Details for: ATP5PO

Gene ID: 539

Symbol: ATP5PO

Ensembl ID: ENSG00000241837

Description: ATP synthase peripheral stalk subunit OSCP

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 281.1280
    Cell Significance Index: -115.8100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 248.4947
    Cell Significance Index: -117.3200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 247.4787
    Cell Significance Index: -100.5400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 221.4488
    Cell Significance Index: -113.9100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 175.2550
    Cell Significance Index: -117.6000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 26.9667
    Cell Significance Index: -72.2400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 19.6063
    Cell Significance Index: -60.2200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 6.2797
    Cell Significance Index: 92.7100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 5.2871
    Cell Significance Index: 80.3000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 3.8693
    Cell Significance Index: 80.9900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 3.7796
    Cell Significance Index: 131.3400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.4756
    Cell Significance Index: 27.7500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.1545
    Cell Significance Index: 433.2000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.1410
    Cell Significance Index: 146.4500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.8541
    Cell Significance Index: 149.8500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.7373
    Cell Significance Index: 193.5900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.6300
    Cell Significance Index: 339.7800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 2.5995
    Cell Significance Index: 28.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.4859
    Cell Significance Index: 448.1400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.4278
    Cell Significance Index: 298.5300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.3909
    Cell Significance Index: 1057.0900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.3638
    Cell Significance Index: 176.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.3038
    Cell Significance Index: 1258.1800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.2309
    Cell Significance Index: 143.9300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.1141
    Cell Significance Index: 62.0900
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.9979
    Cell Significance Index: 54.3800
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.7992
    Cell Significance Index: 20.4400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.4621
    Cell Significance Index: 187.4300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2900
    Cell Significance Index: 127.6100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.1338
    Cell Significance Index: 58.9000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 1.0095
    Cell Significance Index: 17.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8034
    Cell Significance Index: 37.7600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.6538
    Cell Significance Index: 188.1200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.4772
    Cell Significance Index: 7.1500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.4731
    Cell Significance Index: 7.9700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.4715
    Cell Significance Index: 94.5800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4652
    Cell Significance Index: 420.0700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.4121
    Cell Significance Index: 302.1700
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.3041
    Cell Significance Index: 2.8000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2610
    Cell Significance Index: 49.6700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.2418
    Cell Significance Index: 15.2400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.1918
    Cell Significance Index: 145.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.1330
    Cell Significance Index: 4.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0570
    Cell Significance Index: 20.4400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.0154
    Cell Significance Index: 0.2100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0114
    Cell Significance Index: 0.1900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0022
    Cell Significance Index: -0.0600
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0197
    Cell Significance Index: -1.5600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0306
    Cell Significance Index: -1.5500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0386
    Cell Significance Index: -3.9400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0503
    Cell Significance Index: -94.6300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0772
    Cell Significance Index: -142.3900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0940
    Cell Significance Index: -144.7800
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1016
    Cell Significance Index: -11.9900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1084
    Cell Significance Index: -147.4400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1280
    Cell Significance Index: -94.8500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1522
    Cell Significance Index: -96.6900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1871
    Cell Significance Index: -105.5400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2346
    Cell Significance Index: -106.4900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2420
    Cell Significance Index: -41.3200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2426
    Cell Significance Index: -151.4700
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2668
    Cell Significance Index: -10.9300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3715
    Cell Significance Index: -28.5100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4628
    Cell Significance Index: -53.0200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4635
    Cell Significance Index: -11.8400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.5251
    Cell Significance Index: -23.8000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.5445
    Cell Significance Index: -13.6100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5995
    Cell Significance Index: -69.8700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.6172
    Cell Significance Index: -130.0000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.6388
    Cell Significance Index: -13.8400
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.6634
    Cell Significance Index: -45.8800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.7311
    Cell Significance Index: -106.2700
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: -0.7401
    Cell Significance Index: -9.4900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.8659
    Cell Significance Index: -53.2200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.1266
    Cell Significance Index: -117.3100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.1532
    Cell Significance Index: -64.7100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.2151
    Cell Significance Index: -34.8300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.3299
    Cell Significance Index: -34.9700
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.5017
    Cell Significance Index: -92.0700
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.6619
    Cell Significance Index: -28.6500
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -1.8153
    Cell Significance Index: -21.6400
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.8655
    Cell Significance Index: -15.6700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -1.9294
    Cell Significance Index: -100.5000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.9821
    Cell Significance Index: -58.3800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -2.1703
    Cell Significance Index: -76.2600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -2.2503
    Cell Significance Index: -47.9300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -2.3011
    Cell Significance Index: -59.1500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.3126
    Cell Significance Index: -102.2900
  • Cell Name: cerebral cortex neuron (CL0010012)
    Fold Change: -2.3658
    Cell Significance Index: -22.5100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -2.4623
    Cell Significance Index: -90.3900
  • Cell Name: theca cell (CL0000503)
    Fold Change: -2.5089
    Cell Significance Index: -14.7400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -2.5092
    Cell Significance Index: -25.9800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -2.7738
    Cell Significance Index: -97.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -2.7752
    Cell Significance Index: -105.0900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -2.9478
    Cell Significance Index: -96.5100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -3.0251
    Cell Significance Index: -87.1600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -3.0397
    Cell Significance Index: -96.8100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -3.1195
    Cell Significance Index: -77.9100
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -3.4559
    Cell Significance Index: -59.2300
  • Cell Name: seromucus secreting cell (CL0000159)
    Fold Change: -3.4959
    Cell Significance Index: -72.9100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** The ATP5PO gene is primarily expressed in cells that require high levels of energy production, such as muscle cells, pancreatic cells, and hematopoietic stem cells. These cells rely heavily on the ATP synthase complex to generate energy for their rapid growth and division. The ATP5PO protein is a peripheral stalk subunit of the ATP synthase complex, which is composed of multiple subunits that work together to facilitate the rotation of the stalk and the production of ATP. The OSCP subunit plays a crucial role in the regulation of the ATP synthase complex, influencing the enzyme's activity and efficiency. **Pathways and Functions** The ATP5PO gene is involved in several key cellular pathways, including: 1. **Atp biosynthetic process**: The ATP synthase complex is responsible for generating ATP through the process of chemiosmosis, which is a critical component of the cell's energy metabolism. 2. **Cristae formation**: The ATP synthase complex is embedded in the mitochondrial inner membrane and plays a role in the formation of the cristae, which are the infoldings of the inner membrane that increase the surface area for energy production. 3. **Formation of atp by chemiosmotic coupling**: The ATP synthase complex generates ATP through the coupling of the proton motive force (PMF) with the rotation of the stalk, resulting in the production of ATP. 4. **Proton-transporting atp synthase activity**: The ATP synthase complex is responsible for transporting protons across the mitochondrial inner membrane, which drives the production of ATP. **Clinical Significance** Dysregulation of the ATP5PO gene has been implicated in various diseases, including: 1. **Mitochondrial disorders**: Mutations in the ATP5PO gene can lead to mitochondrial disorders, such as Kearns-Sayre syndrome, which is characterized by muscle weakness, hearing loss, and other systemic symptoms. 2. **Neurodegenerative diseases**: The ATP synthase complex has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease, which are characterized by progressive neuronal damage and death. 3. **Cancer**: The ATP synthase complex has been shown to play a role in the regulation of cancer cell metabolism, and dysregulation of the ATP5PO gene may contribute to the development and progression of certain types of cancer. In conclusion, the ATP5PO gene plays a critical role in the functioning of mitochondria and the generation of energy in eukaryotic cells. Dysregulation of this gene has been implicated in various diseases, highlighting the importance of this gene in maintaining cellular homeostasis and overall health.

Genular Protein ID: 541067164

Symbol: ATPO_HUMAN

Name: Oligomycin sensitivity conferral protein

UniProtKB Accession Codes:

P48047 B2R4E2 Q5U042 Q6IBI2

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CORUM 1 CTD 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 8 EMDB 9 Ensembl 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HAMAP 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 NCBIfam 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 9 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TCDB 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7490082

Title: Cloning of the cDNA for the human ATP synthase OSCP subunit (ATP5O) by exon trapping and mapping to chromosome 21q22.1-q22.2.

PubMed ID: 7490082

DOI: 10.1006/geno.1995.1176

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 38297121

Title: Stress response silencing by an E3 ligase mutated in neurodegeneration.

PubMed ID: 38297121

DOI: 10.1038/s41586-023-06985-7

PubMed ID: 34954817

Title: Variants in Mitochondrial ATP Synthase Cause Variable Neurologic Phenotypes.

PubMed ID: 34954817

DOI: 10.1002/ana.26293

Sequence Information:

  • Length: 213
  • Mass: 23277
  • Checksum: 311F53576A31FC93
  • Sequence:
    • MAAPAVSGLS RQVRCFSTSV VRPFAKLVRP PVQVYGIEGR YATALYSAAS KQNKLEQVEK 
ELLRVAQILK EPKVAASVLN PYVKRSIKVK SLNDITAKER FSPLTTNLIN LLAENGRLSN 
TQGVVSAFST MMSVHRGEVP CTVTSASPLE EATLSELKTV LKSFLSQGQV LKLEAKTDPS 
ILGGMIVRIG EKYVDMSVKT KIQKLGRAMR EIV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.