Irf6 | ENSMUSG00000026638 | NCBI 54139

Details for: Irf6

Gene ID: 54139

Symbol: Irf6

Ensembl ID: ENSMUSG00000026638

Description: interferon regulatory factor 6

Associated with

Cell development
(GO:0048468)
Cell differentiation
(GO:0030154)
Cell population proliferation
(GO:0008283)
Cranial skeletal system development
(GO:1904888)
Cytoplasm
(GO:0005737)
Dna-binding transcription activator activity, rna polymerase ii-specific
(GO:0001228)
Dna-binding transcription factor activity
(GO:0003700)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Immune system process
(GO:0002376)
Keratinocyte differentiation
(GO:0030216)
Keratinocyte proliferation
(GO:0043616)
Limb development
(GO:0060173)
Mammary gland epithelial cell differentiation
(GO:0060644)
Negative regulation of cell population proliferation
(GO:0008285)
Negative regulation of keratinocyte proliferation
(GO:0010839)
Negative regulation of stem cell proliferation
(GO:2000647)
Nucleus
(GO:0005634)
Positive regulation of dna-templated transcription
(GO:0045893)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Regulation of dna-templated transcription
(GO:0006355)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Rna polymerase ii cis-regulatory region sequence-specific dna binding
(GO:0000978)
Roof of mouth development
(GO:0060021)
Sequence-specific dna binding
(GO:0043565)
Sequence-specific double-stranded dna binding
(GO:1990837)
Skin development
(GO:0043588)
Stem cell proliferation
(GO:0072089)
Transcription cis-regulatory region binding
(GO:0000976)

Other Information

Proteins

Interferon regulatory factor 6

Genular Protein ID: 239811894

Symbol: IRF6_MOUSE

Name: Interferon regulatory factor 6

UniProtKB Accession Codes:

P97431 Q91VD0

Database IDs:

Citations:

PubMed ID: 16141072

Title: The transcriptional landscape of the mammalian genome.

PubMed ID: 16141072

DOI: 10.1126/science.1112014

PubMed ID: 19468303

Title: Lineage-specific biology revealed by a finished genome assembly of the mouse.

PubMed ID: 19468303

DOI: 10.1371/journal.pbio.1000112

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12219090

Title: Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes.

PubMed ID: 12219090

DOI: 10.1038/ng985

PubMed ID: 17041603

Title: Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch.

PubMed ID: 17041603

DOI: 10.1038/ng1894

PubMed ID: 18212048

Title: Interferon regulatory factor 6 promotes cell cycle arrest and is regulated by the proteasome in a cell cycle-dependent manner.

PubMed ID: 18212048

DOI: 10.1128/mcb.01866-07

PubMed ID: 19036739

Title: Missense mutations that cause Van der Woude syndrome and popliteal pterygium syndrome affect the DNA-binding and transcriptional activation functions of IRF6.

PubMed ID: 19036739

DOI: 10.1093/hmg/ddn381

PubMed ID: 21183079

Title: A tissue-specific atlas of mouse protein phosphorylation and expression.

PubMed ID: 21183079

DOI: 10.1016/j.cell.2010.12.001

PubMed ID: 21574244

Title: Genomic strategy identifies a missense mutation in WD-repeat domain 65 (WDR65) in an individual with Van der Woude syndrome.

PubMed ID: 21574244

DOI: 10.1002/ajmg.a.33980

Sequence Information:

Length: 467
Mass: 53111
Checksum: 1C564BC8D79C5259
Sequence:

MALHPRRVRL KPWLVAQVDS GLYPGLIWLH RDSKRFQIPW KHATRHSPQQ EEENTIFKAW 
AVETGKYQEG VDDPDPAKWK AQLRCALNKS REFNLMYDGT KEVPMNPVKI YQVCDIPQTQ 
GSVINPGSTG SAPWDEKDND VDEDEEEDEL EQSQHHVPIQ DTFPFLNING SPMAPASVGN 
CSVGNCSPES VWPKTEPLEM EVPQAPIQPF YSSPELWISS LPMTDLDIKF QYRGKEYGQT 
MTVSNPQGCR LFYGDLGPMP DQEELFGPVS LEQVKFPGPE HITNEKQKLF TSKLLDVMDR 
GLILEVSGHA IYAIRLCQCK VYWSGPCAPS LAAPNLIERQ KKVKLFCLET FLSELIAHQK 
GQIEKQPPFE IYLCFGEEWP DGKPLERKLI LVQVIPVVAR MIYEMFSGDF TRSFDSGSVR 
LQISTPDIKD NIVAQLKQLY RILQTQESWQ PMQPAPSMQL PQALPAQ

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: Irf6

Associated with

Other Information

The transcriptional landscape of the mammalian genome. PubMed ID: 16141072

Lineage-specific biology revealed by a finished genome assembly of the mouse. PubMed ID: 19468303

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes. PubMed ID: 12219090

Irf6 is a key determinant of the keratinocyte proliferation-differentiation switch. PubMed ID: 17041603

Interferon regulatory factor 6 promotes cell cycle arrest and is regulated by the proteasome in a cell cycle-dependent manner. PubMed ID: 18212048

Missense mutations that cause Van der Woude syndrome and popliteal pterygium syndrome affect the DNA-binding and transcriptional activation functions of IRF6. PubMed ID: 19036739

A tissue-specific atlas of mouse protein phosphorylation and expression. PubMed ID: 21183079

Genomic strategy identifies a missense mutation in WD-repeat domain 65 (WDR65) in an individual with Van der Woude syndrome. PubMed ID: 21574244