Details for: ALDH7A1P2

Gene ID: 542

Symbol: ALDH7A1P2

Ensembl ID: ENSG00000232292

Description: aldehyde dehydrogenase 7 family member A1 pseudogene 2

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.1348
    Cell Significance Index: 3.3700
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.0798
    Cell Significance Index: 0.8400
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.0556
    Cell Significance Index: 0.8000
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.0171
    Cell Significance Index: 0.5400
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.0100
    Cell Significance Index: 0.1100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0001
    Cell Significance Index: 0.1500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0004
    Cell Significance Index: -0.7100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0005
    Cell Significance Index: -0.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0005
    Cell Significance Index: -0.7700
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0013
    Cell Significance Index: -0.5900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0028
    Cell Significance Index: -0.5600
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: -0.0094
    Cell Significance Index: -0.1100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0188
    Cell Significance Index: -0.6600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0268
    Cell Significance Index: -0.6700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0283
    Cell Significance Index: -0.6000
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: -0.0417
    Cell Significance Index: -0.4500
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: -0.0478
    Cell Significance Index: -0.5400
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: -0.0506
    Cell Significance Index: -0.5100
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: -0.0515
    Cell Significance Index: -0.5600
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: -0.0552
    Cell Significance Index: -0.5600
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.0563
    Cell Significance Index: -0.7700
  • Cell Name: basal cell (CL0000646)
    Fold Change: -0.0770
    Cell Significance Index: -0.9200
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.0887
    Cell Significance Index: -1.0900
  • Cell Name: amacrine cell (CL0000561)
    Fold Change: -0.0994
    Cell Significance Index: -1.2500
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: -0.1022
    Cell Significance Index: -1.2800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1024
    Cell Significance Index: -1.2200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.1029
    Cell Significance Index: -1.3400
  • Cell Name: retina horizontal cell (CL0000745)
    Fold Change: -0.1031
    Cell Significance Index: -1.2900
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: -0.1169
    Cell Significance Index: -1.0600
  • Cell Name: astrocyte (CL0000127)
    Fold Change: -0.1180
    Cell Significance Index: -1.3500
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: -0.1259
    Cell Significance Index: -1.3500
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1356
    Cell Significance Index: -1.2900
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.1374
    Cell Significance Index: -1.2900
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.1513
    Cell Significance Index: -1.2500
  • Cell Name: glioblast (CL0000030)
    Fold Change: -0.2060
    Cell Significance Index: -1.2900
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: -0.2073
    Cell Significance Index: -1.2300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ALDH7A1P2 is a pseudogene, meaning that it lacks a functional gene sequence. However, it shares a high degree of sequence similarity with its functional counterpart, ALDH7A1. This pseudogene has been found to be expressed in multiple cell types, including lens fiber cells, which are crucial for maintaining the structural integrity of the lens in the eye. The expression of ALDH7A1P2 in other cell types, such as ependymal cells, astrocytes, and fibroblasts, highlights its potential role in various biological processes beyond the lens. **Pathways and Functions:** The exact mechanisms by which ALDH7A1P2 regulates cellular processes are not yet fully understood. However, its expression in immune cells, such as plasma cells and endothelial cells, suggests that it may play a role in immune responses. Additionally, its presence in oligodendrocyte precursor cells indicates that it may be involved in the development and maintenance of the central nervous system. The pseudogene's ability to interact with its functional counterpart, ALDH7A1, may also contribute to its regulatory effects on cellular processes. One potential function of ALDH7A1P2 is its ability to modulate the activity of aldehyde dehydrogenases, enzymes that catalyze the oxidation of aldehydes to carboxylic acids. This process is crucial for maintaining cellular homeostasis and preventing oxidative stress. The pseudogene's expression in cells with high levels of oxidative stress, such as lens fiber cells, may indicate its role in protecting these cells from damage. **Clinical Significance:** Despite its pseudogenic nature, ALDH7A1P2 has been implicated in several diseases and disorders. For example, its expression in lens fiber cells has been linked to cataract formation, a condition characterized by the clouding of the lens in the eye. The pseudogene's role in maintaining lens integrity may suggest that its dysregulation contributes to the development of cataracts. Furthermore, the expression of ALDH7A1P2 in immune cells has been linked to autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. The pseudogene's ability to modulate immune responses may indicate its role in regulating the activity of immune cells, such as T cells and B cells, which are central to the development of these diseases. In conclusion, the ALDH7A1P2 gene, despite its pseudogenic nature, has been found to have a significant impact on various cellular processes, including immune responses and cellular differentiation. Further research is needed to fully elucidate the mechanisms by which this pseudogene regulates cellular processes and to explore its potential therapeutic applications in diseases and disorders associated with its dysregulation.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.