Slc40a1 | ENSMUSG00000025993 | NCBI 53945

Details for: Slc40a1

Gene ID: 53945

Symbol: Slc40a1

Ensembl ID: ENSMUSG00000025993

Description: solute carrier family 40 (iron-regulated transporter), member 1

Associated with

Iron uptake and transport
(R-MMU-917937)
Metal ion slc transporters
(R-MMU-425410)
Slc-mediated transmembrane transport
(R-MMU-425407)
Transport of bile salts and organic acids, metal ions and amine compounds
(R-MMU-425366)
Transport of small molecules
(R-MMU-382551)
Apoptotic process
(GO:0006915)
Basolateral plasma membrane
(GO:0016323)
Cytosol
(GO:0005829)
Endothelium development
(GO:0003158)
Establishment of localization in cell
(GO:0051649)
Ferrous iron transmembrane transporter activity
(GO:0015093)
Identical protein binding
(GO:0042802)
Intracellular iron ion homeostasis
(GO:0006879)
Iron ion export across plasma membrane
(GO:1903988)
Iron ion transmembrane transport
(GO:0034755)
Iron ion transmembrane transporter activity
(GO:0005381)
Iron ion transport
(GO:0006826)
Lymphocyte homeostasis
(GO:0002260)
Membrane
(GO:0016020)
Metal ion binding
(GO:0046872)
Monoatomic ion transport
(GO:0006811)
Multicellular organismal-level iron ion homeostasis
(GO:0060586)
Negative regulation of apoptotic process
(GO:0043066)
Nucleoplasm
(GO:0005654)
Peptide hormone binding
(GO:0017046)
Plasma membrane
(GO:0005886)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Spleen development
(GO:0048536)
Spleen trabecula formation
(GO:0060345)
Synaptic vesicle
(GO:0008021)
Transcription by rna polymerase ii
(GO:0006366)

Other Information

Proteins

Solute carrier family 40 member 1

Genular Protein ID: 1557531549

Symbol: S40A1_MOUSE

Name: Solute carrier family 40 member 1

UniProtKB Accession Codes:

Q9JHI9 Q3UHZ9 Q8BME5 Q8BUM5 Q9JIM9 Q9JKP4

Database IDs:

Citations:

PubMed ID: 10747949

Title: A novel mammalian iron-regulated protein involved in intracellular iron metabolism.

PubMed ID: 10747949

DOI: 10.1074/jbc.m000713200

PubMed ID: 10693807

Title: Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter.

PubMed ID: 10693807

DOI: 10.1038/35001596

PubMed ID: 10882071

Title: A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation.

PubMed ID: 10882071

DOI: 10.1016/s1097-2765(00)80425-6

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16054062

Title: The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis.

PubMed ID: 16054062

DOI: 10.1016/j.cmet.2005.01.003

PubMed ID: 30213870

Title: Ferroportin deficiency in erythroid cells causes serum iron deficiency and promotes hemolysis due to oxidative stress.

PubMed ID: 30213870

DOI: 10.1182/blood-2018-04-842997

PubMed ID: 29599243

Title: Erythrocytic ferroportin reduces intracellular iron accumulation, hemolysis, and malaria risk.

PubMed ID: 29599243

DOI: 10.1126/science.aal2022

PubMed ID: 30888356

Title: Mice overexpressing hepcidin suggest ferroportin does not play a major role in Mn homeostasis.

PubMed ID: 30888356

DOI: 10.1039/c8mt00370j

PubMed ID: 33895792

Title: RNF217 regulates iron homeostasis through its E3 ubiquitin ligase activity by modulating ferroportin degradation.

PubMed ID: 33895792

DOI: 10.1182/blood.2020008986

Sequence Information:

Length: 570
Mass: 62702
Checksum: 7125CC6171394A0A
Sequence:

MTKARDQTHQ EGCCGSLANY LTSAKFLLYL GHSLSTWGDR MWHFAVSVFL VELYGNSLLL 
TAVYGLVVAG SVLVLGAIIG DWVDKNARLK VAQTSLVVQN VSVILCGIIL MMVFLHKNEL 
LTMYHGWVLT VCYILIITIA NIANLASTAT AITIQRDWIV VVAGENRSRL ADMNATIRRI 
DQLTNILAPM AVGQIMTFGS PVIGCGFISG WNLVSMCVEY FLLWKVYQKT PALAVKAALK 
VEESELKQLT SPKDTEPKPL EGTHLMGEKD SNIRELECEQ EPTCASQMAE PFRTFRDGWV 
SYYNQPVFLA GMGLAFLYMT VLGFDCITTG YAYTQGLSGS ILSILMGASA ITGIMGTVAF 
TWLRRKCGLV RTGLFSGLAQ LSCLILCVIS VFMPGSPLDL SVSPFEDIRS RFVNVEPVSP 
TTKIPETVFT TEMHMSNMSN VHEMSTKPIP IVSVSLLFAG VIAARIGLWS FDLTVTQLLQ 
ENVIESERGI INGVQNSMNY LLDLLHFIMV ILAPNPEAFG LLVLISVSFV AMGHLMYFRF 
AQKTLGNQIF VCGPDEKEVT DENQPNTSVV

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Slc40a1

Associated with

Other Information

A novel mammalian iron-regulated protein involved in intracellular iron metabolism. PubMed ID: 10747949

Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. PubMed ID: 10693807

A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. PubMed ID: 10882071

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. PubMed ID: 16054062

Ferroportin deficiency in erythroid cells causes serum iron deficiency and promotes hemolysis due to oxidative stress. PubMed ID: 30213870

Erythrocytic ferroportin reduces intracellular iron accumulation, hemolysis, and malaria risk. PubMed ID: 29599243

Mice overexpressing hepcidin suggest ferroportin does not play a major role in Mn homeostasis. PubMed ID: 30888356

RNF217 regulates iron homeostasis through its E3 ubiquitin ligase activity by modulating ferroportin degradation. PubMed ID: 33895792