Details for: TSPEAR

Gene ID: 54084

Symbol: TSPEAR

Ensembl ID: ENSG00000175894

Description: thrombospondin type laminin G domain and EAR repeats

Associated with

Other Information

Genular Protein ID: 3269200833

Symbol: TSEAR_HUMAN

Name: Thrombospondin-type laminin G domain and EAR repeat-containing protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 12095917

Title: A common protein interaction domain links two recently identified epilepsy genes.

PubMed ID: 12095917

DOI: 10.1093/hmg/11.15.1757

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 22678063

Title: Defect in the gene encoding the EAR/EPTP domain-containing protein TSPEAR causes DFNB98 profound deafness.

PubMed ID: 22678063

DOI: 10.1093/hmg/dds212

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 27736875

Title: Mutations in TSPEAR, Encoding a Regulator of Notch Signaling, Affect Tooth and Hair Follicle Morphogenesis.

PubMed ID: 27736875

DOI: 10.1371/journal.pgen.1006369

PubMed ID: 30046887

Title: Identification of likely pathogenic and known variants in TSPEAR, LAMB3, BCOR, and WNT10A in four Turkish families with tooth agenesis.

PubMed ID: 30046887

DOI: 10.1007/s00439-018-1907-y

PubMed ID: 32112661

Title: Novel TSPEAR mutations in non-syndromic oligodontia.

PubMed ID: 32112661

DOI: 10.1111/odi.13316

PubMed ID: 34042254

Title: TSPEAR variants are primarily associated with ectodermal dysplasia and tooth agenesis but not hearing loss: A novel cohort study.

PubMed ID: 34042254

DOI: 10.1002/ajmg.a.62347

Sequence Information:

  • Length: 669
  • Mass: 74924
  • Checksum: E3E880708B63812E
  • Sequence:
  • MSALLSLCFV LPLAAPGHGT QGWEPCTDLR PLDILAEVVP SDGATSGIRI VQVHGARGLQ 
    LSVAAPRTMS FPASRIFSQC DLFPEEFSIV VTLRVPNLPP KRNEYLLTVV AEESDLLLLG 
    LRLSPAQLHF LFLREDTAGA WQTRVSFRSP ALVDGRWHTL VLAVSAGVFS LTTDCGLPVD 
    IMADVPFPAT LSVKGARFFV GSRRRAKGLF MGLVRQLVLL PGSDATPRLC PSRNAPLAVL 
    SIPRVLQALT GKPEDNEVLK YPYETNIRVT LGPQPPCTEV EDAQFWFDAS RKGLYLCVGN 
    EWVSVLAAKE RLDYVEEHQN LSTNSETLGI EVFRIPQVGL FVATANRKAT SAVYKWTEEK 
    FVSYQNIPTH QAQAWRHFTI GKKIFLAVAN FEPDEKGQEF SVIYKWSHRK LKFTPYQSIA 
    THSARDWEAF EVDGEHFLAV ANHREGDNHN IDSVIYKWNP ATRLFEANQT IATSGAYDWE 
    FFSVGPYSFL VVANTFNGTS TKVHSHLYIR LLGSFQLFQS FPTFGAADWE VFQIGERIFL 
    AVANSHSYDV EMQVQNDSYV INSVIYELNV TAQAFVKFQD ILTCSALDWE FFSVGEDYFL 
    VVANSFDGRT FSVNSIIYRW QGYEGFVAVH SLPTVGCRDW EAFSTTAGAY LIYSSAKEPL 
    SRVLRLRTR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.