Marker Score: 3834
Cell Name: epithelial cell (CL0000066)
Fold Change: 2.23
Marker Score: 3550
Cell Name: Hofbauer cell (CL3000001)
Fold Change: 2.22
Marker Score: 1223
Cell Name: transitional stage B cell (CL0000818)
Fold Change: 2.22
Marker Score: 785.5
Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
Fold Change: 2.2
Marker Score: 2059
Cell Name: keratinocyte (CL0000312)
Fold Change: 2.18
Marker Score: 1824
Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
Fold Change: 2.18
Marker Score: 2309
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 2.17
Marker Score: 2258
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 2.16
Marker Score: 3187.5
Cell Name: eukaryotic cell (CL0000255)
Fold Change: 2.16
Marker Score: 1114
Cell Name: naive T cell (CL0000898)
Fold Change: 2.15
Marker Score: 1388
Cell Name: unswitched memory B cell (CL0000970)
Fold Change: 2.15
Marker Score: 1262
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 2.15
Marker Score: 3632.5
Cell Name: kidney connecting tubule epithelial cell (CL1000768)
Fold Change: 2.14
Marker Score: 3031
Cell Name: cortical thymic epithelial cell (CL0002364)
Fold Change: 2.14
Marker Score: 7928
Cell Name: peptic cell (CL0000155)
Fold Change: 2.14
Marker Score: 896
Cell Name: intestinal crypt stem cell (CL0002250)
Fold Change: 2.12
Marker Score: 798
Cell Name: naive regulatory T cell (CL0002677)
Fold Change: 2.11
Marker Score: 640
Cell Name: type II pneumocyte (CL0002063)
Fold Change: 2.1
Marker Score: 13716

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**Key characteristics:** - The protein is a peripheral stalk subunit of the mitochondrial ATP synthase. - It is encoded by the ATP5PO gene. - It is a highly conserved protein with a predicted molecular weight of approximately 500 kDa. **Pathways and functions:** - The protein is involved in the citric acid (tca) cycle and respiratory electron transport pathways, where it helps to regulate the flow of protons and electrons. - In the citric acid cycle, it is involved in the production of ATP from pyruvate. - In the respiratory electron transport chain, it is involved in the transfer of protons across the mitochondrial inner membrane, which drives the synthesis of ATP. **Clinical significance:** - Mutations in the ATP5PO gene have been linked to several human diseases, including mitochondrial disorders and metabolic syndromes. - These diseases are characterized by a decrease in ATP production and mitochondrial dysfunction. - Targeting ATP5PO has been investigated as a therapeutic strategy for these diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Oligomycin sensitivity conferral protein

Genular Protein ID: 541067164

Symbol: ATPO_HUMAN

Name: Oligomycin sensitivity conferral protein

UniProtKB Accession Codes:

P48047 B2R4E2 Q5U042 Q6IBI2

Database IDs:

Citations:

PubMed ID: 7490082

Title: Cloning of the cDNA for the human ATP synthase OSCP subunit (ATP5O) by exon trapping and mapping to chromosome 21q22.1-q22.2.

PubMed ID: 7490082

DOI: 10.1006/geno.1995.1176

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 34954817

Title: Variants in Mitochondrial ATP Synthase Cause Variable Neurologic Phenotypes.

PubMed ID: 34954817

DOI: 10.1002/ana.26293

Sequence Information:

Length: 213
Mass: 23277
Checksum: 311F53576A31FC93
Sequence:

MAAPAVSGLS RQVRCFSTSV VRPFAKLVRP PVQVYGIEGR YATALYSAAS KQNKLEQVEK 
ELLRVAQILK EPKVAASVLN PYVKRSIKVK SLNDITAKER FSPLTTNLIN LLAENGRLSN 
TQGVVSAFST MMSVHRGEVP CTVTSASPLE EATLSELKTV LKSFLSQGQV LKLEAKTDPS 
ILGGMIVRIG EKYVDMSVKT KIQKLGRAMR EIV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: ATP5PO

Associated with

Cells (max top 100)

Other Information

Cloning of the cDNA for the human ATP synthase OSCP subunit (ATP5O) by exon trapping and mapping to chromosome 21q22.1-q22.2. PubMed ID: 7490082

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. PubMed ID: 12665801

Lysine acetylation targets protein complexes and co-regulates major cellular functions. PubMed ID: 19608861

Initial characterization of the human central proteome. PubMed ID: 21269460

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome. PubMed ID: 24275569

N-terminome analysis of the human mitochondrial proteome. PubMed ID: 25944712

Variants in Mitochondrial ATP Synthase Cause Variable Neurologic Phenotypes. PubMed ID: 34954817