Irf3 | ENSMUSG00000003184 | NCBI 54131

Details for: Irf3

Gene ID: 54131

Symbol: Irf3

Ensembl ID: ENSMUSG00000003184

Description: interferon regulatory factor 3

Associated with

Activation of irf3, irf7 mediated by tbk1, ikbke
(R-MMU-936964)
Antiviral mechanism by ifn-stimulated genes
(R-MMU-1169410)
Cytokine signaling in immune system
(R-MMU-1280215)
Cytosolic sensors of pathogen-associated dna
(R-MMU-1834949)
Ddx58/ifih1-mediated induction of interferon-alpha/beta
(R-MMU-168928)
Immune system
(R-MMU-168256)
Innate immune system
(R-MMU-168249)
Interferon signaling
(R-MMU-913531)
Irf3 mediated activation of type 1 ifn
(R-MMU-1606341)
Irf3-mediated induction of type i ifn
(R-MMU-3270619)
Isg15 antiviral mechanism
(R-MMU-1169408)
Lrr flii-interacting protein 1 (lrrfip1) activates type i ifn production
(R-MMU-3134973)
Myd88-independent tlr4 cascade
(R-MMU-166166)
Negative regulators of ddx58/ifih1 signaling
(R-MMU-936440)
Regulation of innate immune responses to cytosolic dna
(R-MMU-3134975)
Sting mediated induction of host immune responses
(R-MMU-1834941)
Ticam1-dependent activation of irf3/irf7
(R-MMU-9013973)
Toll-like receptor cascades
(R-MMU-168898)
Toll like receptor 3 (tlr3) cascade
(R-MMU-168164)
Toll like receptor 4 (tlr4) cascade
(R-MMU-166016)
Traf3-dependent irf activation pathway
(R-MMU-918233)
Traf6 mediated irf7 activation
(R-MMU-933541)
Trif(ticam1)-mediated tlr4 signaling
(R-MMU-937061)
Zbp1(dai) mediated induction of type i ifns
(R-MMU-1606322)
Antiviral innate immune response
(GO:0140374)
Cellular response to lipopolysaccharide
(GO:0071222)
Cellular response to virus
(GO:0098586)
Chromatin
(GO:0000785)
Cytoplasm
(GO:0005737)
Cytoplasmic pattern recognition receptor signaling pathway
(GO:0002753)
Cytosol
(GO:0005829)
Defense response to virus
(GO:0051607)
Dna-binding transcription activator activity
(GO:0001216)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Identical protein binding
(GO:0042802)
Immune system process
(GO:0002376)
Innate immune response
(GO:0045087)
Lipopolysaccharide-mediated signaling pathway
(GO:0031663)
Mitochondrion
(GO:0005739)
Mrna transcription
(GO:0009299)
Nucleus
(GO:0005634)
Positive regulation of canonical nf-kappab signal transduction
(GO:0043123)
Positive regulation of cytokine production
(GO:0001819)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of interferon-alpha production
(GO:0032727)
Positive regulation of interferon-beta production
(GO:0032728)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Positive regulation of type i interferon-mediated signaling pathway
(GO:0060340)
Positive regulation of type i interferon production
(GO:0032481)
Programmed necrotic cell death
(GO:0097300)
Promoter-specific chromatin binding
(GO:1990841)
Protein domain specific binding
(GO:0019904)
Protein homodimerization activity
(GO:0042803)
Regulation of apoptotic process
(GO:0042981)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of gene expression
(GO:0010468)
Regulation of inflammatory response
(GO:0050727)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to bacterium
(GO:0009617)
Response to exogenous dsrna
(GO:0043330)
Response to lipopolysaccharide
(GO:0032496)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Toll-like receptor 4 signaling pathway
(GO:0034142)
Trif-dependent toll-like receptor signaling pathway
(GO:0035666)
Type i interferon-mediated signaling pathway
(GO:0060337)
Type i interferon production
(GO:0032606)

Other Information

Proteins

Interferon regulatory factor 3

Genular Protein ID: 1903401152

Symbol: IRF3_MOUSE

Name: Interferon regulatory factor 3

UniProtKB Accession Codes:

P70671

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15800576

Title: IRF-7 is the master regulator of type-I interferon-dependent immune responses.

PubMed ID: 15800576

DOI: 10.1038/nature03464

PubMed ID: 16846591

Title: Distinct functions of IRF-3 and IRF-7 in IFN-alpha gene regulation and control of anti-tumor activity in primary macrophages.

PubMed ID: 16846591

DOI: 10.1016/j.bcp.2006.06.002

PubMed ID: 16979567

Title: Type I interferon gene induction by the interferon regulatory factor family of transcription factors.

PubMed ID: 16979567

DOI: 10.1016/j.immuni.2006.08.009

PubMed ID: 18724932

Title: Trex1 prevents cell-intrinsic initiation of autoimmunity.

PubMed ID: 18724932

DOI: 10.1016/j.cell.2008.06.032

PubMed ID: 20049431

Title: Regulation of immunity and oncogenesis by the IRF transcription factor family.

PubMed ID: 20049431

DOI: 10.1007/s00262-009-0804-6

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 22065572

Title: Inhibitor of kappaB kinase epsilon (IKK(epsilon)), STAT1, and IFIT2 proteins define novel innate immune effector pathway against West Nile virus infection.

PubMed ID: 22065572

DOI: 10.1074/jbc.m111.285205

Sequence Information:

Length: 419
Mass: 46852
Checksum: 1FF67C4E0FC7F027
Sequence:

METPKPRILP WLVSQLDLGQ LEGVAWLDES RTRFRIPWKH GLRQDAQMAD FGIFQAWAEA 
SGAYTPGKDK PDVSTWKRNF RSALNRKEVL RLAADNSKDP YDPHKVYEFV TPGARDFVHL 
GASPDTNGKS SLPHSQENLP KLFDGLILGP LKDEGSSDLA IVSDPSQQLP SPNVNNFLNP 
APQENPLKQL LAEEQWEFEV TAFYRGRQVF QQTLFCPGGL RLVGSTADMT LPWQPVTLPD 
PEGFLTDKLV KEYVGQVLKG LGNGLALWQA GQCLWAQRLG HSHAFWALGE ELLPDSGRGP 
DGEVHKDKDG AVFDLRPFVA DLIAFMEGSG HSPRYTLWFC MGEMWPQDQP WVKRLVMVKV 
VPTCLKELLE MAREGGASSL KTVDLHISNS QPISLTSDQY KAYLQDLVED MDFQATGNI

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Irf3

Associated with

Other Information

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

IRF-7 is the master regulator of type-I interferon-dependent immune responses. PubMed ID: 15800576

Distinct functions of IRF-3 and IRF-7 in IFN-alpha gene regulation and control of anti-tumor activity in primary macrophages. PubMed ID: 16846591

Type I interferon gene induction by the interferon regulatory factor family of transcription factors. PubMed ID: 16979567

Trex1 prevents cell-intrinsic initiation of autoimmunity. PubMed ID: 18724932

Regulation of immunity and oncogenesis by the IRF transcription factor family. PubMed ID: 20049431

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Inhibitor of kappaB kinase epsilon (IKK(epsilon)), STAT1, and IFIT2 proteins define novel innate immune effector pathway against West Nile virus infection. PubMed ID: 22065572