Details for: ACP5

Gene ID: 54

Symbol: ACP5

Ensembl ID: ENSG00000102575

Description: acid phosphatase 5, tartrate resistant

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 85.6664
    Cell Significance Index: -13.3300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 46.6403
    Cell Significance Index: -11.8300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 37.5048
    Cell Significance Index: -15.4500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 37.3901
    Cell Significance Index: -15.1900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 32.1354
    Cell Significance Index: -16.5300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 31.5172
    Cell Significance Index: -14.8800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 10.7546
    Cell Significance Index: -13.2600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.5326
    Cell Significance Index: -13.9400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.4056
    Cell Significance Index: -10.4600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 1.4129
    Cell Significance Index: 36.1000
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 1.3992
    Cell Significance Index: 16.2000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.8451
    Cell Significance Index: 24.8200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7593
    Cell Significance Index: 685.6100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.7215
    Cell Significance Index: 15.3700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6803
    Cell Significance Index: 40.8400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.5866
    Cell Significance Index: 63.8000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4773
    Cell Significance Index: 77.6300
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.4465
    Cell Significance Index: 28.1400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4301
    Cell Significance Index: 42.5500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.4197
    Cell Significance Index: 57.6400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.3845
    Cell Significance Index: 45.3500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3272
    Cell Significance Index: 22.6300
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.2788
    Cell Significance Index: 2.6500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.2209
    Cell Significance Index: 25.7400
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2198
    Cell Significance Index: 2.6200
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1985
    Cell Significance Index: 37.7700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.1939
    Cell Significance Index: 14.4500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1743
    Cell Significance Index: 77.0500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.1677
    Cell Significance Index: 3.1000
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0879
    Cell Significance Index: 1.3600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0729
    Cell Significance Index: 1.5800
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.0675
    Cell Significance Index: 1.1600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0579
    Cell Significance Index: 7.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0576
    Cell Significance Index: 35.9700
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0538
    Cell Significance Index: 9.1900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0353
    Cell Significance Index: 2.5000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0309
    Cell Significance Index: 16.8700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0274
    Cell Significance Index: 5.4300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0268
    Cell Significance Index: 20.2600
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.0256
    Cell Significance Index: 0.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0165
    Cell Significance Index: 0.4600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0123
    Cell Significance Index: 1.5900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0102
    Cell Significance Index: 19.1300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0036
    Cell Significance Index: 0.0900
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0003
    Cell Significance Index: -0.0600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0019
    Cell Significance Index: -1.3800
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: -0.0057
    Cell Significance Index: -0.0500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0075
    Cell Significance Index: -0.3400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0086
    Cell Significance Index: -15.9100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0104
    Cell Significance Index: -15.9800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0107
    Cell Significance Index: -7.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0116
    Cell Significance Index: -6.5300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0118
    Cell Significance Index: -15.9800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0145
    Cell Significance Index: -0.5100
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0146
    Cell Significance Index: -0.7400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0195
    Cell Significance Index: -14.2900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0214
    Cell Significance Index: -13.6200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0255
    Cell Significance Index: -1.0400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0316
    Cell Significance Index: -3.2300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0328
    Cell Significance Index: -14.8900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0328
    Cell Significance Index: -0.3400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0329
    Cell Significance Index: -6.9300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0356
    Cell Significance Index: -1.8500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0384
    Cell Significance Index: -11.0500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0387
    Cell Significance Index: -13.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0450
    Cell Significance Index: -5.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0479
    Cell Significance Index: -6.9600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0566
    Cell Significance Index: -2.6400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0590
    Cell Significance Index: -1.7000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0703
    Cell Significance Index: -14.1000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0893
    Cell Significance Index: -1.3500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0974
    Cell Significance Index: -11.1200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1127
    Cell Significance Index: -12.9100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1265
    Cell Significance Index: -13.1700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1293
    Cell Significance Index: -4.1400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1303
    Cell Significance Index: -7.3100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1304
    Cell Significance Index: -6.1300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1510
    Cell Significance Index: -9.2600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1639
    Cell Significance Index: -4.3900
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: -0.1725
    Cell Significance Index: -1.5200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1748
    Cell Significance Index: -5.0100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1765
    Cell Significance Index: -13.9800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2063
    Cell Significance Index: -15.8300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2116
    Cell Significance Index: -5.4400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.2131
    Cell Significance Index: -13.7500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.2262
    Cell Significance Index: -15.2100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2451
    Cell Significance Index: -12.8700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2556
    Cell Significance Index: -3.8300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.2620
    Cell Significance Index: -16.1100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2754
    Cell Significance Index: -7.5000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2788
    Cell Significance Index: -14.5200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2962
    Cell Significance Index: -12.8800
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.3034
    Cell Significance Index: -2.4000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3075
    Cell Significance Index: -13.6000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.3328
    Cell Significance Index: -4.5400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3449
    Cell Significance Index: -12.6600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3591
    Cell Significance Index: -13.6000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.3736
    Cell Significance Index: -2.8800
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.3823
    Cell Significance Index: -5.3700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** ACP5 is a tartrate-resistant acid phosphatase, which implies its ability to hydrolyze phosphate groups in acidic environments. This characteristic allows it to function in a wide range of cellular compartments, including lysosomes, cytosol, and membranes. 2. **Expression Patterns:** ACP5 is predominantly expressed in cells of the immune system, including alveolar macrophages, lung macrophages, elicited macrophages, and osteoclasts. Its expression is also detected in other cell types, such as tracheal goblet cells, decidual natural killer cells, and B-1 B cells. 3. **Regulatory Functions:** ACP5 acts as a negative regulator of various immune responses, including the production of pro-inflammatory cytokines (IL-1β, IL-12, TNF-α), nitric oxide biosynthesis, and superoxide anion generation. Its regulatory mechanisms are mediated through the dephosphorylation of proteins and the modulation of signaling pathways. **Pathways and Functions:** 1. **Acid Phosphatase Activity:** ACP5's enzymatic activity is crucial for regulating the pH of cellular compartments, which in turn affects protein function and signaling. 2. **Bone Resorption:** ACP5 is involved in the regulation of bone resorption by osteoclasts, which are responsible for the breakdown of bone tissue. 3. **Immune Response Modulation:** ACP5 negatively regulates the production of pro-inflammatory cytokines, nitric oxide, and superoxide anions, thereby preventing excessive inflammation and tissue damage. 4. **Metabolic Functions:** ACP5 is involved in the regulation of vitamin B2 (riboflavin) metabolism and the dephosphorylation of proteins involved in energy metabolism. **Clinical Significance:** 1. **Bone Disorders:** Dysregulation of ACP5 has been implicated in various bone disorders, including osteoporosis, osteopenia, and bone metastases. 2. **Immune-Mediated Diseases:** ACP5's regulatory functions have been linked to immune-mediated diseases, such as rheumatoid arthritis, multiple sclerosis, and inflammatory bowel disease. 3. **Cancer:** ACP5 has been identified as a potential biomarker for cancer diagnosis and prognosis, particularly in the context of bone metastases. 4. **Infectious Diseases:** ACP5's role in regulating the immune response to gram-positive bacteria has significant implications for the treatment of infections. In conclusion, ACP5 is a multifaceted enzyme that plays a critical role in regulating immune responses, bone resorption, and metabolism. Further research is necessary to elucidate the complex mechanisms by which ACP5 exerts its regulatory functions and to explore its potential as a therapeutic target for various diseases.

Genular Protein ID: 2307301133

Symbol: PPA5_HUMAN

Name: Tartrate-resistant acid phosphatase type 5

UniProtKB Accession Codes:

P13686 A8K3V2 Q2TAB1 Q6IAS6 Q9UCJ5 Q9UCJ6 Q9UCJ7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 13 ChiTaRS 1 DEPOD 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 7 Ensembl 11 EvolutionaryTrace 1 ExpressionAtlas 1 GO 21 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PIRSF 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 7 Rhea 1 SABIO-RK 1 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2909539

Title: Molecular cloning of the type 5, iron-containing, tartrate-resistant acid phosphatase from human placenta.

PubMed ID: 2909539

DOI: 10.1016/s0021-9258(17)31295-4

PubMed ID: 2338077

Title: Type 5 acid phosphatase. Sequence, expression and chromosomal localization of a differentiation-associated protein of the human macrophage.

PubMed ID: 2338077

DOI: 10.1111/j.1432-1033.1990.tb15488.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8359686

Title: Isolation and characterization of the genes encoding mouse and human type-5 acid phosphatase.

PubMed ID: 8359686

DOI: 10.1016/0378-1119(93)90420-8

PubMed ID: 2775236

Title: Purification and characterization of a tartrate-resistant acid phosphatase from human osteoclastomas.

PubMed ID: 2775236

DOI: 10.1042/bj2610601

PubMed ID: 1477968

Title: Heterogeneity of hairy cell tartrate-resistant acid phosphatase.

PubMed ID: 1477968

DOI: 10.1016/0009-9120(92)90075-4

PubMed ID: 2610679

Title: Purification and N-terminal sequence of two tartrate-resistant acid phosphatases type-5 from the hairy cell leukemia spleen.

PubMed ID: 2610679

DOI: 10.1016/0006-291x(89)92705-8

PubMed ID: 2334436

Title: Purification and N-terminal amino acid sequence of the tartrate-resistant acid phosphatase from human osteoclastoma: evidence for a single structure.

PubMed ID: 2334436

DOI: 10.1016/0006-291x(90)92391-c

PubMed ID: 1872798

Title: Tartrate-resistant acid phosphatase from human osteoclastomas is translated as a single polypeptide.

PubMed ID: 1872798

DOI: 10.1042/bj2770631

PubMed ID: 15993892

Title: Crystal structures of recombinant human purple acid phosphatase with and without an inhibitory conformation of the repression loop.

PubMed ID: 15993892

DOI: 10.1016/j.jmb.2005.04.014

PubMed ID: 21217755

Title: Tartrate-resistant acid phosphatase deficiency causes a bone dysplasia with autoimmunity and a type I interferon expression signature.

PubMed ID: 21217755

DOI: 10.1038/ng.748

PubMed ID: 21217752

Title: Genetic deficiency of tartrate-resistant acid phosphatase associated with skeletal dysplasia, cerebral calcifications and autoimmunity.

PubMed ID: 21217752

DOI: 10.1038/ng.749

Sequence Information:

  • Length: 325
  • Mass: 36599
  • Checksum: 079174A71A5BA264
  • Sequence:
    • MDMWTALLIL QALLLPSLAD GATPALRFVA VGDWGGVPNA PFHTAREMAN AKEIARTVQI 
LGADFILSLG DNFYFTGVQD INDKRFQETF EDVFSDRSLR KVPWYVLAGN HDHLGNVSAQ 
IAYSKISKRW NFPSPFYRLH FKIPQTNVSV AIFMLDTVTL CGNSDDFLSQ QPERPRDVKL 
ARTQLSWLKK QLAAAREDYV LVAGHYPVWS IAEHGPTHCL VKQLRPLLAT YGVTAYLCGH 
DHNLQYLQDE NGVGYVLSGA GNFMDPSKRH QRKVPNGYLR FHYGTEDSLG GFAYVEISSK 
EMTVTYIEAS GKSLFKTRLP RRARP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.