Details for: ACP5

Gene ID: 54

Symbol: ACP5

Ensembl ID: ENSG00000102575

Description: acid phosphatase 5, tartrate resistant

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.95
    Marker Score: 75,568
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 2.2
    Marker Score: 2,512
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 2.19
    Marker Score: 13,315
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 2.03
    Marker Score: 847
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 2.02
    Marker Score: 5,696
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 1.99
    Marker Score: 991
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 1.78
    Marker Score: 4,925
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.78
    Marker Score: 1,676
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.65
    Marker Score: 2,878
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.5
    Marker Score: 1,670
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 1.43
    Marker Score: 312
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 1.39
    Marker Score: 3,612
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.32
    Marker Score: 793
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.19
    Marker Score: 499
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.14
    Marker Score: 655
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.09
    Marker Score: 385
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 1.04
    Marker Score: 6,780
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251,725
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 1.03
    Marker Score: 1,286
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 1.02
    Marker Score: 563
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 1.02
    Marker Score: 598
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 1.02
    Marker Score: 235
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1.01
    Marker Score: 905
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.01
    Marker Score: 3,575
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,743
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47,970
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,401
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.98
    Marker Score: 741
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.98
    Marker Score: 1,855
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.95
    Marker Score: 955
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 489
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,405
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 443
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,717
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.91
    Marker Score: 3,710
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9
    Marker Score: 360
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.89
    Marker Score: 1,807
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.89
    Marker Score: 13,854
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.88
    Marker Score: 5,658
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 313
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,254
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.86
    Marker Score: 4,932
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.86
    Marker Score: 1,148
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.86
    Marker Score: 8,538
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 0.85
    Marker Score: 1,368
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 0.85
    Marker Score: 4,471
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.83
    Marker Score: 898
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 0.83
    Marker Score: 889
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.82
    Marker Score: 685
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.81
    Marker Score: 3,192
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.81
    Marker Score: 206
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.79
    Marker Score: 9,146
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.78
    Marker Score: 2,050
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 597
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.78
    Marker Score: 6,732
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,268
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 0.78
    Marker Score: 940
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.78
    Marker Score: 867
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 0.74
    Marker Score: 229
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 381
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.73
    Marker Score: 550
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.71
    Marker Score: 2,980
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.71
    Marker Score: 780
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.69
    Marker Score: 630
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.68
    Marker Score: 1,122
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 0.68
    Marker Score: 5,277
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.67
    Marker Score: 201
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.67
    Marker Score: 10,804
  • Cell Name: Langerhans cell (CL0000453)
    Fold Change: 0.67
    Marker Score: 200
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 0.67
    Marker Score: 405
  • Cell Name: B-1a B cell (CL0000820)
    Fold Change: 0.66
    Marker Score: 159
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.66
    Marker Score: 386
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.66
    Marker Score: 1,284
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.64
    Marker Score: 306
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.64
    Marker Score: 469
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.64
    Marker Score: 222
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.64
    Marker Score: 258
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.63
    Marker Score: 1,119
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 0.63
    Marker Score: 520
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.62
    Marker Score: 375
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.62
    Marker Score: 1,778
  • Cell Name: ionocyte (CL0005006)
    Fold Change: 0.61
    Marker Score: 186
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.61
    Marker Score: 578
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.6
    Marker Score: 511
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.59
    Marker Score: 762
  • Cell Name: classical monocyte (CL0000860)
    Fold Change: 0.59
    Marker Score: 2,434
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.58
    Marker Score: 425
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.58
    Marker Score: 334
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.56
    Marker Score: 6,313
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.56
    Marker Score: 154
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 443
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.55
    Marker Score: 375
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.55
    Marker Score: 533
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.55
    Marker Score: 2,372
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.55
    Marker Score: 1,631
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.54
    Marker Score: 30,368
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.53
    Marker Score: 475
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.53
    Marker Score: 251
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.53
    Marker Score: 1,269

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** ACP5 is a tartrate-resistant acid phosphatase, which implies its ability to hydrolyze phosphate groups in acidic environments. This characteristic allows it to function in a wide range of cellular compartments, including lysosomes, cytosol, and membranes. 2. **Expression Patterns:** ACP5 is predominantly expressed in cells of the immune system, including alveolar macrophages, lung macrophages, elicited macrophages, and osteoclasts. Its expression is also detected in other cell types, such as tracheal goblet cells, decidual natural killer cells, and B-1 B cells. 3. **Regulatory Functions:** ACP5 acts as a negative regulator of various immune responses, including the production of pro-inflammatory cytokines (IL-1β, IL-12, TNF-α), nitric oxide biosynthesis, and superoxide anion generation. Its regulatory mechanisms are mediated through the dephosphorylation of proteins and the modulation of signaling pathways. **Pathways and Functions:** 1. **Acid Phosphatase Activity:** ACP5's enzymatic activity is crucial for regulating the pH of cellular compartments, which in turn affects protein function and signaling. 2. **Bone Resorption:** ACP5 is involved in the regulation of bone resorption by osteoclasts, which are responsible for the breakdown of bone tissue. 3. **Immune Response Modulation:** ACP5 negatively regulates the production of pro-inflammatory cytokines, nitric oxide, and superoxide anions, thereby preventing excessive inflammation and tissue damage. 4. **Metabolic Functions:** ACP5 is involved in the regulation of vitamin B2 (riboflavin) metabolism and the dephosphorylation of proteins involved in energy metabolism. **Clinical Significance:** 1. **Bone Disorders:** Dysregulation of ACP5 has been implicated in various bone disorders, including osteoporosis, osteopenia, and bone metastases. 2. **Immune-Mediated Diseases:** ACP5's regulatory functions have been linked to immune-mediated diseases, such as rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease. 3. **Cancer:** ACP5 has been identified as a potential biomarker for cancer diagnosis and prognosis, particularly in the context of bone metastases. 4. **Infectious Diseases:** ACP5's role in regulating the immune response to gram-positive bacteria has significant implications for the treatment of infections. In conclusion, ACP5 is a multifaceted enzyme that plays a critical role in regulating immune responses, bone resorption, and metabolism. Further research is necessary to elucidate the complex mechanisms by which ACP5 exerts its regulatory functions and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 2307301133

Symbol: PPA5_HUMAN

Name: Tartrate-resistant acid phosphatase type 5

UniProtKB Accession Codes:

P13686 A8K3V2 Q2TAB1 Q6IAS6 Q9UCJ5 Q9UCJ6 Q9UCJ7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 13 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 7 Ensembl 11 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 2 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 7 Rhea 1 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2909539

Title: Molecular cloning of the type 5, iron-containing, tartrate-resistant acid phosphatase from human placenta.

PubMed ID: 2909539

DOI: 10.1016/s0021-9258(17)31295-4

PubMed ID: 2338077

Title: Type 5 acid phosphatase. Sequence, expression and chromosomal localization of a differentiation-associated protein of the human macrophage.

PubMed ID: 2338077

DOI: 10.1111/j.1432-1033.1990.tb15488.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8359686

Title: Isolation and characterization of the genes encoding mouse and human type-5 acid phosphatase.

PubMed ID: 8359686

DOI: 10.1016/0378-1119(93)90420-8

PubMed ID: 2775236

Title: Purification and characterization of a tartrate-resistant acid phosphatase from human osteoclastomas.

PubMed ID: 2775236

DOI: 10.1042/bj2610601

PubMed ID: 1477968

Title: Heterogeneity of hairy cell tartrate-resistant acid phosphatase.

PubMed ID: 1477968

DOI: 10.1016/0009-9120(92)90075-4

PubMed ID: 2610679

Title: Purification and N-terminal sequence of two tartrate-resistant acid phosphatases type-5 from the hairy cell leukemia spleen.

PubMed ID: 2610679

DOI: 10.1016/0006-291x(89)92705-8

PubMed ID: 2334436

Title: Purification and N-terminal amino acid sequence of the tartrate-resistant acid phosphatase from human osteoclastoma: evidence for a single structure.

PubMed ID: 2334436

DOI: 10.1016/0006-291x(90)92391-c

PubMed ID: 1872798

Title: Tartrate-resistant acid phosphatase from human osteoclastomas is translated as a single polypeptide.

PubMed ID: 1872798

DOI: 10.1042/bj2770631

PubMed ID: 15993892

Title: Crystal structures of recombinant human purple acid phosphatase with and without an inhibitory conformation of the repression loop.

PubMed ID: 15993892

DOI: 10.1016/j.jmb.2005.04.014

PubMed ID: 21217755

Title: Tartrate-resistant acid phosphatase deficiency causes a bone dysplasia with autoimmunity and a type I interferon expression signature.

PubMed ID: 21217755

DOI: 10.1038/ng.748

PubMed ID: 21217752

Title: Genetic deficiency of tartrate-resistant acid phosphatase associated with skeletal dysplasia, cerebral calcifications and autoimmunity.

PubMed ID: 21217752

DOI: 10.1038/ng.749

Sequence Information:

  • Length: 325
  • Mass: 36599
  • Checksum: 079174A71A5BA264
  • Sequence:
    • MDMWTALLIL QALLLPSLAD GATPALRFVA VGDWGGVPNA PFHTAREMAN AKEIARTVQI 
LGADFILSLG DNFYFTGVQD INDKRFQETF EDVFSDRSLR KVPWYVLAGN HDHLGNVSAQ 
IAYSKISKRW NFPSPFYRLH FKIPQTNVSV AIFMLDTVTL CGNSDDFLSQ QPERPRDVKL 
ARTQLSWLKK QLAAAREDYV LVAGHYPVWS IAEHGPTHCL VKQLRPLLAT YGVTAYLCGH 
DHNLQYLQDE NGVGYVLSGA GNFMDPSKRH QRKVPNGYLR FHYGTEDSLG GFAYVEISSK 
EMTVTYIEAS GKSLFKTRLP RRARP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.