ACP5 | ENSG00000102575 | NCBI 54

Details for: ACP5

Gene ID: 54

Symbol: ACP5

Ensembl ID: ENSG00000102575

Description: acid phosphatase 5, tartrate resistant

Associated with

Metabolism
(R-HSA-1430728)
Metabolism of vitamins and cofactors
(R-HSA-196854)
Metabolism of water-soluble vitamins and cofactors
(R-HSA-196849)
Vitamin b2 (riboflavin) metabolism
(R-HSA-196843)
Acid phosphatase activity
(GO:0003993)
Bone morphogenesis
(GO:0060349)
Bone resorption
(GO:0045453)
Cytosol
(GO:0005829)
Defense response to gram-positive bacterium
(GO:0050830)
Dephosphorylation
(GO:0016311)
Ferric iron binding
(GO:0008199)
Ferrous iron binding
(GO:0008198)
Lysosome
(GO:0005764)
Membrane
(GO:0016020)
Negative regulation of inflammatory response
(GO:0050728)
Negative regulation of interleukin-1 beta production
(GO:0032691)
Negative regulation of interleukin-12 production
(GO:0032695)
Negative regulation of macrophage cytokine production
(GO:0010936)
Negative regulation of nitric oxide biosynthetic process
(GO:0045019)
Negative regulation of superoxide anion generation
(GO:0032929)
Negative regulation of tumor necrosis factor production
(GO:0032720)
Nitric oxide biosynthetic process
(GO:0006809)
Response to cytokine
(GO:0034097)
Response to lipopolysaccharide
(GO:0032496)
Superoxide anion generation
(GO:0042554)

Other Information

Proteins

Tartrate-resistant acid phosphatase type 5

Genular Protein ID: 2307301133

Symbol: PPA5_HUMAN

Name: Tartrate-resistant acid phosphatase type 5

UniProtKB Accession Codes:

P13686 A8K3V2 Q2TAB1 Q6IAS6 Q9UCJ5 Q9UCJ6 Q9UCJ7

Database IDs:

Citations:

PubMed ID: 2909539

Title: Molecular cloning of the type 5, iron-containing, tartrate-resistant acid phosphatase from human placenta.

PubMed ID: 2909539

DOI: 10.1016/s0021-9258(17)31295-4

PubMed ID: 2338077

Title: Type 5 acid phosphatase. Sequence, expression and chromosomal localization of a differentiation-associated protein of the human macrophage.

PubMed ID: 2338077

DOI: 10.1111/j.1432-1033.1990.tb15488.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8359686

Title: Isolation and characterization of the genes encoding mouse and human type-5 acid phosphatase.

PubMed ID: 8359686

DOI: 10.1016/0378-1119(93)90420-8

PubMed ID: 2775236

Title: Purification and characterization of a tartrate-resistant acid phosphatase from human osteoclastomas.

PubMed ID: 2775236

DOI: 10.1042/bj2610601

PubMed ID: 1477968

Title: Heterogeneity of hairy cell tartrate-resistant acid phosphatase.

PubMed ID: 1477968

DOI: 10.1016/0009-9120(92)90075-4

PubMed ID: 2610679

Title: Purification and N-terminal sequence of two tartrate-resistant acid phosphatases type-5 from the hairy cell leukemia spleen.

PubMed ID: 2610679

DOI: 10.1016/0006-291x(89)92705-8

PubMed ID: 2334436

Title: Purification and N-terminal amino acid sequence of the tartrate-resistant acid phosphatase from human osteoclastoma: evidence for a single structure.

PubMed ID: 2334436

DOI: 10.1016/0006-291x(90)92391-c

PubMed ID: 1872798

Title: Tartrate-resistant acid phosphatase from human osteoclastomas is translated as a single polypeptide.

PubMed ID: 1872798

DOI: 10.1042/bj2770631

PubMed ID: 15993892

Title: Crystal structures of recombinant human purple acid phosphatase with and without an inhibitory conformation of the repression loop.

PubMed ID: 15993892

DOI: 10.1016/j.jmb.2005.04.014

PubMed ID: 21217755

Title: Tartrate-resistant acid phosphatase deficiency causes a bone dysplasia with autoimmunity and a type I interferon expression signature.

PubMed ID: 21217755

DOI: 10.1038/ng.748

PubMed ID: 21217752

Title: Genetic deficiency of tartrate-resistant acid phosphatase associated with skeletal dysplasia, cerebral calcifications and autoimmunity.

PubMed ID: 21217752

DOI: 10.1038/ng.749

Sequence Information:

Length: 325
Mass: 36599
Checksum: 079174A71A5BA264
Sequence:

MDMWTALLIL QALLLPSLAD GATPALRFVA VGDWGGVPNA PFHTAREMAN AKEIARTVQI 
LGADFILSLG DNFYFTGVQD INDKRFQETF EDVFSDRSLR KVPWYVLAGN HDHLGNVSAQ 
IAYSKISKRW NFPSPFYRLH FKIPQTNVSV AIFMLDTVTL CGNSDDFLSQ QPERPRDVKL 
ARTQLSWLKK QLAAAREDYV LVAGHYPVWS IAEHGPTHCL VKQLRPLLAT YGVTAYLCGH 
DHNLQYLQDE NGVGYVLSGA GNFMDPSKRH QRKVPNGYLR FHYGTEDSLG GFAYVEISSK 
EMTVTYIEAS GKSLFKTRLP RRARP

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: ACP5

Associated with

Other Information

Molecular cloning of the type 5, iron-containing, tartrate-resistant acid phosphatase from human placenta. PubMed ID: 2909539

Type 5 acid phosphatase. Sequence, expression and chromosomal localization of a differentiation-associated protein of the human macrophage. PubMed ID: 2338077

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Isolation and characterization of the genes encoding mouse and human type-5 acid phosphatase. PubMed ID: 8359686

Purification and characterization of a tartrate-resistant acid phosphatase from human osteoclastomas. PubMed ID: 2775236

Heterogeneity of hairy cell tartrate-resistant acid phosphatase. PubMed ID: 1477968

Purification and N-terminal sequence of two tartrate-resistant acid phosphatases type-5 from the hairy cell leukemia spleen. PubMed ID: 2610679

Purification and N-terminal amino acid sequence of the tartrate-resistant acid phosphatase from human osteoclastoma: evidence for a single structure. PubMed ID: 2334436

Tartrate-resistant acid phosphatase from human osteoclastomas is translated as a single polypeptide. PubMed ID: 1872798

Crystal structures of recombinant human purple acid phosphatase with and without an inhibitory conformation of the repression loop. PubMed ID: 15993892

Tartrate-resistant acid phosphatase deficiency causes a bone dysplasia with autoimmunity and a type I interferon expression signature. PubMed ID: 21217755

Genetic deficiency of tartrate-resistant acid phosphatase associated with skeletal dysplasia, cerebral calcifications and autoimmunity. PubMed ID: 21217752