POLE3 | ENSG00000148229 | NCBI 54107

Details for: POLE3

Gene ID: 54107

Symbol: POLE3

Ensembl ID: ENSG00000148229

Description: DNA polymerase epsilon 3, accessory subunit

Associated with

Activation of the pre-replicative complex
(R-HSA-68962)
Base excision repair
(R-HSA-73884)
Cell cycle
(R-HSA-1640170)
Cell cycle, mitotic
(R-HSA-69278)
Dna damage bypass
(R-HSA-73893)
Dna double-strand break repair
(R-HSA-5693532)
Dna repair
(R-HSA-73894)
Dna replication initiation
(R-HSA-68952)
Dna replication pre-initiation
(R-HSA-69002)
Dual incision in gg-ner
(R-HSA-5696400)
Dual incision in tc-ner
(R-HSA-6782135)
G1/s transition
(R-HSA-69206)
Gap-filling dna repair synthesis and ligation in gg-ner
(R-HSA-5696397)
Gap-filling dna repair synthesis and ligation in tc-ner
(R-HSA-6782210)
Global genome nucleotide excision repair (gg-ner)
(R-HSA-5696399)
Hdr through homologous recombination (hrr)
(R-HSA-5685942)
Hdr through homologous recombination (hrr) or single strand annealing (ssa)
(R-HSA-5693567)
Homology directed repair
(R-HSA-5693538)
Mitotic g1 phase and g1/s transition
(R-HSA-453279)
Nucleotide excision repair
(R-HSA-5696398)
Pcna-dependent long patch base excision repair
(R-HSA-5651801)
Recognition of dna damage by pcna-containing replication complex
(R-HSA-110314)
Resolution of abasic sites (ap sites)
(R-HSA-73933)
Resolution of ap sites via the multiple-nucleotide patch replacement pathway
(R-HSA-110373)
S phase
(R-HSA-69242)
Synthesis of dna
(R-HSA-69239)
Termination of translesion dna synthesis
(R-HSA-5656169)
Transcription-coupled nucleotide excision repair (tc-ner)
(R-HSA-6781827)
Translesion synthesis by y family dna polymerases bypasses lesions on dna template
(R-HSA-110313)
Atac complex
(GO:0140672)
Chrac
(GO:0008623)
Chromatin dna binding
(GO:0031490)
Chromatin remodeling
(GO:0006338)
Dna-directed dna polymerase activity
(GO:0003887)
Dna-templated dna replication
(GO:0006261)
Dna biosynthetic process
(GO:0071897)
Dna damage response
(GO:0006974)
Dna replication
(GO:0006260)
Epsilon dna polymerase complex
(GO:0008622)
Heterochromatin formation
(GO:0031507)
Leading strand elongation
(GO:0006272)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Nucleoplasm
(GO:0005654)
Nucleosome assembly
(GO:0006334)
Nucleus
(GO:0005634)
Pericentric heterochromatin
(GO:0005721)
Protein binding
(GO:0005515)
Protein heterodimerization activity
(GO:0046982)
Regulation of dna replication
(GO:0006275)

Other Information

Proteins

DNA polymerase epsilon subunit 3

Genular Protein ID: 4159513930

Symbol: DPOE3_HUMAN

Name: DNA polymerase epsilon subunit 3

UniProtKB Accession Codes:

Q9NRF9 Q5W0U1 Q8N758 Q8NCE5 Q9NR32

Database IDs:

Citations:

PubMed ID: 10880450

Title: HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins.

PubMed ID: 10880450

DOI: 10.1093/emboj/19.13.3377

PubMed ID: 10801849

Title: Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon.

PubMed ID: 10801849

DOI: 10.1074/jbc.m002548200

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15164053

Title: DNA sequence and analysis of human chromosome 9.

PubMed ID: 15164053

DOI: 10.1038/nature02465

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12434153

Title: An ACF1-ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin.

PubMed ID: 12434153

DOI: 10.1038/ng1046

PubMed ID: 14759371

Title: The histone-fold protein complex CHRAC-15/17 enhances nucleosome sliding and assembly mediated by ACF.

PubMed ID: 14759371

DOI: 10.1016/s1097-2765(03)00523-9

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

Sequence Information:

Length: 147
Mass: 16860
Checksum: DC0A4D2097046569
Sequence:

MAERPEDLNL PNAVITRIIK EALPDGVNIS KEARSAISRA ASVFVLYATS CANNFAMKGK 
RKTLNASDVL SAMEEMEFQR FVTPLKEALE AYRREQKGKK EASEQKKKDK DKKTDSEEQD 
KSRDEDNDED EERLEEEEQN EEEEVDN

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: POLE3

Associated with

Other Information

HuCHRAC, a human ISWI chromatin remodelling complex contains hACF1 and two novel histone-fold proteins. PubMed ID: 10880450

Identification and cloning of two histone fold motif-containing subunits of HeLa DNA polymerase epsilon. PubMed ID: 10801849

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

DNA sequence and analysis of human chromosome 9. PubMed ID: 15164053

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

An ACF1-ISWI chromatin-remodeling complex is required for DNA replication through heterochromatin. PubMed ID: 12434153

The histone-fold protein complex CHRAC-15/17 enhances nucleosome sliding and assembly mediated by ACF. PubMed ID: 14759371

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. PubMed ID: 19413330

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. PubMed ID: 20068231

Initial characterization of the human central proteome. PubMed ID: 21269460

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. PubMed ID: 21406692